Critical analysis of the formulation of Morosil and its commercialization in the treatment of obesity
Keywords:Morosil; Phytotherapy; Obesity.
Herbal treatments have gained strength in recent years, mainly for the treatment of obesity, but there is little scientific evidence about them. Thus, the present study aimed to conduct a critical analysis of its commercialization and effectiveness in the treatment of obesity. The research was carried out in manipulation pharmacies and drugstores in the city of Teresina - PI, through an observational analysis, the technical information of the products whose active ingredient is the Grapefruit Citrussinensis (morosil) was analyzed. In addition, a search for articles will also be carried out in the following databases Science Direct, PubMed and MEDLINE. The table below shows the specifications of the morosil formulations sold in pharmacies in Teresina-PI, where they are mostly sold in the presentation of capsules, with the exception of pharmacy C type 2, which also has the sachet presentation. All formulations have a dosage of 500mg, with the exception of Pharmacy E type 1, consequently, all have a dosage once a day, except Pharmacy E type 1 which has a dosage twice a day. All have free sales. Prices between pharmacies range from 188 R$ to 90 R$, with Pharmacy D having the morosil options associated with other components or in isolation. Given the above, it is possible to infer the information contained in the masterful formulations of the products handled are essentially important to ensure good pharmacological adherence, minimize potential adverse effects, ensure safety and efficacy.
Akhlaghi, M., Shabanian, G., Rafieian-Kopaei, M., Parvin, N., Saadat, M., & Akhlaghi, M. (2011). Flor de Citrus aurantium e ansiedade pré-operatória. Revista Brasileira de Anestesiologia, 61(6), 707–712. https://doi.org/10.1590/s0034-70942011000600002
Guimarães, G. P., Reis, M. Y. de F. A., da Silva, D. T. C., Mendonça Junior, F. J. B., Converti, A., Pessoa, A., … da Silva, J. A. (2014). Antifungal activity of topical microemulsion containing a thiophene derivative. Brazilian Journal of Microbiology, 45(2), 545–550. https://doi.org/10.1590/S151783822014000200024.
Jaisin, Y., Ratanachamnong, P., Wongsawatkul, O., Watthammawut, A., Malaniyom, K., & Natewong, S. (2020). Antioxidant and anti-inflammatory effects of piperine on UV-B-irradiated human HaCaT keratinocyte cells. Life Sciences, 263, 118607. https://doi.org/10.1016/j.lfs.2020.118607
Karimi, E., Oskoueian, E., Hendra, R., Oskoueian, A., & Jaafar, H. Z. E. (2012). Phenolic Compounds Characterization and Biological Activities of Citrus aurantium Bloom. Molecules, 17(2), 1203–1218. https://doi.org/10.3390/molecules17021203
Kostopoulou, Z., Therios, I., Roumeliotis, E., Kanellis, A. K., & Molassiotis, A. (2015). Melatonin combined with ascorbic acid provides salt adaptation in Citrus aurantium L. seedlings. Plant Physiology and Biochemistry, 86, 155–165. https://doi.org/10.1016/j.plaphy.2014.11.021
Leite, M. P., Fassin, J., Baziloni, E. M. F., Almeida, R. N., Mattei, R., & Leite, J. R. (2008). Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats. Revista Brasileira de Farmacognosia, 18(SUPPL.), 661–666. https://doi.org/10.1590/S0102-695X2008000500003
Moraes, T. M., Kushima, H., Moleiro, F. C., Santos, R. C., Machado Rocha, L. R., Marques, M. O., … Hiruma-Lima, C. A. (2009). Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: Role of prostaglandins and gastric mucus secretion. Chemico-Biological Interactions, 180(3), 499–505. https://doi.org/10.1016/j.cbi.2009.04.006
Morais, T. L., Neves, C. A., Borges, N. C., Lima, A. M. V., Silva, L. F. L., Castro, L. T. S., … Cunha, P. H. J. (2019). Evaluation of tear production, intraocular pressure, retinography and ocular biometry in bovine Nelore and Gir breeds. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 71(1), 177–186. https://doi.org/10.1590/1678-4162-10263
Namazi, M., Ali Akbari, S. A., Mojab, F., Talebi, A., Majd, H. A., & Jannesari, S. (2014). Effects of citrus Aurantium (bitter orange) on the severity of first-stage labor pain. Iranian Journal of Pharmaceutical Research, 13(3), 1011–1018. https://doi.org/10.22037/ijpr.2014.1553
Pimenta, F. C. F., Alves, M. F., Pimenta, M. B. F., Melo, S. A. L., Almeida, A. A. F. de, Leite, J. R., … Almeida, R. N. de. (2016). Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia. Phytotherapy Research, 30(4), 613–617. https://doi.org/10.1002/ptr.5566
Rahnama, S., Rabiei, Z., Alibabaei, Z., Mokhtari, S., Rafieian-kopaei, M., & Deris, F. (2015). Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurological Sciences, 36(4), 553–560. https://doi.org/10.1007/s10072-014-1991-2
Sarrou, E., Chatzopoulou, P., Dimassi-Theriou, K., & Therios, I. (2013). Volatile Constituents and Antioxidant Activity of Peel, Flowers and Leaf Oils of Citrus aurantium L. Growing in Greece. Molecules, 18(9), 10639–10647. https://doi.org/10.3390/molecules180910639
Stohs, S. J., Preuss, H. G., & Shara, M. (2011). The Safety of Citrus aurantium (Bitter Orange) and its Primary Protoalkaloid p -Synephrine. Phytotherapy Research, 25(10), 1421–1428. https://doi.org/10.1002/ptr.3490
Teixeira, F. O., & Dos Santos, S. R. (2019). MÉTODOS ESTATÍSTICOS APLICADOS NA ANÁLISE DO FITOTERÁPICO MOROSIL. In Simpósio de Engenharia de Produção (Vol. 0). Retrieved from http://www.dep.uem.br/gdct/index.php/simeprod/article/view/1725
Tomasello, B., Malfa, G. A., La Mantia, A., Miceli, N., Sferrazzo, G., Taviano, M. F., … Acquaviva, R. (2019). Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes. Natural Product Research. https://doi.org/10.1080/14786419.2019.1660337
Wang, Q. H., Shu, Z. P., Xu, B. Q., Xing, N., Jiao, W. J., Yang, B. Y., & Kuang, H. X. (2014). Structural characterization and antioxidant activities of polysaccharides from Citrus aurantium L. International Journal of Biological Macromolecules, 67, 112–123. https://doi.org/10.1016/j.ijbiomac.2014.03.004
Yang, L., Cao, Y.-L., Jiang, J.-G., Lin, Q.-S., Chen, J., & Zhu, L. (2010). Response surface optimization of ultrasound-assisted flavonoids extraction from the flower of Citrus aurantium L. var. amara Engl. Journal of Separation Science, 33(9), 1349–1355. https://doi.org/10.1002/jssc.200900776
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