Analysis of the gastroprotective potential of the essential oil of Lippia gracilis Schauer (Verbenaceae) in experimental models of gastric ulcer: a brief review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i3.13669

Keywords:

Gastroprotective effect; Lippia gracilis Schauer; Gastric ulcer.

Abstract

Gastric ulcer is a disease that affects a large portion of the world population, with a prevalence of 2.4% in the Western population and annual incidence rates of 0.10% to 0.19%, with a high cure rate, but with a high recurrence rate. The aim of this research is to perform a literature review on the gastroprotective potential of the essential oil of Lippia gracilis Schauer. To this end, an integrative review study was carried out, which selected 26 scientific articles found in virtual platforms that approached the proposed theme. Based on the established criteria, the literature suggests that the essential oil of Lippia gracilis Schauer is a compound with several biological activities, including some already described in the literature, however, its gastroprotective potential is still lacking many evidences in the literature. The findings show that the EO of L. gracilis can delay and bring an improvement in the degree of involvement by the ulcerative disorder. However, new scientific approaches are necessary to better elucidate the effect of this oil, which can then become an additional therapeutic method for cases of gastric lesions.

References

Abraham, N. S. (2012). Proton pump inhibitors: potential adverse effects. Current opinion in gastroenterology, 28(6), 615-620.

AlRashdi, A. S., Salama, S. M., Alkiyumi, S. S., Abdulla, M. A., Hadi, A. H. A., Abdelwahab, S. I., ... & Asykin, N. (2012). Mechanisms of gastroprotective effects of ethanolic leaf extract of Jasminum sambac against HCl/ethanol-induced gastric mucosal injury in rats. Evidence-Based Complementary and Alternative Medicine, 2012.

Bi, W. P., Man, H. B., & Man, M. Q. (2014). Efficacy and safety of herbal medicines in treating gastric ulcer: a review. World Journal of Gastroenterology: WJG, 20(45), 17020.

Brasil. Ministério da Saúde. SUS tem fitoterápicos para doenças simples. Disponível em http://www.brasil.gov.br/saude/2012/11/sus-tem-fitoterapicos-paradoencas-simples. Acesso em 09 de Agosto de 2016.

Carli, D. M. D., Pires, R. C., Rohde, S. L., Kavalco, C. M., & Fagundes, R. B. (2015). Peptic ulcer frequency differences related to h. Pylori or aines. Arquivos de gastroenterologia, 52(1), 46-49.

Dutra, R. C., Campos, M. M., Santos, A. R., & Calixto, J. B. (2016). Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacological research, 112, 4-29.

Ferraz, R. P., Bomfim, D. S., Carvalho, N. C., Soares, M. B., da Silva, T. B., Machado, W. J., ... & Bezerra, D. P. (2013). Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae). Phytomedicine, 20(7), 615-621.

Fox, R. K., & Muniraj, T. (2016). Pharmacologic therapies in gastrointestinal diseases. Medical Clinics, 100(4), 827-850.

Gomes, S. V. F., Nogueira, P. C. L., & Moraes, V. R. S. (2011). Aspectos químicos e biológicos do gênero Lippia enfatizando Lippia gracilis Schauer. Eclética Química, 36(1), 64-77.

Guilhon, C. C., Raymundo, L. J., Alviano, D. S., Blank, A. F., Arrigoni-Blank, M. F., Matheus, M. E., ... & Fernandes, P. D. (2011). Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil. Journal of ethnopharmacology, 135(2), 406-413.

Kangwan, N., Park, J. M., Kim, E. H., & Hahm, K. B. (2014). Quality of healing of gastric ulcers: natural products beyond acid suppression. World journal of gastrointestinal pathophysiology, 5(1), 40.

Leontiadis, G. I., Molloy-Bland, M., Moayyedi, P., & Howden, C. W. (2013). Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. American Journal of Gastroenterology, 108(3), 331-345.

Martins, J. D. L., silva Ribeiro, A. R., da Silva, L. M., de Andrade, S. F., & Thomazzi, S. M. (2018). EFEITO PROTETOR E ANTISECRETÓRIO DA Lippia gracilis SOBRE A MUCOSA ESTOMACAL DE ROEDORES. Semana de Pesquisa da Universidade Tiradentes-SEMPESq, (19).

Martins, J. D. L. (2017). Efeito gastroprotetor do óleo essencial da Lippia gracilis Schauer (verbenaceae).

Mendes, S. S., Bomfim, R. R., Jesus, H. C. R., Alves, P. B., Blank, A. F., Estevam, C. S., ... & Thomazzi, S. M. (2010). Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves. Journal of Ethnopharmacology, 129(3), 391-397.

Oliveira, A. F. D., Carvalho, J. R. D., Costa, M. D. F. D. S., Lobato, L. C. D. P., Silva, R. S. D., & Schramm, J. M. D. A. (2015). Estimativa da prevalência e da mortalidade por complicações da úlcera péptica, Brasil, 2008: uma proposta metodológica. Epidemiologia e Serviços de Saúde, 24, 145-154.

Oliveira, I. S., da Silva, F. V., Viana, A. F. S., dos Santos, M. R., Quintans-Júnior, L. J., Maria do Carmo, C. M., ... & de CM Oliveira, R. (2012). Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents. Naunyn-Schmiedeberg's archives of pharmacology, 385(9), 899-908.

Overmier, J. B., & Murison, R. (2013). Restoring psychology's role in peptic ulcer. Applied Psychology: Health and Well‐Being, 5(1), 5-27.

Rashidian, A., Farhang, F., Vahedi, H., Dehpour, A. R., Mehr, S. E., Mehrzadi, S., & Rezayat, S. M. (2016). Anticonvulsant effects of Lippia citriodora (Verbenaceae) leaves ethanolic extract in mice: role of gabaergic system. International journal of preventive medicine, 7.

Ribeiro, A. R. S., Diniz, P. B., Pinheiro, M. S., Albuquerque-Júnior, R. L., & Thomazzi, S. M. (2016). Gastroprotective effects of thymol on acute and chronic ulcers in rats: The role of prostaglandins, ATP-sensitive K+ channels, and gastric mucus secretion. Chemico-biological interactions, 244, 121-128.

Riella, K. R., Marinho, R. R., Santos, J. S., Pereira-Filho, R. N., Cardoso, J. C., Albuquerque-Junior, R. L. C., & Thomazzi, S. M. (2012). Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents. Journal of Ethnopharmacology, 143(2), 656-663.

Rozza, A. L., & Pellizzon, C. H. (2013). Essential oils from medicinal and aromatic plants: a review of the gastroprotective and ulcer‐healing activities. Fundamental & clinical pharmacology, 27(1), 51-63.

Silva, W. J., Dória, G. A. A., Maia, R. T., Nunes, R. S., Carvalho, G. A., Blank, A. F., ... & Cavalcanti, S. C. H. (2008). Effects of essential oils on Aedes aegypti larvae: alternatives to environmentally safe insecticides. Bioresource technology, 99(8), 3251-3255.

Silveira, P. F. D., Bandeira, M. A. M., & Arrais, P. S. D. (2008). Farmacovigilância e reações adversas às plantas medicinais e fitoterápicos: uma realidade. Revista Brasileira de Farmacognosia, 18(4), 618-626.

Veras, H. N. H., Rodrigues, F. F. G., Botelho, M. A., Menezes, I. R. A. D., Coutinho, H. D. M., & Da Costa, J. G. M. (2014). Antimicrobial effect of Lippia sidoides and thymol on Enterococcus faecalis biofilm of the bacterium isolated from root canals. The Scientific World Journal, 2014.

Vieira, B. M., & Nunes, C. P. (2017). H. Pylori versus úlcera gástrica nas eda do hctco. Revista da Faculdade de Medicina de Teresópolis, 1(01).

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Published

23/03/2021

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ARAÚJO, D. L.; SOUZA, M. S. .; NERY, S. B. M. .; EUFRAZINO JÚNIOR, J. .; LOURES, L. L. da S. .; MOURA, L. C. de .; LOBÃO, A. G. S. R. .; SANTOS, S. L. dos .; APOLINÁRIO, J. M. dos S. da S. .; SOUSA, S. L. F. de .; SOBRINHO, W. D. .; PAULO, M. da S. .; BRITO, J. S. .; MELO, V. dos S. .; SANTOS, A. V. .; CARVALHO, S. B. de .; FAGUNDES, G. R. S. .; RIBEIRO FILHO, M. A. .; SILVA, M. P. B. .; BARROSO, M. L. . Analysis of the gastroprotective potential of the essential oil of Lippia gracilis Schauer (Verbenaceae) in experimental models of gastric ulcer: a brief review. Research, Society and Development, [S. l.], v. 10, n. 3, p. e51310313669, 2021. DOI: 10.33448/rsd-v10i3.13669. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/13669. Acesso em: 22 dec. 2024.

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Vol. 10 No. 3

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Review Article

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Copyright (c) 2021 Daniel Lopes Araújo; Mariana Silva Souza; Sabrina Beatriz Mendes Nery; José Eufrazino Júnior; Leandro Luiz da Silva Loures; Layanne Cavalcante de Moura; Ana Graziela Soares Rêgo Lobão; Samuel Lopes dos Santos; Joelma Maria dos Santos da Silva Apolinário; Samilly Lorâna Farias de Sousa; Weberton Dorásio Sobrinho; Matheus da Silva Paulo; Jhônata Santos Brito; Viviane dos Santos Melo; Amanda Viana Santos; Simone Barroso de Carvalho; Guilia Rivele Souza Fagundes; Moacir Andrade Ribeiro Filho; Mariana Pereira Barbosa Silva; Marianna Leite Barroso

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