New alkaloids from Ocotea duckei vattimo (Lauraceae)

Authors

DOI:

https://doi.org/10.33448/rsd-v10i4.12800

Keywords:

Ocotea; Lauraceae; Alkaloids; Chemical compounds.

Abstract

Ocotea duckei Vattimo, popularly known as “louro-de-cheiro”, “louro-pimenta”, and “louro-canela”  is a member of the Lauraceae family found in the Northeast region of Brazil. It is popularly used to treat neuralgia, dyspepsia, anorexia and pain. This current study aimed to promote the isolation and the identification / determination of new secondary metabolites of the species O. duckei Vattimo. In order to obtain the vegetable drug of O. duckei, its stem barks were harvested and submitted to a drying process followed by pulverization. The Crude Ethanolic Extract (BSE), obtained from the vegetable drug, was then subjected to an alkaloid extraction protocol in order to generate its Total Alkaloid Fraction (TAF). The isolation and identification of chemical compounds were carried out by chromatographic and spectroscopic methods respectively. The chemical investigation of O. duckei resulted in the isolation of three compounds: Ocoteaduccin A (OD-1, 0.020 g), Ocoteaduccin B (OD-2, 0.015 g), and N-methylcoclaurine (OD-3, 0.008 g). O. duckei proved to be a promising species, due to the variety of isolated chemical compounds. Further chemical, pharmacological and toxicological studies must be conducted in order to improve the phytochemical knowledge about this plant.

References

Barbosa-Filho, J. M., Yoshida, M., & Gottlieb, O. R. (1989). Lignoids from Nectandra amazonum and N. glabrescens. Phytochemistry, 28 (7), 1989.

Beech, E., Rivers, M., Oldfield, S., & Smith, P. P. (2017). GlobalTreeSearch: The first complete global database of tree species and country distributions. Journal of Sustainable Forestry, 36 (5), 454-489.

Da Silva, I. G., Barbosa-Filho, J. M., Da Silva, M. S., De Lacerda, C. D. G., & da-Cunha, E. V. L. (2002). Coclaurine from Ocotea duckei. Biochemical Systematics and Ecology, 30 (9), 881-883.

Dias, C. S., Silva, I. G., Cunha, E. V. L., Silva, M. S., Braz-Filho, R., & Barbosa-Filho, J. M. (2003). Isolation and identification of new alkaloids from Ocotea duckei Vattimo (Lauraceae). Revista Brasileira de Pharmacognosia, 13, 62-63.

Lacerda, C. D. G. (2004) Review of Lauraceae alkaloids and phytochemical study of Ocotea duckei Vattimo (Doctoral Thesis in Natural and Bioactive Synthetic Products).

Martins, E. R. (2018). Biological and Chemical Evaluation of Volatile Oils from leaves of Iryanthera Polyneura Ducke (Myristicaceae) and the Influence of climatic factors (Doctoral dissertation, Universidade Paulista).

Morais, L. L., Pachú, C. O., Santos, V. L., & Barbosa-Filho, T. M. (1996). New lignan from Ocotea duckei. Phytotherapy (Milano), 67 (6).

Morais, L. L., Pachú, C. O., Santos, V. L., Athayde-Filho, P. F., & Almeida, R. N. (1998a). (+) - 4'-O-demethylepimagnolin A from Ocotea duckei. Phytotherapy (Milano), 69 (1), 91-92.

Morais, L. C. S. L., Barbosa-Filho, J. M., & Almeida, R. N. (1998b). Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice. Journal of Ethnopharmacology, 62 (1), 57-61.

Oliveira, J. G. D. S. (2018). Bioprospecting of alkaloids in extracts of endophytic fungi of Duroia macrophylla Huber (Rubiaceae).

Oliveira ‐ Filho, A. T., & Fontes, M. A. L. (2000). Patterns of floristic differentiation among Atlantic Forests in Southeastern Brazil and the influence of climate 1. Biotropica, 32 (4b), 793-810.

Pino, J. A., Marbot, R., Payo, A., Chao, D., Herrera, P., & Martí, M. P. (2005). Leaf oil of Licaria triandra (Sw.) Kostermans. Journal of Essential Oil Research, 17 (4), 382-383.

Quinet, A.; Baitello, J.B .; Moraes, P.L.R .; Assis, L .; Alves, F.M. 2015. Lauraceae. In: List of Species of Flora of Brazil. Botanical Garden of Rio de Janeiro. Available at http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/ FB143. (accessed on 25/10/2019).

Santos, S. O., & Alves, M. (2012). Flora of the São José Plant, Igarassu, Pernambuco: Lauraceae. Rodriguésia, 63 (3), 689-703.

The Plant List. 2013. Available at http://theplantlist.org/1.1/browse/A/Lauraceae/Ocotea/ (accessed on 12/10/19).

Villamizar, V. E. M. (2010). Secondary metabolites with biological (pharmacological) activity, ethnobotanical application; and phytochemistry of some species of the genera: Ocotea, Cryptocarya, Litsea, Caryodaphnosis, Machilus and Actinodaphne (Lauraceae). Duazary, 7 (1), 152-170.

Downloads

Published

11/04/2021

How to Cite

PEIXOTO, L. R. .; TAVARES, J. F. .; NASCIMENTO, Y. M. do .; SOUTO, A. L. .; BRAZ FILHO, R.; SOUZA, F. S. de .; BARBOSA FILHO, J. M. New alkaloids from Ocotea duckei vattimo (Lauraceae) . Research, Society and Development, [S. l.], v. 10, n. 4, p. e28910412800, 2021. DOI: 10.33448/rsd-v10i4.12800. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12800. Acesso em: 21 jun. 2021.

Issue

Section

Agrarian and Biological Sciences