Photobiomodulatory effect of red, blue and green lights on collagen during the healing process of skin burns: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i3.12855

Keywords:

Phototherapy; Low intensity light therapy; Burns; Healing.

Abstract

Introduction: Wound healing is a mechanism that involves a sequence of molecular events for the purpose of tissue repair. In this sense, the use of LED and laser phototherapy stands out due to its bio-stimulating characteristics for a cell during the repair process. Objective: to carry out a literature review in order to observe the photobiomodulator effect of red, blue and green lights on collagen during the healing process of burns. Methodology: this is an integrative literature review, carried out in the Pubmed, Web of Science and Lilacs databases. Results: among the 1,721 studies found, only 18 articles, published between 2011 and 2020, were used for the results. Conclusion: The photobiomodulation of red, blue and green lights in the skin burn repair process satisfactory results mainly in relation to collagen production, angiogenesis, reduction of inflammation, reduction of the size of the lesion and stimulation of fibroblasts.

References

Beheregaray, W. K., Gianotti, G. C., Oliveira, F., Terraciano, P., Bianchi, S., Vidor, S., Marcolan, C. F., Contesini, E. A., & Cirne-Lima, E. O. (2017). Células-tronco mesenquimais aplicadas nas fases inflamatória e proliferativa da cicatrização de feridas cutâneas. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 69(6), 1591-1600. https://dx.doi.org/10.1590/1678-4162-9461.

Brassolatti, P., Bossini, P. S., Oliveira, M. C., Kido, H. W., Tim, C. R., Almeida-Lopes, L., De Avó, L. R., Araújo-Moreira, F. M., & Parizotto, N. A. (2016). Comparative effects of two different doses of low-level laser therapy on wound healing third-degree burns in rats. Microsc Res Tech, 79(4), 313-320. https://doi.org/10.1002/jemt.22632.

Campos, A. C. L., Borges-Branco, A., & Groth, A. K. (2007). Cicatrização de feridas. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, 20(1), 51-58. http://dx.doi.org/10.1590/S0102-67202007000100010.

Castilho Filho, T. (2003). Avaliação da ação da radiação laser em baixa intensidade no processo de ósseo-integração de implantes de titânio inseridos em tíbia de coelhos. Dissertação de Mestrado, Instituto de pesquisa energéticas nucleares da Faculdade de Odontologia da Universidade de São Paulo; São Paulo, SP, Brasil.

Catão M. H. C. V., Nonaka, C. F. W., de Albuquerque Júnior, R. L. C., Bento, P. M., & Costa, R. O. (2015). Effects of red laser, infrared, photodynamic therapy, and green LED on the healing process of third-degree burns: clinical and histological study in rats. Lasers in Medical Science, 30(1), 421–428. https://doi.org/10.1007/s10103-014-1687-0.

Catão, M. H. C. V., Costa R. O., Nonaka C. F. W., Albuquerque Junior, R. C., & Costa, I. R. R. S. (2016). Green LED light has anti-inflammatory effects on burns in rats. Burns, 42(2), 392-396. https://doi.org/10.1016/j.burns.2015.07.003.

Cavalcanti, T. M., Almeida-Barros, R. Q., Catão, M. H. C. V., Feitosa, A. P. A., & Lins, R. D. A. U. (2011). Conhecimento das propriedades físicas e da interação do laser com os tecidos biológicos na odontologia. Anais Brasileiros de Dermatologia, 86(5), 955-960. https://doi.org/10.1590/S0365-05962011000500014.

Chiarotto, G. B., Neves, L. M. G., Esquisatto, M. A. M., Amaral M. E. C., Santos G. M. T., & Mendonça F. A. S. (2014). Effects of laser irradiation (670-nm InGaP and 830-nm GaAlAs) on burn of second-degree in rats. Lasers in Medical Science, 29(5), 1685–1693. https://doi.org/10.1007/s10103-014-1573-9.

de Mendonça, R. J., & Coutinho-Netto, J. (2009). Aspectos celulares da cicatrização. Anais Brasileiros de Dermatologia, 84(3), 257-262. https://doi.org/10.1590/S0365-05962009000300007.

de Moraes, J. M., Mendonça, D. E. O., Moura, V. B. L., Oliveira, M. A. P., Afonso, C. L., Vinaud, M. C., Bachion, M. M., & Lino Junior, R. Jr. (2013). Anti-inflammatory effect of low-intensity laser on the healing of third-degree burn wounds in rats. Lasers in Medical Science, 28(4), 1169-1176. https://doi.org/10.1007/s10103-012-1213-1.

de Oliveira, R. A., Boson, L. L. B., Portela, S. M. M., Maia Filho, A. L. M., & de Oliveira, D. S. (2017). Low-intensity LED therapy (658 nm) on burn healing: a series of cases. Lasers in Medical Science, 33(4), 729-735. https://doi.org/10.1007/s10103-017-2399-z.

Fantinati, M. S., Mendonça, D. E. O., Fantinati, A. M. M., Barbosa, D. A., Araújo, L. C., Afonso, C. L., Vinaud, M. C., & Lino Júnior, R. S. (2016). Activity of low level laser therapy on burning wounds in diabetic rats. Rev Bras Queimaduras, 15(1), 42-49.

Fekrazad, R., Nikkerdar, A., Khojasteh J., Kalhori, K. A, M., Abbas, F. M., & Vahid, F. S. (2017). Evaluation of therapeutic laser influences on the healing of third-degree burns in rats according to different wavelengths. Journal of Cosmetic and Laser Therapy, 19(4), 232-236. https://doi.org/10.1080/14764172.2017.1288255.

Fernandes Neto, J. A., Nonaka C. F. W., & Catão M. H. C. V. (2018). Effect of blue LED on the healing process of third-degree skin burns: clinical and histological evaluation. Lasers in Medical Science, 34(4), 721-728. https://doi.org/10.1007/s10103-018-2647-x.

Fiório, B. F., Silveira Junior L., Munin E., Lima C. J., Fernandes K. P. S., R., Mesquita-Ferrari R. A., Carvalho, P. T. C., Lopes-Martins R. A. B., Aimbire F., & Carvalho R. A. (2011). Effect of incoherent LED radiation on third-degree burning wounds in rats. Journal of Cosmetic and Laser Therapy, 13(6), 315-322. https://doi.org/10.3109/14764172.2011.630082.

Fiório, F. B., Albertini, R., Leal-Junior, E. C. P., & Carvalho P. T. C. (2014). Effect of low-level laser therapy on types I and III collagen and inflammatory cells in rats with induced third-degree burns. Lasers in Medical Science, 29(1), 313–319. https://doi.org/10.1007/s10103-013-1341-2.

Jin, J., Zheng, X., He, F., Zhang, Y., Zhou, H., Luo, P., Hu, X., & Xia, Z. (2018). Therapeutic efficacy of early photobiomodulation therapy on the zones of stasis in burns: An experimental rat model study. Wound Repair and Regeneration, 26(6), 426-436. https://doi.org/10.1111/wrr.12661.

Lins, R. D. A. U., Dantas, E. M., Lucena, K. C. R., Catão, M. H. C. V, Granville-Garcia, A. F, & Carvalho Neto, L. G. (2010). Efeitos bioestimulantes do laser de baixa potência no processo de reparo. Anais Brasileiros de Dermatologia, 85(6), 849-855. https://doi.org/10.1590/S0365-05962010000600011.

Maligieri, L. A. O., Neves, L. M. G., de Morais, D. T., Domingues, R. F., de Aro, A. A., Pimentel, E. R., do Amaral, M. E. C., Esquisatto, M. A. M., Dos Santos, G. M. T., & Mendonça, F. A. S. (2017). Differing energy densities with laser 670nm InGaP controls inflammation and collagen reorganization in burns. Burns, 43(7), 1524-1531. https://doi.org/10.1016/j.burns.2017.04.008.

Melo, M. S., Alves, L. P., Fernandes, A. B. Carvalho, H., C., de Lima, C. J., Munin, E., Gomes, M. F., Salgado, M. A. C., & Zângaro, R. A. (2018). LED phototherapy in full-thickness burns induced by CO2 laser in rats skin. Lasers in Medical Science, 33, 1537–1547. https://doi.org/10.1007/s10103-018-2515-8.

Meyer, P. F., Araújo, H. G., Carvalho, M. G. F., Tatum, B. I. S., Fernandes, I. C. A. G., Ronzio, O. A., & Pinto, M. V. M. (2010). Avaliação dos efeitos do LED na cicatrização de feridas cutâneas em ratos Wistar. Fisioterapia Brasil, 11(6), 428-432. http://dx.doi.org/10.33233/fb.v11i6.1592.

Nogueira, V. C., Coelho, N. P. M. F., de Barros, T. L., Silva, S. M. M. S., Martins, M., & Arisawa, E. A. L. (2014). Biomodulation effects of LED and therapeutic ultrasound combined with semipermeable dressing in the repair process of cutaneous lesions in rats. Acta cir. Bras, 29(9), 588-595. https://doi.org/10.1590/S0102-8650201400150006.

Pereira, A. N., Eduardo, C. P., Matson, E., & Marques, M. M. (2002). Effect of low‐power laser irradiation on cell growth and procollagen synthesis of cultured fibroblastos. Lasers in Surgery and Medicine, 31(4), 263–267. https://doi.org/10.1002/lsm.10107.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica: UAB/NTE/UFSM.

Piva, J. A. A. C., Abreu, E. M. C., Silva, V., & Nicolau, R. A. (2011). Ação da terapia com laser de baixa potência nas fases iniciais do reparo tecidual: princípios básicos. An. Bras. Dermatol, 86(5), 947-954. https://doi.org/10.1590/S0365-05962011000500013.

Rathnakar, B., Rao, B. S. S., Prabhu, V., Chandra, S., Rai, S., Rao, A. C. K., Sharma, M., Gupta, P. K., & Mahato, K. K. (2016). Photo-biomodulatory response of low-power laser irradiation on burn tissue repair in mice. Lasers in Medical Science, 31(9), 1741–1750. https://doi.org/10.1007/s10103-016-2044-2.

Renno, A. C., Iwama, A. M., Shima, P., Fernandes, K. R., Carvalho, J. G., De Oliveira P., & Ribeiro, D. A. (2011). Effect of low-level laser therapy (660 nm) on the healing of second-degree skin burns in rats. J Cosmet Laser Ther, 13(5), 237-242. https://doi.org/10.3109/14764172.2011.606466.

Robson, M. C., Steed, D. L., & Franz, M. G. (2001). Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg, 38(2), 72-140. https://doi.org/10.1067/msg.2001.111167.

Silveira, P. C. L., Ferreira, K. B., da Rocha, F. R., Pieri B. L. S., Pedroso G. S., de Souza C. T., Nesi, R. T., & Pinho, R. A. (2016). Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on inflammatory response in burn wound healing. Inflammation, 39(4), 1395–1404. https://doi.org/10.1007/s10753-016-0371-x.

Simões, T. M. S., Fernandes Neto, J. A., de Oliveira, T. K. B., Nonaka C. F. W., & Catão, M. H. C. V. (2019). Photobiomodulation of red and green lights in the repair process of third-degree skin burns. Lasers in Medical Science, 35(1), 51–61. https://doi.org/10.1007/s10103-019-02776-7.

Published

03/03/2021

How to Cite

SOUZA, A. O. N. de; CATÃO, M. H. C. de V. Photobiomodulatory effect of red, blue and green lights on collagen during the healing process of skin burns: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 3, p. e3010312855, 2021. DOI: 10.33448/rsd-v10i3.12855. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12855. Acesso em: 14 apr. 2021.

Issue

Section

Health Sciences