Pharmacological, medicinal and toxicological properties of lavender essential oil: A review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i5.14933

Keywords:

Lavenders; Essential oils; Therapeutic potentials; Biological properties.

Abstract

The natural products extracted from plants are part of traditional medicine and are also therapeutic possibilities for treating many diseases. Recently, its use in the development of new drugs has shown much visibility for its efficiency and few adverse effects. Essential oils extracted from medicinal plants are indicated to treat numerous diseases due to their antimicrobial, antiviral, antimutagenic, anticancer, antioxidant, anti-inflammatory, immunomodulatory, and antiprotozoal properties. Among essential oils, lavender essential oil stands out for having several important pharmacological properties. This review detailed the main studies on essential oils from different species of lavender and obtained a valuable collection on all their pharmacological, medicinal and toxicological potential. In this context, we evaluated lavender essential oil as a promising substance that can help treat several diseases. We provide some evidence and an overview of the potential therapeutic effect of lavender essential oil to guide new research.

References

Aboutaleb, N., Jamali, H., Abolhasani, M., & Pazoki Toroudi, H. (2019). Lavender oil (Lavandula angustifolia) attenuates renal ischemia/reperfusion injury in rats through suppression of inflammation, oxidative stress and apoptosis. Biomedicine & Pharmacotherapy, 110, 9–19.

Altaei, D. T. (2012). Topical lavender oil for the treatment of recurrent aphthous ulceration. American Journal of Dentistry, 25(1), 39–43.

Angioni, A., Barra, A., Coroneo, V., Dessi, S., & Cabras, P. (2006). Chemical Composition, Seasonal Variability, and Antifungal Activity of Lavandula stoechas L. ssp. stoechas Essential Oils from Stem/Leaves and Flowers. Journal of Agricultural and Food Chemistry, 54(12), 4364–4370.

Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils – A review. Food and Chemical Toxicology, 46(2), 446–475.

Ben Djemaa, F. G., Bellassoued, K., Zouari, S., El Feki, A., & Ammar, E. (2016). Antioxidant and wound healing activity of Lavandula aspic L. ointment. Journal of Tissue Viability, 25(4), 193–200.

Blažeković, B., Vladimir-Knežević, S., Brantner, A., & Štefan, M. (2010). Evaluation of Antioxidant Potential of Lavandula x intermedia Emeric ex Loisel. “Budrovka”: A Comparative Study with L. angustifolia Mill. Molecules, 15(9), 5971–5987.

Bradley, B. F., Starkey, N. J., Brown, S. L., & Lea, R. W. (2007). Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze. Journal of Ethnopharmacology, 111(3), 517–525.

Buckle, J. (1999). Aromatherapy inperianesthesia nursing. Journal of PeriAnesthesia Nursing, 14(6), 336–344.

Cardia, G. F. E., Silva-Comar, F. M. de S., Silva, E. L., Rocha, E. M. T. da, Comar, J. F., Silva-Filho, S. E., Zagotto, M., Uchida, N. S., Bersani-Amado, C. A., & Cuman, R. K. N. (2021).

Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response. Research, Society and Development, 10(3), e43410313461.

Cardia, G. F. E., Silva-Filho, S. E., Silva, E. L., Uchida, N. S., Cavalcante, H. A. O., Cassarotti, L. L., Salvadego, V. E. C., Spironello, R. A., Bersani-Amado, C. A., & Cuman, R. K. N. (2018).

Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response. Evidence-Based Complementary and Alternative Medicine, 2018, 1–10.

Carson, C. F., & Riley, T. V. (2003). Non-antibiotic therapies for infectious diseases. Communicable Diseases Intelligence Quarterly Report, 27 Suppl, S143-6.

Carvalho, I. T., Estevinho, B. N., & Santos, L. (2016). Application of microencapsulated essential oils in cosmetic and personal healthcare products - a review. International Journal of Cosmetic Science, 38(2), 109–119.

Cavanagh, H. M. A., & Wilkinson, J. M. (2002). Biological activities of Lavender essential oil. Phytotherapy Research, 16(4), 301–308.

Cheng, S.-S., Chua, M.-T., Chang, E.-H., Huang, C.-G., Chen, W.-J., & Chang, S.-T. (2009). Variations in insecticidal activity and chemical compositions of leaf essential oils from Cryptomeria japonica at different ages. Bioresource Technology, 100(1), 465–470.

Cooke, B., & Ernst, E. (2000). Aromatherapy: a systematic review. The British Journal of General Practice : The Journal of the Royal College of General Practitioners, 50(455), 493–496.

Costa, P., Gonçalves, S., Andrade, P. B., Valentão, P., & Romano, A. (2011). Inhibitory effect of Lavandula viridis on Fe(2+)-induced lipid peroxidation, antioxidant and anti-cholinesterase properties. Food Chemistry, 126(4), 1779–1786.

Costa, P., Grosso, C., Gonçalves, S., Andrade, P. B., Valentão, P., Gabriela Bernardo-Gil, M., & Romano, A. (2012). Supercritical fluid extraction and hydrodistillation for the recovery of bioactive compounds from Lavandula viridis L’Hér. Food Chemistry, 135(1), 112–121.

Coulson, I. H., & Khan, A. S. (1999). Facial “pillow” dermatitis due to lavender oil allergy. Contact Dermatitis, 41(2), 111.

Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., & Mnif, W. (2016). Essential Oils’ Chemical Characterization and Investigation of Some Biological Activities: A Critical Review. Medicines, 3(4), 25.

Di Sotto, A., Mazzanti, G., Carbone, F., Hrelia, P., & Maffei, F. (2011). Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro. Environmental and Molecular Mutagenesis, 52(1), 69–71.

Dif, M. M., Benyahia, M., Toumi Benali, F., Rahmani, M., & Bouazza, S. (2017). Phenolic content and antioxidant activity of three algerian species of lavenders. Phytothérapie, 15(6), 367–372.

Djenane, D., Aïder, M., Yangüela, J., Idir, L., Gómez, D., & Roncalés, P. (2012). Antioxidant and antibacterial effects of Lavandula and Mentha essential oils in minced beef inoculated with E. coli O157:H7 and S. aureus during storage at abuse refrigeration temperature. Meat Science, 92(4), 667–674.

Dobetsberger, C., & Buchbauer, G. (2011). Actions of essential oils on the central nervous system: An updated review. Flavour and Fragrance Journal, 26(5), 300–316. .

Dreger, M., & Wielgus, K. (2013). Application of essential oils as natural cosmetic preservatives. Herba Polonica, 59(4), 142–156.

Dunn, C., Sleep, J., & Collett, D. (1995). Sensing an improvement: an experimental study to evaluate the use of aromatherapy, massage and periods of rest in an intensive care unit. Journal of Advanced Nursing, 21(1), 34–40.

Ebadollahi, A., Ziaee, M., & Palla, F. (2020). Essential Oils Extracted from Different Species of the Lamiaceae Plant Family as Prospective Bioagents against Several Detrimental Pests. Molecules, 25(7), 1556.

Eftekharsadat, B., Roomizadeh, P., Torabi, S., Heshmati-Afshar, F., Jahanjoo, F., & Babaei-Ghazani, A. (2018). Effectiveness of Lavendula stoechas essential oil in treatment of mild to moderate carpal tunnel syndrome: A randomized controlled trial. Journal of Hand Therapy, 31(4), 437–442.

Es-Safi, I., Mechchate, H., Amaghnouje, A., El Moussaoui, A., Cerruti, P., Avella, M., Grafov, A., & Bousta, D. (2020). Marketing and legal status of phytomedicines and food supplements in Morocco. Journal of Complementary and Integrative Medicine.

Ez zoubi, Y., Bousta, D., & Farah, A. (2020). A Phytopharmacological review of a Mediterranean plant: Lavandula stoechas L. Clinical Phytoscience, 6(1), 9.

Ezzo, J. (2007). What Can Be Learned from Cochrane Systematic Reviews of Massage That Can Guide Future Research? The Journal of Alternative and Complementary Medicine, 13(2), 291–296.

Field, T., Field, T., Cullen, C., Largie, S., Diego, M., Schanberg, S., & Kuhn, C. (2008). Lavender bath oil reduces stress and crying and enhances sleep in very young infants. Early Human Development, 84(6), 399–401.

Generoso, M. B., Soares, A., Taiar, I. T., Cordeiro, Q., & Shiozawa, P. (2017). Lavender Oil Preparation (Silexan) for Treating Anxiety. Journal of Clinical Psychopharmacology, 37(1), 115–117.

Ghica, M. V., Albu, M. G., Kaya, D. A., Popa, L., Öztürk, Șevket, Rusu, L.-C., Dinu-Pîrvu, C., Chelaru, C., Albu, L., Meghea, A., & Nitipir, C. (2016). The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates. Korean Journal of Chemical Engineering, 33(4), 1325–1330.

Goel, N., Kim, H., & Lao, R. P. (2005). An Olfactory Stimulus Modifies Nighttime Sleep in Young Men and Women. Chronobiology International, 22(5), 889–904.

Gonçalves, S., & Romano, A. (2013). In vitro culture of lavenders (Lavandula spp.) and the production of secondary metabolites. Biotechnology Advances, 31(2), 166–174.

Hajhashemi, V., Ghannadi, A., & Sharif, B. (2003). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. Journal of Ethnopharmacology, 89(1), 67–71.

Hallschmid, M., Benedict, C., Born, J., Fehm, H.-L., & Kern, W. (2004). Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man. Physiology & Behavior, 83(1), 55–64.

Hanamanthagouda, M. S., Kakkalameli, S. B., Naik, P. M., Nagella, P., Seetharamareddy, H. R., & Murthy, H. N. (2010). Essential oils of Lavandula bipinnata and their antimicrobial activities. Food Chemistry, 118(3), 836–839.

Herman, A., Bochenek, J., & Herman, A. P. (n.d.). [Effect of cinnamon and lavender oils on FtsZ gene expression in the Staphylococus aureus ATCC 29213]. Prikladnaia Biokhimi

ia i Mikrobiologiia, 49(5), 476–480.

Holmes, C., Hopkins, V., Hensford, C., MacLaughlin, V., Wilkinson, D., & Rosenvinge, H. (2002). Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study. International Journal of Geriatric Psychiatry, 17(4), 305–308.

Hudson, R. (1996). The value of lavender for rest and activity in the elderly patient. Complementary Therapies in Medicine, 4, 52–57.

Hui, L., He, L., Huan, L., XiaoLan, L., & AiGuo, Z. (2010). Chemical composition of Lavender essential oil and its antioxidant activity and inhibition against rhinitis-related bacteria. African Journal of Microbiology Research, 4(4), 309–313.

Isman, M. B., Miresmailli, S., & Machial, C. (2011). Commercial opportunities for pesticides based on plant essential oils in agriculture, industry and consumer products. Phytochemistry Reviews, 10(2), 197–204.

Jenner, P. M., Hagan, E. C., Taylor, J. M., Cook, E. L., & Fitzhugh, O. G. (1964). Food flavourings and compounds of related structure I. Acute oral toxicity. Food and Cosmetics Toxicology, 2, 327–343.

Joy Bowles, E. (2002). Effects of essential oils and touch on resistance to nursing care procedures and other dementia-related behaviours in a residential care facility. International Journal of Aromatherapy, 12(1), 22–29.

Kasper, S., Gastpar, M., Müller, W. E., Volz, H.-P., Möller, H.-J., Dienel, A., & Schläfke, S. (2010). Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder – evidence from clinical trials. Wiener Medizinische Wochenschrift, 160(21–22), 547–556.

Koca Kutlu, A., Çeçen, D., Gürgen, S. G., Sayın, O., & Çetin, F. (2013). A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing. Evidence-Based Complementary and Alternative Medicine, 2013, 1–9.

Kozics, K., Srancikova, A., Sedlackova, E., Horvathova, E., Melusova, M., Melus, V., Krajcovicova, Z., & Sramkova, M. (2017). Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells. Neoplasma, 64(04), 485–493.

Kritsidima, M., Newton, T., & Asimakopoulou, K. (2010). The effects of lavender scent on dental patient anxiety levels: a cluster randomised-controlled trial. Community Dentistry and Oral Epidemiology, 38(1), 83–87.

Kumar, V. (2013). Characterization of anxiolytic and neuropharmacological activities of Silexan. Wiener Medizinische Wochenschrift, 163(3–4), 89–94.

Lesage-Meessen, L., Bou, M., Sigoillot, J.-C., Faulds, C. B., & Lomascolo, A. (2015). Essential oils and distilled straws of lavender and lavandin: a review of current use and potential application in white biotechnology. Applied Microbiology and Biotechnology, 99(8), 3375–3385.

Leung, Y., & Foster, S. (1996). Encyclopedia of Common Natural Ingredients used in Food, Drugs and Cosmetics..

Li, X.-J., Yang, Y.-J., Li, Y.-S., Zhang, W. K., & Tang, H.-B. (2016). α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. Journal of Ethnopharmacology, 179, 22–26.

Lis-Balchin, M., & Hart, S. (1999). Studies on the mode of action of the essential oil of lavender (Lavandula angustifolia P. Miller). Phytotherapy Research : PTR, 13(6), 540–542.

Lis-Balchin M. (2002). Lavender: The Genus Lavandula. Taylor and Francis.

Mamadalieva, N., Akramov, D., Ovidi, E., Tiezzi, A., Nahar, L., Azimova, S., & Sarker, S. (2017). Aromatic Medicinal Plants of the Lamiaceae Family from Uzbekistan: Ethnopharmacology, Essential Oils Composition, and Biological Activities. Medicines, 4(1), 8.

Matos, F., Miguel, M. G., Duarte, J., Venâncio, F., Moiteiro, C., Correia, A. I. D., Figueiredo, A. C., Barroso, J. G., & Pedro, L. G. (2009). Antioxidant Capacity of the Essential Oils From Lavandula luisieri, L. stoechas subsp. lusitanica, L. stoechas subsp. lusitanica x L. luisieri and L. viridis Grown in Algarve (Portugal). Journal of Essential Oil Research, 21(4), 327–336.

Miladinović, D. L., Ilić, B. S., Mihajilov-Krstev, T. M., Nikolić, N. D., Miladinović, L. C., & Cvetković, O. G. (2012). Investigation of the chemical composition–antibacterial activity relationship of essential oils by chemometric methods. Analytical and Bioanalytical Chemistry, 403(4), 1007–1018.

Mirzaei F., Keshtgar S., Kaviani M., R. A. (2015). The effect of lavender essence smelling during labor on cortisol and serotonin plasma levels and anxiety reduction in nulliparous women. Journal of Kerman University of Medical Sciences, 16, 245–254.

Moon, T., Cavanagh, H. M. A., & Wilkinson, J. M. (2007). Antifungal Activity of Australian Grown Lavandula spp. Essential Oils Against Aspergillus nidulans, Trichophyton mentagrophytes, Leptosphaeria maculans and Sclerotinia sclerotiorum. Journal of Essential Oil Research, 19(2), 171–175.

Mori, H.-M., Kawanami, H., Kawahata, H., & Aoki, M. (2016). Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model. BMC Complementary and Alternative Medicine, 16(1), 144.

Nasiri, A., Mahmodi, M. A., & Nobakht, Z. (2016). Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Complementary Therapies in Clinical Practice, 25, 75–80.

Neves, Â., Rosa, S., Gonçalves, J., Rufino, A., Judas, F., Salgueiro, L., Lopes, M., Cavaleiro, C., & Mendes, A. (2010). Screening of Five Essential Oils for Identification of Potential Inhibitors of IL-1-induced Nf- κ B Activation and NO Production in Human Chondrocytes: Characterization of the Inhibitory Activity of α -Pinene. Planta Medica, 76(03), 303–308.

Newman, D. J., & Cragg, G. M. (2012). Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010. Journal of Natural Products, 75(3), 311–335.

Niksic, H., Kovac-Besovic, E., Omeragic, E., Muratovic, S., Kusturica, J., & Duric, K. (2017). Antiproliferative, antimicrobial, and antioxidant activity of Lavandula angustifolia Mill. essential oil. Journal of Health Sciences, 7(1), 35–43.

Olapour, A., Behaeen, K., Akhondzadeh, R., Soltani, F., al Sadat Razavi, F., & Bekhradi, R. (2013). The Effect of Inhalation of Aromatherapy Blend containing Lavender Essential Oil on Cesarean Postoperative Pain. Anesthesiology and Pain Medicine, 3(1), 203–207.

Ou, M.-C., Hsu, T.-F., Lai, A. C., Lin, Y.-T., & Lin, C.-C. (2012). Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: A randomized, double-blind clinical trial. Journal of Obstetrics and Gynaecology Research, 38(5), 817–822.

Peana, A. T., Marzocco, S., Popolo, A., & Pinto, A. (2006). (-)-Linalool inhibits in vitro NO formation: Probable involvement in the antinociceptive activity of this monoterpene compound. Life Sciences, 78(7), 719–723.

Prashar, A., Locke, I. C., & Evans, C. S. (2004). Cytotoxicity of lavender oil and its major components to human skin cells. Cell Proliferation, 37(3), 221–229.

Predoi, D., Iconaru, S., Buton, N., Badea, M., & Marutescu, L. (2018). Antimicrobial Activity of New Materials Based on Lavender and Basil Essential Oils and Hydroxyapatite. Nanomaterials, 8(5), 291.

Rahimzadeh, S., Sohrabi, Y., Heidari, G., Pirzad, A., & Golezani, K. G. (2016). Effect of Bio-fertilizers on the Essential Oil Yield and Components Isolated from Dracocephalum moldavica L. Using Nanoscale Injection Method. Journal of Essential Oil Bearing Plants, 19(3), 529–541.

Raja, R. R. (2012). Medicinally Potential Plants of Labiatae (Lamiaceae) Family: An Overview. Research Journal of Medicinal Plant, 6(3), 203–213.

Salehi, B., Mnayer, D., Özçelik, B., Altin, G., Kasapoğlu, K. N., Daskaya-Dikmen, C., Sharifi-Rad, M., Selamoglu, Z., Acharya, K., Sen, S., Matthews, K. R., Fokou, P. V. T., Sharopov, F., Setzer, W. N., Martorell, M., & Sharifi-Rad, J. (2018). Plants of the Genus Lavandula : From Farm to Pharmacy. Natural Product Communications, 13(10), 1934578X1801301.

Samuelson, R., Lobl, M., Higgins, S., Clarey, D., & Wysong, A. (2020). The Effects of Lavender Essential Oil on Wound Healing: A Review of the Current Evidence. The Journal of Alternative and Complementary Medicine, 26(8), 680–690.

Sant’Anna Ramos Vosgerau, D., & Paulin Romanowski, J. (2014). Estudos de revisão: implicações conceituais e metodológicas. Revista Diálogo Educacional, 14(41), 165.

Sarkic, A., & Stappen, I. (2018). Essential Oils and Their Single Compounds in Cosmetics—A Critical Review. Cosmetics, 5(1), 11.

Schuwald, A. M., Nöldner, M., Wilmes, T., Klugbauer, N., Leuner, K., & Müller, W. E. (2013). Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels. PLoS ONE, 8(4), e59998.

Sharifi-Rad, J., Sureda, A., Tenore, G., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M., Ademiluyi, A., Sharifi-Rad, R., Ayatollahi, S., & Iriti, M. (2017). Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems. Molecules, 22(1), 70.

Shaw, D., Annett, J. M., Doherty, B., & Leslie, J. C. (2007). Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. Phytomedicine, 14(9), 613–620.

Shaw, D., Norwood, K., & Leslie, J. C. (2011). Chlordiazepoxide and lavender oil alter unconditioned anxiety-induced c-fos expression in the rat brain. Behavioural Brain Research, 224(1), 1–7.

Silva-Filho, S., De Souza Silva-Comar, F., Wiirzler, L., Do Pinho, R., Grespan, R., Bersani-Amado, C., & Cuman, R. (2015). Effect of Camphor on the Behavior of Leukocytes In vitro and In vivo in Acute Inflammatory Response. Tropical Journal of Pharmaceutical Research, 13(12), 2031.

Silva, G. L. da, Luft, C., Lunardelli, A., Amaral, R. H., Melo, D. A. da S., Donadio, M. V. F., Nunes, F. B., de Azambuja, M. S., Santana, J. C., Moraes, C. M. B., Mello, R. O., Cassel, E., Pereira, M. A. de A., & de Oliveira, J. R. (2015). Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil. Anais Da Academia Brasileira de Ciências, 87(2 Suppl), 1397–1408.

Smallwood, J., Brown, R., Coulter, F., Irvine, E., & Copland, C. (2001). Aromatherapy and behaviour disturbances in dementia: a randomized controlled trial. International Journal of Geriatric Psychiatry, 16(10), 1010–1013.

Soltani, R., Soheilipour, S., Hajhashemi, V., Asghari, G., Bagheri, M., & Molavi, M. (2013). Evaluation of the effect of aromatherapy with lavender essential oil on post-tonsillectomy pain in pediatric patients: A randomized controlled trial. International Journal of Pediatric Otorhinolaryngology, 77(9), 1579–1581.

Spiridon, I., Colceru, S., Anghel, N., Teaca, C. A., Bodirlau, R., & Armatu, A. (2011). Antioxidant capacity and total phenolic contents of oregano ( Origanum vulgare ), lavender ( Lavandula angustifolia ) and lemon balm ( Melissa officinalis ) from Romania. Natural Product Research, 25(17), 1657–1661.

Sugiura, M., Hayakawa, R., Kato, Y., Sugiura, K., & Hashimoto, R. (2000). Results of patch testing with lavender oil in Japan. Contact Dermatitis, 43(3), 157–160. 2

Takahashi, M., Yoshino, A., Yamanaka, A., Asanuma, C., Satou, T., Hayashi, S., Masuo, Y., Sadamoto, K., & Koike, K. (2012). Effects of inhaled lavender essential oil on stress-loaded animals: changes in anxiety-related behavior and expression levels of selected mRNAs and proteins. Natural Product Communications, 7(11), 1539–1544.

Tasev, T., Toléva, P., & Balabanova, V. (1969). Neurophysical effect of Bulgarian essential oils from rose, lavender and geranium. Folia Medica, 11(5), 307–317.

Thomford, N. E., Senthebane, D. A., Rowe, A., Munro, D., Seele, P., Maroyi, A., & Dzobo, K. (2018). Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery. International Journal of Molecular Sciences, 19(6).

Thomson, K. F., & Wilkinson, S. M. (2000). Allergic contact dermatitis to plant extracts in patients with cosmetic dermatitis. British Journal of Dermatology, 142(1), 84–88.

Tisserand, R. (1988). The essential oil safety data manual. Tisserand Aromatherapy Institute.

Touati, B., Chograni, H., Hassen, I., Boussaïd, M., Toumi, L., & Brahim, N. Ben. (2011). Chemical Composition of the Leaf and Flower Essential Oils of Tunisian Lavandula dentata L. (Lamiaceae). Chemistry & Biodiversity, 8(8), 1560–1569.

Tsai, T.-H., Tsai, T.-H., Chien, Y.-C., Lee, C.-W., & Tsai, P.-J. (2008). In vitro antimicrobial activities against cariogenic streptococci and their antioxidant capacities: A comparative study of green tea versus different herbs. Food Chemistry, 110(4), 859–864.

Vasireddy, L., Bingle, L. E. H., & Davies, M. S. (2018). Antimicrobial activity of essential oils against multidrug-resistant clinical isolates of the Burkholderia cepacia complex. PLOS ONE, 13(8), e0201835.

Wells, R., Truong, F., Adal, A. M., Sarker, L. S., & Mahmoud, S. S. (2018). Lavandula Essential Oils: A Current Review of Applications in Medicinal, Food, and Cosmetic Industries of Lavender. Natural Product Communications, 13(10), 1934578X1801301.

Wittchen, H. U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jönsson, B., Olesen, J., Allgulander, C., Alonso, J., Faravelli, C., Fratiglioni, L., Jennum, P., Lieb, R., Maercker, A., van Os, J., Preisig, M., Salvador-Carulla, L., Simon, R., & Steinhausen, H.-C. (2011). The size and burden of mental disorders and other disorders of the brain in Europe 2010. European Neuropsychopharmacology, 21(9), 655–679.

Woelk, H., & Schläfke, S. (2010). A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 17(2), 94–99.

Woronuk, G., Demissie, Z., Rheault, M., & Mahmoud, S. (2011). Biosynthesis and Therapeutic Properties of Lavandula Essential Oil Constituents. Planta Medica, 77(01), 7–15.=

Yazdkhasti, M., & Pirak, A. (2016). The effect of aromatherapy with lavender essence on severity of labor pain and duration of labor in primiparous women. Complementary Therapies in Clinical Practice, 25, 81–86.

Ziaee, M., Khorrami, A., Ebrahimi, M., Nourafcan, H., Amiraslanzadeh, M., Rameshrad, M., Garjani, M., & Garjani, A. (2015). Cardioprotective Effects of Essential Oil of Lavandula angustifolia on Isoproterenol-induced Acute Myocardial Infarction in Rat. Iranian Journal of Pharmaceutical Research : IJPR, 14(1), 279–289.

Zuzarte, M., Gonçalves, M. J., Cavaleiro, C., Cruz, M. T., Benzarti, A., Marongiu, B., Maxia, A., Piras, A., & Salgueiro, L. (2013). Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils. Industrial Crops and Products, 44, 97–103.

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08/05/2021

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CARDIA, G. F. E. .; SILVA-COMAR , F. M. de S.; ROCHA, E. M. T. da; SILVA-FILHO, S. E. .; ZAGOTTO, M.; UCHIDA, N. S.; AMARAL, V. do .; BERSANI-AMADO, C. A.; CUMAN, R. K. N. Pharmacological, medicinal and toxicological properties of lavender essential oil: A review. Research, Society and Development, [S. l.], v. 10, n. 5, p. e23310514933, 2021. DOI: 10.33448/rsd-v10i5.14933. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14933. Acesso em: 24 apr. 2024.

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Health Sciences