Comparative study of the effectiveness of treatments for androgenetic alopecia through the capillary intradermotherapy technique: minoxidil and finasteride

Authors

DOI:

https://doi.org/10.33448/rsd-v10i10.18832

Keywords:

Androgenetic Alopecia; Capillary intradermotherapy; Minoxidil; Finasteride

Abstract

Objective: to compare relevant results regarding the effectiveness of the use of Minoxidil, growth factors and some vitamins with the association Finasteride, growth factors and vitamins by the capillary intradermotherapy technique for the treatment of Androgenetic Alopecia. Methods: The research was carried out in a private clinic in the city of Patos-PB. Ten patients with Androgenetic Alopecia were evaluated, divided into two groups of five people each, according to similar characteristics. Group A received capillary intradermotherapy with Minoxidil, growth factors and vitamins, while Group B received Finasteride, growth factors and vitamins. The criteria used for comparison were evaluated by the medical evolution questionnaire, taking into account the increase or decrease in capillary volume and the decrease in alopecia. After that, the data were systematized and compared with the updated literature on the proposed theme. Results: A slight superiority related to the increase in capillary volume of patients in group A was illustrated. With regard to capillary drop, the results remained practically similar between patients in both groups. Conclusion: There is a need for studies with a larger sample size, aiming at a more reliable result in search of a more significant clinical effect for this disease.

References

Adil A., & Godwin M. (2017). The effectiveness of treatments for androgenetic alopecia: a systematic review and meta-analysis. Journal Of The American Academy Of Dermatology, 77(1), 136-141.

Caserini, M., Radicioni, M., Leuratti, C., Terragni, E., Iorizzo, M., & Palmieri, R. (2016). Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia. International journal of clinical pharmacology and therapeutics, 54(1), 19–27. https://doi.org/10.5414/CP202467

Cavalcanti, C. P., & Arruda T. A. (2015). Protocolos de tratamento da alopecia: uma revisão. Trabalho de Conclusão de Curso (Graduação em Farmácia) – Universidade Estadual da Paraíba, Campina Grande, 30 p.

Dhurat, R., Chitallia, J., May, T. W., Jayaraaman, A. M., Madhukara, J., Anandan, S., Vaidya, P., & Klenk, A. (2017). An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia. Skin pharmacology and physiology, 30(6), 298–305. https://doi.org/10.1159/000481141

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Frano, J., & Tassinary J. (2018). Revisão bibliográfica dos principais recursos terapêuticos utilizados no tratamento da alopécia androgenética. Revista Destaques Acadêmicos, 10(3): 8-14.

Hillmann, K., Garcia Bartels, N., Kottner, J., Stroux, A., Canfield, D., & Blume-Peytavi, U. (2015). A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men. Skin pharmacology and physiology, 28(5), 236–244. https://doi.org/10.1159/000375320

Gupta, A. K., Carviel, J., Macleod, M. A., & Shear, N. (2017). Assessing finasteride-associated sexual dysfunction using the FAERS database. Journal Of The European Academy Of Dermatology And Venereology, 31(6), 1069-1075. http://dx.doi.org/10.1111/jdv.14223.

Gupta, A. K., Mays, R. R., Dotzert, M. S., Versteeg, S. G., Shear, N. H., & Piguet, V. (2018). Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis. Journal of the European Academy of Dermatology and Venereology: JEADV, 32(12), 2112–2125. https://doi.org/10.1111/jdv.15081

Keaney T. (2015). Emerging therapies for androgenetic alopecia. Journal of Drugs in Dermatology, 14(9): 1036-1040.

Kiguradze, T., Temps, W. H., Yarnold, P. R., Cashy, J., Brannigan, R. E., Nardone, B., Micali, G., West, D. P., & Belknap, S. M. (2017). Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride. PeerJ, 5, e3020. https://doi.org/10.7717/peerj.3020

Lee, S. W., Juhasz, M., Mobasher, P., Ekelem, C., & Mesinkovska, N. A. (2018). A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. Journal of drugs in dermatology: JDD, 17(4), 457–463.

Louzada, L. M., Mendes, R. de F., & Leite, S. A. (2019). Alopécia Androgenética: principais abordagens terapêuticas. Trabalho de Conclusão de Curso (Graduação em Medicina) – Centro Universitário UNIFACIG, 2019, 22 p.

Machado I. O. C. C., & Marques L. T. (2017). Calvície e alopecia: revisão bibliográfica. Dissertação (Mestrado em Ciências Farmacêuticas) – Universidade Lusófona de Humanidade e Tecnologias, 65 p.

Mulinari-Brenner F., Seidel, G., & Hepp, T. (2011). Understanding androgenetic alopecia. Surgical & Cosmetic Dermatology, 3(4): 329-37.

Nantes, M. C., De Paiva, N. S., Soares, A. L. F., Santos, J. L., Eler, J. F. de C., & Lopes, L. de A. (2018). Action of minoxidil and finasteride through intradermotherapy in the treatment of androgenetic alopecia. Brazilian Journal of Surgery and Clinical Research, 24(2): 166-175.

Pereira, J. M. et al. (2016). Tratado das doenças dos cabelos e do couro cabeludo: Tricologia. Di Livros Editora, 503 p.

Pereira, L. A. (2018). Principais tipos de alopecias não cicatriciais e suas Fisiopatogenias. Revista Estética em Movimento, 1:1-18

Rossi, A., Anzalone, A., Fortuna, M. C., Caro, G., Garelli, V., Pranteda, G., & Carlesimo, M. (2016). Multi-therapies in androgenetic alopecia: review and clinical experiences. Dermatologic therapy, 29(6), 424–432. https://doi.org/10.1111/dth.12390

Sei, M. C. K., & Brandão B. J. F. (2020). Use of Mesotherapy for Androgenetic Alopecia: a literature review. BWS Journal, 3, e20060080: 1-7.

Suchonwanit, P., Srisuwanwattana, P., Chalermroj, N., & Khunkhet, S. (2018). A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia. Journal of the European Academy of Dermatology and Venereology: JEADV, 32(12), 2257–2263. https://doi.org/10.1111/jdv.15171

Published

09/08/2021

How to Cite

FORMIGA, M. W. M. .; SOUSA, M. N. A. de .; EGYPTO, L. e V. do . Comparative study of the effectiveness of treatments for androgenetic alopecia through the capillary intradermotherapy technique: minoxidil and finasteride. Research, Society and Development, [S. l.], v. 10, n. 10, p. e251101018832, 2021. DOI: 10.33448/rsd-v10i10.18832. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18832. Acesso em: 27 oct. 2021.

Issue

Section

Health Sciences