Drug treatment of vestibular migraine
DOI:
https://doi.org/10.33448/rsd-v10i8.17414Keywords:
Migraine disorders; Vestibular diseases; Drug therapy.Abstract
Vestibular migraine corresponds to one of the most frequent diagnoses in otoneurology. It is considered the most common cause of balance disorders. Its diagnosis is based on recurrent vestibular symptoms, history of migraine and association of migraine symptoms with vestibular symptoms over a period ranging from 5 minutes to 72 hours. The drug treatment of vestibular migraine aims to control the patient's symptoms in the acute phase, as well as in the prophylaxis of eventual crises. The present work is an integrative literature review, whose objective is to identify and describe the drug treatment of vestibular migraine, in order to control the patient's symptoms in the acute phase and in the prophylaxis of possible crises. The search was carried out in the electronic databases SCIELO, PUBMED and LILACS, including works published between 2016 and 2021, in Portuguese and English. The selection of studies, data extraction and validation were carried out independently by two authors, obtaining a sample of 14 articles. All research data were analyzed in Microsoft Excel and later the results were transformed into tables for a better interpretation of the information collected. It was found, through the analysis of the 14 articles, that 7 (50%) studies used treatment with antidepressants, beta-blockers and anticonvulsants concomitantly; 9 (64%) used propranolol with symptom improvement; 2 (14%) used botulinum toxin and only 1 (7%) used gentamicin injection. Thus, it was possible to systematically structure the drugs most used in prophylaxis and in the vestibular migraine crisis, laying the basis for a more adequate choice of the drug.
References
Barbosa, F., & Villa, T. R. (2016). Vestibular migraine: Diagnosis challenges and need for targeted treatment. In Arquivos de Neuro-Psiquiatria, 74(5), 416–422. Associação Arquivos de Neuro-Psiquiatria. Recuperado em 3 abril, 2021, de https://doi.org/10.1590/0004-282X20160037
Beh, S. C. (2019). Vestibular Migraine: How to sort it out and what to do about it. Journal of Neuro-Ophthalmology, 39(2), 208–219. Recuperado em 6 maio, 2021, de https://doi.org/10.1097/WNO.0000000000000791
Çelebisoy, N., Gökçay, F., Karahan, C., Bilgen, C., Kirazlı, T., Karapolat, H., & Köse, T. (2016). Acetazolamide in vestibular migraine prophylaxis: a retrospective study. European Archives of Oto-Rhino-Laryngology, 273(10), 2947–2951. Recuperado em 3 abril, 2021, de https://doi.org/10.1007/s00405-015-3874-4
Çelik, O., Toker, G. T., Eskiizmir, G., İncesulu, A., & Süyür, N. S. (2020). The effectiveness of medical prophylactic treatment on vestibular migraine and its effect on the quality of life. Journal of International Advanced Otology, 16(1), 28–33. Recuperado em 3 abril, 2021, de https://doi.org/10.5152/iao.2019.6522
Domínguez-Durán, E., Montilla-Ibáñez, M. A., Álvarez-Morujo de Sande, M. G., Domènech-Vadillo, E., Bécares-Martínez, C., González-Aguado, R., & Guerra-Jiménez, G. (2020). Analysis of the effectiveness of the prophylaxis of vestibular migraine depending on the diagnostic category and the prescribed drug. European Archives of Oto-Rhino-Laryngology, 277(4), 1013–1021. Recuperado em 3 abril, 2021, de https://doi.org/10.1007/s00405-020-05802-5
Dornhoffer, J. R., Liu, Y. F., Donaldson, L., & Rizk, H. G. (2021). Factors implicated in response to treatment/prognosis of vestibular migraine. European Archives of Oto-Rhino-Laryngology, 278(1), 57–66. Recuperado em 3 abril, 2021, de https://doi.org/10.1007/s00405-020-06061-0
Ercole, F. F., Melo, L. D., & Alcoforado, C. L. G. C. (2014). Integrative review versus systematic review. Rev Min Enferm, 18(1), 9-12. Recuperado em 1 abril, 2021, de http://www.dx.doi.org/10.5935/1415-2762.20140001
Green, K., Ender, L., & Winters, R. (2016). What is optimal treatment for vertiginous migraine? In Laryngoscope, 126(12), 2647–2648. John Wiley and Sons Inc. Recuperado em 3 abril, 2021, de https://doi.org/10.1002/lary.26092
Huang, T. C., Wang, S. J., & Kheradmand, A. (2020). Vestibular migraine: An update on current understanding and future directions. Cephalalgia, 40(1), 107–121. Recuperado em 6 maio, 2021, de https://doi.org/10.1177/0333102419869317
Kalla, R., Teufel, J., Feil, K., Muth, C., & Strupp, M. (2016). Update on the pharmacotherapy of cerebellar and central vestibular disorders. In Journal of Neurology, 263, 24–29. Dr. Dietrich Steinkopff Verlag GmbH and Co. KG. Recuperado em 3 abril, 2021, de https://doi.org/10.1007/s00415-015-7987-x
Kaya, I., Eraslan, S., Tarhan, C., Bilgen, C., Kirazli, T., Gokcay, F., Karapolat, H., & Celebisoy, N. (2019). Can verapamil be effective in controlling vertigo and headache attacks in vestibular migraine accompanied with Menière’s disease? A preliminary study. In Journal of Neurology, 266, 62–64. Dr. Dietrich Steinkopff Verlag GmbH and Co. KG. Recuperado em 3 abril, 2021, de https://doi.org/10.1007/s00415-019-09309-w
Lapira, A. (2019). Vestibular migraine treatment and prevention. In HNO. Springer Verlag. Recuperado em 3 abril, 2021, de https://doi.org/10.1007/s00106-019-0661-3
Lempert, T. (2013). Vestibular migraine. Seminars in Neurology, 33(3), 212–218. Recuperado em 28 março, 2021, de https://doi.org/10.1055/s-0033-1354596
Liu, Y. F., Macias, D., Donaldson, L., Dornhoffer, J. R., & Rizk, H. G. (2020). Pharmacotherapy failure and progression to botulinum toxin injection in vestibular migraine. Journal of Laryngology and Otology, 134(7), 586–591. Recuperado em 3 abril, 2021, de https://doi.org/10.1017/S002221512000095X
Liu, Yuan F., Renk, E., Rauch, S. D., & Xu, H. X. (2017). Efficacy of intratympanic gentamicin in Menière’s disease with and without migraine. Otology and Neurotology, 38(7), 1005–1009. Recuperado em 3 abril, 2021, de https://doi.org/10.1097/MAO.0000000000001460
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. PLoS Medicine, 6(7), e1000097. Recuperado em 28 março, 2021, de https://doi.org/10.1371/journal.pmed.1000097
Morganti, L. O. G., Salmito, M. C., Duarte, J. A., Bezerra, K. C., Simões, J. C., & Ganança, F. F. (2016). Migrânea vestibular: aspectos clínicos e epidemiológicos. Brazilian Journal of Otorhinolaryngology, 82(4), 397–402. Recuperado em 19 março, 2021, de https://doi.org/10.1016/j.bjorl.2015.06.003
Ferster, A. P., Priesol, A. J., & Isildak, H. (2017). The clinical manifestations of vestibular migraine: A review. In Auris Nasus Larynx, 44(3), 249–252. Elsevier Ireland Ltd. Recuperado em 3 abril, 2021, de https://doi.org/10.1016/j.anl.2017.01.014
Salmito, M. C., Duarte, J. A., Morganti, L. O. G., Brandão, P. V. C., Nakao, B. H., Villa, T. R., & Ganança, F. F. (2017). Tratamento profilático da migrânea vestibular. Brazilian Journal of Otorhinolaryngology, 83(4), 404–410. Recuperado em 28 março, 2021, de https://doi.org/10.1016/j.bjorl.2016.04.022
Salmito, M. C., e Maia, F. C. Z., Gretes, M. E., Venosa, A., Ganança, F. F., Ganança, M. M., Mezzalira, R., Bittar, R. S. M., Gasperin, A. C., Pires, A. P. B. de Á., Ramos, B. F., Bertoldo, C., Ferreira, C., Real, D., Guimarães, H. A., Oiticica, J., Lavinsky, J., Lopes, K. C., Duarte, J. A., Carvalho, R. C. B. de. (2020). Neurotology: definitions and evidence-based therapies – Results of the I Brazilian Forum of Neurotology. Brazilian Journal of Otorhinolaryngology, 86(2), 139–148. Recuperado em 28 março, 2021, de https://doi.org/10.1016/j.bjorl.2019.11.002
Sarna, B., Abouzari, M., Lin, H. W., & Djalilian, H. R. (2020). A hypothetical proposal for association between migraine and Menière’s disease. Medical Hypotheses, 134. Recuperado em 3 abril, 2021, de https://doi.org/10.1016/j.mehy.2019.109430
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