Benefits of Moringa oleifera for human and animal health: Literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i8.17495

Keywords:

Therapeutic functions; Phytotherapic; Moringa; Nutraceutical.

Abstract

Moringa oleifera Lam. It is a species belonging to the Moringaceae family, arboreal, cultivated all over the world, for presenting several applications, from human and animal health to use for environmental purposes, such as water purification. From the leaves, the roots of the plant have a high medicinal value and several studies have proven their therapeutic effects, such as powerful anti-inflammatory, glucose reduction, anti-cholesterol, hepatoprotective, anti-cancer and antimicrobial properties. The purpose of this review article is to present the various benefits of Moringa oleifera in human and animal health. Therefore, an integrative review was carried out in this article, and a total of 63 scientific articles were studied, in English, Spanish and Portuguese. Based on the studies reviewed, it was confirmed that several parts of the plant have therapeutic effects, such as leaves, seeds, flowers and roots have phytochemicals, such as flavonoids, phenols, alkaloids, tannins, saponins, glucosinalates, phytates, oxalates, proteins and vitamins, responsible for their therapeutic action, and their effectiveness in responding to treatments, depends on the forms of presentation and the dose administered.

References

Abd, M. A., Shaban, A. E. A., & Abd, E. S. A. (2017). An aqueous extract from Moringa oleifera leaves ameliorates hepatotoxicity in alloxan-induced diabetic rats. Biochem. Cell Biology, 95, 524-530.

Ademiluyi, A, O., et al. (2018). Drying alters the phenolic constituents, antioxidante properties, amylase, and glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf. Food Science Nutrition, 6, 2123-2133.

Abdull, R., Ahmad, F., Ibrahim, M. D., & Kntayya, S. B (2014). Health benefits of Moringa oleifera. Asian Pacific Journal of Cancer Prevention, 15, 8571-8576.

Aguiar, F. L. N. (2010) Avaliação do potencial antifúngico de produtos de plantas em cepas de Candida albicans e Microsporum canis isolados de cães e gatos: um destaque para Moringa oleifera e Vernonia sp. 2010. 63f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Estadual do Ceará – Fortaleza.

Anwar, F., et al. (2007). Moringa oleifera: a food plant with multiple medicinal uses. Phytother Reserach, 21(1),17-25.

Arais, L. R., et al. (2016). Antimicrobial resistance, integron carriage, and gyrA and gyrB mutations in Pseudomonas aeruginosa isolated from dogs with otitis externa and pyoderma in Brazil. Veterinary Dermatology, 27(2), 113-117.

Arora, D. S., & Onsare, J. G (2014). In vitro antimicrobial evaluation and phytoconstituents of Moringa oleifera pod husks. Industrial Crops and Products, 52, 125-135.

Barhoi, D ., et al. (2020). Aqueous Extract Of Moringa Oleifera Exhibit Potential Anticancer Activity And Can Be Used As A Possible Cancer Therapeutic Agent: A Study Involving In Vitro And In Vivo Approach. Journal Of The American College Of Nutrition, 40, 70-85.

Barbagallo, I., Venella, L., Cambria, M. T., Tibullo, D., Godos, J., Guarnaccia, L., Zapalla, A., Galvano, F & Li Volti, G (2015). Silibinin regulates lipid metabolism and differentiation in functional human adipocytes. Frontiers in Pharmacology, 6, 309.

Beever, L., Bond, R., Graham, P. A., Jackson, B., Lloyd, D. H., & Loeffler, A (2015). Increasing antimicrobial resistance in clinical isolates of Staphylococcus intermedius group bacteria and emergence of MRSP in the UK. Veterinary Record, 176(7), 172.

Brilhante, R. S. N., et al. 2017). Research advances on the multiple uses of Moringa oleifera: A sustainable alternative for socially neglected population. Asian Pacific Journal of Tropical Medicine, 10(7), 621-630.

Boothe, D. M. (1997). Nutraceuticals in veterinary medicine, part 1: definitions and regulations. Compendium on Continuing Education for the Practicing Veterinarian, 19(11), 1248-1255.

Brower, V. (1998). Nutraceuticals: poised for a healthy slice of the healthcare market? Nature Biotechnology, 16(8), 728-731.

Cáceres, A. O., et al. (1991). Propriedades farmacológicas de Moringa oleifera: detección preliminar de actividad antimicrobiana. 33(3), 213.

Cheng, W. N., et al. (2019). Moringa extract attenuates inflammatory responses and increases gene expression of casein in bovine mammary epithelial cells. Revista Animals, 9(7), 391.

Cysne, J. R B. (2006). Propagação in vitro da Moringa oleifera Lam. 2006. 81 f. Dissertação (Mestrado). Universidade Federal do Ceará – UFC, Ceará.

Cushnie, T. P. T., et al. (2014). Alkaloids: and overview of their bacterial, antibiotic-enhancing and antivirulence activities. International Jounal of Antimicrobial Agents, 44 (5), 377-386.

Divi, S. B. D. S. (2012). Evaluación del potencial antidiabético y antihiperlipedémico zdel extracto acuoso de Moringa oleifera en ratas diabéticas resistentes a la insulina alimentadas con fructosa e inducida por STZ: un estudio comparativo. Asian Journal of Pharmaceutical and Clinical Research, 5, 67-72.

Doughari, J. H., et al. (2007). Antibacterial effects of Balanites aegyptiaca L. Drel. and Moringa oleifera Lam. on Salmonella thyphi. African J Biotechnology, 6(19), 2212-2215.

Ercole, F. F., et al. (2014). Revisão integrativa versus revisão sistemática. Revista Mineira de Enfermagem, 18(1), 9-12.

Eilert, U., Wolter, B., & Nahrstedt, A (1981). The antibiotic principle of seeds of Moringa oleifera and Moringa stenopetala. Planta Medicinal, 42(1), 55-61.

Fahey, J (2005). Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees for life Journal, 157-164.

Faizi, S. S. B. R. (1994). Elucidación del aislamiento y la estructura de nuevos glucósidos de nitrilo y aceite de mostaza de Moringa oleifera y su efecto sobre la presión arterial. Jounal of Natural Products, 57, 1256-1261.

Fatima, T., et al. (2014). Phytomedicinal value of Moringa oleifera with special reference to antiparasitics. Pak. J. Agri Sciences, 51(1), 251-262.

Foild, N., Mayorga, L., & Vásquez, W. (2003). Utilización del marango (Moringa oleifera) como forraje fresco para ganado. Universidad Nacional de Ingeniería, Manágua, Nicarágua.

Gilani, A. H., & Aksasssrs, B. (1994). Estudios farmacológicos hipotensivas y espasmolíticas sobre actividades de compuestos puros de Moringa oleifera. Phytotherapy Research, 8(2), 87-91.

Gopalakrishnan, L., Doriya, K., & Kumar, D. S (2016). Moringa oleifera: A review on nutritive importance and its medicinais application. Food Science and Human Wellness, 5, 49-56.

Halliwell, R. (2006) Revised nomenclature for veterinary allergy. Veterinary Immunology and Immunopathology, 114(3), 207-8.

Hand, M. S., et al. (2010). Small animal clinical nutrition. 5. ed. Topeka, KS: Mark Morris Institute, 1314.

Hillier, A., & Griffin, C. E (2001). The ACVD task force on canine atopic dermatitis (I): incidence and prevalence. Veterinary Immunology and Immunopathology, 81(3-4), 147-151.

Jahn, S. A., Musnad, H., & Burgastaller, H (1986). Tree that purifies water: Cultivating multipurpose Moringaceae in the Sudan. Unasylva, 38(152), 23-28.

Kersey, K. M., et al. (2013). Emergências dermatológicas: identificação e tratamento. Compend (Yardley, PA), 35.

Kurup, P. A., & Rao, P. L. N. (1954a.) Antibiotic principle from Moringa pterigosperma. Part II. Chemical nature of pterygospermin. Indian Journal of Medical Research, 42(1), 85-95.

Kurup, P. A., & Rao, P. L. N. (1954b). Antibiotic principle from Moringa pterigosperma. Part V. effect of pterygospermin in the assimilation of glutamic acid by micrococcus pyogenes var. aureus. Indian Journal of Medical Research, 42(1), 109-114.

Lalas, S., & Tsaknis, T (2002). Caracterização de Moringa oleifera variedade óleo de semente “Periyakulam1”. Journal of Food Composition and Analysis, 15, 65-77.

Leone, A., et al. (2016). Sementes e óleo de Moringa oleifera: Características e usos para a saúde humana. Revista Internacional de Ciências Moleculares, 17.

Logas, D., & Kunkle, G. A. (1994). Double-blinded crossover study with marine oil supplementation containing high-dose icosapentaenoic acid for the treatment of canine pruritic skin disease. Veterinary Dermatology, 5(3), 99-104.

Macedo, L. C., et al. GF (2010). Prospecção tecnológica da Moringa oleifera Lam. In: II Encontro Nacional de Moringa, 1-3.

Mallya RPV NCPMp (2017). Moringa oleifera leaf extract: Beneficial effects on cadmium induced toxicities. A review. Journal of clinical and Diagnostic, 11(4), 01-04.

Makkar, H. P. S., & Becker, K. (1996). Nutrional value and antinutritional components of whole and ethanol extracted Moringa oleifera leaves. Animal Feed Science Technology, 63, 211-228.

Martín, C., et al. (2013). Potential applications of Moringa oleifera. A critical review. Pastos y Forrajes, 36(2), 150-158.

Matu, E. M., & Van Staden, J. (2003). Antibacterial and anti-inflammatory activies of some plants used for medicinal purposes in Kenya. Journal Ethnopharmacol, 87(1), 35-41.

Mahmood, K. T., Mugal, T & Haq, I. U (2010). Moringa oleifera: A natural gift-a review. Journal of Pharmaceutical Sciences and Research, 2(11), 775-781.

Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Review of Microbiology, 55, 165-199.

Muller, M. R., et al. 2016). Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis. Veterinary Journal, 210, 77-81.

Muyibi, S. A., & Evison, L. M (1995). Optimizing physical parameters affecting coagulation of turbid water with Moringa oleifera seeds. Watar Research, 29(12), 2689-2695.

Olivry, T., et al. (2010). Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the international task force on canine atopic dermatitis. Veterinary Dermatology, 21(3), 233-48.

Olson, M. F. (2013). Moringa olifera un árbol multiusos para la zonas tropicales secas. Mexicana biodiversidade, 82(4).

Proetti, S. (2018). As pesquisas qualitativa e quantitativa como métodos de investigação científica: Um estudo comparativo e objetivo. Revista Lumen -ISSN, 2(4), 2447-8717.

Qiu, S., et al. (2014). Natural alkaloids: basic aspects, biological roles, and future perspectives. Chinese Journal of Natural Medicines, 12(6), 401-406.

Rahman, M. M., et al. (2010). Control de bactérias coliformes detectadas en pacientes con diarrea asociada a extractos de Moringa oleifera. Nepal Medical College Journal, 12, 12-19.

Rego, E A. (2012). Avaliação da actividade anti-inflamatória de plantas dos açores. 119p. Dissertação [Mestrado em Ciências Biomédicas]. Departamento de Ciências Tecnológicas e Desenvolvimento, Universidade dos Açores, Ponta Delgada, Açores.

Rocha, M. F G., et al. Extratos de Moringa oleifera e Vernonia sp. sobre Candida albicans e Microsporum canis isolados de cães e gatos e análise da toxicidade em Artemia sp. Ciência Rural, 41(10), 1807-1812.

Shanker, K., et al. (2007). Determination of bioactive nitrile glycoside (s) in drumstick (Moringa oleifera) by reverse phase HPLC. Food Chemistry, 105(1), 376-382.

Schuarz, D. (2000). Water purification using Moringa Oleifera. GATE Technical Information. 1.

Silva, A. K. S. (2010). Avaliação de atividades biológicas de flavonoides isolados da entrecasca de Sebastiania jacobinensis (MUILL. ARG.) MUILL. ARG. 62p. Dissertação [Mestrado em Bioquímica e Fisiologia]. Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Sulaiman, MRZZBASMIDMS (2008). Evaluatión of Moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. Pharmaceutica Biology, 46(12), 838-845.

Scott, D. W., et al. (2001). Small animal dermatology. 6.ed. Philadelphia: W. B. Sauders Company, 667-779.

Sousa, C. A, & Halliwell, R. E. W (2001). The ACVD task force on canine atopic dermatitis (XI): the relationship between arthropod hypersensitivity and atopic dermatitis in the dog. Veterinary Immunology and Immunopathology, 81(3-4), 233-237.

Valere, P. (2015). Medicinal plants in there west african. Ethopharmacologycal, 172, 297-311.

Vergara, J. M., et al. (2017). Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants, 6(4), 91.

White, P. D. (1998). Atopia. In: Bichard, S. J., Sherding, R. G. Manual saunders: clínica de pequenos animais, 343-351.

Zaku, S., et al. (2015). Moringa oleifera: An underutilized tree in Nigeria with amazing versatility: A review. African Journal Food Science, 9, 456-46.

Zaine, L., et al. (2014). Nutracêuticos imunomoduladores com potencial uso clínico para cães e gatos. Semina: Ciências Agrárias, 35(4), 2513-2530.

Published

16/07/2021

How to Cite

SILVA, M. V. S. da .; PADILHA, R. T. .; PADILHA, D. de M. M. . Benefits of Moringa oleifera for human and animal health: Literature review. Research, Society and Development, [S. l.], v. 10, n. 8, p. e50010817495, 2021. DOI: 10.33448/rsd-v10i8.17495. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17495. Acesso em: 13 nov. 2024.

Issue

Section

Review Article