Immune repercussions in patients with functional dyspepsia: A systematic review
Keywords:Dyspepsia; Immune System; Mood Disorders; Gastrointestinal diseases.
Introduction: Functional Dyspepsia (FD) is a chronic or intermittent stomach disorder due to loss of homeostatic balance, being part of Functional Gastrointestinal Diseases (FGIDs). Several factors can be involved with the disease and its immune repercussions. Objective: To evaluate, in patients with Functional Dyspepsia, the risk of immunological repercussions. Method: Systematic Literature Review. The data search strategy used was obtained through two databases: Biblioteca Virtual em Saúde (BVS) and PubMed. The guiding question follows the acronym PO, with P being patients with FD and O as immune repercussions. A combination of descriptors was used: “Dyspepsia” AND “Immune System”. The inclusion criteria used were any year of publication, in Portuguese and English, full online articles and Cohort and Cross-sectional studies that address the PO issue. After the initial identification of the articles, they were read in pairs and selected according to eligibility criteria. Results: Five articles were selected, with Cohort and Cross-sectional studies. In patients with FD, there is a greater probability of developing certain diseases caused by immune dysregulation, such as atopy and mood disorders. One of the main causal factors is inflammation caused by infections, in which stress has led to an increase in inflammatory cytokines throughout the body, which can lead to allergic conditions and neurological disorders. Conclusion: There was evidence of a correlation between FD and the onset of atopy and later mood disorders. However, it is necessary to invest in more articles to better elucidate the overlap between such diseases.
Aro, P., Talley, N. J., Johansson, S., Agréus, L., Ronkainen, J. (2015). Anxiety is linked to new-onset dyspepsia in the Swedish population: a 10-year follow-up study. Gastroenterology, 148(5), 928-937. DOI: https://doi.org/10.1053/j.gastro.2015.01.039
Burns, G., Pryor, J., Holtmann, G., Walker, MM, Talley, NJ, & Keely, S. (2019). Immune Activation in Functional Gastrointestinal Disorders. Gastroenterology & hepatology, 15 (10), 539–548.
Collins S. M. (2014). A role for the gut microbiota in IBS. Nature reviews. Gastroenterology & hepatology, 11(8), 497–505. DOI: https://doi.org/10.1038/nrgastro.2014.40
Donato, Helena & Donato, Mariana. (2019). Etapas na Condução de uma Revisão Sistemática. Acta Médica Portuguesa, 32(3), 227-235. DOI: 10.20344/amp.11923
Du, L. J., Chen, B. R., Kim, J. J., Kim, S., Shen, J. H., & Dai, N. (2016). Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis. World journal of gastroenterology, 22(12), 3486–3495. DOI: https://doi.org/10.3748/wjg.v22.i12.3486
Fan, K., Talley, N. J. (2017). Functional dyspepsia and duodenal eosinophilia: A new model. Journal of Digestive Diseases, v. 18(12), 667-677. DOI: https://doi.org/10.1111/1751-2980.12556
Fock K. M. (2011). Functional dyspepsia, H. pylori and post infectious FD. Journal of gastroenterology and hepatology, 26 Suppl 3, 39–41. DOI: https://doi.org/10.1111/j.1440-1746.2011.06649.x
Ford, A. C., Thabane, M., Collins, S. M., Moayyedi, P., Garg, A. X., Clark, W. F., & Marshall, J. K. (2010). Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study. Gastroenterology, 138(5), 1727–e12. DOI: https://doi.org/10.1053/j.gastro.2010.01.043
Futagami, S., Itoh, T., & Sakamoto, C. (2015). Systematic review with meta-analysis: post-infectious functional dyspepsia. Alimentary pharmacology & therapeutics, 41(2), 177–188. DOI: https://doi.org/10.1111/apt.13006
Galvão, Taís Freire, & Pereira, Mauricio Gomes. (2015). Avaliação da qualidade da evidência de revisões sistemáticas. Epidemiologia e Serviços de Saúde, 24(1), 173-175. DOI: http://dx.doi.org/10.5123/S1679-49742015000100019
Jones, M. P., Walker, M. M., Ford, A. C., & Talley, N. J. (2014). The overlap of atopy and functional gastrointestinal disorders among 23,471 patients in primary care. Alimentary pharmacology & therapeutics, 40(4), 382–391. DOI: https://doi.org/10.1111/apt.12846
Jones, M. P., Faresjö, Å., Beath, A., Faresjö, T., & Ludvigsson, J. (2020). Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 18(2), 360–367.e1. DOI: https://doi.org/10.1016/j.cgh.2019.04.036
Kindt, S., Van Oudenhove, L., Broekaert, D., Kasran, A., Ceuppens, J. L., Bossuyt, X., Fischler, B., & Tack, J. (2009). Immune dysfunction in patients with functional gastrointestinal disorders. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society, 21(4), 389–398. DOI: https://doi.org/10.1111/j.1365-2982.2008.01220.x
Kindt, S., Tertychnyy, A., de Hertogh, G., Geboes, K., & Tack, J. (2009). Intestinal immune activation in presumed post-infectious functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 21(8), 832–e56. DOI: https://doi.org/10.1111/j.1365-2982.2009.01299.x
Koloski, N. A., Jones, M., Weltman, M., Kalantar, J., Bone, C., Gowryshankar, A., Walker, M. M., & Talley, N. J. (2015). Identification of early environmental risk factors for irritable bowel syndrome and dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(9), 1317–1325. DOI: https://doi.org/10.1111/nmo.12626
Liebregts, T., Adam, B., Bredack, C., Gururatsakul, M., Pilkington, K. R., Brierley, S. M., Blackshaw, L. A., Gerken, G., Talley, N. J., & Holtmann, G. (2011). Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. The American journal of gastroenterology, 106(6), 1089–1098. DOI: https://doi.org/10.1038/ajg.2010.512
Luzza, F., Imeneo, M., Maletta, M., Monteleone, G., Doldo, P., Biancone, L., & Pallone, F. (1995). Isotypic analysis of specific antibody response in serum, saliva, gastric and rectal homogenates of Helicobacter pylori-infected patients. FEMS immunology and medical microbiology, 10(3-4), 285–288. DOI: https://doi.org/10.1111/j.1574-695X.1995.tb00045.x
Sousa, M. N. A., & Santos, E. V. L. (2016). Medicina e pesquisa: um elo possível. Editora Prisma.
Spiller R. (2010). Postinfectious functional dyspepsia and postinfectious irritable bowel syndrome: different symptoms but similar risk factors. Gastroenterology, 138(5), 1660–1663. DOI: https://doi.org/10.1053/j.gastro.2010.03.024
Talley, N. J., Holtmann, G., & Walker, M. M. (2015). Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology. Journal of gastroenterology, 50(6), 601–613. DOI: https://doi.org/10.1007/s00535-015-1076-x
Walker, M. M., Salehian, S. S., Murray, C. E., Rajendran, A., Hoare, J. M., Negus, R., Powell, N., & Talley, N. J. (2010). Implications of eosinophilia in the normal duodenal biopsy - an association with allergy and functional dyspepsia. Alimentary pharmacology & therapeutics, 31(11), 1229–1236. DOI: https://doi.org/10.1111/j.1365-2036.2010.04282.x
Wouters, M. M. & Boeckxstaens, G. E. (2016) Is there a causal link between psychological disorders and functional gastrointestinal disorders?. Expert Review of Gastroenterology & Hepatology, 10: 1, 5-8, DOI: 10.1586 / 17474124.2016.1109446
Wu, H. & Wu, E. (2012) The role of gut microbiota in immune homeostasis and autoimmunity, Gut Microbes, 3:1, 4-14, DOI: 10.4161/gmic.19320
How to Cite
Copyright (c) 2021 Natálhya Furtado Oliveira Nobre; Matusalém Marcelino Cândido; Larissa Mercielly Nóbrega Medeiros; Milena Nunes Alves Sousa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.