Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression
DOI:
https://doi.org/10.33448/rsd-v10i8.16634Keywords:
Depression; Probiotics; Microbiota.Abstract
Objective: This study aimed to investigate whether probiotics improved symptoms of depression and anxiety as assessed by different psychometric scales. Methodology: The present study is an integrative bibliographic review, carried out through a literature survey bibliographic research in PubMed combining the terms "Probiotics", "Intestinal Modulation" and "Depression" to identify clinical trial studies in humans who investigated the relationship between depressive, anxious aspects and the microbiota. Results: Data were extracted from 12 studies of clinical trials (922 humans), randomized, controlled, doubleblind. In the assessed context, probiotics reduced scores on different psychometric scales, reducing anxiety-like and depressive behavior. Analyzes of analyzes at the level of probiotic species, identified subspecies of the genus Lactobacillus and Bifidobacterium the capacity for anxiolytic activity. ⩾60% improvements in evaluation scales were demonstrated with supplementation of probiotics and even improvements in quality of life in individuals with inflammatory bowel diseases. Conclusion: The microbiota was raised to a potential target for the treatment of psychiatric and antidepressant disorders. Depression is a challenge for global health, as it requires multidisciplinary interventions since this disease is characterized as a cerebral metabolic disorder and probiotics would play an essential role on the individual's health and disease status.
References
Akbari, M. J., et al. The effects of probiotics on mental health and hypothalamicpituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers. Nutr Neurosci. 9, 387-395
Akkasheh, G. K. J., et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: a randomized, double-blind, placebocontrolled trial. Nutrition, 32, 315–20
Allen, A. H., et al. Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl Psychiatry, 6, 939
Amirani, E., Milajerdi, A, Mirzaei, H., Jamilian, H., Mansournia, M. A., & Hallajzadeh, J. The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 49, 102361
Barrett, E., et al. Gamma-Aminobutyric acid productio bacteria from the human intestine. J. Appl. Microbiol, 13, 411–417
Bhandari, et al. Association of Inflammatory Bowel Disease, (IBD) with depressive symptoms in the United States population and independent predictors of depressive symptoms in an IBD population: a NHANES study. Gut Liver, 11,512–9
Bromet, E. A., et al. Cross-national epidemiology of DSM-IV major depressive episode. BMC Med, 9, 90
Ebrahim, K. O. P., et al. Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled trial. Clin Nutr, 5, 1245-1249
Emiko, A., Hirokazu, T., Takashi, A., Takuya. T. Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. Journal of Affective Disorders, 202 254–257
Ercole, F. F.; Melo, L. S.; Alcoforado, C. L. G. C. Revisão Integrativa versus Revisão Sistemática. Rev Min Enferm. 8, 1-260
Gelenberg. A. A. review of the current guidelines for depression treatment. J Clin Psychiatry, 7, e15
Gil, A.C. Métodos e técnicas de pesquisa social. Ediitora Atlas SA
Gracie, P. H. D. et al. The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment. The Lancet Gastroenterology & Hepatology
Guillemin, G. J. Quinolinic acid, the inescapable neurotoxin. FEBS J, 279, 1356–65
John, et al. More than a Gut Feeling: The Microbiota Regulates Neurodevelopment and Behavior. Neuropsychopharmacology Reviews, 40, 241–242
Kato-Kataoka, K. A., et al. Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress. Appl Environ Microbiol, 12, 3649-58.6
Kwak, M. J., et al. Evolutionary architecture of the infant-adapted group of Bifidobacterium species associated with the probiotic function. Syst Appl Microbiol, 39, 429–39
Lorenzo-Zúñiga, V. E. L., et al. A new combination of probiotics, improves irritable bowel syndrome-related quality of life. World J Gastroenterol, 26, 8709-16
Lyra, A., et al. Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. World J Gastroenterol, 48, 10631-10642
Michelle, S. et al Metabolismo do triptofano em transtornos mentais: um enfoque em esquizofrenia. VITTALLE - Revista de Ciências da Saúde, 2, 44-56
Ministério da Saúde. Artigo Saúde Mental. Disponível em: https://antigo.saude.gov.br/saude-de-a-z/depressao/851-saude-mental. Acessado 20/10/2020
Naseribafrouei A, Hestad K, Avershina E, Sekelja M, Linløkken A, Wilson R, Rudi K. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil, 8, 1155-62
Rahimlou M, Hosseini SA, Majdinasab N, Haghighizadeh MH, Husain D. Effects of long-term administration of Multi-Strain Probiotic on circulating levels of BDNF, NGF, IL-6 and mental health in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled trial. Nutr Neurosci, 5, 1-12
Sandhu K.V, et al. Feeding the microbiota-gut-brain axis: Diet, microbiome, and neuropsychiatry. Translational Research, 179, 223-244
Steenbergen, R. S., et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun, 4, 8258-64
Sudo N. Stress and gut microbiota: does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response? International Congress Series, Elsevier, 12, 350-354
Vajihe Akbari, Fatemeh Hendijani.Effects of probiotic supplementation in patients with type 2 diabetes: systematic review and meta-analysis. Nutr Ver, 12, 774-784
Wei, D. H Probiotics for the prevention or treatment of chemotherapy- or radiotherapyrelated diarrhoea in people with cancer. Cochrane Database Syst Rev.Aug, 8, 8
World H (2017). Organization. Depression Fact https://www.who.int/news-room/fact-sheets/detail/depression.
Yang H, Z. X, et al. Probiotics reduce psychological stress in patients before laryngeal cancer surgery. Asia Pac J Ciln Oncol. 12(1), e92-96.
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Copyright (c) 2021 Erick Michell Bezerra Oliveira; Manoel Augusto de Moura; Luanna da Silva de Assunção; Aline Cristina Ribeiro da Luz; Adyelle Karoline Atan; Rubenilson Luna Matos; Julianne de Area Leão Pereira da Silva; Thiago Henrique Gonçalves Moreira; Jonas Alves Cardoso; Flávio Bruno Rodrigues de Assunção; Domingas Marlyene Silva Conceição; Francisco de Assis Viana dos Santos; Géofrey Henrick Silva Galvão; Hernandys Ribeiro Bezerra; Nathália Cássia Martins Sampaio
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