The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori

Authors

DOI:

https://doi.org/10.33448/rsd-v10i4.12938

Keywords:

Helicobacter pylori; Virulence factors; CagA; VacA; Gastropathies.

Abstract

The virulence factors cagA and vacA, are closely related to the pathogenicity of Helicobacter pylori. These factors are widely studied and associated with a higher risk of developing several gastroduodenal clinical outcomes, such as gastric cancer. Besides presenting several genetic polymorphisms, which can vary according to the geographic region, leading to different levels of toxicity and clinical gastric manifestations. Through an integrative review of the literature we analyzed the clinical/epidemiological studies published between 2015 and 2020 in the LILACS, Scielo and PubMed databases, aiming to gather the most recent and important data on the various polymorphisms in the factors of virulence cagA and vacA and gastroduodenal clinical outcomes. Nineteen studies were identified that contemplated the objective of this review and a great variety of polymorphisms and genetic combinations of these virulence factors were observed in association with several clinical outcomes. It was also noted the existence of genetic profiles of prevalence of H. pylori strains and associations with distinct gastric pathologies in certain geographical regions. Although some conflicting results were identified, the understanding of these findings and the identification of possible contributing genes in gastric pathologies may serve as markers for the development of strategies for the prevention of these pathologies and better treatment efficacy.

References

Aftab, H., Miftahussurur, M., Subsomwong, P., Ahmed, F., Khan, A. K. A., Matsumoto, T., Suzuki, R., & Yamaoka, Y. (2017). Two populations of less-virulent Helicobacter pylori genotypes in Bangladesh. Plos One, 12(8).

Akeel, M., Shehata, A., Elhafey, A., Elmakki, E., Aboshouk, T., Ageely, H., & Mahfouz, M. (2019). Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes. BMC Gastroenterology, 19 (1), 16.

Ansari S, Yamaoka Y. (2019). Helicobacter pylori Virulence Factors Exploiting Gastric Colonização e sua Patogenicidade. Toxinas (Basileia).11(11):677.

Archampong, T. N., Asmah, R. H., Aidoo, E. K., Wiredu, E. K., Gyasi, R. K., Adjei, D. N., Beleza, S., Bayliss, C. D., & Krogfelt, K. (2017). Helicobacter pylori cagA and vacA genes in dyspeptic Ghanaian patients. BMC Research Notes, 10(1), 231.

Backert, S., Blaser, M. J. (2016). The Role of CagA in the Gastric Biology of Helicobacter pylori. Cancer Res. 76(14), 4028–4031.

Bibi, F., Alvi, S. A., Sawan, S. A., Yasir, M., Sawan, A., Jiman-Fatani, A. A., & Azhar, E. I. (2017). Detection and Genotyping of Helicobacter pylori among Gastric ulcer and Cancer Patients from Saudi Arabia. Pakistan journal of medical sciences, 33(2), 320–324.

Diaconu, S., Predescu, A., Moldoveanu, A., Pop, C. S., & Fierbințeanu-Braticevici, C. (2017). Helicobacter pylori infection: old and new. J Med Life. 10(2):112-117.

El Khadir, M., Alaoui Boukhris, S., Benajah, D. A., El Rhazi, K., Ibrahimi, S. A., El Abkari, M., Harmouch, T., Nejjari, C., Mahmoud, M., Benlemlih, M., & Bennani, B. (2017). VacA and CagA Status as Biomarker of Two Opposite End Outcomes of Helicobacter pylori Infection (Gastric Cancer and Duodenal Ulcer) in a Moroccan Population. PloS one, 12(1).

Foegeding, N. J., Caston, R. R., McClain, M. S., Ohi, M. D., & Cover, T. L. (2018). An Overview of Helicobacter pylori VacA Toxin Biology. Toxins. 8(6), 173-194.

Hatakeyama, M. (2017). Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc Jpn Acad Ser B Phys Biol Sci. 93(4):196-219.

Hooi, J. K. Y., et al (2017). Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 153(2):420-429.

Idowu, A., Mzukwa, A., Harrison, U., Palamides, P., Haas, R., Mbao, M., Mamdoo, R., Bolon, J., Jolaiya, T., Smith, S., Ally, R., Clarke, A., & Njom, H. (2019). Detection of Helicobacter pylori and its virulence genes (cagA, dupA, and vacA) among patients with gastroduodenal diseases in Chris Hani Baragwanath Academic Hospital, South Africa. BMC gastroenterology, 19(1), 73.

Imkamp, F., Lauener, F. N., Pohl, D., Lehours, P., Vale, F. F., Jehanne, Q., Zbinden, R., Keller, P. M., & Wagner, K. (2019). Rapid Characterization of Virulence Determinants in Helicobacter pylori Isolated from Non-Atrophic Gastritis Patients by Next-Generation Sequencing. Journal of clinical medicine, 8(7), 1030.

Inagaki, T., Nishiumi, S., Ito, Y., Yamakawa, A., Yamazaki, Y., Yoshida, M., & Azuma, T. (2017). Associations Between CagA, VacA, and the Clinical Outcomes of Helicobacter Pylori Infections in Okinawa, Japan. The Kobe journal of medical sciences, 63(2), E58–E67.

Kao, C. Y., Sheu, B. S., & Wu, J. J. (2016). Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J. 39(1):14-23.

Leyva, L. M., Aleaga, Y. M., González, B. L. R., Zamora, O. R., & González, S. R. M. (2016). Presencia del gen cagA y de la citotoxina vacA del Helicobacter pylori en pacientes dispépticos. Revista Cubana de Medicina Militar, 45(4), 1-9.

McClain, M. S., Beckett, A. C., & Cover, T. L. (2017). Helicobacter pylori Vacuolating Toxin and Gastric Cancer. Toxins (Basel). 9(10), 316.

Melo-Narváez, M. C., Rojas-Rengifo, D. F., Jiménez-Soto, L. F., Delgado, M. d. P., Molano, B. M. d., Vera-Chamorro, J. F., & Jaramillo, C. (2018). Genotyping of cagA and the intermediate region of vacA in strains of Helicobacter pylori isolated from Colombian adult patients and associations with gastric diseases. Rev Colomb Gastroenterol, 33(2), 103-110.

Mendes, K. D. S., Silveira, R. C. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto Enfermagem. 17(4): 758-764.

Molina-Castro, S., Garita-Cambronero, J., Malespín-Bendaña, W., Une, C., & Ramírez, V. (2019). Virulence factor genotyping of Helicobacter pylori isolated from Costa Rican dyspeptic patients. Microbial pathogenesis, 128, 276–280.

Pajavand, H., Alvandi, A., Mohajeri, P., Bakhtyari, S., Bashiri, H., Kalali, B., Gerhard, M., Najafi, F., & Abiri, R. (2015). High Frequency of vacA s1m2 Genotypes Among Helicobacter pylori Isolates From Patients With Gastroduodenal Disorders in Kermanshah, Iran. Jundishapur journal of microbiology, 8(11), e25425.

Paredes-Osses, E., Sáez, K., Sanhueza, E., Hebel, S., González, C., Briceño, C., & García Cancino, A. (2017). Association between cagA, vacAi, and dupA genes of Helicobacter pylori and gastroduodenal pathologies in Chilean patients. Folia microbiologica, 62(5), 437–444.

Pinto-Ribeiro, I., Ferreira, R. M., Batalha, S., Hlaing, T., Wong, S. I., Carneiro, F., & Figueiredo, C. (2016). Helicobacter pylori vacA Genotypes in Chronic Gastritis and Gastric Carcinoma Patients from Macau, China. Toxins, 8(5), 142.

Saeidi, Y., Pournajaf, A., Gholami, M., Hasannejad-Bibalan, M., Yaghoubi, S., Khodabandeh, M., Emadi, B., Ferdosi-Shahandashti, E., & Rajabnia, R. (2017). Determination of Helicobacter pylori virulence-associated genes in duodenal ulcer and gastric biopsies. Medical journal of the Islamic Republic of Iran, 31, 95.

Sheikh, A. F., Yadyad, M. J., Goodarzi, H., Hashemi, S. J., Aslani, S., Assarzadegan, M. A., & Ranjbar, R. (2018). CagA and vacA allelic combination of Helicobacter pylori in gastroduodenal disorders. Microbial pathogenesis, 122, 144–150.

Souza, M. T., Silva, M. D.,& Carvalho, R. (2010). Revisão Integrativa: o que é e como fazer. Einstein, 8(1), 102-106.

Sterbenc, A., Jarc, E., Poljak, M., & Homan, M. (2019). Helicobacter pylori virulence genes. World Journal of Gastroenterology. 25(33), 4870-4884.

Szkaradkiewicz, A., Karpiński, T. M., Linke, K., Majewski, P., Rożkiewicz, D., & Goślińska-Kuźniarek, O. (2016). Expression of cagA, virB/D Complex and/or vacA Genes in Helicobacter pylori Strains Originating from Patients with Gastric Diseases. PloS one, 11(2), e0148936.

Thi Huyen Trang, T., Thanh Binh, T., & Yamaoka, Y. (2016). Relationship between vacA Types and Development of Gastroduodenal Diseases. Toxins. 8(6), 182-192.

Tserentogtokh, T., Gantuya, B., Subsomwong, P., Oyuntsetseg, K., Bolor, D., Erdene-Ochir, Y., Azzaya, D., Davaadorj, D., Uchida, T., Matsuhisa, T., & Yamaoka, Y. (2019). Western-Type Helicobacter pylori CagA are the Most Frequent Type in Mongolian Patients. Cancers, 11(5), 725.

Vinagre, I. D., Queiroz, A. L., Silva Júnior, M. R., Vinagre, R. M., & Martins, L. C. (2015). Helicobacter pylori infection in patients with different gastrointestinal diseases from northern brazil. Arquivos de gastroenterologia, 52(4), 266–271.

Whitmire, J. M., & Merrell, D. S. (2019). Helicobacter pylori Genetic Polymorphisms in Gastric Disease Development. Adv Exp Med Biol.

Published

04/04/2021

How to Cite

SANTANA, C. M.; SANTOS, R. L.; PALMA, T. de F.; OLIVEIRA, A. C. S. de. The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori. Research, Society and Development, [S. l.], v. 10, n. 4, p. e28610412938, 2021. DOI: 10.33448/rsd-v10i4.12938. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12938. Acesso em: 20 apr. 2021.

Issue

Section

Review Article