Epidemiological analysis of Alcoholic Hepatic Disease deaths between 2006 and 2015 in Rio Grande do Sul

Authors

DOI:

https://doi.org/10.33448/rsd-v10i6.16105

Keywords:

Alcohol liver disease (ALD); Rio Grande do Sul (RS); Mortality.

Abstract

Objective: The research aims to describe the epidemiological profile of deaths due to ALD between the years 2006 and 2015 in the state of Rio Grande do Sul (RS). Methods: Analysis of DATASUS database and demographic population of each region. The mortality rate was calculated for every 100,000 inhabitants and the analysis was divided into sex (female and male), year (2006 to 2015), age group (0-19, 20-59 and 60+) and macro-regions of RS (Valleys, South, Serra, North, Missionary, Metropolitan and Midwest). Results: The Metropolitan region had the highest total number of deaths (2277 men and 279 women), followed by North, Serra, Midwest and Missioneira Sul. Analyzing the number of deaths per 100,000 inhabitants, the North region had the highest mortality rate. Regarding the sexes, there was a higher prevalence of males with significant difference (p0.012) for the two variables and, regarding the age group, the highest rates were found in the elderly group (60 years or older). Conclusion:  ALD remains a condition with a major impact on Brazilian’s public health system. Strategies to improve screening, public policies aimed to prevent the consumption of alcoholic beverages and the epidemiological knowledge of the disease are essential to reduce morbimortality in RS and others brazilian’s states. Incluir o resumo em inglês.

References

Atkins, D., Ross, D., & Kelley, M. (2014). Acting in the Face of Uncertainty. Annals of Internal Medicine, 161(4), 300. https://doi.org/10.7326/m14-1344.

Crabb, D. W. (1999). Pathogenesis of Alcoholic Liver Disease. Newer Mechanisms of Injury. The Keio Journal of Medicine, 48(4), 184–188. https://doi.org/10.2302/kjm.48.184.

Crabb, D. W., Im, G. Y., Szabo, G., Mellinger, J. L., & Lucey, M. R. (2020). Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases. Hepatology, 71(1), 306–333. https://doi.org/10.1002/hep.30866.

Degré, D., Stauber, R. E., Englebert, G., Sarocchi, F., Verset, L., Rainer, F., Spindelboeck, W., Njimi, H., Trépo, E., Gustot, T., Lackner, C., Deltenre, P., & Moreno, C. (2020). Long-term outcomes in patients with decompensated alcohol-related liver disease, steatohepatitis and Maddrey's discriminant function <32. Journal of Hepatology, 72(4), 636–642. https://doi.org/10.1016/j.jhep.2019.12.023.

Fernandes, G. dos., Campos, D., Ballalai, A., Palhares, R., Alvares-da-Silva, M. R., Palhares, D. M., Neto, B.-H. F., Barros, F. M., Gil, R. de, Chagas, A., & Carrilho, F. J. (2020). Author Correction: Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data. Journal of Gastrointestinal Cancer. https://doi.org/10.1007/s12029-020-00539-0.

Ganne-Carrié, N., & Nahon, P. (2019). Hepatocellular carcinoma in the setting of alcohol-related liver disease. Journal of Hepatology, 70(2), 284–293. https://doi.org/10.1016/j.jhep.2018.10.008.

Guirguis, J., Chhatwal, J., Dasarathy, J., Rivas, J., McMichael, D., Nagy, L. E., McCullough, A. J., & Dasarathy, S. (2015). Clinical Impact of Alcohol-Related Cirrhosis in the Next Decade: Estimates Based on Current Epidemiological Trends in the United States. Alcoholism: Clinical and Experimental Research, 39(11), 2085–2094. https://doi.org/10.1111/acer.12887.

Hagström, H., Hemmingsson, T., Discacciati, A., & Andreasson, A. (2018). Alcohol consumption in late adolescence is associated with an increased risk of severe liver disease later in life. Journal of Hepatology, 68(3), 505–510. https://doi.org/10.1016/j.jhep.2017.11.019.

Kansagara, D., Papak, J., Pasha, A. S., O’Neil, M., Freeman, M., Relevo, R., Quiñones, A., Motu’apuaka, M., & Jou, J. H. (2014). Screening for Hepatocellular Carcinoma in Chronic Liver Disease. Annals of Internal Medicine, 161(4), 261. https://doi.org/10.7326/m14-0558.

Ludke, M., & Andre, M. E. D. A. (2013). Pesquisas em educação: uma abordagem qualitativa: E.P.U. F.

Lyra, A. C., Almeida, L. M., Mise, Y. F., & Cavalcante, L. N. (2020). Epidemiological profile of alcoholic liver disease hospital admissions in a Latin American country over a 10-year period. World Journal of Hepatology, 12(5), 230–238. https://doi.org/10.4254/wjh.v12.i5.230.

Mahmud, N., Fricker, Z., Hubbard, R. A., Ioannou, G. N., Lewis, J. D., Taddei, T. H., Rothstein, K. D., Serper, M., Goldberg, D. S., & Kaplan, D. E. (2020). Risk Prediction Models for Post‐Operative Mortality in Patients With Cirrhosis. Hepatology, 73(1), 204–218. https://doi.org/10.1002/hep.31558.

Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J. (1997). Excess weight risk factor for alcoholic liver disease. Hepatology, 25(1), 108–111. https://doi.org/10.1002/hep.510250120.

Pereira, A. S, Shitsuka D. M., Parreira F. J., Shitsuka R. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed.UAB/NTE/UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 25 jan. 2021.

Rachakonda, V., Bataller, R., & Duarte-Rojo, A. (2020). Recent advances in alcoholic hepatitis. F1000Research, 9, 97. https://doi.org/10.12688/f1000research.20394.1.

Shah, N. D., Ventura-Cots, M., Abraldes, J. G., Alboraie, M., Alfadhli, A., Argemi, J., Badia-Aranda, E., Arús-Soler, E., Barritt, A. S., Bessone, F., Biryukova, M., Carrilho, F. J., Fernández, M. C., Dorta Guiridi, Z., El Kassas, M., Eng-Kiong, T., Queiroz Farias, A., George, J., Gui, W., & Bataller, R. (2019). Alcohol-Related Liver Disease Is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide. Clinical Gastroenterology and Hepatology, 17(11). https://doi.org/10.1016/j.cgh.2019.01.026.

Singal, A. K., Bataller, R., Ahn, J., Kamath, P. S., & Shah, V. H. (2018). ACG Clinical Guideline: Alcoholic Liver Disease. American Journal of Gastroenterology, 113(2), 175–194. https://doi.org/10.1038/ajg.2017.469.

Stein, E., Cruz-Lemini, M., Altamirano, J., Ndugga, N., Couper, D., Abraldes, J. G., & Bataller, R. (2016). Heavy daily alcohol intake at the population level predicts the weight of alcohol in cirrhosis burden worldwide. Journal of Hepatology, 65(5), 998–1005. https://doi.org/10.1016/j.jhep.2016.06.018.

Ventura‐Cots, M., Watts, A. E., Cruz‐Lemini, M., Shah, N. D., Ndugga, N., McCann, P., Barritt, A. S., Jain, A., Ravi, S., Fernandez‐Carrillo, C., Abraldes, J. G., Altamirano, J., & Bataller, R. (2019). Colder Weather and Fewer Sunlight Hours Increase Alcohol Consumption and Alcoholic Cirrhosis Worldwide. Hepatology, 69(5), 1916–1930. https://doi.org/10.1002/hep.30315.

Villanueva, A. (2019). Hepatocellular Carcinoma. New England Journal of Medicine, 380(15), 1450–1462. https://doi.org/10.1056/nejmra1713263.

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Published

09/06/2021

How to Cite

MILANI, T. Z. .; ZIN, J. V. B.; BAMBERG, F. W.; MROGINSKI, L. S. C.; CORRÊA , N. B.; BORDIGNON, V. R.; ZANIN, G. T.; FRANCESCON, H. T.; REICHERT, P. R. Epidemiological analysis of Alcoholic Hepatic Disease deaths between 2006 and 2015 in Rio Grande do Sul. Research, Society and Development, [S. l.], v. 10, n. 6, p. e54010616105, 2021. DOI: 10.33448/rsd-v10i6.16105. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16105. Acesso em: 16 nov. 2024.

Issue

Vol. 10 No. 6

Section

Health Sciences

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Copyright (c) 2021 Tomás Zanetti Milani; Joao Vitor Barcellos Zin; Fernanda Werlang Bamberg; Leonardo Sérgio Chiodi Mroginski; Nathalia Beck Corrêa ; Vitória Razera Bordignon; Gabriel Tarasconi Zanin; Heloisa Todeschini Francescon; Paulo Roberto Reichert

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