Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS

Authors

DOI:

https://doi.org/10.33448/rsd-v10i10.18516

Keywords:

Muscle cells; Elderly; Acquired immunodeficiency syndrome.

Abstract

Introduction: The Acquired Immunodeficiency Syndrome (AIDS), an infectious disease, where the main characteristic is the suppression of immunity by T CD4 lymphocytes. Objective: To analyze the percentage of myocytes and collagen fiber density from autopsied fragments of skeletal striated musculature from elderly and non-elderly patients with and without AIDS. Methodology: Retrospective, observational, analytical and quantitative study carried out from 78 divided into four groups, elderly and non-elderly with and without AIDS, aged between 44 and 63 years. Results: For histomorphometric analysis of the percentage of myocytes using Hematoxylin and eosin methods and for collagen fibers and Picrosirius under polarized light, both were performed under ordinary light microscopy. Results: There was a statistically defined decrease in nuclei in the non-elderly groups with and without AIDS and elderly with AIDS compared to the elderly groups without AIDS (p˂0,001). Collagen fibers in the non-elderly and non-deaf AIDS groups were higher when compared to the elderly groups with and without AIDS (p=0,001). The correlation between nucleus and cytoplasm was negative and low in the four groups (p <0,0001), between collagen fibers and nucleus, non-elderly people without AIDS (p<0,0012) and non-elderly people with AIDS (p<0,0368) was negative and decreased, between cytoplasm and collagen fibers the non-elderly group with AIDS (p<0,0353) and non-elderly without AIDS (p<0,0012) was negative and decreased. Conclusion: Aging and AIDS influence the loss of muscle mass and contribute to the reduction of collagen fibers.

References

Akselrod, S., Gordon, D., Ubel, F. A., Shannon, D. C., Berger, A. C., & Cohen, R. J. (1981). Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 213(4504):220-2.

Adigun, R., & Singh R. Tuberculosis. (2021). Oct 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls.

Avila Rodríguez, M. I., Rodríguez Barroso, L. G., & Sánchez, M. L. (2018). Collagen: A review on its sources and potential cosmetic applications. J Cosmet Dermatol. 17(1):20-26.

Barreto, A. L. S. (2019). Estudo histomorfológico do efeito de membranas de colágeno contendo própolis vermelha sobre o processo de reparo cicatricial por segunda intenção em ratos. Dissertação de mestrado - Universidade Tiradentes.

Bonato, M., Turrini, F., Galli, L., Banfi, G., & Cinque, P. (2020). The Role of Physical Activity for the Management of Sarcopenia in People Living with HIV. Int J Environ Res Public Health. 17(4):1283.

Carnevale, V., Castriotta, V., Piscitelli, P. A., Nieddu, L., Mattera, M., Guglielmi, G., & Scillitani, A. (2018). Assessment of Skeletal Muscle Mass in Older People: Comparison Between 2 Anthropometry-Based Methods and Dual-Energy X-ray Absorptiometry. J Am Med Dir Assoc. 19(9):793-796.

Cavalcante R. O., Cavalcante, A. V. O., Araújo, L. M., Cavalcante, M. C. O., & Vandesmet, L. C. S. (2020). Alterações epiteliais no envelhecimento. Mostra Científica em Biomedicina. 4(2).

Cervi, A., Franceschini, S. C. C., & Priori, S. E. (2005). Análise crítica do uso do índice de massa corporal para idosos. Rev. Nutr. 18(6): 765-775.

Cruz-Jentoft, A.J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A.A., Schneider, S.M., Sieber, Et Al. C. C., Toponkova, E., Vandewoude, M., Visser, M., & Zamboni. (2019). sarcopenia: revised european consensus on definition and diagnosis. age ageing. 48(1):16-31.

Da Silva, A. A., Gehlen, M. H., Ferreira, C. L. L., & Pereira, A. D. A. (2020). Diagnóstico e intervenções de enfermagem do sistema tegumentar em idosos hospitalizados. South American Journal of Basic Education, Technical and Technological. 7 (2): 351-360.

De Santana, F., Domiciano, D. S., Gonçalves, M. A., Machado, L. G., Figueiredo, C. P., Lopes, J. B., Caparbo, V. F., Takayama, L., Menezes, P. R., & Pereira, R. M. R. (2019). Association of appendicular lean mass, and subcutaneous and visceral adipose tissue with mortality in older brazilians: the são paulo ageing & health study. j. bone miner res. 34 (7): 1264–1274.

Erlandson, K. M., Guaraldi, G., & Falutz, J. (2016). . More than osteoporosis: age-specific issues in bone health. Current Opinion in HIV and AIDS. 3(11): 343–350.

Evans, W. J., Roubenoff, R., & Shevitz, A. (1998). Exercise and the treatment of wasting: aging and human immunodeficiency virus infection. Semin. Encol.25(2- 6):112-22.

Ferreira, F. J. P. A., Cardoso, F. A. G., Pereira, V. G., Nascentes, G. A. N., Monteiro, V. S., & Espindula, A. P. (2021). A síndrome da imunodeficiência humana adquirida como fator na redução da espessura e aumento do colágeno nas trabéculas ósseas de adultos e idosos. Research, Society and Development. 10 (8): 22510817215. DOI: 10.33448/rsd-v10i8.17215. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17215.

He, N., & Ye, H. (2020). Exercise and Muscle Atrophy. Adv Exp Med Biol. 228:255-267.

Knauth, D,R., Hentges, B., Macedo, J. L., Pilecco, F. B., Teixeira, L. B., & Leal, A. F. (2020). O diagnóstico do HIV/aids em homens heterossexuais: a surpresa permanece mesmo após mais de 30 anos de epidemia.Cadernos de Saúde Pública. 36: e00170118.

Langholz, P. L., Strand, B. H., Cook, S., & Hopstock. (2018). Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Troms Study 2001-2016. Geriatr Gerontol Int. 18(8):1200-1205.

Mccomsey, G. A., Tebas, P., Shane, E., Yin, M. T., Overton, E. T., Huang, J. S., Adrovandi, G. M., Cardoso, S. W., Santana, J. L., & Brown, T. T. (2010). Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin Infect Dis. 51 (8):937-946.

Nakagawa, F., Lodwick, R. K., Smith, C. J., Smith, R., Cambiano, V., Lundgren, J. D., Delpech, v., & Phillips, A. N. (2012). Projected life expectancy of people with HIV according to timing of diagnosis. AIDS. 28;26(3):335-43.

Nassr, M., & Nasri, G. (2019). Atrofia muscular esquelética: relação entre ciências básicas e aplicadas (Cinesiologia/Fisioterapia). Fisioterapia e Pesquisa. 26 (1):1-2.

Panwar, P., Butler, G. S., Jamroz, A., Azizi, P., Overall, C. M., & Bromme, D. (2018). Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases. Matrix Biol. 65 (30-44): 28634008.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J & Shitsuka, R. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM.https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1

Pretell-Mazzini, J., Subhawong, T.Y., Hernandez, V. H., & Campo, R. (2016). HIV and orthopaedics: musculoskeletal manifestations and outcomes. J Bone Joint Surg Am. 98(9):775-86.

Sanches-da-Silva, G. N., Medeiros, L. F. S., & Lima, F. M. (2019). The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy. Int J Genomics. 2019:14.

Sui, S. X., Williams, L. J., Kew-Holloway, K. L., Hyde, N. K., & Pasco, J. A. (2020). Skeletal Muscle Health and Cognitive Function: A Narrative Review. Int J Mol Sci. 22(1):255.

Sweeney, H. L., & Hammers, D. W. (2018). Muscle Contraction. Cold Spring Harb Perspect Biol. 10(2).

Unaids.(2013). Nações Unidas. GLOBAL REPORT: Unaids report on the global aids epidemic 2013. Genebra, 2013. Disponível em: https://www.unaids.org/en. Acesso em: 20 Mai. 2021.

Yarasheski, K. E., Scherzer, R., Kotler, D. P., Dobs, A. S., Tien, P. C., Lewis, C. E., Kronmal, R. A., Heymsfield, S. B., Bacchetti, P., & Grunfeld, C. (2011). Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM). Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals. J Gerontol a Biol Sci Med Sci. 66(3):332-40.

Yilmaz Çankaya, B., Karaman, A., Albez, F.S., Polat, G., Alper, F., & Akgun, M. (2021). The association of silicosis severity with pectoralis major muscle and subcutaneous fat volumes and the pulmonary artery/aorta ratio evaluated by CT. Diagn Interv Radiol. 27(1):37-41.

Zanker, J., & Duque, G. (2019). Osteoporose em pessoas idosas: velhos e novos jogadores. Journal of the American Geriatrics Society. 67(4): 831-840.

Downloads

Published

07/08/2021

How to Cite

PEREIRA , V. G. .; ROCHA, L. A. .; FERREIRA , F. J. P. de A. .; TEIXEIRA, V. de P. A. .; SILVA , A. C. S. da .; ROSA, R. C. .; ESPINDULA, A. P. Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS. Research, Society and Development, [S. l.], v. 10, n. 10, p. e151101018516, 2021. DOI: 10.33448/rsd-v10i10.18516. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18516. Acesso em: 15 nov. 2024.

Issue

Vol. 10 No. 10

Section

Health Sciences

License

Copyright (c) 2021 Vandair Gonçalves Pereira ; Lourrayne Andressa Rocha; Flávio José Pereira de Almeida Ferreira ; Vicente de Paula Antunes Teixeira; Aline Cristina Souza da Silva ; Rodrigo César Rosa; Ana Paula Espindula

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.