Pemphigus vulgaris in advanced condition in primary care: case report
DOI:
https://doi.org/10.33448/rsd-v10i2.12270Keywords:
Pemphigus vulgaris; Basic health unit; Oral manifestations.Abstract
Pemphigus Vulgaris is a chronic autoimmune disease characterized by the formation of blisters on the skin and mucous membranes, which results in the loss of adhesion between keratinocytes, causing the disintegration of cells, a phenomenon called acantholysis. In addition to immunoglobulin G (IgG) antibodies directed against desmosomal proteins. Among immunological mediated dermatological pathologies, pemphigus vulgaris is the most common disease among pemphigus types, becoming aggressive when not previously diagnosed, initially presenting its manifestations in the oral cavity, thus the Dental Surgeon plays a crucial role in the diagnosis and management clinical presentation of oral manifestations. The case reported in this article is configured as a condition of pemphigus vulgaris that was treated and followed up, in parallel with medical treatment, at the basic health unit in the municipality of Belém-PB. However, it is concluded that it is important for the dentist to have knowledge for the recognition of autoimmune diseases, specifically pemphigus vulgaris, since early diagnosis is essential for the treatment of the pathology, avoiding posterior systemic disorders. In addition to emphasizing the role of the dental approach and the importance of multiprofessional performance.
References
Arpita R. et al. (2015). Oral Pemphigus Vulgaris: Case Report. Ethiopian-Journal of Health Sciences, 25 (4): 367–372.
Bascones-Martínez, A. et al. (2015). Immune-mediated diseases: what can be found in the oral cavity? International Journal of Dermatology, 54(3): 258–270.
Buonavoglia, A. et al. (2019). Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy. Autoimmunity Reviews, 18 (4): 349-358.
Cozzani E. et al. (2013). Are clinical phenotype and autoantibody profile always concordant in pemphigus? A study in a cohort of pemphigus patients. European Journal of Dermatology, 23(1), 40–48.
Dagistan, S. et al. (2008). Oral Pemphigus Vulgaris: A Case Report with review of literature. Journal of Oral Science, 50(3):359-62.
Deyhimi, P. & Alishahi, B. (2018). Study of Extrinsic Apoptotic Pathway in Oral Pemphigus Vulgaris Using TNFR 1 and FasL Immunohistochemical Markers and TUNEL Technique. Journal of Shiraz University Medical Sciences, 19(2): 132-141.
Ibsen, O. A. C. & Phelan, J. A. (2009) Oral Pathology for Dental Hygienist. Saunders (W.B.) Co Ltd [ebook], 5th edition.
llebrecht C.T. & Payne A.S. (2017). Setting the target for pemphigus vulgaris therapy. JCI Insight, 2(5): e92021.
Mays, J. W. et al. (2020). WWOM VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus. Oral Disease, 25(1): 111-121.
Mota, M. S. et al. (2020). Theoretical-practical reflection of multiprofessional assistance to a patient with pegphic vegetant. Research, Society and Development, 9(7): e-32973786.
Nascimento, M. A. et al. (2020). Cuidado multiprofissional ao paciente portador de pênfigo vulgar. Research, Society and Development, 9(8), e-778986596.
Saccucci, M. et al. (2018). Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management. Journal of Immunology Research, 2018: 6061825.
Shamin, T. et al. (2008). Pênfigo vulgar em cavidade oral: análise clínica de 71 casos. Medicina Oral Patologia Oral y Cirugia Bucal, 13 (10): E622-6.
Siu, A., Landon, K. & Ramos, D. M. (2015). Differential diagnosis and management of oral ulcers. Seminars in Cutaneous Medicine and Surgery, 34: 171-177.
Tavakolpour, S. (2018). Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. Springer-Verlag GmbH Germany. Archives of Dermatological Research, 310 (2): 95-106.
Vega Memíje1, M. E. et al. (2015). Is there a causal relationship between HSV 1 and pemphigus vulgaris? SpringerPlus, 4: 811.
Virgolini, L. & Marzocchi, V. (2003). Anti-CD20 monoclonal antibody (rituximab) in the treatment of autoimmune diseases. Successful result in refractory Pemphigus vulgaris: report of a case. Haematologica, 88(7): ELT24.
Uzun S. & Durdu, M. (2006). The specificity and sensitivity of Nikolskiy sign in the diagnosis of pemphigus. Journal of the American Academy of Dermatology, 54(3):411–5.
Yousefi, M. et al. (2017). The Effect of Low Level Laser Therapy on Pemphigus Vulgaris Lesions: A Pilot Study. Journal of Lasers in Medical Sciences, 8(4): 177-180.
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Copyright (c) 2021 Ramon Rodrigues de Lima; Lílian Gabriely de Sá Barreto Leite Torres ; Brenno Anderson Santiago Dias; José Martí Luna Palhano; Maria Izabela Brandão Vasconcelos; Fábio Gabriel de Sousa Carvalho; Matheus Andrade Rodrigues ; Matheus Harllen Gonçalves Veríssimo; Diego Tomaz Lacerda; Rayane Cinthia Dino do Nascimento
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