Clinical behavior of bioactive glass ionomer (45S5) in moderate caries injuries: Study protocol of a clinical trial
Keywords:Pit and fissure sealants; Bioglass; Glass ionomer cements; Randomized controlled trial.
Bioactive materials that are capable of releasing remineralizing ions may be an interesting alternative treatment to prevent the development of carious lesions. The purpose of this study is to evaluate the effectiveness of the association of 45S5 with resin-modified glass ionomer cement (GIC-MR) for conservation and prevention of the progression of initial carious lesions in permanent molars. A total of 36 patients, aged 8 to 14 years, with at least two permanent molars homologous with ICDAS (International Caries Detection and Assessment System) 3 or 4 will be selected to participate in a clinical study of the split-mouth type. The DLF-T (Decayed, Lost and Filled Teeth index), ICDAS, BOP (Bleeding on probing), and VPI (Visible Plaque Index) will be analyzed. A complementary radiographic exam will be performed to assess the dentin underlying lesion. The selected teeth will be randomly assigned into two groups: GIC-MR and GIC-MR + 45S5. Parameters such as retention, the clinical performance of materials, and caries evolution will be evaluated into the two studied groups. Two calibrated evaluators will perform clinical, radiographic, and microscopic evaluations at one, six, 12, and 24 months of follow-up. The results obtained will be evaluated using a Chi-square test. The intention-to-treat protocol will be followed. The results of this study will help to assess the behavior of a bioactive glass ionomer in lesions with enamel microcavities. Innovative research projects, such as the one described here, are needed to determine whether new materials can be used as a treatment alternative.
Bakry, A., Takahashi, H., Otsuki, M., & Tagami, J. (2014). Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass. Dental Materials, 30(3), 314–320. https://doi.org/10.1016/j.dental.2013.12.002
Barbosa, T., & Gavião, M. (2008). Oral health-related quality of life in children: Part II. Effects of clinical oral health status. A systematic review. International Journal of Dental Hygiene, 6(2), 100–107. https://doi.org/10.1111/j.1601-5037.2008.00293.x
Barbosa, T., Tureli, M., Nobre-dos-Santos, M., Puppin-Rontani, R., & Gavião, M. (2013). The relationship between oral conditions , masticatory performance and oral health-related quality of life in children. Archives of Oral Biology, 58, 1070–1077. https://doi.org/10.1016/j.archoralbio.2013.01.012
Bauer, J., Silva e Silva, A., Carvalho, E. M., Ferreira, P. V. C., Carvalho, C. N., Manso, A. P., & Carvalho, R. M. (2019). Dentin pretreatment with 45S5 and niobophosphate bioactive glass: Effects on pH, antibacterial, mechanical properties of the interface and microtensile bond strength. Journal of the Mechanical Behavior of Biomedical Materials, 90(July 2018), 374–380. https://doi.org/10.1016/j.jmbbm.2018.10.029
Bertassoni, L., Habelitz, S., Marshall, S., & Marshall, G. (2011). Mechanical recovery of dentin following remineralization in vitro - an indentation study. J Biomech, 44(1), 176–181. https://doi.org/10.1038/jid.2014.371
Dermata, A., Papageorgiou, S., Fragkou, S., & Kotsanos, N. (2018). Comparison of resin modified glass ionomer cement and composite resin in class II primary molar restorations: a 2-year parallel randomised clinical trial. European Archives of Paediatric Dentistry, 19(6), 393–401. https://doi.org/10.1007/s40368-018-0371-7
Di Nicolo, R., Shintome, L., Myaki, S., & Nagayassu, M. (2007). Bond strength of resin modified glass ionomer cement to primary dentin after cutting with different bur types and dentin conditioning. Journal of Applied Oral Science, 15(5), 459–464. https://doi.org/10.1590/S1678-77572007000500016
Ekstrand, K., Gimenez, T., Ferreira, F., Mendes, F., & Braga, M. (2018). The International Caries Detection and Assessment System – ICDAS : A Systematic Review. Caries Research, 52, 406–419. https://doi.org/10.1159/000486429
Featherstone, J. (2004). The continuum of dental caries - Evidence for a dynamic disease process. Journal of Dental Research, 83(SPEC. ISS. C), 39–42. https://doi.org/10.1177/154405910408301S08
Fontana, M., Platt, J., Eckert, G., González-Cabezas, C., Yoder, K., Zero, D., Ando, M., Soto-Rojas, A., & Peters, M. (2014). Monitoring of Sound and Carious Surfaces under Sealants over 44 Months. Journal of Dental Research, 93(11), 1070–1075. https://doi.org/10.1177/0022034514551753
Frencken, J. (2017). Atraumatic restorative treatment and minimal intervention dentistry. British Dental Journal, 223(3), 183–189. https://doi.org/10.1038/sj.bdj.2017.664
Giacaman, R. (2017). Preserving healthy teeth throughout the life cycle, the biological asset. Journal of Oral Research, 6(4), 80–81. https://doi.org/10.17126/joralres.2017.027
Griffin, S., Oong, E., Kohn, W., Vidakovic, B., Gooch, B., Bader, J., Clarkson, J., Fontana, M., Meyer, D., Rozier, R., Weintraub, J., & Zero, D. (2008). The effectiveness of sealants in managing caries lesions. Journal of Dental Research, 87(2), 169–174. https://doi.org/10.1177/154405910808700211
Hench, L. (2006). The story of Bioglass®. Journal of Materials Science: Materials in Medicine, 17(11), 967–978. https://doi.org/10.1007/s10856-006-0432-z
Innes, N., Chu, C., Fontana, M., Lo, E., Thomson, W., Uribe, S., Heiland, M., Jepsen, S., & Schwendicke, F. (2019). A Century of Change towards Prevention and Minimal Intervention in Cariology. Journal of Dental Research, 98(6), 611–617. https://doi.org/10.1177/0022034519837252
Ismail, A., Sohn, W., Tellez, M., Amaya, A., Sen, A., Hasson, H., & Pitts, N. (2007). The International Caries Detection and Assessment System ( ICDAS ): an integrated system for measuring dental caries. Community Dentistry and Oral Epidemiology, 1, 170–178. https://doi.org/10.1111/j.1600-0528.2007.00347x
Jassal, M., Mittal, S., & Tewari, S. (2018). Clinical effectiveness of a resin-modified glass ionomer cement and a mild one-step self-etch adhesive applied actively and passively in noncarious cervical lesions: An 18-month clinical trial. Operative Dentistry, 43(6), 581–592. https://doi.org/10.2341/17-147-C
Kucukyilmaz, E., Savas, S., Kavrik, F., Yasa, B., & Botsali, M. (2017). Fluoride release/recharging ability and bond strength of glass ionomer cements to sound and caries-affected dentin. Nigerian Journal of Clinical Practice, 20(2), 226–234. https://doi.org/10.4103/1119-3077.178917
Lavigne, O., Vu, A., Richards, L., & Xie, Z. (2018). Effect of demineralization time on the mineral composition and mechanical properties of remineralized dentin. Journal of Oral Science, 60(1), 121–128. https://doi.org/10.2334/josnusd.17-0038
Lima, S., Santana, C., Paschoal, M., Paiva, S., & Ferreira, M. (2018). Impact of untreated dental caries on the quality of life of Brazilian children : population-based study. International Journal of Paediatric Dentistry, 1–10. https://doi.org/10.1111/ipd.12365
Martins, C., Carvalho, T., Souza, M., Ravagnani, C., Peitl, O., Zanotto, E., Panzeri, H., & Casemiro, L. (2011). Assessment of antimicrobial effect of Biosilicate ® against anaerobic, microaerophilic and facultative anaerobic microorganisms. Journal of Materials Science: Materials in Medicine, 22(6), 1439–1446. https://doi.org/10.1007/s10856-011-4330-7
Muñoz-Sandoval, C., Gambetta-Tessini, K., & Giacaman, R. (2019). Microcavitated ( ICDAS 3 ) carious lesion arrest with resin or glass ionomer sealants in first permanent molars : A randomized controlled trial. Journal of Dentistry, 88. https://doi.org/10.1016/j.jdent.2019.07.001
Perdigão, J., Dutra-Corrêa, M., Saraceni, C., Ciaramicoli, M., Kiyan, V., & Queiroz, C. (2012). Randomized clinical trial of four adhesion strategies: 18-month results. Operative Dentistry, 37(1), 3–11. https://doi.org/10.2341/11-222-C
Pereira, A., Pardi, V., Mialhe, F., Meneghim, M., & Ambrosano, G. (2003). A 3-year clinical evaluation of glass-ionomer cements used as fissure sealants. American Journal of Dentistry, 16(1), 23–26.
Peres, M., Antunes, J., & Peres, K. (2006). Is water fluoridation effective in reducing inequalities in dental caries distribution in developing countries ? Recent findings from Brazil. Soz Praventiv Med, 51, 302–310. https://doi.org/10.1007/s00038-006-5057-y
Pitts, N. (2004). “ICDAS”--an international system for caries detection and assessment being developed to facilitate caries epidemiology, research and appropriate clinical management. Community Dent Health, 21(3), 193–198.
Pitts, NB, & Stamm, J. (2004). International Consensus Workshop on Caries Clinical Trials (ICW-CCT) - Final consensus statements: Agreeing where the evidence leads. Journal of Dental Research, 83(SPEC. ISS. C), C125-128. https://doi.org/10.1177/154405910408301S27
Qvist, V., Poulsen, A., Teglers, P., & Mjor, I. (2010). Fluorides leaching from restorative materials and the effect on adjacent teeth. International Dental Journal, 60, 156–160. https://doi.org/10.1922/IDJ
Schulz, K., Altman, D., & Moher, D. (2011). CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomized trials. International Journal of Surgery, 9, 672–677. https://doi.org/10.1136/bmj.c332
Simonsen, R. (1991). Retention and effectiveness of dental sealant after 15 years. The Journal of the American Dental Association, 122(11), 34–42. https://doi.org/10.14219/jada.archive.1991.0289
Söderholm, K. (1995). Does resin based dentine bonding work? Int Dent J, 45(6), 371–381.
Tagliaferro, E., Pardi, V., Ambrosano, G., Meneghim, M., Paschoal, M., Cordeiro, R., & Pereira, A. (2017). Influence of caries risk on the retention of a resin-modified glass ionomer used as occlusal sealant: a clinical trial. Rev Odontol UNESP, 46(4), 208–213.
Waltimo, T., Brunner, T., Vollenweider, M., Stark, W., & Zehnder, M. (2007). Antimicrobial effect of nanometric bioactive glass 45S5. Journal of Dental Research, 86(8), 754–757. https://doi.org/10.1177/154405910708600813
Wright, J., Tampi, M., Estrich, C., Crall, J., Fontana, M., Gillette, E., Nový, B., Dhar, V., Donly, K., Hewlett, E., Quinonez, R., Chaffin, J., Crespin, M., Iafolla, T., Siegal, M., & Carrasco-Labra, A. (2016). Sealants for preventing and arresting pit-and-fissure occlusal caries in primary and permanent molars: A systematic review of randomized controlled trials - a report of the American Dental Association and the American Academy of Pediatric Dentistry. JADA, 147(8), 631–645. https://doi.org/10.1016/j.adaj.2016.06.003
Yengopal, V., & Mickenautsch, S. (2011). Caries-preventive effect of resin-modified glass-ionomer cement (RM-GIC) versus composite resin: a quantitative systematic review. European Archives of Paediatric Dentistry, 12(1), 5–14. https://doi.org/10.1007/BF03262772
Yli-Urpo, H., Närhi, M., & Närhi, T. (2005). Compound changes and tooth mineralization effects of glass ionomer cements containing bioactive glass (S53P4), an in vivo study. Biomaterials, 26(30), 5934–5941. https://doi.org/10.1016/j.biomaterials.2005.03.008
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Copyright (c) 2021 Ana Carolina Soares Diniz; Geyna Aguiar do Couto; Thaís Bordinassi da Silva; José Roberto Bauer; Leily Macedo Firoozmand
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