Vitamin d supplementation in postmenopausal women: an analysis of current scientific publications

Authors

DOI:

https://doi.org/10.33448/rsd-v10i7.16574

Keywords:

Post-menopause; Nutritional supplementation; D vitamin.

Abstract

Menopause is defined as the permanent interruption of the menstrual cycle, being diagnosed after a period of 12 consecutive months of amenorrhea. In these women, vitamin D levels can be changed. Thus, some studies have suggested the exogenous supplementation of this nutrient as a therapeutic alternative. The objective was to conduct a literature review on exogenous isolated and/or combined vitamin D supplementation in postmenopausal women. Several articles published between 2016 and 2020 were collected. The following descriptors were used: “post-menopause”, “nutritional supplementation” and “vitamin D”, defined according to the Health Sciences Descriptors - DeCS platform. The databases used were Scielo, LILACS and PUBMED. The selection of articles followed inclusion and exclusion criteria, previously established. 21 articles were included in the study, most of which were published in 2018 (n= 9.42.85%). The selected studies evaluated the effects of this supplementation in different aspects. The high and low doses of supplementation were compared, the effects of a combination of vitamin D with other nutrients were analyzed, as well as the influence of an educational process on the topic with the participants. These women were evaluated for such therapy, considering the practice of physical activity, the serum profile of sex hormones, the risk of cancer in smokers, as well as muscle and inflammatory parameters. In view of the above, it was observed that exogenous supplementation with vitamin D is a therapeutic option under constant evaluation. It was also found that combined supplementation was the most developed approach among studies.

References

Apaydin, M., Can, A. G., Kizilgul, M., Beysel, S., Kan, S., Caliskan, M., & Cakal, E. (2018). The effects of single high-dose or daily low-dosage oral colecalciferol treatment on vitamin D levels and muscle strength in postmenopausal women. BMC endocrine disorders, 18(1), 1-8. https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0277-8.

Argyrou, C., Karlafti, E., Lampropoulou-Adamidou, K., Tournis, S., Makris, K., Trovas, G., & Triantafyllopoulos, I. K. (2020). Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia. Journal of musculoskeletal & neuronal interactions, 20(1), 12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104583/.

Barral, D., Barros, A. C., & de ARAÚJO, R. P. C. (2007). Vitamina D: uma abordagem molecular. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 7(3), 309-315. https://www.redalyc.org/pdf/637/63770319.pdf.

Bislev, L. S., Rødbro, L. L., Bech, J. N., Pedersen, E. B., Kjaergaard, A. D., Ladefoged, S. A., & Rejnmark, L. (2018). The effect of vitamin D3 supplementation on markers of cardiovascular health in hyperparathyroid, vitamin D insufficient women: a randomized placebo-controlled trial. Endocrine, 62(1), 182-194. https://link.springer.com/article/10.1007/s12020-018-1659-4.

Bislev, L. S., Rødbro, L. L., Rolighed, L., Sikjaer, T., & Rejnmark, L. (2018). Effects of vitamin D3 supplementation on muscle strength, mass, and physical performance in women with vitamin D insufficiency: a randomized placebo-controlled trial. Calcified tissue international, 103(5), 483-493. https://link.springer.com/article/10.1007/s00223-018-0443-z.

Boursiquot, B. C., Larson, J. C., Shalash, O. A., Vitolins, M. Z., Soliman, E. Z., & Perez, M. V. (2019). Vitamin D with calcium supplementation and risk of atrial fibrillation in postmenopausal women. American heart journal, 209, 68-78. https://www.sciencedirect.com/science/article/abs/pii/S0002870318303454.

Brasil. Ministério da Saúde (2016). Protocolos da Atenção Básica: Saúde das Mulheres / Ministério da Saúde, Instituto Sírio-Libanês de Ensino e Pesquisa – Brasília: Ministério da Saúde. http://bvsms.saude.gov.br/bvs/publicacoes/protocolos_atencao_basica_saude_mulheres.pdf.

Brech, G. C., Ciolac, E. G., Peterson, M. D., & Greve, J. M. D. A. (2017). Serum 25-hydroxyvitamin D levels are associated with functional capacity but not with postural balance in osteoporotic postmenopausal women. Clinics, 72(1), 11-16. https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000100011.

Bueloni-Dias, F. N., Orsatti, C. L., Cangussu, L. M., Poloni, P. F., Spadoto-Dias, D., Nahas-Neto, J., & Nahas, E. A. (2018). Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial. Menopause, 25(8), 897-903. https://journals.lww.com/menopausejournal/Abstract/2018/08000/Isolated_vitamin_D_supplementation_improves_the.9.aspx.

Cangussu, L. M., Nahas-Neto, J., Orsatti, C. L., Poloni, P. F., Schmitt, E. B., Almeida-Filho, B., & Nahas, E. A. P. (2016). Effect of isolated vitamin D supplementation on the rate of falls and postural balance in postmenopausal women fallers: a randomized, double-blind, placebo-controlled trial. Menopause, 23(3), 267-274. https://journals.lww.com/menopausejournal/Abstract/2016/03000/Effect_of_isolated_vitamin_D_sup plementation_on.8.aspx.

Castro, L. C. G. D. (2011). O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia & Metabologia, 55(8), 566-575. https://www.scielo.br/scielo.php?pid=S0004-27302011000800010&script=sci_arttext&tlng=pt.

Cheng, T. Y. D., Song, X., Beresford, S. A., Ho, G. Y., Johnson, K. C., Datta, M., & Neuhouser, M. L. (2017). Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women. Cancer Causes & Control, 28(10), 1053-1063. https://link.springer.com/article/10.1007/s10552-017-0956-1.

El Khoudary, S. R., Greendale, G., Crawford, S. L., Avis, N. E., Brooks, M. M., Thurston, R. C., & Matthews, K. (2019). The menopause transition and women's health at midlife: a progress report from the Study of Women's Health Across the Nation (SWAN). Menopause (New York, NY), 26(10), 1213. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784846/.

Ercole, F. F., Melo, L. S., Alcoforado, C. L. G. C. (2014). Revisão integrativa versus revisão sistemática. Revista Mineira de Enfermagem, 18(1), 9-12. http://www.reme.org.br/artigo/detalhes/904.

Ferreira, P. P., Cangussu, L., Bueloni-Dias, F. N., Orsatti, C. L., Schmitt, E. B., Nahas-Neto, J., & Nahas, E. A. P. (2020). Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women. Climacteric, 23(1), 24-31. https://www.tandfonline.com/doi/abs/10.1080/13697137.2019.1611761.

Grimnes, G., Emaus, N., Cashman, KD, & Jorde, R. (2017). O efeito da suplementação de vitamina D em altas doses na função muscular e na qualidade de vida em mulheres na pós-menopausa - um ensaio clínico randomizado. Clinical endocrinology, 87 (1), 20-28. https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13353.

Harlow, S. D., Gass, M., Hall, J. E., Lobo, R., Maki, P., Rebar, R. W., & STRAW+ 10 Collaborative Group. (2012). Executive summary of the Stages of Reproductive Aging Workshop+ 10: addressing the unfinished agenda of staging reproductive aging. The Journal of Clinical Endocrinology & Metabolism, 97(4), 1159-1168. https://academic.oup.com/jcem/article/97/4/1159/2833227?login=true.

Kamronrithisorn, T., Manonai, J., Vallibhakara, SAO, Sophonsritsuk, A., & Vallibhakara, O. (2020). Efeito do suplemento de vitamina D na atrofia vulvovaginal da menopausa. Nutrients, 12 (9), 2876. https://www.mdpi.com/2072-6643/12/9/2876.

Lee, C. J., Kim, S. S., Suh, W. Y., Kim, J. S., Jung, J. G., Yoon, S. J., & Yang, H. J. (2019). The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women. Journal of bone metabolism, 26(3), 193. https://synapse.koreamed.org/upload/SynapseData/PDFData/2187JBM/jbm-26-193.pdf.

Lee, J. S., & Kim, J. W. (2018). Prevalence of vitamin D deficiency in postmenopausal high-and low-energy fracture patient. Archives of osteoporosis, 13(1), 1-6. https://link.springer.com/article/10.1007/s11657-018-0524-7.

Lerchbaum, E. (2014). Vitamin D and menopause—A narrative review. Maturitas, 79(1), 3-7. https://www.sciencedirect.com/science/article/abs/pii/S0378512214001996.

Lui Filho, J. F., Baccaro, L. F. C., Fernandes, T., Conde, D. M., Costa-Paiva, L., & Pinto Neto, A. M. (2015). Epidemiologia da menopausa e dos sintomas climatéricos em mulheres de uma região metropolitana no sudeste do Brasil: inquérito populacional domiciliar. Revista Brasileira de Ginecologia e Obstetrícia, 37(4), 152-158. https://www.scielo.br/scielo.php?pid=S0100-72032015000400152&script=sci_arttext.

Mason, C., Tapsoba, J. D. D., Duggan, C., Imayama, I., Wang, C. Y., Korde, L. A., & McTiernan, A. (2016). Effects of vitamin D supplementation during weight loss on sex hormones in postmenopausal women. Menopause (New York, NY), 23(6), 645. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874908/.

Monteleone, P., Mascagni, G., Giannini, A., Genazzani, A. R., & Simoncini, T. (2018). Symptoms of menopause—global prevalence, physiology and implications. Nature Reviews Endocrinology, 14(4), 199. https://www.nature.com/articles/nrendo.2017.180.

Nahas-Neto, J., Cangussu, L. M., Orsatti, C. L., Bueloni-Dias, F. N., Poloni, P. F., Schmitt, E. B., & Nahas, E. A. P. (2018). Effect of isolated vitamin D supplementation on bone turnover markers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial. Osteoporosis International, 29(5), 1125-1133. https://link.springer.com/article/10.1007/s00198-018-4395-y.

National Collaborating Centre for Women's and Children's Health (Reino Unido. (2015). Menopause: Full Guideline. https://pubmed.ncbi.nlm.nih.gov/26598775/.

Nolasco, R., Moreira, L. D., Bocalini, D. S., Fronza, F. C., Marin, R. V., & Lazaretti-Castro, M. (2017). Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program. Archives of endocrinology and metabolism, 61(1), 28-35. https://www.scielo.br/scielo.php?pid=S2359-39972016005005105&script=sci_arttext.

Oberg, J., Verelst, M., Jorde, R., Cashman, K., & Grimnes, G. (2017). High dose vitamin D may improve lower urinary tract symptoms in postmenopausal women. The Journal of steroid biochemistry and molecular biology, 173, 28-32. https://www.sciencedirect.com/science/article/abs/pii/S096007601730078X.

Ogata, M., Iwasaki, N., Ide, R., Takizawa, M., Tanaka, M., Tetsuo, T., & Uchigata, Y. (2018). Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6‐month follow‐up evaluation. Journal of diabetes investigation, 9(1), 211-222. https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12666.

Oliveri, B., Mastaglia, S. R., Brito, G. M., Seijo, M., Keller, G. A., Somoza, J., & Di Girolamo, G. (2015). Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach. European journal of clinical nutrition, 69(6), 697-702. https://www.nature.com/articles/ejcn201516?page=4&page=2.

Pérez-López, F. R., Brincat, M., Erel, C. T., Tremollieres, F., Gambacciani, M., Lambrinoudaki, I., & Rees, M. (2012). EMAS position statement: vitamin D and postmenopausal health. Maturitas, 71(1), 83-88. https://www.sciencedirect.com/science/article/abs/pii/S0378512211003653.

Pérez-López, F. R., Chedraui, P., & Pilz, S. (2020). Vitamin D supplementation after the menopause. Therapeutic Advances in Endocrinology and Metabolism, 11, 2042018820931291. https://journals.sagepub.com/doi/full/10.1177/2042018820931291.

Potter, B.; Schrager, S.; Dalby, J.; Torell, E.; Hampton, A. (2018). Menopause. Primary Care: Clinics in Office Practice 45(4), 625-641. https://www.sciencedirect.com/science/article/abs/pii/S0095454318300745?via%3Dihub

Prodanov, C. C., & de Freitas, E. C. (2013). Metodologia do trabalho científico: métodos e técnicas da pesquisa e do trabalho acadêmico. Editora Feevale.

Rejnmark, L. (2011). Efeitos da vitamina D na função e desempenho muscular: uma revisão das evidências de ensaios clínicos randomizados. Avanços terapêuticos em doenças crônicas, 2 (1), 25-37. https://journals.sagepub.com/doi/abs/10.1177/2040622310381934.

Rother, E. T. (2007). Revisão sistemática X revisão narrativa. Acta paulista de enfermagem, 20(2), v-vi. https://www.scielo.br/pdf/ape/v20n2/a01v20n2.pdf.

Schmitt, E. B., Nahas-Neto, J., Bueloni-Dias, F., Poloni, P. F., Orsatti, C. L., & Nahas, E. A. P. (2018). Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas, 107, 97-102. https://www.sciencedirect.com/science/article/abs/pii/S037851221730628X.

Suebthawinkul, C., Panyakhamlerd, K., Yotnuengnit, P., Suwan, A., Chaiyasit, N., & Taechakraichana, N. (2018). O efeito da suplementação de vitamina D2 na força muscular em mulheres na pós-menopausa: um estudo randomizado, duplo-cego e controlado por placebo. Climatério, 21 (5), 491-497. https://www.tandfonline.com/doi/abs/10.1080/13697137.2018.1480600.

Tao, M. H., Dai, Q., Chen, S., Freudenheim, J. L., Rohan, T., Wakelee, H., & Wactawski-Wende, J. (2017). Calcium plus vitamin D supplementation and lung cancer incidence among postmenopausal women in the Women’s Health Initiative. Lung Cancer, 110, 42-47. https://www.sciencedirect.com/science/article/abs/pii/S0169500217303550.

Vaes, A. M., Tieland, M., de Regt, M. F., Wittwer, J., van Loon, L. J., & de Groot, L. C. (2018). Dose–response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: a randomized controlled trial in older adults. Clinical nutrition, 37(3), 808-814. https://www.sciencedirect.com/science/article/abs/pii/S0261561417301206.

Watcharanon, W., Kaewrudee, S., Soontrapa, S., Somboonporn, W., Srisaenpang, P., Panpanit, L., & Pongchaiyakul, C. (2018). Effects of sunlight exposure and vitamin D supplementation on vitamin D levels in postmenopausal women in rural Thailand: A randomized controlled trial. Complementary therapies in medicine, 40, 243-247. https://www.sciencedirect.com/science/article/abs/pii/S0965229918302504.

Published

19/06/2021

How to Cite

SANTOS , R. M. de M. .; VIANA , V. F. .; VÉRAS, Y. P. R. .; PACÍFICO , D. K. dos S. .; SILVA , F. D. de S. e .; CUNHA, M. A. A. .; BALDOINO , F. R. R. .; BENÍCIO , M. J. dos S. .; BENÍCIO , P. J. dos S. .; MELO, H. P. .; RAMOS NETO, J. de R.; TRAJANO, E. V. .; CARVALHO , G. D. .; ARAÚJO, T. de S. L. .; SOUZA, A. P. P. de . Vitamin d supplementation in postmenopausal women: an analysis of current scientific publications. Research, Society and Development, [S. l.], v. 10, n. 7, p. e29710716574, 2021. DOI: 10.33448/rsd-v10i7.16574. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16574. Acesso em: 23 apr. 2024.

Issue

Section

Health Sciences