Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS

Authors

DOI:

https://doi.org/10.33448/rsd-v10i10.18516

Keywords:

Muscle cells; Elderly; Acquired immunodeficiency syndrome.

Abstract

Introduction: The Acquired Immunodeficiency Syndrome (AIDS), an infectious disease, where the main characteristic is the suppression of immunity by T CD4 lymphocytes. Objective: To analyze the percentage of myocytes and collagen fiber density from autopsied fragments of skeletal striated musculature from elderly and non-elderly patients with and without AIDS. Methodology: Retrospective, observational, analytical and quantitative study carried out from 78 divided into four groups, elderly and non-elderly with and without AIDS, aged between 44 and 63 years. Results: For histomorphometric analysis of the percentage of myocytes using Hematoxylin and eosin methods and for collagen fibers and Picrosirius under polarized light, both were performed under ordinary light microscopy. Results: There was a statistically defined decrease in nuclei in the non-elderly groups with and without AIDS and elderly with AIDS compared to the elderly groups without AIDS (p˂0,001). Collagen fibers in the non-elderly and non-deaf AIDS groups were higher when compared to the elderly groups with and without AIDS (p=0,001). The correlation between nucleus and cytoplasm was negative and low in the four groups (p <0,0001), between collagen fibers and nucleus, non-elderly people without AIDS (p<0,0012) and non-elderly people with AIDS (p<0,0368) was negative and decreased, between cytoplasm and collagen fibers the non-elderly group with AIDS (p<0,0353) and non-elderly without AIDS (p<0,0012) was negative and decreased. Conclusion: Aging and AIDS influence the loss of muscle mass and contribute to the reduction of collagen fibers.

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Published

07/08/2021

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PEREIRA , V. G. .; ROCHA, L. A. .; FERREIRA , F. J. P. de A. .; TEIXEIRA, V. de P. A. .; SILVA , A. C. S. da .; ROSA, R. C. .; ESPINDULA, A. P. Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS. Research, Society and Development, [S. l.], v. 10, n. 10, p. e151101018516, 2021. DOI: 10.33448/rsd-v10i10.18516. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18516. Acesso em: 19 apr. 2024.

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Vol. 10 No. 10

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Health Sciences

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Copyright (c) 2021 Vandair Gonçalves Pereira ; Lourrayne Andressa Rocha; Flávio José Pereira de Almeida Ferreira ; Vicente de Paula Antunes Teixeira; Aline Cristina Souza da Silva ; Rodrigo César Rosa; Ana Paula Espindula

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