Congenital malformations caused by viruses

Authors

DOI:

https://doi.org/10.33448/rsd-v10i4.14110

Keywords:

Congenital abnormalities; Vírus; Zika virus; Rubella; HIV; Cytomegalovirus.

Abstract

The article aims to analyze congenital anomalies caused by viruses, with a specific focus on Zika viruses (Zikavirus), rubella virus (Rubivirus), HIV (Human Immunodeficiency Virus) and cytomegalovirus. The method used was a qualitative review of scientific articles, performed by means of an electronic search in the database of published articles and scielo for: index, title, using the keywords in English: malformations, viruses, congenital malformation, prevalence and incidence, zika virus, cytomegalovirus. The results demonstrate the prevalence of four infectious agents in the genesis of the main congenital malformations today. Therefore, we conclude the need to know these diseases and their manifestations in depth in order to, based on such knowledge, implement them as correct medical procedures.

References

Aagaard, K. M., Lahon, A., Suter, M. A., Arya, R. P., Seferovic, M. D., Vogt, M. B., Hu, M., Stossi, F., Mancini, M. A., Harris, R. A., Kahr, M., Eppes, C., Rac, M., Belfort, M. A., Park, C. S., Lacorazza, D., & Rico-Hesse, R. (2017). Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication. Scientific Reports, 7(January), 1–14. https://doi.org/10.1038/srep41389

Alvarado, M. G., & Schwartz, D. A. (2017). Zika virus infection in pregnancy, microcephaly, and maternal and fetal health: What we think, what we know, and what we think we know. Archives of Pathology and Laboratory Medicine, 141(1), 26–32. https://doi.org/10.5858/arpa.2016-0382-RA

Annie, K., Dasar, S., & Joshi, S. K. (2016). A case of congenital rubella-osseous manifestations. RadiologyofInfectiousDiseases, 3(4), 181-183. https://doi.org/10.1016/j.jrid.2016.11.002

Aragao, M. F. V. V., Holanda, A. C., Brainer-Lima, A. M., Petribu, N. C. L., Castillo, M., Van Der Linden, V., Serpa, S. C., Tenório, A. G., Travassos, P. T. C., Cordeiro, M. T., Sarteschi, C., Valenca, M. M., & Costello, A. (2017). Nonmicrocephalic infants with congenital zika syndrome suspected only after neuroimaging evaluation compared with those with microcephaly at birth and postnatally: How large is the Zika virus “iceberg”? American Journal of Neuroradiology, 38(7), 1427–1434. https://doi.org/10.3174/ajnr.A5216

Aragao, M. F. V. V. (2017). Zika in focus: Postnatal clinical, laboratorial and radiological aspects. Zika in Focus: Postnatal Clinical, Laboratorial and Radiological Aspects, 1–156. https://doi.org/10.1007/978-3-319-53643-9

Bartlett, A. W., Mcmullan, B., Rawlinson, W. D., Palasanthiran, P. (2017)Hearing and neurodevelopmental outcomes for children with asymptomatic congenital cytomegalovirus infection: A systematic review. Reviews in Medical Virology, 27(5), 1–10. https://doi.org/10.1002/rmv.1938

Beaufrère, A., Bessières, B., Bonnière, M., Driessen, M., Alfano, C., Couderc, T., Thiry, M., Thelen, N., Lecuit, M., Attié Bitach, T., Vekemans, M., Ville, Y., Nguyen, L., Leruez‐Ville, M., & Encha‐Razavi, F. (2019). A clinical and histopathological study of malformations observed in fetuses infected by the Zika virus. Brain Pathology, 29(1), 114–125. https://doi.org/10.1111/bpa.12644

Besnard, M., Lastère, S., Teissier, A., Cao-Lormeau, V. M., & Musso, D. (2014). Evidence of perinatal transmission of zika virus, French Polynesia, December 2013 and February 2014. Eurosurveillance, 19(13), 8–11. https://doi.org/10.2807/1560-7917.ES2014.19.13.20751

Capretti, M. G., Marsico, C., GuidelliGuidi, S., Ciardella, A., Simonazzi, G., Galletti, S., Gabrielli, L., Lazzarotto, T., & Faldella, G. (2017)Neonatal and long-term ophthalmological findings in infants with symptomatic and asymptomatic congenital cytomegalovirus infection. JournalofClinicalVirology, 97(November), 59–63. DOI: 10.1016/j.jcv.2017.11.001. Disponível em: http://dx.doi.org/10.1016/j.jcv.2017.11.001.

Costello, A., Dua, T., Duran, P., Gülmezoglu, M., Oladapo, O. T., Perea, W., Pires, J., Ramon-Pardo, P., Rollins, N., & Saxena, S. (2016). Defining the syndrome associated with congenital Zika virus infection. Bulletin of the World Health Organization, 94(6), 406-406A. https://doi.org/10.2471/BLT.16.176990

Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., Polonio, C. M., Cunha, I., Freitas, C. L., Brandaõ, W. N., Rossato, C., Andrade, D. G., Faria, D. D. P., Garcez, A. T., Buchpigel, C. A., & Beltrao-Braga, P. C. B. B. (2016). The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534(7606), 267–271. https://doi.org/10.1038/nature18296

Cui, L., Zou, P., Chen, E., Yao, H., Zheng, H., Wang, Q., Zhu, J. N., Jiang, S., Lu, L., & Zhang, J. (2017). Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection. EBioMedicine, 20, 193–201. https://doi.org/10.1016/j.ebiom.2017.04.029

de Castro, J. D. V., Pereira, L. P., Dias, D. A., Aguiar, L. B., Maia, J. C. N., da Costa, J. I. F., de Castro, E. C. M., Feitosa, F. E. de L., & Carvalho, F. H. C. (2017). Malformações congênitas do encéfalo presumivelmente relacionadas ao zika vírus: Espectro de achados de RM e TC em fetos e neonatos. Arquivos de Neuro-Psiquiatria, 75(10), 703–710. https://doi.org/10.1590/0004-282x20170134

Melo, A. S. O., Aguiar, R. S., Amorim, M. M. R., Arruda, M. B., Melo, F. O., Ribeiro, S. T. C., Batista, A. G. M., Ferreira, T., Dos Santos, M. P., Sampaio, V. V., Moura, S. R. M., Rabello, L. P., Gonzaga, C. E., Malinger, G., Ximenes, R., De Oliveira-Szejnfeld, P. S., Tovar-Moll, F., Chimelli, L., Silveira, P. P., … Tanuri, A. (2016). Congenital Zika virus infection: Beyond neonatal microcephaly. JAMA Neurology, 73(12), 1407–1416. https://doi.org/10.1001/jamaneurol.2016.3720

Guimarães, C. P., Macedo, M. S., Barbosa, M. A., Marques, S. M., Costa, P. S., & De Oliveira, Ê. C. (2019). Clinical findings in congenital infection by Zika virus: A retrospective study in a reference hospital in Central-West Brazil. BMC Pediatrics, 19(1), 389. https://doi.org/10.1186/s12887-019-1762-6

Faria, N. R., Do Socorro Da Silva Azevedo, R., Kraemer, M. U. G., Souza, R., Cunha, M. S., Hill, S. C., Thézé, J., Bonsall, M. B., Bowden, T. A., Rissanen, I., Rocco, I. M., Nogueira, J. S., Maeda, A. Y., Da Silva Vasami, F. G., De Lima Macedo, F. L., Suzuki, A., Rodrigues, S. G., Cruz, A. C. R., Nunes, B. T., & Vasconcelos, P. F. C. (2016). Zika virus in the Americas: Early epidemiological and genetic findings. Science, 352(6283), 345–349. https://doi.org/10.1126/science.aaf5036

Forshey, T. M., Byrum, B. A., Machesky, K. D., Stephen Roney, C., Gomez, T. M., Mitchell, J. R., Behravesh, C. B., Hausman, L. B., & O’Connor, K. A. (2016). Notes from the field. Morbidity and Mortality Weekly Report, 61(11), 195. https://www.cdc.gov/mmwr/volumes/65/wr/mm6506e1.htm

França, G. V. A., Schuler-Faccini, L., Oliveira, W. K., Henriques, C. M. P., Carmo, E. H., Pedi, V. D., Nunes, M. L., Castro, M. C., Serruya, S., Silveira, M. F., Barros, F. C., & Victora, C. G. (2016). Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. The Lancet, 388(10047), 891–897. https://doi.org/10.1016/S0140-6736(16)30902-3

Furtado, R. F. F., Carvalho, R. L., Sousa, E. P., Abrantes-Coutinho, V. E., Moreira, J. A., & Pinto, M. G. (2019). Malformações congênitas relacionadas ao sistema nervoso de recém-nascidos das macrorregiões do estado do Ceará.Revista Interdisciplinar em Saúde, 6 (5): 72-84. DOI 10.35621/23587490.v6.n5.p72-90

Halpern, D. G., Weinberg, C. R., Pinnelas, R., Mehta-Lee, S., Economy, K. E., & Valente, A. M. (2019). Use of medication for cardiovascular disease during pregnancy: JACC state-of-the-art review. Journal of the American College of Cardiology, 73(4), 457-476. https://doi.org/10.1016/j.jacc.2018.10.075

Jaenisch, T., Rosenberger, K. D., Brito, C., Brady, O., Brasil, P., & Marques, E. T. A. (2017). Risque de microcéphalie après une infection à virus Zika au Brésil, de 2015 à 2016. Bulletin of the World Health Organization, 95(3), 191–198. https://doi.org/10.2471/BLT.16.178608

Jedlińska-pijanowska, D.,Kasztelewicz, B.,Czech-kowalska, J., Jaworski, M.,Charusta-Sienkiewicz, K., &Dobrzańska, A.(2020). Association between single nucleotide polymorphisms (SNPs) of IL1, IL12, IL28 and TLR4 and symptoms of congenital cytomegalovirus infection. PLoS ONE, 15(5), 1–22. https://doi.org/10.1371/journal.pone.0233096

Johansson, M. A., Mier‑y‑Teran‑Romero, L., Reefhuis, J., Gilboa, S. M., & Hills, S. L. (2016). Zika and the Risk of Microcephaly Michael. The New England Journal of Medicine, 375(1), 1–4. https://doi.org/10.1056/NEJMp1605367

Jin, H. D.,Demmler-Harrison, G. J.,Coats, D. K.,Paysse, E. A.,Bhatt, A.,Edmond, J. C., Yen, K. G.,Steinkuller, P., & Miller, J.(2017). Long-term Visual and Ocular Sequelae in Patients with Congenital Cytomegalovirus Infection. Pediatric Infectious Disease Journal, 36(9), 877–882. https://doi.org/10.1097/INF.0000000000001599.

Lanzieri, T. M., Dollard, S. C., Bialek, S. R., & Grosse, S. D. (2014). Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries. International Journal of Infectious Diseases, v. 22, 44–48. https://doi.org/10.1016/j.ijid.2013.12.010.

Leal, M. C., van der Linden, V., Bezerra, T. P., de Valois, L., Borges, A. C. G., Antunes, M. M. C., Brandt, K. G., Moura, C. X., Rodrigues, L. C., & Ximenes, C. R. (2017). Characteristics of dysphagia in infants with microcephaly caused by congenital zika virus infection, Brazil, 2015. Emerging Infectious Diseases, 23(8), 1253–1259. https://doi.org/10.3201/eid2308.170354

Leruez-ville, M., &Ville, Y. (2017). Fetal cytomegalovirus infection. Best Practice and Research: Clinical Obstetrics and Gynaecology, 38, 97–107. https://doi.org/10.1016/j.bpobgyn.2016.10.005.

Martines, R. B., Bhatnagar, J., Ramos, A. M. O., Davi, H. P. F., Iglezias, S. D. A., Kanamura, C. T., Keating, M. K., Hale, G., Silva-Flannery, L., Muehlenbachs, A., Ritter, J., Gary, J., Rollin, D., Goldsmith, C. S., Reagan-Steiner, S., Ermias, Y., Suzuki, T., Luz, K. G., de Oliveira, W. K., & Zaki, S. R. (2016). Pathology of congenital Zika syndrome in Brazil: a case series. The Lancet, 388(10047), 898–904. https://doi.org/10.1016/S0140-6736(16)30883-2

Mehrjardi, M. Z., Poretti, A., Huisman, T. A. G. M., Werner, H., Keshavarz, E., & Araujo Júnior, E. (2017). Neuroimaging findings of congenital Zika virus infection: a pictorial essay. Japanese Journal of Radiology, 35(3), 89–94. https://doi.org/10.1007/s11604-016-0609-4

Mendes, I. C., Jesuino, R. S. A., Pinheiro, D. D. S., & Rebelo, A. C. S. (2018). Anomalias congênitas e suas principais causas evitáveis: uma revisão. Revista Médica de Minas Gerais, 28. https://doi.org/10.5935/2238-3182.20180011

Moore, C. A., Staples, J. E., Dobyns, W. B., Pessoa, A., Ventura, C. V., Da Fonseca, E. B., Ribeiro, E. M., Ventura, L. O., Neto, N. N., Arena, J. F., & Rasmussen, S. A. (2017). Characterizing the pattern of anomalies in congenital zika syndrome for pediatric clinicians. JAMA Pediatrics, 171(3), 288–295. https://doi.org/10.1001/jamapediatrics.2016.3982

Moore, K., Persaud, T. & Torchia, M. (2016). Embriologia Clínica. (10th ed.), Elsevier.

Pacheco, O., Beltrán, M., Nelson, C. A., Valencia, D., Tolosa, N., Farr, S. L., Padilla, A. V., Tong, V. T., Cuevas, E. L., Espinosa-Bode, A., Pardo, L., Rico, A., Reefhuis, J., González, M., Mercado, M., Chaparro, P., Martínez Duran, M., Rao, C. Y., Muñoz, M. M., & Ospina Martínez, M. L. (2016). Zika Virus Disease in Colombia — Preliminary Report. New England Journal of Medicine, 1–10. https://doi.org/10.1056/nejmoa1604037

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica. Universidade Federal de Santa Maria. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.

Pomar, L., Malinger, G., Benoist, G., Carles, G., Ville, Y., Rousset, D., Hcini, N., Pomar, C., Jolivet, A., & Lambert, V. (2017). Association between Zika virus and fetopathy: a prospective cohort study in French Guiana. Ultrasound in Obstetrics and Gynecology, 49(6), 729–736. https://doi.org/10.1002/uog.17404

Rawlinson, W. D., Boppana, S. B., Fowler, K. B., Kimberlin, D. W., Lazzarotto, T., Alain, S.,Daly, K., Doutré, S., Gibson, L., Giles, M. L., Greenlee, J., Hamilton, S. T., Harrison, G. J., Hui, L., Jones, C. A.,Palasanthiran, P.,Schleiss, M. R., Shand, A. W., &van Zuylen, W. J.(2017). Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. The Lancet Infectious Diseases, 17 (6), e177–e188. https://doi.org/10.1016/S1473-3099(17)30143-3

Ribeiro, B. G., Werner, H., Lopes, F. P. P. L., da Cruz, L. C. H., Fazecas, T. M., Daltro, P. A. N., & Nogueira, R. A. (2017). Central nervous system effects of intrauterine zika virus infection: A pictorial review. Radiographics, 37(6), 1840–1850. https://doi.org/10.1148/rg.2017170023

Ribeiro, B. N. de F., Muniz, B. C., Gasparetto, E. L., Ventura, N., & Marchiori, E. (2017). Congenital Zika syndrome and neuroimaging findings: What do we know so far? Radiologia Brasileira, 50(5), 314–322. https://doi.org/10.1590/0100-3984.2017.0098

Rosenberg, A. Z., Weiying, Y., Hill, D. A., Reyes, C. A., & Schwartz, D. A. (2017). Placental pathology of zika virus: Viral infection of the placenta induces villous stromal macrophage (Hofbauer Cell) proliferation and hyperplasia. Archives of Pathology and Laboratory Medicine, 141(1), 43–48. https://doi.org/10.5858/arpa.2016-0401-OA

Russo, F. B., & Beltrão-Braga, P. C. B. (2017). The impact of Zika virus in the brain. Biochemical and Biophysical Research Communications, 492(4), 603–607. https://doi.org/10.1016/j.bbrc.2017.01.074

Sanín-Blair, J. E., Gutiérrez-Márquez, C., Herrera, D. A., & Vossough, A. (2017). Fetal Magnetic Resonance Imaging Findings in Prenatal Zika Virus Infection. Fetal Diagnosis and Therapy, 42(2), 153–157. https://doi.org/10.1159/000454860

Santos, V. S., Oliveira, S. J. G., Gurgel, R. Q., Lima, D. R. R., Dos Santos, C. A., & Martins-Filho, P. R. S. (2017). Case report: Microcephaly in twins due to the Zika Virus. American Journal of Tropical Medicine and Hygiene, 97(1), 151–154. https://doi.org/10.4269/ajtmh.16-1021

Sarno, M., Aquino, M., Pimentel, K., Cabral, R., Costa, G., Bastos, F., & Brites, C. (2017). Progressive lesions of central nervous system in microcephalic fetuses with suspected congenital Zika virus syndrome. Ultrasound in Obstetrics & Gynecology, 50(6), 717–722. https://doi.org/10.1002/uog.17303

Schwartz, D. A. (2017). The origins and emergence of zika virus, the newest torch infection: What’s old is new again. Archives of Pathology and Laboratory Medicine, 141(1), 18–24. https://doi.org/10.5858/arpa.2016-0429-ED

Shepard, T. H. (1994). “Proof” of human teratogenicity. Teratology, 50(2), 97–98. https://doi.org/10.1002/tera.1420500202

Shweta, B., Nupur, G., Archana, A., Inderjeet, G., Suman, G., Manisha, B., & Shashi, K. (2015). The study of congenital cytomegalovirus, Rubella and Herpes Simplex Virus-2 infections in infants. Apollo Medicine, 12(1), 11-14. https://doi.org/10.1016/j.apme.2015.02.001

Silva, A. F. C. D., & Cueto, M. (2018). HIV/Aids, os estigmas e a história. História, Ciências, Saúde-Manguinhos, 25(2), 311-314. https://doi.org/10.1590/s0104-59702018000200001

Tsutsui, Y. (2009). Effects of cytomegalovirus infection on embryogenesis and brain development. Congenital Anomalies, 49(2), 47–55. https://doi.org/10.1111/j.1741-4520.2009.00222.x.

van der Linden, V., Pessoa, A., Dobyns, W., Barkovich, A. J., Júnior, H. van der L., Filho, E. L. R., Ribeiro, E. M., Leal, M. de C., Coimbra, P. P. de A., Aragão, M. F. V. V., Verçosa, I., Ventura, C., Ramos, R. C., Cruz, D. D. C. S., Cordeiro, M. T., Mota, V. M. R., Dott, M., Hillard, C., & Moore, C. A. (2016). Description of 13 Infants Born During October 2015–January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth — Brazil. MMWR. Morbidity and Mortality Weekly Report, 65(47), 1343–1348. https://doi.org/10.15585/mmwr.mm6547e2

Van Nguyen, T., & Abe, K. (2015). Pathogenesis of congenital rubella virus infection in human fetuses: viral infection in the ciliary body could play an important role in cataractogenesis. EBioMedicine, 2(1), 59-63. https://doi.org/10.1016/j.ebiom.2014.10.021

Ventura, C. V., Maia, M., Ventura, B. V., Van Der Linden, V., Araújo, E. B., Ramos, R. C., Rocha, M. A. W., Carvalho, M. D. C. G., Belfort, R., & Ventura, L. O. (2016). Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arquivos Brasileiros de Oftalmologia, 79(1), 1–3. https://doi.org/10.5935/0004-2749.20160002

Vissoci, J. R. N., Rocha, T. A. H., da Silva, N. C., de Sousa Queiroz, R. C., Thomaz, E. B. A. F., Amaral, P. V. M., & Staton, C. (2018). Zika virus infection and microcephaly: Evidence regarding geospatial associations. PLoS neglected tropical diseases, 12(4), e0006392. https://doi.org/10.1371%2Fjournal.pntd.0006392

Wu, K. Y., Zuo, G. L., Li, X. F., Ye, Q., Deng, Y. Q., Huang, X. Y., Cao, W. C., Qin, C. F., & Luo, Z. G. (2016). Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Research, 26(6), 645–654. https://doi.org/10.1038/cr.2016.58

Yazigi, A., De Pecoulas, A. E., Vauloup-Fellous, C., Grangeot-Keros, L., Ayoubi, J. M., & Picone, O. (2017). Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. The Journal of Maternal-Fetal & Neonatal Medicine, 30(3), 274-278. https://doi.org/10.3109/14767058.2016.1169526

Zhang, N., Qin, C. F., Liu, X., Shi, L., & Xu, Z. (2016). Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell, 19(1), 120–126. https://doi.org/10.1016/j.stem.2016.04.017

Zhang, X. Y., & Fang, F. (2019). Congenital human cytomegalovirus infection and neurologic diseases in newborns. Chinese Medical Journal, 132(17), 2109–2118. https://doi.org/10.1097/CM9.0000000000000404

Zhou, K., Wang, L., Yu, D., Huang, H., Ji, H., & Mo, X. (2017). Molecular and cellular insights into Zika virus-related neuropathies. Journal of NeuroVirology, 23(3), 341–346. https://doi.org/10.1007/s13365-017-0514-3

Zorrilla, C. D.,García, I. G., Fragoso, L. G., & De La Vega, A. (2017). Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations. Journal of Infectious Diseases, 216, S891–S896. https://doi.org/10.1093/infdis/jix448

Published

17/04/2021

How to Cite

MACHADO, V. G. V. .; DANTAS, P. H. de A. .; ALMEIDA, R. C. P. de .; LIMA FILHO, J. A. de .; SILVA, I. M. da .; MOURA, R. B. de .; COUTINHO, V. E. A. . Congenital malformations caused by viruses. Research, Society and Development, [S. l.], v. 10, n. 4, p. e44610414110, 2021. DOI: 10.33448/rsd-v10i4.14110. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14110. Acesso em: 14 nov. 2024.

Issue

Section

Review Article