Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
DOI:
https://doi.org/10.33448/rsd-v10i3.13451Keywords:
Vanillic acid; Isopropyl vanylate; Inflammation.Abstract
Inflammation is the body's response to harmful stimuli such as infections, trauma, or injury. The inflammatory cascade can lead to the development of numerous diseases, and the current drug-therapeutic intervention consists of the use of corticosteroids and non-steroidal anti-inflammatory drugs. However, the use of these is associated with several serious side effects, so it is necessary to search for new alternatives that can minimize this effect. In this prospecting, the objective was to conduct a study on biological activities already described for vanillic acid, with special emphasis on its semi-synthetic derivative of isopropyl vanylate as an anti-inflammatory agent. For this, information was obtained on patent documents based on the INPI, USPTO and EPO databases, using the keywords: vanillic acid, anti-inflammatory agents, isopropyl vanylate, always used in the search field related to the summary of works. As results obtained in the present technological prospection study, it was found that in the international patent databases the documents related to the theme were very scarce and some had a higher number of patents, on vanillic acid, few refer to its anti- inflammatory, and no documents were found on the use of isopropyl vanillate as an anti-inflammatory agent, reinforcing the innovative character of research involving its use in this technology.
References
Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., & Supuran, C. T. (2021). Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery, 1-17.
Butler, M. S., Robertson, A. A., & Cooper, M. A. (2014). Natural product and natural product derived drugs in clinical trials. Natural product reports, 31(11), 1612-1661.
Calixto-Campos, C., Carvalho, T. T., Hohmann, M. S., Pinho-Ribeiro, F. A., Fattori, V., Manchope, M. F., ... & Verri Jr, W. A. (2015). Vanillic acid inhibits inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NFκB activation in mice. Journal of natural products, 78(8), 1799-1808.
Choi, E., Roland, J. T., Barlow, B. J., O'Neal, R., Rich, A. E., Nam, K. T., ... & Goldenring, J. R. (2014). Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut, 63(11), 1711-1720.
Choi, Y. J., Kim, N., Lee, J. Y., Nam, R. H., Seo, J. H., Lee, S., ... & Lee, D. H. (2016). Gastroprotective effects of PMK-S005 against ethanol-induced acute gastric damage in rats. Gut and liver, 10(3), 348.
Cragg, G. M., & Newman, D. J. (2013). Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA)-General Subjects, 1830(6), 3670-3695.
David, B., Wolfender, J. L., & Dias, D. A. (2015). The pharmaceutical industry and natural products: historical status and new trends. Phytochemistry Reviews, 14(2), 299-315.
Dianat, M., Radmanesh, E., Badavi, M., Mard, S. A., & Goudarzi, G. (2016). Disturbance effects of PM 10 on iNOS and eNOS mRNA expression levels and antioxidant activity induced by ischemia–reperfusion injury in isolated rat heart: protective role of vanillic acid. Environmental Science and Pollution Research, 23(6), 5154-5165.
El-Dash, Y., Khalil, N. A., Ahmed, E. M., & Hassan, M. S. (2021). Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme. Bioorganic Chemistry, 107, 104610.
Gabay, C., & Kushner, I. (1999). Acute-phase proteins and other systemic responses to inflammation. New England journal of medicine, 340(6), 448-454.
Gunter, B. R., Butler, K. A., Wallace, R. L., Smith, S. M., & Harirforoosh, S. (2017). Non‐steroidal anti‐inflammatory drug‐induced cardiovascular adverse events: a meta‐analysis. Journal of clinical pharmacy and therapeutics, 42(1), 27-38.
Headland, S. E., & Norling, L. V. (2015). The resolution of inflammation: Principles and challenges. In Seminars in immunology (Vol. 27, No. 3, pp. 149-160). Academic Press.
Horadagoda, N. U., Knox, K. M. G., Gibbs, H. A., Reid, S. W. J., Horadagoda, A., Edwards, S. E. R., & Eckersall, P. D. (1999). Acute phase proteins in cattle: discrimination between acute and chronic inflammation. Veterinary Record, 144(16), 437-441.
Hou, J., Michael K., Beicheng S .(2021). "Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?." Nature Reviews Clinical Oncology ,1-19.
Hu, M. M., & Shu, H. B. (2020). Innate immune response to cytoplasmic DNA: mechanisms and diseases. Annual review of immunology, 38, 79-98.
Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., & Sugimoto, Y. (2015). Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1851(4), 414-421.
Killeen, M. J., Linder, M., Pontoniere, P., & Crea, R. (2014). NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities. Drug discovery today, 19(4), 373-378.
Koeberle, A., & Werz, O. (2014). Multi-target approach for natural products in inflammation. Drug Discovery Today, 19(12), 1871-1882.
Kumar, S., Chan, C. J., & Coussens, L. (2016). Inflammation and cancer. In Immunity to Pathogens and Tumors (pp. 406-415). Elsevier Inc.
Lalrinzuali, K., Vabeiryureilai, M., & Jagetia, G. C. (2016). Investigation of the anti-inflammatory and analgesic activities of ethanol extract of stem bark of Sonapatha Oroxylum indicum in vivo. International journal of inflammation, 2016.
Newman, D. J. (2008). Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. Journal of medicinal chemistry, 51(9), 2589-2599.
Newman, D. J., & Cragg, G. M. (2016). Natural products as sources of new drugs from 1981 to 2014. Journal of natural products, 79(3), 629-661.
Nogueira, K. M., de Souza, L. K., de Oliveira, A. P., Pacheco, G., Iles, B., Alencar, M. S., ... & Medeiros, J. V. (2019). Efficacy of a phenol derivative, isopropyl vanillate, as an anti‐inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration. Drug development research, 80(5), 666-679.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica. [e-book]. Santa Maria: UAB/NTE/UFSM. Recuperado de https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa -Cientifica.pdf?sequence=1.
Perkins, J. R., Sanak, M., Canto, G., Blanca, M., & Cornejo-García, J. A. (2015). Unravelling adverse reactions to NSAIDs using systems biology. Trends in pharmacological sciences, 36(3), 172-180.
Rodrigues, T., Reker, D., Schneider, P., & Schneider, G. (2016). Counting on natural products for drug design. Nature chemistry, 8(6), 531.
Schubert, M. L. (2015). Functional anatomy and physiology of gastric secretion. Current opinion in gastroenterology, 31(6), 479-485.
Sevgi, K., Tepe, B., & Sarikurkcu, C. (2015). Antioxidant and DNA damage protection potentials of selected phenolic acids. Food and Chemical Toxicology, 77, 12-21.
Tili, E., & Michaille, J. J. (2016). Promiscuous effects of some phenolic natural products on inflammation at least in part arise from their ability to modulate the expression of global regulators, namely microRNAs. Molecules, 21(9), 1263.
Tripathi, S., Flobak, Å., Chawla, K., Baudot, A., Bruland, T., Thommesen, L., ... & Lægreid, A. (2015). The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms. BMC systems biology, 9(1), 1-15.
Vinothiya, K., & Ashokkumar, N. (2017). Modulatory effect of vanillic acid on antioxidant status in high fat diet-induced changes in diabetic hypertensive rats. Biomedicine & Pharmacotherapy, 87, 640-652.
Waldum, H. L., Kleveland, P. M., & Fossmark, R. (2015). Upper gastrointestinal physiology and diseases. Scandinavian journal of gastroenterology, 50(6), 649-656.
Willet, S. G., & Mills, J. C. (2016). Stomach organ and cell lineage differentiation: from embryogenesis to adult homeostasis. Cellular and molecular gastroenterology and hepatology, 2(5), 546-559.
Wolfender, J. L., Marti, G., Thomas, A., & Bertrand, S. (2015). Current approaches and challenges for the metabolite profiling of complex natural extracts. Journal of Chromatography A, 1382, 136-164.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Kerolayne Melo Nogueira; Luan Kelves Miranda de Souza; Jand Venes Rolim Medeiros
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
