Cadmio complexes with biological activity: Scientific and technological prospection

Authors

DOI:

https://doi.org/10.33448/rsd-v10i5.15152

Keywords:

Cadmium; Prospection; Biological activity.

Abstract

Cadmium is a toxic metal from 12th group and 5th period of the periodic table. It’s common its use in batteries manufacturing and metal alloys production. It is absorbed by the organism of animals and plants causing risks to human health by bioaccumulation. Even with proven levels of toxicity, complexes involving this atom have biological activity according to several studies. As a study methodology, data were prospected in different databases for patents and the scientific papers published in the period up 1962 to 2021. Only 3 patents were found regarding the biological activity of complexes containing cadmium, although 3.257 results have been found for Cd (II) articles. The database with the highest number of published articles was Scifinder with 63% (2.037) of the articles. Few articles approached anthelmintic activity, showing that future research related to chemical substances containing this metal is a possibility in the new anthelmintic drugs investigation.

Author Biography

Ruan Sousa Bastos, Universidade Federal do Pará

Graduado em Ciências Naturais / Química pela Universidade Federal do Maranhão - UFMA, Campus de Grajaú. Mestrando em Química Medicinal e Modelagem Molecular - UFPA. Participou do Programa Institucional de Bolsa de Iniciação a Docência - PIBID e do Programa de Residência Pedagógica. Membro do Grupo de Pesquisa em Química Medicinal e Biotecnologia - QUIMEBIO e Membro do Grupo de Pesquisa em Ciências Naturais e Biotecnologia - CIENATEC. Atua nas linhas de Biotecnologia e Química Quântica Computacional. E-mail: sonruanquimica@gmail.com

References

Ahmad, S., & Isab, A. A. (2006). A1i S, et a1. Perspectives in bioinorganie ehemisstr of some metal—based therapeutic agents lJj. Polyhedron, 25(7), 1633-1645. https://doi.org/10.1016/j.poly.2005.11.004

Allab, Y., Chikhi, S., Zaater, S., Brahimi, M., & Djebbar, S. (2020). Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives. Inorganica Chimica Acta, 504, 119436. https://doi.org/10.1016/j.ica.2020.119436

Araújo, J. L., Bastos, R. S., Santos, G. T., de Moraes Alves, M. M., Figueiredo, K. A., de Sousa, L. A., ... & Rocha, J. A. (2020). Molecular docking and evaluation of antileishmania activity of a ruthenium complex with epiisopiloturine and nitric oxide. Journal of Biosciences and Medicines, 8(5), 42-53. https://doi.org/10.4236/jbm.2020.85005

Bansal, Y., & Silakari, O. (2012). The therapeutic journey of benzimidazoles: a review. Bioorganic & medicinal chemistry, 20(21), 6208-6236. https://doi.org/10.1016/j.bmc.2012.09.013

Benite, A. M. B. M. (2007). Considerações sobre a química bioinorgânica medicinal. Revista eletrônica de Farmácia, 4(2). https://doi.org/10.5216/ref.v4i2.3027

Biswas, F. B., Roy, T. G., Rahman, M. A., & Emran, T. B. (2014). An in vitro antibacterial and antifungal effects of cadmium (II) complexes of hexamethyltetraazacyclotetradecadiene and isomers of its saturated analogue. Asian Pacific journal of tropical medicine, 7, S534-S539. https://doi.org/10.1016/S1995-7645(14)60286-8

Burlov, A. S., Vlasenko, V. G., Koshchienko, Y. V., Makarova, N. I., Zubenko, A. A., Drobin, Y. D., ... & Garnovskii, D. A. (2018). Complexes of zinc (II) with N-[2-(hydroxyalkyliminomethyl) phenyl]-4-methylbenzenesulfonamides: synthesis, structure, photoluminescence properties and biological activity. Polyhedron, 144, 249-258. https://doi.org/10.1016/j.poly.2018.01.020

Caini, S., Bendinelli, B., Masala, G., Saieva, C., Lundh, T., Kyrtopoulos, S. A., & Palli, D. (2018). Predictors of erythrocyte cadmium levels in 454 adults in Florence, Italy. Science of the total environment, 644, 37-44. https://doi.org/10.1016/j.scitotenv.2018.06.347

Dias, L. C., Dessoy, M. A., Guido, R. V., Oliva, G., & Andricopulo, A. D. (2013). Doenças tropicais negligenciadas: uma nova era de desafios e oportunidades. Química Nova, 36(10), 1552-1556. https://doi.org/10.1590/S0100-40422013001000011

dos Santos Araújo, K., de Sousa, S. F., Sousa, A. A. A., da Silva, J. S., & Rocha, J. A. (2016). PROSPECÇÃO CIENTÍFICA E TECNOLÓGICA DA DENGUE NO BRASIL E NO MARANHÃO NO PERÍODO DE 1994 A 2014. Cadernos de Prospecção, 9(3), 337. https://doi.org/dx.doi.org/10.9771/S.CPROSP.2016.009.036

Freitas, J. E. F., & Oliveira, L. G. (2013). A importância da prospecção para a orientação da pesquisa científica visando a inovação. Espacios, 34(2), 6. https://www.revistaespacios.com/a13v34n02/13340206.html

Gaber, M., El-Ghamry, H. A., Fathalla, S. K., & Mansour, M. A. (2018). Synthesis, spectroscopic, thermal and molecular modeling studies of Zn2+, Cd2+ and UO22+ complexes of Schiff bases containing triazole moiety. Antimicrobial, anticancer, antioxidant and DNA binding studies. Materials Science and Engineering: C, 83, 78-89. https://doi.org/10.1016/j.msec.2017.11.004

Gray, H. B. (2003). Biological inorganic chemistry at the beginning of the 21st century. Proceedings of the National Academy of Sciences, 100(7), 3563-3568. https://doi.org/10.1073/pnas.0730378100

Hamdani, H. E., & Amane, M. E. (2019). Preparation, spectral, antimicrobial properties and anticancer molecular docking studies of new metal complexes [M (caffeine) 4](PF6) 2; M= Fe (II), Co (II), Mn (II), Cd (II), Zn (II), Cu (II), Ni (II). Journal of Molecular Structure, 1184, 262-270. https://doi.org/10.1016/j.molstruc.2019.02.049

Hassoon, A. A., Harrison, R. G., Nawar, N., Smith, S. J., & Mostafa, M. M. (2020). Synthesis, single crystal X-ray, spectroscopic characterization and biological activities of Mn2+, Co2+, Ni2+ and Fe3+ complexes. Journal of Molecular Structure, 1203, 127240. https://doi.org/10.1016/j.molstruc.2019.127240

Kiremire, E. (2013). U.S. Patent Application No. 13/642,692. https://patents.google.com/patent/US20130109857A1/en

Leite, H. S., & Porto, P. A. (2015). Análise da abordagem histórica para a Tabela Periódica em livros de Química Geral para o Ensino Superior usados no Brasil no século XX. Química Nova, 38(4), 580-587. https://doi.org/10.5935/0100-4042.20150064

Lemes, M. R., & Pino Junior, A. D. (2008). Periodic table of the elements in the perspective of artificial neural networks. Química Nova, 31(5), 1141-1144. https://doi.org/10.1590/S0100-40422008000500040

Lippard, S. J. (2006). The inorganic side of chemical biology. Nature chemical biology, 2(10), 504-507. https://doi.org/10.1038/nchembio1006-504

Pereira, S. A., Alves, H. P., de Sousa, C. M., & Costa, G. L. S. (2013). Prospecção sobre o conhecimento de espécies amazônicas-Inajá (Maximiliana maripa aublt.) E Bacaba (Oenocarpus bacaba mart.). Revista GEINTEC-Gestão, Inovação e Tecnologias, 3(2), 110-122. https://doi.org/https://doi.org/10.7198/geintec.v3i2.106

Płachetka-Bożek, A., Kafel, A., & Augustyniak, M. (2018). Reproduction and development of Spodoptera exigua from cadmium and control strains under differentiated cadmium stress. Ecotoxicology and environmental safety, 166, 138-145. https://doi.org/10.1016/j.ecoenv.2018.09.016

Rocha, D. P., Pinto, G. F., Ruggiero, R., Oliveira, C. A. D., Guerra, W., Fontes, A. P. S., ... & Pereira-Maia, E. C. (2011). Coordenação de metais a antibióticos como uma estratégia de combate à resistência bacteriana. Química Nova, 34(1), 111-118. https://doi.org/10.1590/S0100-40422011000100022

Rocha, J. A., Rego, N. C., Carvalho, B. T., Silva, F. I., Sousa, J. A., Ramos, R. M., ... & Lima, F. C. (2018). Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties. PloS one, 13(6), e0198476. https://doi.org/10.1371/journal.pone.0198476

Sessler, J. L., Hemmi, G. W., & Murai, T. (1990). U.S. Patent No. 4,935,498. Washington, DC: U.S. Patent and Trademark Office. https://patents.google.com/patent/US5272142A/en

Sharma, H., Rawal, N., & Mathew, B. B. (2015). The characteristics, toxicity and effects of cadmium. International journal of nanotechnology and nanoscience, 3, 1-9. https://www.researchgate.net/profile/Blessy-Mathew-4/publication/305778858_The_characteristics_toxicity_and_effects_of_cadmium/links/57a19fe508aeb1604832e9d9/The-characteristics-toxicity-and-effects-of-cadmium.pdf

Singh, R. B., Jain, P., & Singh, R. P. (1982). Hydrazones as analytical reagents: a review. Talanta, 29(2), 77-84. https://doi.org/10.1016/0039-9140(82)80024-6

Tabrizi, L., Chiniforoshan, H., & McArdle, P. (2015). Synthesis, crystal structure and spectroscopy of bioactive Cd (II) polymeric complex of the non-steroidal anti-inflammatory drug diclofenac sodium: antiproliferative and biological activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 136, 429-436. https://doi.org/10.1016/j.saa.2014.09.053

Viñuelas-Zahínos, E., Luna-Giles, F., Torres-García, P., & Fernández-Calderón, M. C. (2011). Co (III), Ni (II), Zn (II) and Cd (II) complexes with 2-acetyl-2-thiazoline thiosemicarbazone: Synthesis, characterization, X-ray structures and antibacterial activity. European journal of medicinal chemistry, 46(1), 150-159. https://doi.org/10.1016/j.ejmech.2010.10.030

Wiangkham, N., & Prapagdee, B. (2018). Potential of Napier grass with cadmium-resistant bacterial inoculation on cadmium phytoremediation and its possibility to use as biomass fuel. Chemosphere, 201, 511-518. https://doi.org/10.1016/j.chemosphere.2018.03.039

Xin, C., Chi, J., Zhao, Y., He, Y., & Guo, J. (2019). Cadmium stress alters cytosine methylation status and expression of a select set of genes in Nicotiana benthamiana. Plant Science, 284, 16-24. https://doi.org/10.1016/j.plantsci.2019.03.021

Yonglan, F., Wujiu, J., Daizhi, K., Yaping, O., Yuxing, T., Jiangxi, Y., Fuxing, Z. and Xiaoming, Z., 2016. Cadmium complex containing naphthyl methyl carboxyl and phenanthroline and preparation method and application of cadmium complex. CN106317090A.

Zhang, H., & Reynolds, M. (2019). Cadmium exposure in living organisms: A short review. Science of the Total Environment, 678, 761-767. https://doi.org/10.1016/j.scitotenv.2019.04.395

Zhang, J., Li, Q., Zeng, Y., Zhang, J., Lu, G., Dang, Z., & Guo, C. (2019). Bioaccumulation and distribution of cadmium by Burkholderia cepacia GYP1 under oligotrophic condition and mechanism analysis at proteome level. Ecotoxicology and environmental safety, 176, 162-169. https://doi.org/10.1016/j.ecoenv.2019.03.091

Zong, X. J., Liu, X. R., Zhao, S. S., & Yang, Z. W. (2019). Preparation, thermal analyses and biological activities of Co (II) and Cr (III) complexes with 2-acetylpyridine-6-bromo-2-naphthoyl acylhydrazone. Polyhedron, 170, 303-311. https://doi.org/10.1016/j.poly.2019.05.059

Downloads

Published

07/05/2021

How to Cite

BASTOS, R. S.; ARAÚJO, J. L.; AZEVEDO, V. S.; FERREIRA, M. de L. de A. S.; LIMA, L. R. de; ROCHA, J. A. Cadmio complexes with biological activity: Scientific and technological prospection. Research, Society and Development, [S. l.], v. 10, n. 5, p. e45610515152, 2021. DOI: 10.33448/rsd-v10i5.15152. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/15152. Acesso em: 20 apr. 2024.

Issue

Section

Exact and Earth Sciences