Orofacial pain and its relation with hypocalcemia associated with chronic kidney disease: an overlook differential diagnosis

Authors

DOI:

https://doi.org/10.33448/rsd-v10i2.12359

Keywords:

Facial pain; Hypocalcemia; Muscles.

Abstract

Although orofacial pain is a condition of multifactorial etiopathogenesis and sometimes it is difficult to diagnose it, a possible cause for this condition is muscle changes, which in turn can originate in systemic conditions, such as hypocalcemia. The present article aims to present a clinical situation of orofacial pain due to hypocalcemia in a young female patient with chronic kidney disease. The patient attended hospital care with strong pain complaints in the face, being evaluated by the Maxillofacial Surgery team and the Neurology medical team, without the precise determination of an etiology. Despite being prescribed oral medication, the patient returned with the complaint of pain and with a new symptom of cramping in the face, in face of that, hematological tests were requested where hypocalcemia condition was found. The therapeutic approach consisted of oral calcium supplementation, which was sufficient to suppress facial complaints. It is concluded that there is a correlation between blood calcium concentration and muscle changes in the face, requiring clinical studies that better explain this relationship.

References

Al-Shebani, T., Azeem, M., & Elhassan, E. A. (2019). A case of advanced chronic kidney disease with severe hypocalcemia, how to safely manage and dialyze? In Saudi J Kidney Dis Transpl (Vol. 30, pp. 1166-1170). https://doi.org/10.4103/1319-2442.270275

Ayouni, I., Chebbi, R., Hela, Z., & Dhidah, M. (2019). Comorbidity between fibromyalgia and temporomandibular disorders: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol, 128(1), 33-42. https://doi.org/10.1016/j.oooo.2019.02.023

Bilezikian, J. P., Brandi, M. L., Cusano, N. E., Mannstadt, M., Rejnmark, L., Rizzoli, R., Rubin, M. R., Winer, K. K., Liberman, U. A., & Potts, J. T., Jr. (2016). Management of Hypoparathyroidism: Present and Future. J Clin Endocrinol Metab, 101(6), 2313-2324. https://doi.org/10.1210/jc.2015-3910

de Brito Galvão, J. F., Schenck, P. A., & Chew, D. J. (2017). A Quick Reference on Hypocalcemia. Veterinary Clinics of North America: Small Animal Practice, 47(2), 249-256. https://doi.org/https://doi.org/10.1016/j.cvsm.2016.10.017

Hannan, F. M., & Thakker, R. V. (2013). Investigating hypocalcaemia. Bmj, 346, f2213. https://doi.org/10.1136/bmj.f2213

Hans, S. K., & Levine, S. N. (2020). Hypoparathyroidism. In StatPearls. StatPearls Publishing Copyright © 2020, StatPearls Publishing LLC.

Levin, A., Bakris, G. L., Molitch, M., Smulders, M., Tian, J., Williams, L. A., & Andress, D. L. (2007). Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int, 71(1), 31-38. https://doi.org/10.1038/sj.ki.5002009

Omerovic, S., & J, M. D. (2020). Chvostek Sign. In StatPearls. StatPearls Publishing Copyright © 2020, StatPearls Publishing LLC.

Pepe, J., Colangelo, L., Biamonte, F., Sonato, C., Danese, V. C., Cecchetti, V., Occhiuto, M., Piazzolla, V., De Martino, V., Ferrone, F., Minisola, S., & Cipriani, C. (2020). Diagnosis and management of hypocalcemia. Endocrine, 69(3), 485-495. https://doi.org/10.1007/s12020-020-02324-2

Racich, M. J. (2018). Occlusion, temporomandibular disorders, and orofacial pain: An evidence-based overview and update with recommendations. J Prosthet Dent, 120(5), 678-685. https://doi.org/10.1016/j.prosdent.2018.01.033

Scrivani, S. J., & Spierings, E. L. (2016). Classification and Differential Diagnosis of Oral and Maxillofacial Pain. Oral Maxillofac Surg Clin North Am, 28(3), 233-246. https://doi.org/10.1016/j.coms.2016.04.003

Shrimanker, I., & Bhattarai, S. (2020). Electrolytes. In StatPearls. StatPearls Publishing Copyright © 2020, StatPearls Publishing LLC.

Spencer, C. J., & Gremillion, H. A. (2007). Neuropathic orofacial pain: proposed mechanisms, diagnosis, and treatment considerations. Dent Clin North Am, 51(1), 209-224, viii. https://doi.org/10.1016/j.cden.2006.09.006

Vikrant, S., & Parashar, A. (2016). Prevalence and severity of disordered mineral metabolism in patients with chronic kidney disease: A study from a tertiary care hospital in India. Indian J Endocrinol Metab, 20(4), 460-467. https://doi.org/10.4103/2230-8210.183457

Webster, A. C., Nagler, E. V., Morton, R. L., & Masson, P. (2017). Chronic Kidney Disease. Lancet, 389(10075), 1238-1252. https://doi.org/10.1016/s0140-6736(16)32064-5

Wong, W. H., & Bullard, D. S. (2016). Male With Numbness and Muscle Spasms. Ann Emerg Med, 68(4), e71-72. https://doi.org/10.1016/j.annemergmed.2016.02.045

Pereira, A. S. (2018). Metodologia da pesquisa científica. Santa Maria, Brasil: UFSM, NTE.

Zakrzewska, J. M. (2013). Differential diagnosis of facial pain and guidelines for management. Br J Anaesth, 111(1), 95-104. https://doi.org/10.1093/bja/aet125

Zakrzewska, J. M., & Jensen, T. S. (2017). History of facial pain diagnosis. Cephalalgia, 37(7), 604-608. https://doi.org/10.1177/0333102417691045

Published

09/02/2021

How to Cite

SANTOS, A. M. de S.; BARBOSA, S.; PALIN , L. P.; SILVA, W. P. P. da .; SANTOS , J. M. F. e .; MACHADO , N. E. da S. .; LIMA NETO, T. J. de .; RIOS , B. R. .; VIEIRA , . E. H. .; FAVERANI, L. P. Orofacial pain and its relation with hypocalcemia associated with chronic kidney disease: an overlook differential diagnosis. Research, Society and Development, [S. l.], v. 10, n. 2, p. e17710212359, 2021. DOI: 10.33448/rsd-v10i2.12359. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12359. Acesso em: 12 nov. 2024.

Issue

Section

Health Sciences