Can anti-hypertensives drugs be associated with the development of Granuloma annulare?

Authors

DOI:

https://doi.org/10.33448/rsd-v10i8.17015

Keywords:

Malignancy; Diabetes; Dyslipidemia; Dermatology.

Abstract

Granuloma annulare (GA) is a granulomatous inflammatory disease, considered benign, but of uncertain etiology. GA is associated with several conditions, such as diabetes mellitus, malignancy, in addition to other conditions and medications. The present article is a cross-sectional, observational and retrospective study whose objective was to analyze the association between the types of AG and antihypertensive drugs used by patients before the onset of this lesion. We also propose to investigate the associations with certain comorbidities (hypertension, diabetes, dyslipidemia, leprosy and malignancy), as well as to map the most affected areas of the body. The main result was the statistically significant association between the use of atenolol and the disseminated clinical type (p=0.024) and the association of the localized clinical type with losartan (p=0.0604). Despite the intriguing results, more robust studies of these associations are needed in order to establish definitive conclusions.

Author Biographies

Luciana Pantaleão, Universidade Federal Fluminense

Professora Associada do Departamento de Patologia da Universidade Federal Fluminense, Brasil

Dermatopatologista do Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense, Brasil

 

Enoï Guedes Vilar, Universidade Federal Fluminense

Professora do Departamento de Patologia da Universidade Federal Fluminense, Brasil

Dermatopatologista do Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense, Brasil

Miguel Augusto Martins Pereira, Universidade Federal Fluminense

Iniciação Científica pela Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro,Brasil

Universidade Federal Fluminense, Brasil

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Published

04/07/2021

How to Cite

PANTALEÃO, L. .; VILAR, E. G. .; PEREIRA, M. A. M.; CONSTANTINO , V. M. P. .; FREITAS, R. J. . Can anti-hypertensives drugs be associated with the development of Granuloma annulare?. Research, Society and Development, [S. l.], v. 10, n. 8, p. e5310817015, 2021. DOI: 10.33448/rsd-v10i8.17015. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17015. Acesso em: 2 nov. 2024.

Issue

Section

Health Sciences