Assessment of adherence to antiretroviral therapy schemes containing dolutegravir in a municipality of Goiás

Authors

DOI:

https://doi.org/10.33448/rsd-v10i6.15963

Keywords:

Medication Adherence; Public Health; Antiretroviral Therapy, Highly Active;; Medication adherence; Highly active; Public health; Antiretroviral therapy.

Abstract

Individual infected with the Human Immunodeficiency Virus (HIV) have free access to Antiretroviral Therapy (ART), however for it to work it is necessary that the patient conducts the maintenance of the treatment, as the effectiveness of ART depends directly on the patient's compliance. The aim of the present study was to describe the adherence to ART of patients with HIV / AIDS treated by the Unified Health System in the State of Goiás. This is a cross-sectional descriptive study, developed at the health unit Dr. Ilion Fleury Jr., reference in diagnosis and treatment of STIs / AIDS in the city of Anápolis / GO. The “Survey for the assessment of adhesion to antiretroviral treatment - CEAT-HIV” was used to assess adherence to ART. The patients' medical records were analyzed to obtain laboratory results. Among the 88 patients included in the study, 74% (n = 65) were male, with a mean age of 37 years and 49% (n = 43) declared themselves to be heterosexual. When analyzing adherence, it was found that 81% (n = 72) had strict adherence, more than 87% of the participants had an undetectable viral load, with a TCD4 + lymphocyte count of ± 555 cells / mm³. The results of this study allow us to suggest a good adherence to the new ART scheme with dolutegravir, in addition to better viral load control.

References

BRASIL MDS. (2018). Protocolo clínico e diretrizes terapêuticas para Profilaxia Pré-Exposição (PrEP) de risco à infecção pelo HIV. Ministério da Saúde Brasil.

Cabral, R. J., Moraes, D. C. A., Cabral, L. R., Corrêa, C.A., Oliveira E. C. S., & Oliveira, R. C. (2018) Adesão à terapia antirretroviral e a associação no uso de álcool e substâncias psicoativas. Enfermería global, 17(4), 1-35.

Cardoso, T. S., Costa, J. O., Reis, E. A., Silveira, M. R., Bonolo, P. F., Santos, S. F., & Ceccato, M. G. B.(2019). Which antiretroviral regimen is associated with higher adherence in Brazil? A comparison of single, multi, and dolutegravir-based regimens. Cad Saude Publica, 35:e00115518.

Carvalho, P. P., Barroso, S. M., Coelho, H. C., & Penaforte, F. R. O. (2019) Factors associated with antiretroviral therapy adherence in adults: an integrative review of literature. Cien Saude Colet, 24, 2543-55.

Cruciani, M., & Parisi, S. G. (2019) Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis. PLoS One,14(9), e0222229.

Ehlers, V. J., & Tshisuyi, E. T. (2015) Adherence to antiretroviral treatment by adults in a rural area of Botswana. Curationis, 38(1), 1-8.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Garbin, C. A. S., Gatto, R. C. J., & Garbin, A. J. I. (2017) Adesão à terapia antirretroviral em pacientes HIV soropositivos no Brasil: uma revisão da literatura. Archives of Health Investigation, 6(2), 65-70.

Guillén, S. M., García, J. E. L., Berenguer, J. B., Sesmero, J. M. M., Gomis, S. C., Graefehain, R., Sánchez-Cambronero D. L. & García, F. J. P. (2017) Cost-utility analysis of the fixed-dose combination of dolutegravir/abacavir/lamivudine as initial treatment of HIV+ patients in Spain. Farm Hosp, 41(5), 601-610.

Moraes, R., Ferreira, M., Vaz, R., Coelho, I., Pinheiro, G., Gonçalves, J., França, M., & Almeida, I. (2019) Prevalência de Efeitos Neuropsiquiátricos em Doentes com Infecção VIH sob Dolutegravir. Med Interna (Bucur), 26(1),14-20.

Nunn, A. S., Fonseca, E. M., Bastos, F. I., Gruskin, S., & Salomon, J. A. (2007) Evolution of antiretroviral drug costs in Brazil in the context of free and universal access to AIDS treatment. PLoS Med. 2007;4(11):e305

Oliveira, L. S., Caixeta, L. M., Martins, J. L. R., Segati, K. D., Moura, R. S., Daher, M. C., & Pinto, E. M. H. (2018) Adherence to antiretroviral therapy and correlation with adverse effects and coinfections in people living with HIV/AIDS in the municipality of Goiás State. Rev Soc Bras Med Trop, 51(4), 436-44.

Organization WH. (2003). Adherence to long-term therapies: evidence for action. World Health Organization.

Paramesha, A. E., & Chacko, L. K. (2019) Predictors of adherence to antiretroviral therapy among PLHIV. Indian J Public Health, 63(4), 367.

Polejack, L., & Seidl, E. M. F. (2010) Monitoramento e avaliação da adesão ao tratamento antirretroviral para HIV/aids: desafios e possibilidades. Psicologia, 70910, 900.

Remor, E., Milner-Moskovics, J., & Preussler, G. (2007). Brazilian adaptation of the assessment of adherence to antiretroviral therapy questionnaire. Revista de saude publica, 41(5), 685-694.

Rocha, G. M., Machado, C. J., Acurcio, F. A., & Guimarães, M. D. C. (2011) Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge. Cad Saude Publica, 27, s67-78.

Santos, É. I., Silva, A. L., Santana, P. P. C., & Teixeira P. A. (2016) Evidências científicas brasileiras sobre adesão à terapia antirretroviral por pessoas que vivem com HIV/AIDS. Revista Eletrônica Gestão & Saúde, (1), 454-70.

Schaurich, D., Coelho, D. F., & Motta, M. G. C. (2006) A cronicidade no processo saúde-doença: repensando a epidemia da AIDS após os anti-retrovirais. Revista Enfermagem UERJ, 14(3), 455-462.

Silva, R. A. R., Nelson, A. R. C., Duarte, F. H. S., Prado N. C. C., Holanda, J. R. R., & Costa, D. A.R. S. (2017) Avaliação da adesão à terapia antirretroviral em pacientes com AIDS Evaluation of adherence to antiretroviral therapy for AIDS patients. Revista de Pesquisa Cuidado é Fundamental Online, 9(1), 15-20.

Soares, R. C. A., Brito, A. M., Lima, K., & Lapa, T. M. (2019) Adherence to antiretroviral therapy among people living with HIV/AIDS in northeastern Brazil: a cross-sectional study. Sao Paulo Med J, 137(6), 479-85.

Velame, K. T., Silva, R. S., Cerutti, & Junior, C. (2020) Factors related to adherence to antiretroviral treatment in a specialized care facility. Rev Assoc Med Bras, 66(3), 290-5.

Published

08/06/2021

How to Cite

COSTA, T. B. F. da .; MORAIS, Álice C. B. .; MIRANDA, K. G. .; SIQUEIRA, L. da S. O.; SIQUEIRA, G. D. de J. .; MARTINS, J. L. R.; DAHER , M. C. .; FREITAS, A. de A. .; PINTO, E. M. H. . Assessment of adherence to antiretroviral therapy schemes containing dolutegravir in a municipality of Goiás. Research, Society and Development, [S. l.], v. 10, n. 6, p. e50910615963, 2021. DOI: 10.33448/rsd-v10i6.15963. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/15963. Acesso em: 14 jun. 2021.

Issue

Section

Health Sciences