What oral cavity can show in COVID-19 patients? Literature integrative review
DOI:
https://doi.org/10.33448/rsd-v10i4.14072Keywords:
Coronavirus; Dentistry; Oral medicine.Abstract
COVID-19, a pandemic disease, does not have its pathogenesis completely clarified although it is a polysystemic infection that may even present oral manifestations, due to the ability of the SARS-CoV-2 virus to bind to the angiotensin-converting enzyme 2 (ACE-2). This integrative literature review aims to identify the main oral manifestations of SARS-CoV2 virus infection and seek to establish whether or not there is a relationship between the appearance of oral manifestations and the systemic condition and prognosis of this patient. To perform this work, the Pubmed database was used, with the selection of 11 articles, after applying the inclusion and exclusion criteria, based on the PRISMA-ScR strategy for qualitative analysis. The results show that the most prevalent oral manifestations associated with COVID-19 are oral candidiasis and ulcerated lesions, but herpetic lesions, desquamative gingivitis, necrotizing periodontitis, among others, can also occur. In addition, they present taste impairment as the most common symptom, with dysgeusia being the most prevalent. And although some researchers already report an association between more severe manifestations of the disease and dissemination of oral lesions, more clinical and randomized studies are needed to definitively elucidate the relationship between oral manifestations and the prognosis of the systemic syndrome of COVID-19.
References
Amorim Dos Santos, J., Normando, A., Carvalho da Silva, R. L., De Paula, R. M., Cembranel, A. C., Santos-Silva, A. R., & Guerra, E. (2020). Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations?. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases, 97, 326–328. https://doi.org/10.1016/j.ijid.2020.06.012
Amorim Dos Santos, J., Normando, A., Carvalho da Silva, R. L., Acevedo, A. C., De Luca Canto, G., Sugaya, N., Santos-Silva, A. R., & Guerra, E. (2021). Oral Manifestations in Patients with COVID-19: A Living Systematic Review. Journal of Dental Research, 100(2), 141–154. https://doi.org/10.1177/0022034520957289
Brandão, T. B., Gueiros, L. A., Melo, T. S., Prado-Ribeiro, A. C., Nesrallah, A., Prado, G., Santos-Silva, A. R., & Migliorati, C. A. (2021). Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 131(2), e45–e51. https://doi.org/10.1016/j.oooo.2020.07.014
Brasil., (2021). Plano Nacional de operacionalização da vacinação contra a COVID- 19. Ministério da Saúde. Brasília- DF, (2), 1-104. https://www.gov.br/saude/pt-br/media/pdf/2020/dezembro/16/plano_vacinacao_versao_eletronica.pdf
Câmara, F. P; Câmara, D. C. P.; Moreno, M.(2020). Contágio e virulência: covid-19 e a próxima pandemia / contágio e virulência. Brazilian Journal of Health Review, [S.L.], v. 3, n. 5, p. 13353-13357, 2020. http://dx.doi.org/10.34119/bjhrv3n5-160.
Galvão, T. F., Pansani, T. S. D. A., & Harrad, D. (2015). Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiologia e Serviços de Saúde, 24(2), 335-342. https://doi.org/10.5123/S1679-49742015000200017
Gurgel, B. C. V., Borges, S. B., Borges, R. E. A., & Calderon, P. S. (2020). COVID-19: Perspectives for the management of dental care and education. Journal of Applied Oral Science, 28, e20200358. Epub September 28, 2020.https://dx.doi.org/10.1590/1678-7757-2020-0358
Hocková, B., Riad, A., Valky, J., Šulajová, Z., Stebel, A., Slávik, R., Bečková, Z., Pokorná, A., Klugarová, J., & Klugar, M. (2021). Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. Journal of Clinical Medicine, 10(4), 581. https://doi.org/10.3390/jcm10040581
Iranmanesh, B., Khalili, M., Amiri, R., Zartab, H., & Aflatoonian, M. (2021). Oral manifestations of COVID-19 disease: A review article. Dermatologic Therapy, 34(1), e14578. https://doi.org/10.1111/dth.14578
Iser, B. P. M., Sliva, I., Raymundo, V. T., Poleto, M. B., Schuelter-Trevisol, F., & Bobinski, F. (2020). Definição de caso suspeito da COVID-19: uma revisão narrativa dos sinais e sintomas mais frequentes entre os casos confirmados. Epidemiologia e Serviços de Saúde, 29(3), e2020233. Epub 18 de junho de 2020.https://dx.doi.org/10.5123/s1679-49742020000300018
Joseph, B., & Prasanth, C. S. (2021). Can Photodynamic therapy be repurposed to treat oral lesions of COVID-19? Photodiagnosis and Photodynamic Therapy, 33, 102175. Advance online publication. https://doi.org/10.1016/j.pdpdt.2021.102175
Oliveira, A. C. D., Lucas, T. C., & Iquiapaza, R. A. (2020). O que a pandemia da covid-19 tem nos ensinado sobre adoção de medidas de precaução? Texto & Contexto - Enfermagem, 29, e20200106. Epub 08 de maio de 2020.https://dx.doi.org/10.1590/1980-265x-tce-2020-0106
Painter, E. M.; Ussery, E. N; Patel, A.; Zell, E. R.; Moulia, D. L.; Scharf, L. G.; Lynch, M.; Ritchey, M. D.; Toblin, R. L.; Murthy, B. P.; Harris, la T. Q.; Wasley, A.; Rose, D.A.; Cohn,A.; Messonnier, N.E.. (2021). Demographic Characteristics of Persons Vaccinated During the First Month of the COVID-19 Vaccination Program — United States, December 14, 2020–January 14, 2021. Morbidity And Mortality Weekly Report, 0(5), 174-177. https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7005e1-H.pdf .
Riad, A., Gad, A., Hockova, B., & Klugar, M. (2020). Oral Candidiasis in Non-Severe COVID-19 Patients: Call for Antibiotic Stewardship. Oral Surgery, 10.1111/ors.12561. Advance online publication. https://doi.org/10.1111/ors.12561
Riad, A., Kassem, I., Hockova, B., Badrah, M., & Klugar, M. (2020). Tongue ulcers associated with SARS-CoV-2 infection: A case series. Oral Diseases, 10.1111/odi.13635. Advance online publication. https://doi.org/10.1111/odi.13635
Santos, C. M. C., Pimenta, C. A. M., & Nobre, M. R. C., (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem, 15(3), 508-511. https://doi.org/10.1590/S0104-11692007000300023
Sarode, G. S., Sarode, S. C., Gadbail, A. R., Gondivkar, S., Sharma, N. K., & Patil, S. (2021). Are oral manifestations related to SARS-CoV-2 mediated hemolysis and anemia?. Medical Hypotheses, 146, 110413. https://doi.org/10.1016/j.mehy.2020.110413
Sinadinos, A., & Shelswell, J. (2020). Oral ulceration and blistering in patients with COVID-19. Evidence-Based Dentistry, 21(2), 49. https://doi.org/10.1038/s41432-020-0100-z
Sinjari, B., D'Ardes, D., Santilli, M., Rexhepi, I., D'Addazio, G., Di Carlo, P., Chiacchiaretta, P., Caputi, S., & Cipollone, F. (2020). SARS-CoV-2 and Oral Manifestation: An Observational, Human Study. Journal of Clinical Medicine, 9(10), 3218. https://doi.org/10.3390/jcm9103218
Uddin, M., Mustafa, F., Rizvi, T. A., Loney, T., Suwaidi, H. A., Al-Marzouqi, A., Eldin, A. K., Alsabeeha, N., Adrian, T. E., Stefanini, C., Nowotny, N., Alsheikh-Ali, A., & Senok, A. C. (2020). SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions. Viruses, 12(5), 526. https://doi.org/10.3390/v12050526
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Copyright (c) 2021 Thiago de Amorim Carvalho; Dayviddy Lucas Magalhães Silva; Laura Cesário Oliveira; Fabrício Campos Machado; Rodrigo Soares de Andrade; Veridiana Resende Novais
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