Relationship of vitamin D on obesity inflammation
DOI:
https://doi.org/10.33448/rsd-v9i1.1726Keywords:
Micronutrient; Metabolism; Chronic Diseases.Abstract
Introduction: The literature has shown vitamin D deficiency in obese individuals, which contributes to the manifestation of low-grade chronic inflammation. Therefore, this review aims to provide updated information on the relationship of vitamin D with the inflammatory process triggered in obesity. Methodology: A bibliographic survey was performed in the Pubmed, SciELO, LILACS and Cochrane databases, using the following keywords: "vitamin D" and "inflammation"; "obesity" and "inflammation"; "vitamin D", " obesity” and“ inflammation ”. Results and Discussion: Obese individuals appear to have vitamin D deficiency due to inadequate intake or increased uptake of this vitamin by adipose tissue which may contribute to the increase of chronic low grade inflammation present in obesity. Conclusion: The inadequate intake of vitamin D contributes to the manifestation of its deficiency in obese. However, further studies are needed, considering that the metabolism of this micronutrient is not completely elucidated.
References
Al-Daghri, N.M., Guerini, F.R., Al-Attas, O.S., Alokail, M.S., Alkharfy, K.M., Draz, H.M., Agliardi, C., Costa, A.S., Saulle, I., Mohammed, A.K., Biasin, M & Clerici, M.(2014). Vitamina D receptor gene polymorphisms are associated inflammosome activity. PLoS One, 9(7):102-141.
Amer, M & Qayyum, R.(2012). Relation between serum 25-hydroxyvitamin d and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006). American Journal of Cardiology, 109:226–230.
Bellan, M., Pirisi, M & Sainaghi, P.P.(2015). Osteoporosis in rheumatoid arthritis: role of the vitamin D/parathyroid hormone system. Revista Brasileira de Reumatologia, 55(3):256-263.
Brasil, A.R., Norton, R.C., Rossetti, M.B., Leão, E & Mendes, R.P.(2007). C-reactive protein as an indicator of low intensity inflammation in children and adolescents with and without obesity. Jornal de Pediatria, 83(5):477-480, 2007.
Cardoso-Saldaña G.C., Medina-Urrutia, A.X., Posadas-Romero, C., Juárez-Rojas, J.G., Jorge-Galarza, E., Vargas-Alarcón, G & Posadas-Sánchez, R.(2015). Fatty liver and abdominal fat relationship with high C-reative protein in adults. Annals of Hepatology, 14(5):658-665.
Castro, L.C.G.(2011). O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia & Metabologia, 55(8):566–575.
Cavalcante., I.G.M., Silva, A.S., Costa, M.J., Persuhn, D.C., Issa, C.T., Freire, T.L.L & Gonçalves, M.C.R.(2015). Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers. Experimental Gerontology, 66(1):10-6.
Ceglia, L., Nelson, J., Ware, J., Alysandratos, K.D., Bray, G.A., Garganta, C., Nathan, D.M., Hu, F.B., Hughes, D.B & Pittas, A.G.(2017). Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. European Journal of Nutrition, 56(1):161-170.
Chang, E.J., Yi, D.Y &Yang, H.R.(2015). Vitamin D Status and Bone Mineral Density in Obese Children with Nonalcoholic Fatty Liver Disease. Journal of Korean Medical Science, 30: 1821-1827.
Cordero, M.J.A., Jiménez, E.G., Perona, J.S., López, C.A.P., Ferre, J.A. Hita, E.O., Baeza, M.R., Barrilao, R.G & Rivas, F.G.(2012). Obesidad y su relacion con marcadores de inflamacion y acidos grasos de eritrocito en un grupo de adolescentes obesos. Nutrição Hospitalar. 27(1):161-164.
Gaffen, S & Hajishengallis, G.(2008). A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. Journal of Dental Research, 87(9):817–28.
Gangloff, A., Bergeron, J., Beaumont, E. P., Nazare, J.A., Smith, J., Borel, A.L., Lemieux, I., Tremblay, A., Poirier, P., Alméras, N & Després, J.P.(2015). Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men. International Journal of Obesity, 39(11):1638–43.
Gomes, F., Telo, D.F., Souza, H.P., Nicolau, J.C., Halpern, A & Serrano Junior, C.V.(2010). Obesidade e Doença Arterial Coronariana: Papel da Inflamação Vascular. Arquivos Brasileiros de Cardiologia, 94(2):273-279.
Hauschild, D.B., Shiefe, M.E.M & Thieme, R.D. Vitaminas, minerais e eletrólitos: aspectos fisiológicos, nutricionais e dietéticos. Ed Rubio, 344 p, 2015.
Holick, M.F., Binkley N.C., Ferrari, H.A.B., Gordon, C.M., Hanley, D.A., Heaney, R.P., Murad, M.H & Weaver, C.M.(2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 96(7):1911-1930.
Inda Filho, A.J & Melamed, M.L.(2013). Vitamin D and kidney disease: what we know and what we do not know. Jornal Brasileiro de Nefrologia, 35:323–331.
Jamka, M., Woźniewicz, M., Walkowiak, J., Bogdański, P., Jeszka, J & Stelmach-Mardas, M.(2015). The effect of vitamin D supplementation on select inflammatory biomarker in obese and overweight subjects: a systematic review with meta-analysis. European Journal of Nutrition, 55(6)2163-2176.
Kohen, V.L.,Candela, C.G., Fernández., C.F., Rosa, L.Z., Milla, S.P.,Urbieta, M & López, L.M.B.(2011). Parametros hormonales en mujeres con sobrepeso. Nutrição Hospitalar, 26(4):884-889.
Koul, P.A., Ahmad, S.H., Ahmad, F., Jan, R.A., Shah, S.U & Khan, U.H.(2011).Vitamin D toxicity in adults: A case series from an area with endemic hypovitaminosis D. Oman Medical Journal, 26(3):201-204, 2011.
Maeda, S.S., Borba, V.Z.C., Camargo, M.B.R., Silva, D.M.W., Borges, J.L.C., Bandeira, F & Castro, M.L.(2014). Recomendações da Sociedade Brasileira de Edocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, 58(1):411 – 433.
Mangin, M., Sinha, R & Fincher, K.(2014). Inflammation and vitamin D: the infection connection. Inflammation Research, 63(2):803–819.
Matilainen, J.M., Husso, T., Toropainen, S., Seuter, S., Turunen, M.P., Gynther, P., Ylä-Herttuala, S., Carlberg, C & Väisänen, S.(2010). Primary effect of 1, 25(OH)2D3 on IL-10 expression in monocytes is short-term downregulation. Biochimica et Biophysica Acta, 1803(11):1276 –1286.
Mcdade, T W., Rutherford, J.N., Adair, L & Kuzawa, C.(2008). Adiposity and Pathogen Exposure Predict C-Reactive Protein in Filipino Women. Journal of Nutricion, 138(12):2442-2447.
Mousa, A., Naderpoor, N., Teede, H., Scragg, R & De Courten, B.(2018). Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews. 76:380–94.
Mutt, S.J., Hyppönen, E., Saarnio, J., Järvelin, M.R & Herzig, K.H.(2014). Vitamin D and adipose tissue-more than storage. Frontiers in Physiology, 24(5):228
Oliveira, A.R., Cruz, K.J.C., Morais, J.B.S., Severo, J.S., Freitas, T.E.,
Veras, A.L., Romero, A.B.R., Colli, C., Nogueira, N.N., Leal, F.L.T & Marreiro, D.N. Magnesium status and its relationship with c-reactive protein in obese women. Biological Trace Element Research. 168(2):296-302, 2015.
Pedersen, J.M., Jørgensen, E.B., Mortensen, E.L., Bruunsgaard, H., Osler, M., Sørensen, T.I., Rod, N & Lund, R.(2015). Late Midlife C-Reactive Protein and Interleukin-6 in Middle Aged Danish Men in Relation to Body Size History Within and Across Generations. Obesity, 24(2):461-468.
Peters, B. S. E., Martini, A. Funçõe Planamente Rechonhecidas de Nutrientes: Vitamina D. 2ª ed. São Paulo, 2014.
Ramalho, R, Guimarães, C. Papel do tecido adiposo e dos Macrófagos no estado de inflamação Crônica associada à obesidade. Acta Médica Portuguesa, v. 21:489-496, 2008.
Schmidt, A. Relação entre a deficiência de vitamina d e obesidade: uma revisão atual. Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 9(53):207-212, 2015.
Slusher, A.L., Mcallister, M.J & Huang, C.J.(2015). A therapeutic role for vitamin D on obesity-associated inflammation and weight-loss intervention. Inflammation Research, 64(8):565-575.
Tao, R.X.(2015). Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns. Nutrients, 7(11):9218–9228.
Vimaleswaran, K.S., Berry, D.J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L.T., Cooper, J.D., Dastani, Z., Li, R., Houston, D.K., Madeira, A.R., Michaelsson, K, et al. . Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medic, v. 10, n. 2, p.1001-1383, 2013.
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