Cannabis and Breast Cancer: Evidence with In Vitro Cells
DOI:
https://doi.org/10.33448/rsd-v10i10.18387Keywords:
Cannabis; Cannabidiol; Breast câncer; Anticancer treatment.Abstract
Breast cancer is considered the most incident cancer in women worldwide. Evidence has shown that cannabinoids can modulate signaling pathways responsible for cancer growth and spread. Thus, this literature review sought to summarize the evidence that existed so far on the use of cannabis for the treatment of breast cancer. Data collection was carried out from May to June 2021, in the electronic database PubMed. Articles from their origin to June 1, 2021 were included, with the combination of the following descriptors: ((Cannabidiol OR cannabis) AND “breast neoplasms”). The results demonstrated the paucity of studies that sought to assess the effects of medicinal cannabis in the treatment of breast cancer in humans. In conclusion, the study allowed us to understand the importance that medicinal cannabis, in particular cannabidiol, has been providing for advances in anticancer treatment in cells in vitro.
References
Alexander, A., Smith, P. F., & Rosengren, R. J. (2009). Cannabinoids in the treatment of cancer. Cancer Lett, 285, 6–12.
American Cancer Society. (2019). Hormone Therapy for Breast Cancer. Disponível em: https://www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html. Acessado em: 08 de setembro de 2020. Anderson, D.E., Holstein, S.A., & Kedar, S. (2020). Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research. Neuro-Ophthalmology, 1-9. Doi:10.1080/01658107.2019.1702703.
Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M.H., Vogel, Z., Bisogno, T., De Petrocellis, L., Di Marzo, V., & Mechoulam, R. (1998). An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol, 353(1), 23-31.
Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., Piñeros, M., Znaor, A., Soerjomataram, I., & Bray, F. (2018). Cancer Today (powered by GLOBOCAN 2018). Disponível em: https://publications.iarc.fr/Databases/Iarc-Cancerbases/Cancer-Today-Powered-By-GLOBOCAN-2018--2018. Acessado em: 04 julho 2021.
INCA. (2019). Estimativa 2020: Incidência do Câncer no Brasil. Rio de Janeiro: INCA.
Jin, U. H., Lee, S. O., Pfent, C., & Safe, S., (2014). The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. BMC Cancer, 14, 498.
Ligresti, A., Moriello, A.S., Starowicz, K., Matias, I., Pisanti, S., De Petrocellis, L., Laezza, C., Portella, G., Bifulco, M., & Di Marzo, V. (2006). Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther, 318, 1375–1387.
Marzo, V., & Matias, I. (2005). Endocannabinoid control of food intake and energy balance. Nat Neurosci, 8, 585-589.
Mendes, K. D. S., Silveira, R. C. P. S. & Galvão, C. M. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto e Contexto Enfermagem. 17(4), 2008.
Nadal, X., Del Rio, C., Casano, S., Palomares, B., Ferreiro-Vera, C., Navarrete, C., Sanchez-Carnerero, C., Cantarero, I., Bellido, M. L., Meyer, S., Morello, G., Appendino, G., & Muñoz, E. (2017). Tetrahydrocannabinolic acid is a potent PPARgamma agonist with neuroprotective activity. Br J Pharmacol, 174 (23), 4263-4276. DOI: 10.1111/bph.14019.
Oliveira, K. L. B., Lima, T. P. S. Cannabis Sativa: Potencial Terapêutico. [Trabalho de Conclusão de Curso]. Bacharelado em Biomedicina. Faculdade São Lucas: Porto Velho – RO, 30p.
Pertwee, R. G., & Ross, R. A. (2002). Cannabinoid receptors and their ligands. Prostaglandins Leukot Essent Fatty Acids, 66, 101–121.
Rojas – Raras, C., Polanco-Carrasco, R. Cisterna, A., Hernandez, V., Miranda, F., Moreno, A., Alarcon, L. Uso medicinal de cannabis: una revisión de la evidencia. Tarapia Psicológica, 37(2), 2019.
Salazar, M., Carracedo, A., Salanueva, I.J., Hernandez-Tiedra, S., Lorente, M., Egia, A., Vásquez, P., Blázquez, C., Torres, S., García, S., Nowak, J., Fimia, G. M., Piacentini, M., Cecconi, F., Pandolfi, P. P., González-Feria, L., Lovanna, J. L., Guzmán, M., Boya, P., & Velasco, G. (2009). Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest, 119, 1359–1372.
Souza, L. M. M., Marques-Vieira, C. M. A., Severino, S. S. P. & Antunes, A. V. A metodologia de revisão integrativa da literatura em Enfermagem. Revista Investigação em Enfermagem. 21(2), 2017.
Vieira, L. S., Marques, A. E. F., Sousa, V. A. O uso de Cannabis sativa para fins terapêuticos no Brasil: uma revisão de literatura. Scientia Naturalis, 2(2), 901-919, 2020
Waks, A. G., & Winer, E. P. (2019). Breast Cancer Treatment: A Review. JAMA, 321(3):288-300. Doi: 10.1001/jama.2018.19323.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Milena Edite Casé de Oliveira; Kedma Anne Lima Gomes; Waleska Fernanda Souto Nóbrega; Gustavo Correia Basto da Silva; Danilo Vieira Barbosa; Ramonyele Gomes Franklin; Rayane Dantas dos Santos
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
