A new formula to calculate the medicine dosage in function of the weight
DOI:
https://doi.org/10.33448/rsd-v10i7.16594Keywords:
Drug dosage calculations; Relation área/volume; Mathematics model.Abstract
A problem in relation to medicine concentration is linked to difference of age of the patients when the medicine was formulated for a pattern age, for instance, for adults. The use of this kind of medicine for children must be calculate correctly and some formulas based in the empirical mathematical methods were suggested and they are used nowadays; however, patients form a same pattern age but with different weight shows a different biotype and requires a different concentration of medicines, as well as the children and the elderly people. According, in this work, based on the mechanical mathematical model using the relation area/volume, a more exact calculus including the metabolism, was proposed to generate a more accuracy formula to calculate the medicine concentration for children and for people of different weight.
References
Andrade, S. M. de, Cunha, M. A., Holanda, E. C., Coutinho, G. S. L., Verde, R. M. C. L., & Oliveira, E. H. de (2020). Characterization of the profile of drug intoxications by self-medication in Brazil, from 2010 to 2017. Research, Society and Development, 9(7), e236973952.
Aversi-Ferreira, T. A. (2014). Biologia Celular e Molecular. (2a ed). Editora Átomo.
Balakrishnan, K., et al. (2006a). Pediatric licensing status and the availability of suitable formulations for new medical entities approved in the United States between 1998 and 2002. Journal of Clinical Pharmacology. 46(9), 1038-1043.
Balakrishnan, K., et al. (2006b). Establishing a baseline for the monitoring of medicines availability for children in the UK: 1998-2002. British Journal Clinical Pharmacology. 63(1), 85-91.
Bates, D. W., et al. (1995). Relationship Between Medication Erros and Adverse Drug Events. Journal of General Internal Medicine. 10(4), 199-205.
Brasil, Ministério da Saúde. (2008). Formulário Terapêutico Nacional 2008.
Elias, G. P., & Mariano, R. C. (2004). Estudo comparativo de fórmulas disponíveis para o cálculo de doses medicamentosas infantis. Rev. Íbero-americana de Odontopediatria & Odontologia. 7(38), 347-348.
Ernest, T. B, et al. (2007). Developing paediatric medicines: identifying the needs and recognizing the challenges. Journal Pharmacy and Pharmacol. 59(8), 1043-1055.
Galilei, G. (1638). Discorsi e Dimostrazioni Matematiche intorno à due nuove scienze, Attinenti ala Mecanica & i Movimenti Local.
Gould, S. J. (1969). An evolutionary microcosm: Pleistocene and recent history of the land snail P. (Poecilozonites) in Bermuda. Bull. Mus. Comp. Zool. 138, 407-532.
Ivanovska, V., et al. (2014). Pediatric drug formulations: a review of challenges and progress. Pediatrics. 134(2), 361-372.
Lack, J. A., & Stuart-Taylor, M. E. (1991). Calculation of drug and body surfasse área of children. Bristish Journal Anaesthesia, 78, 601-605.
Lesar, T. S. (1998). Errors in the use of medication dosage equations. Archives of Pediatrics and Adolescent Medicine. 152, 340-344.
Lesar, T. S., Bricelnad, L. & Stein, D. (1997). Factors Related to Errors in Medication Prescribing. Journal of the American Medical Association. 277(4), 312-317.
Liu, F., et al. (2014). Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations. Rev. Drugs. 74(16), 1871-1889.
Preis, M., & Breitkreutz, J. (2017). Pediatric drug development and dosage form design. AAPS PharmSciTech. 18(2), 239-240.
Rodman, J. H. (1994). Pharmacokinetic variability in the adolescent: implications of body size and organ function for dosage regimen design. Journal of Adolecent Healt. 15(8), 654-662.
Salunke, S., et al. (2017). European Paediatric Formulation Initiative (EuPFI). European Paediatric Formulation Initiative (EuPFI) - formulating ideas for better medicines for children. Rev. AAPS PharmSciTech. 18(2), 257-262.
Silva, M. de A., Jesus, L. L. S., & Branco, A. C. da S.C. (2020). Drug poisoning: a study over secondary data in Brazil. Research, Society and Development. 9(2), e200922254.
Walsh, J. (2017). Reflection on the pharmaceutical formulation challenges associated with a paediatric investigation plan for an off-patent drug. Rev. AAPS PharmSciTech. 18(2), 250-256.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Dyecika Souza-Couto; Amanda Barcelos-Faria; Emmanuel Freitas-Ferreira; Tales Alexandre Aversi-Ferreira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
