Risk of cardiovascular diseases with intestinal profile influenced by vitamin D deficiency

Authors

DOI:

https://doi.org/10.33448/rsd-v10i6.16449

Keywords:

Vitamin D; Cardiovascular diseases; Intestine.

Abstract

Introduction: as NCDs portray a major and important public health problem in all countries, among these diseases are cardiovascular diseases (CVD), responsible for a large mortality rate worldwide. Objective: Thus, the present study aims to describe findings in the literature that establish the relationship between vitamin D deficiency, with the imbalance of the microbiota and the development of cardiovascular diseases. Methodology: The methodology used was a literature review of narrative character. Data collection was carried out on sites such as Scielo (Scientific Electronic Library Online), PubMed (Database of Medical Publications) and Google Scholar in Portuguese and English. Articles, theses, monographs and websites were included that presented contents and titles that fit the studied theme and in the period from 2011 to 2021, in Portuguese or other languages ​​such as English, and those that did not meet these criteria were excluded. . Results and speeches: There are indications of the participation of vitamin D in homeostasis of the cardiovascular system through the mediation of microbiota regulation and the inflammatory state. Conclusion: Even with current studies, more studies and research are needed to evaluate such a relationship in order to clarify the processes involving vitamin D, microbiota and cardiovascular system and their respective roles in increased cardiovascular risk, so that it is possible to establish not only future one’s lines of treatment, but also means of prevention.

References

Adamczak, Daria Maria et al. (2014). The Role of Toll-Like Receptores and Vitamin D in Diabetes Mellitus Type 1- A Review. Scandinavian J Immunol, 80(2), 75-84.

Adams, J. S. & Hewison, M. (2010). Update in vitamin D. J Clin Endocrinol Metab, 95(2), 471-478.

Ajabshir, S., Asif, A. & Nayer, A. (2014). The effects of vitamin D on the renin-angiotensin system. J Nephropathol, 3(2), 41-3.

Ananthakrishnan, Ashwin N. et al. (2014). Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases. Alimentary pharmacology and therapeutics, 39(10), 1136-1142.

Andrade, Paula Caroline de Oliveira et al. (2015). Alimentação, foto exposição e suplementação: influência nos níveis séricos de vitamina D. Rev Med Minas Gerais, 25(3), 432-437.

Barbáchano, Antonio et al. (2016). The endocrine vitamin D system in the gut. Molecular and Cellular Endocrinology.

Barebgolts, Elena. (2013). Vitamin D And Prebiotics May Benefit The Intestinal Microbacteria And Improve Glucose Homeostasis In Prediabetes And Type 2 Diabetes. Endocr Pract, 19(3), 497-510.

Borges, Ana Clara do Nascimento et al. (2020). Vitamina D associada à hipertensão. Research, Society and Development, 9(1), 110911691.

Brasil. (2020). Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Análise em Saúde e Vigilância de Doenças Não Transmissíveis. Vigitel Brasil 2019: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico: estimativas sobre frequência e distribuição sociodemográfica de fatores de risco e proteção para doenças crônicas nas capitais dos 26 estados brasileiros e no Distrito Federal em 2019. 1 ed., Brasília, 137.

Brasil. (2020). Ministério da Saúde. Tabagismo custa R$ 56,9 bilhões por ano ao Brasil. INCA, Instituto Nacional de Câncer-Ministério da Saúde, 2017. http://www2.inca.gov.br/wps/wcm/connect/agencianoticias/site/home/noticias/2017/tabagismo-custa-59-bilhoes-por-ano-ao-brasil.

Body, Jean Jacques et al. (2012). Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. Osteoporos Int, 23(1), 1-23.

Bourbon, Mafalda et al. (2016). Doenças cardiovasculares. Sabe como prevenir? Instituto Nacional de Saúde Doutor Ricardo Jorge. Departamento de Promoção da Saúde e Prevenção de Doenças Não Transmissíveis.

Carbone, Federico et al. (2014). Potential pathophysiological role for the vitamin D deficiency in essential hypertension. World J Cardiol, 6(5), 260-76.

Castro, Luiz Claudio Gonçalves de. (2011). O sistema endocrinológico vitamina D. Arq Bras Endocrinol Metab, 55(8), 566-575, http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800010&lng=pt&nrm=iso.

Cerulho, Viviane Rodrigres. (2017). Vitamina D e saúde intestinal. 2017. Trabalho de Conclusão do Curso (Bacharelado em Nutrição) - Centro Universitário IBMR/Laurete International Universites, Rio de Janeiro.

Clark, A. & Mach, N. Role of Vitamin D in the Hygiene Hypothesis: The Interplay. Frontiers in immunology, 7, 01-12.

Cozzolino, S. M. & Cominetti, C. (2013). Bases bioquímicas e Fisiológicas da nutrição: nas diferentes fases da vida, na saúde e na doença. 1 ed., Baurueri: Manole, 1257.

Ferreira, Ana Carolina Freitas Reis. (2013). Vitamina D. Tese de mestrado (Mestrado Integrado em Medicina) - Faculdade de Medicina da Universidade de Coimbra, Coimbra.

Filho, A. J. I. & Melamed, M. L. Vitamina D e doença renal. O que nós sabemos e o que nós não sabemos. J.Bras.Nefrol. , 35(4), 323-331, 2013. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S010128002013000400012&lng=en&nrm=iso.

Fonseca, Marília Izar Helfenstein. (2015). Hipertensão arterial, risco cardiovascular e vitamina D. Rev Bras Hipertens, 22(1), 2-8.

Garcia, V. C. & Martini, L. A. (2010). Vitamin D and cardiovascular disease. Nutrients, 2(4), 426-37.

Hewison, M. (2010). Vitamin D and the imune system: new perspective on a old theme. Endocrinology Metabolism Clinics of North America, 39(2), 365-379.

Holick, Michael F. et al. (2011). Evaluation, treatment, and prevention of Vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism, 96(30), 1911.

Holick, Michael F. (2012). Vitamina D. 1 ed., São Paulo: Editora Fundamento Educacional Ltda, 320.

Jorge, Antonio José Lagoeiro et al. (2018). Vitamina D e doença cardiovascular. Int J Cardiovasc Sci. 31(4), 422-432.

Juonala, Markus et al. (2015). Childhood 25-OH vitamin D levels and carotid intima-media thickness in adulthood: the cardiovascular risk in Young Finns Study. J Clin Endocrinol Metab, 100(4), 1469-1476.

Kennel, K., Drake, M. & Hurley, D. (2010). Vitamin D Deficiency in adults: when to test and how to treat. Mayo Clinic Proc, 85(8), 752-8.

Kich, Daiana Manuele et al. (2012). Determination of 25-hidroxy-vitamin D2 and D3 in plasma by HPLC-DAD. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 48, n. 5, p. 329-336. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442012000500005&lng=en&nrm=iso.

Lichtenstein, Arnaldo et al. (2013). Vitamina D: ações extra ósseas e uso racional. Rev. Assoc. Med. Bras., 59(5), 495-506. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500015&lng=en&nrm=iso.

Liu, Xiao et al. (2019). The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies. Nutrition journal, 18(1), 73.

Ly, Nogoc P. el at. (2011). Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol, 127(5), 1087–1094.

Luthold, Renata Vidonscky. (2017). Vitamina D na modulação da microbiota intestinal: associações com os perfis inflamatório e cardiometabólico. Dissertação (Mestrado em Nutrição em Saúde Pública) - Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo. Doi:10.11606/D.6.2017.tde-06042017-095924.

Maeda, Sergio Setsuo et al. (2014). Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arq Bras Endocrinol Metabol, 58(5), 411-33.

Nadir, M. A., Szwejkowski, B. R. & Witham, M. D. (2010). Vitamin D and Cardiovascular Prevention. Cardiovascular Therapeutics, 28(4), 5-12.

Norman, P. E. & Powell J. T. (2014). Vitamin D and cardiovascular disease. Circ Res, 114(2), 379-393.

Oliveira, Renata M. S. et al. (2013). Association of vitamin D insuffi ciency with adiposity and metabolic disorders in Brazilian adolescents. Public Health Nutr, 17(4), 787-794.

Oliveira, Vanessa de et al. (2014). Influência da vitamina D na saúde humana. Acta Bioquímica Clínica Latinoamericana, 48(03), 339-347.

Pavlović, D., Josipović, J. & Pavlović, N. (2011). Vitamin D and hypertension. Period biol, 113, 3.

Pereira, Simão Pedro Torres. (2014). Sistema Renina Angiotensina, para além da Hipertensão Arterial. Dissertação (Mestrado em Ciências Farmacêuticas) - Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto.

Rafaelli, Rafael Algusto et al. (2015). Influência da vitamina D nas doenças endocrinometabólicas. Semina: Ciências Biológicas e da saúde, 36(1), 333-348.

Rhodes, Jonathan Michael et al. (2020). Perspective: Vitamin D deficiency and COVID-19 severity – plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis. Journal of Internal Medicine, 289(1), 97-115.

Rother, Edna Terezinha. (2007). Revisão sistemática X revisão narrativa. Acta paul. Enferm, 20(2), 5-6.

Russo, Guilherme Vargas Gomes Almeida. (2017). A importância da vitamina D na sua saúde: uma revisão de literatura. International Journal of Science Dentistry, 2.

Santos, Robson A. S. et al. (2013). Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: New players of the renin-angiotensin system. Journal of Endocrinology, 216, 1-17.

Santos, Alejandro. (2011). Papel da vitamina D no risco cardiovascular. Rev Facto de Ris, 20(9), 18-23.

Scaldaferri, Franco et al. (2012). The Gut Barrier: New Acquisitions and Therapeutic Approaches. Journal of Clinical Gastroenterology. 46(1), 12-17.

Shoback, D., Sellmeyer, D. & Bikle, D. (2011). Metabolic Bone Disease. In: GARDNER D. G.; SHOBACK, D. Greenspan's Basic and Clinical Endocrinology. 9th ed., New York: McGraw-Hill Companies. 227-284.

Thacher, T.D. & Clarke, B.L. (2011). Vitamin D insufficiency. Mayo Clinic Proceedings, 86(01), 50-60.

Wang, Jun et al. (2016). Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48(11), 1396- 1406.

Weiss, Scott T. (2011). Bacterial componentes plus vitamin D: the ultimate solution to the asthma (autoimmune disease) edpidemic? J Allergy Clin Immunol, 127(5), 1128.

Weiss, S. T. & Lintojua, A. A. (2015). Vitamin D, the gut microbiome, and the hygiene hipothesis. How does asthma begin? Am J Respir Crit Care Med, 191(5), 492-493.

White, Christopher. (2014). Update on vitamin D: More than just a nutrient. Obstetric Medicine, 7(01), 04-07.

Zittermann, A. & Gummert, J. F. (2010). Nonclassical vitamin D action. Nutrients, 2(4), 408-25.

Published

02/06/2021

How to Cite

SOUZA, A. A. de .; VERAS, M. da S.; PANTOJA, M. T. A.; FERREIRA, J. C. de S. Risk of cardiovascular diseases with intestinal profile influenced by vitamin D deficiency. Research, Society and Development, [S. l.], v. 10, n. 6, p. e29510616449, 2021. DOI: 10.33448/rsd-v10i6.16449. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16449. Acesso em: 20 jun. 2021.

Issue

Section

Review Article