Comparison of hemodynamic changes between two benzodiazepines in conscious sedation of the third molar exodontics: a systematic review protocol




Conscious sedation; Midazolam; Diazepam; Third, molar; Systematic review.


Objectives: This study intends to present a protocol for a systematic review that seeks to compare hemodynamic changes in patients who underwent conscious oral sedation with diazepam versus midazolam during lower third molar extraction. Methods: Protocol for a systematic review of randomized clinical trials, using the databases Embase, PubMed/MEDLINE, Cochrane Library, Regional Portal of the VHL, gray literature and manual searches in the main journals in the field of maxillofacial surgery. This protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), emphasizing that this review will be conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Final considerations: The need to maintain greater hemodynamic stability during lower third molar extraction, in the face of conscious oral sedation, makes it relevant that this systematic review be carried out.


Araújo, J. O., Motta, R. H. L., Bergamaschi, C. C., Guimarães, C. C., Ramacciato, J. C., Andrade, N. K., et al. (2018). Effectiveness And Safety Of Oral Sedation In Adult Patients Undergoing Dental Procedures: Protocol For A Systematic Review. Bmj Open, 8, 1–5.

Astramskaitė, I., Poškevičius, L, & Juodžbalys, G. (2016). Factors Determining Tooth Extraction Anxiety And Fear In Adult Dental Patients: A Systematic Review. International Journal Of Oral And Maxillofacial Surgery, 45, 1630–1643.

Aznar-Arasa, L, Figueiredo, R, Valmaseda-Castellón, E., & Gay-Escoda, C. (2014). Patient Anxiety And Surgical Difficulty In Impacted Lower Third Molar Extractions: A Prospective Cohort Study. International Journal Of Oral And Maxillofacial Surgery, 43, 1131–1136.

Balaguer-Martí, J. C, Aloy-Prósper, A., Peñarrocha-Oltra, A., & Peñarrocha-Diago, M. (2016) Non Surgical Predicting Factors For Patient Satisfaction After Third Molar Surgery. Medicina Oral Patologia Oral Y Cirugia Bucal, 21, 201–205.

Beaton, L., Freeman, R., & Humphris, G. (2014). Why Are People Afraid Of The Dentist? Observations And Explanations. Medical Principles And Practice, 23, 295–301.

Calcaterra, N. E., & Barrow, J. C. (2014) Classics In Chemical Neuroscience: Diazepam (Valium). Acs Chemical Neuroscience, 5, 253–260.

Consolaro, A., & Hadaya, O. (2021). Ten Reasons To Not Ignore The Third Molar. Dental Press Journal Of Orthodontics, 26, 1–26.

Corcuera-Flores, J. R., Silvestre-Rangil, J., Cutando-Soriano, A., & López-Jiménez, J. (2016). Current Methods Of Sedation In Dental Patients - A Systematic Review Of The Literature. Medicina Oral Patologia Oral Y Cirugia Bucal, 21, 579–586.

De Moares, M. B., Barbier, W. S., Raldi, F. V., Nascimento, R. D., Santos, L. M., & Sato, F. R. L. (2019) Comparison of Three Anxiety Management Protocols for Extraction of Third Molars With the Use of Midazolam, Diazepam, and Nitrous Oxide: A Randomized Clinical Trial. Journal of Oral and Maxillofacial Surgery, 77, 2258.

Frazão, V. T., & Filippe, A. C. Z. (2020). Midazolam: Aspectos Farmacológicos e seu uso em diferentes níveis de sedação. Revista de Saúde, 11, 36–41.

Gadve, V. R., Shenoi, R., Vats, V., & Shrivastava, A. (2018) Evaluation of Anxiety, Pain, and Hemodynamic Changes during Surgical Removal of Lower Third Molar under Local Anesthesia. Ann Maxillofac Surg. 8, 247-53.

Galvão, T. F., & Pereira, M. G. (2015) Avaliação da Qualidade da Evidência de Revisões Sistemáticas. Epidemiologia e Serviços de Saúde, 24, 775–778.

Khader, R., Oreadi, D., Finkelma, M., Jamoc, M., Chaudhary, S., Schumann, R., et al. (2015) A Prospective Randomized Controlled Trial Of Two Different Sedation Sequences For Third Molar Removal In Adults. Journal Of Oral And Maxillofacial Surgery, 73, 224–231.

Kapur, A., & Kapur, V. (2018) Conscious Sedation in Dentistry. Ann Maxillofac Surg. 8 (2): 320-323.

Lino, P. A., Martins, M. A. P., Silva, M. E. S., & Abreu, M. H. N. G. (2017). Anxiolytics, Sedatives, And Hypnotics Prescribed By Dentists In Brazil In 2010. Biomed Research International, 1-5.

Melini, M., Forni, A., Cavallin, F., Parotto, M., & Zanett, G. (2020). Conscious Sedation For The Management Of Dental Anxiety In Third Molar Extraction Surgery: A Systematic Review. Bmc Oral Health, 20, 1–10.

Morais, H. H. A., Barbalho, J. C. M., Vasconcellos, R. J. H., Landim, F. S., Araújo, F. A. C., & Dias, T. G. S. (2015). Comparative Study Of Hemodynamic Changes Caused By Diazepam And Midazolam During Third Molar Surgery: A Randomized Controlled Trial. Oral And Maxillofacial Surgery, 19, 267–273.

Picciani, B. L. S., Santos, B. M., Silva-Júnior, G. O., Marinho, M. A., Papa, E. G., Faria, M. D. B., et al. (2019) Contribution Of Benzodiazepines In Dental Care Of Patients With Special Needs. Journal Of Clinical And Experimental Dentistry, 11, 1170–1174.

Sancak, K. T., & Akal, Ü. K. (2019). Effect Of Verbal And Written Information And Previous Surgical Experience On Anxiety During Third Molar Extraction. Journal Of Oral And Maxillofacial Surgery, 77, 1769e1-1769e7.

Sharma, V. Singh, A, Sharma, P., Kaur, S., & Zutshi, A. (2019) Comparative Study Between Oral Lorazepam And Diazepam As Sedation In Oral And Maxillofacial Surgery. Journal Of Maxillofacial And Oral Surgery, 18, 256–259.

Souza Junior, E. F., Silva, J. A., Brito, J. I. P., Lucena, E. E. S., & Morais, H. H. A. (2021) Association between Pell and Gregory classification and the difficulty of the extraction of the lower third parties. RGO, Rev Gaúch Odontol. 69, 1-9.

Tarazona-Álvarez, P., Pellicer-Chover, H., Tarazona-Álvarez, B., Peñarrocha-Oltra, D., & Peñarrocha-Diago, M. (2019) Hemodynamic Variations And Anxiety During The Surgical Extraction Of Impacted Lower Third Molars. Journal Of Clinical And Experimental Dentistry, 11, 27–32.

Wannmacher, L.; & Ferreira, M. B. C. (1999) Farmacologia Clínica Para Dentistas. (2a ed.), Guanabara Koogan. 349.



How to Cite

SILVA, J. A.; SOUZA JUNIOR, E. F. de .; ANDRADE, M. F. de .; MORAIS, H. H. A. de. Comparison of hemodynamic changes between two benzodiazepines in conscious sedation of the third molar exodontics: a systematic review protocol. Research, Society and Development, [S. l.], v. 10, n. 10, p. e304101018740, 2021. DOI: 10.33448/rsd-v10i10.18740. Disponível em: Acesso em: 21 oct. 2021.



Health Sciences