Clinical use of Cymbopogon citratus stapf products in bucal pathologies: integration review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i3.12844

Keywords:

Candida; Buccal candidiasis; Cymbopogon citratus Stapf.

Abstract

This work aims to present an integrative review on the potential of Cymbopogon citratus (DC.) Stapf on candidiasis in the oral cavity. Articles published in the LILACS, MEDLINE/PUBMED databases were selected, using the descriptors: CymbopogonCandida and oral candidiasis. Studies that were related to the purpose of the review and the presence of the aforementioned descriptors in the title, abstract and body of the text were included in Portuguese and or English. The selection of articles resulted in 67 studies, of which 16 were selected to compose the manuscript, which demonstrated the ways of using C. citratus and its action in the treatment of oral candidiasis. It was possible to demonstrate the effectiveness of using C. citratus to treat infections of the genus Candida that affect the oral cavity, mainly as a complement to conventional treatment. However, caution is required when prescribing use, since most studies were carried out in laboratories and have not been tested in vivo. It is concluded that both the essential oil and the extract of C. citratus have antifungal action against the genus Candida, although some studies show cytotoxicity and mutagenicity, which must be considered for the safety of its use.

References

Almeida, R. B. A., et al (2008). Atividade antimicrobiana de Cymbopogon citratus (DC.) stapf sobre Candida spp. Revista. Odontologia UNESP, 37(2), 147-153. https://www.revodontolunesp.com.br/article/588018447f8c9d0a098b4b48

Almeida, R. B. A., et al (2013). Antimicrobial activity of the essential oil of Cymbopogon citratus (DC) Stapf. on Staphylococcus spp., Streptococcus mutans and Candida spp. Revista Brasileira de Plantas Medicinais, (Botucatu), 15(4), 474-482. 10.1590/S1516-05722013000400002

Bhatti, M. A., et al (2018). Evalution of antibacterial and antifungal activities of cymbopogon citratus & psidium guajava from Sialkot orogin. PharmacologyOnLine, 1, 155–163. https://www.researchgate.net/publication/325263205_Evaluation_of_antibacterial_and_antifungal_act ivities_of_cymbopogon_citratus_and_psidium_Guajava_from_Sialkot_origin

Boukhatem, M. N., Ferhat, M. A., Kameli, A., Saidi, F., & Kebir, H. T. (2014). Lemon grass (cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan Journal of Medicine, 9, 25431.10.3402/LJM.V9.25431

Chatrath, A., Gangwar, R., Kumari, P., & Prasad, R. (2019). In Vitro Anti-Biofilm Activities of Citral and Thymol Against Candida Tropicalis. Journal of Fungi, 5(1), 13. 10.3390/jof5010013

Crocco, E. I., et al (2004). Identificação de espécies de Candida e susceptibilidade antifúngica in vitro: estudo de 100 pacientes com candidíases superficiais. Anais Brasileiros de Dermatologia, 79(6), 689-97. 10.1590/S0365-05962004000600005

Dutta, B. K., Karmakar, S., Naglot, A., Aich, J. C., & Begam, M. (2007). Anticandidial activity of some essential oils of a mega biodiversity hotspot in India. Mycoses, 50(2), 121–124. 10.1111/j.1439-0507.2006.01332.x

Ekpenyong, C. E., & Akpan, E. E. (2015). Use of Cymbopogon citratus essential oil in food preservation: Recent advances and future perspectives. Critical Reviews in Food Science and Nutrition, 57(12), 2541-2559. 10.1080/10408398.2015.1016140

Irkin, R., & Korukluoglu, M. (2009). Effectiveness of Cymbopogon citratus L. essential oil to inhibit the growth of some filamentous fungi and yeasts. Journal of Medicine Food, 12(1), 193-197. 10.1089/jmf.2008.0108

Juniatik, M., Hidayati, K., Wulandari, F.P., Pangestuti, N., Munawaroh, N., Martien, R., & Utami, S. (2017). Formulation of nanoemulsion mouthwash combination of lemongrass oil (cymbopogon citratus) and kaffir lime oil (Citrus hystrix) AGAINST Candida albicans ATCC 10231. Traditional Medicine Journal, 22(1), 7-15. 10.22146/tradmedj.24255

Khan, M. S., & Ahmad, I. (2012). Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans. Journal of Ethnopharmacology, 140(2), 416–423. 10.1016/j.jep.2012.01.045

Khosravi, A.R., Sharifzadeh, A., Nikaein, D., Almaie, Z., & Gandomi, N.H. (2018). Chemical composition, antioxidant activity and antifungal effects of five Iranian essential oils against Candida strains isolated from urine samples. Journal of Medical Mycology, 28(2), 355–360. 10.1016/j.mycmed.2018.01.005

Koseki, Y., Tanaka, R., & Murata, H. (2018). Development of antibacterial denture cleaner for brushing containing tea tree and lemongrass essential oils. Dental Materials Journal, 37(4), 659–666. 10.4012/dmj.2017-295

Leite, M. C., De Brito Bezerra, A. P, De Sousa, J. P., & De Oliveira L.E. (2015). Investigating the antifungal activity and mechanism(s) of geraniol against Candida albicans strains. Medical Mycology, 53(3), 275–284. 10.1093/mmy/myu078

Lemos, G. C. S., Santos, A. D., Freitas S. P., & Gravina, G. A. (2013). Controle de plantas invasoras em cultivo orgânico e convencional de capim-limão (Cymbopogoncitratus). Revista Brasileira de Plantas Medicinais, 15(3), 405-414. 10.1590/S1516-05722013000300014

Machado, A.C., & Oliveira, R. (2014). Medicamentos Fitoterápicos na odontologia : evidências e perspectivas sobre o uso da aroeira-do-sertão (Myracrodruon urundeuva Allemão ). Revista Brasileira de Plantas Medicinais, 16(2), 283–289. 10.1590/S1516-05722014000200018

Madeira, P. L. B., et al (2016). In vitro Effects of Lemongrass Extract on Candida albicans Biofilms, Human Cells Viability, and Denture Surface. Frontiers in Cellular and Infection Microbiology, 6, 71.10.3389/fcimb.2016.00071

Melo, I. A., & Guerra, R. C. (2014). Candidíase oral: um enfoque sobre a estomatite por prótese. Salusvita, 33(3), 389–414. https://www.researchg ate.net/publication/270498018_candidiase_oral_um_enfoque_sobre_a_estomatite_por_protese

Mendes, K. D. S., et al (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto-contexto Enfermagem, 17(4), 758-764. 10.1590/S0104-07072008000400018

Miranda-Cadena, K., Marcos-Arias, C., Mateo, E., Aguirre, J. M., Quindós, G., & Eraso, E. ( 2018). Prevalence and antifungal susceptibility profiles of Candida glabrata, Candida parapsilosis and their close-related species in oral candidiasis. Archives of Oral Biology, 95, 100–107. 10.1016/j.archoralbio.2018.07.017

Orlando, J. B., et al (2019). Genotoxic effects induced by beta-myrcene following metabolism by liver HepG2/C3A human cells. Journal of Toxicoogyl and Environmental Health, Part A, 82(3), 176–185. 10.1080/15287394.2019.1577195

Pavithra, J. A., Srinikethan, G., Shubhada, C., Pradeep, K., Gopala, M., Kulkarni, R., & Praveenchandra, Kr. (2014) .Effect of five plant extracts on adhesion of Candida albicans onto human buccal epithelial cells: an in-vitro study. Egyptian Pharmaceutical Journal, 13(2), 137. 10.4103/1687-4315.147089

Pereira, A. S., et al (2018). Metodologia da pesquisa científica. UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1

Pokpong, A., Suwan, C., & Theerathavaj, S. (2014). Lemongrass-Incorporated Tissue Conditioner Against Candida albicans Culture. Journal of clinical and diagnostic research : JCDR, 8(7), ZC50–ZC52. 10.7860/JCDR/2014/8378.4607

Prakash, S., Ramasubburayan, R., Ramkumar, V. S., Kannapiran, E., Palavesam, A., & Immanuel, G. (2016). In vitro-scientific evaluation on antimicrobial, antioxidant, cytotoxic properties and phytochemical constituents of traditional coastal medicinal plants. Biom Pharmaceuticals, 83, 648-657. 10.1016/J.BIOPHA.2016.07.019

Queiroz, T. B., et al (2017). Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2). Genetics and Molecular Research, 16(3). 10.4238/gmr16039777

Sharifzadeh, A., Khosravi, A. R., Shokri, H., Asadi Jamnani, F., Hajiabdolbaghi, M., & Ashrafi Tamami, I. (2013). Oral microflora and their relation to risk factors in HIV+patients with oropharyngeal candidiasis. Journal of Medical Mycology, 23(2), 105–112. 10.1016/j.mycmed.2013.02.001

Silva, C. B., Guterres, S. S., Weisheimer, V., & Schapoval, E. R. S. (2008). Antifungal activity of the lemongrass oil and citral against Candida spp. Brazilian Journal of Infectious Diseases, 12(1), 63-66. 10.1590/S1413-86702008000100014

Silva, N. B., et al (2017). Antifungal Activity of the Essential Oil of Cymbopogon citratus (DC) Stapf. An in vitro study. Journal of Oral Research, [S.l.], 6(12), 319-323. 10.17126/joralres.2017.092

Sousa, J. P., et al (2016). Antifungal Activity of Citral by Disruption of Ergosterol Biosynthesis in Fluconazole Resistant Candida tropicalis. International Journal of Tropical Disease & Health, 11(4), 1–11. 10.9734/IJTDH/2016/21423

Souza, A. C. S., et al (2019). Citral presents cytotoxic and genotoxic effects in human cultured cells. Drug and Chemical Toxicology, 43(4), 2019.

1080/01480545.2019.1585445

Spalanzani, R. N., et al (2018). Clinical and laboratorial features of oral candidiasis in HIV-positive patients. Revista da Sociedade Brasileira de Medicina Tropical, 51(3), 352–356. 10.1590/0037-8682-0241-2017

Swetha, T., Peter, D., Mccall, A., Hwang-Wong, E., Rojas, I.G., Cormack, B., & Edgerton, M. (2016). Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis. PLoS Pathogens, 12(3), 1–21. 10.1371/journal.ppat.1005522

Taweechaisupapong, S., Aieamsaard, J., Chitropas, P., & Khunkitti, C.W. (2012). Inhibitory effect of lemongrass oil and its major constituents on Candida biofilm and germ tube formation. South African Journal of Botany, 81, 95–102. 10.1016/j.sajb.2012.06.003

Taweechaisupapong, S., Ngaonee, P., Patsuk, P., Pitiphat, W., & Khunkitti, W. (2012). Antibiofilm activity and post antifungal effect of lemongrass oil on clinical Candida dubliniensis isolate. South African Journal of Botany, 78, 37–43. 10.1016/j.sajb.2011.04.003

Taweechaisupapong, S., Boonmars. T., Satthanakul, P., Chatchanayuenyong, V., Nitinon, S., Soodtoetong, U., Thipsongkroh, W., & Khunkitti1, W. (2018). Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis. Songklanakarin Journal of Science and Technology, 42(2), 299-304. 10.1456/sjst-psu.2020.39

Tyagi, A. K., & Malik, A. (2010). Liquid And Vapour-Phase Antifungal Activities Of Selected Essential Oils Against Candida Albicans: Microscopic Observations And Chemical Characterization Of Cymbopogon Citratus. Bmc Complementary And Alternative Medicine, 10, 65. 10.1186/1472-6882-10-65

Published

08/03/2021

How to Cite

VIANA, M. A. C. B. M.; ALVERGA, C. C. F. .; RODRIGUES, G. M. de F.; CORDEIRO, L. V.; LIMA, E. O. Clinical use of Cymbopogon citratus stapf products in bucal pathologies: integration review. Research, Society and Development, [S. l.], v. 10, n. 3, p. e13010312844, 2021. DOI: 10.33448/rsd-v10i3.12844. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12844. Acesso em: 12 apr. 2021.

Issue

Section

Health Sciences