Clinical and diagnostic aspects of Crohn Syndrome




Crohn's disease; Intestinal disease; Immune system disease.


Crohn's disease (CD) is an inflammatory bowel disease that affects part of the population between 20 and 50 years of age, of both sexes. This disease affects people from different socioeconomic classes and nationalities, and affects approximately 1.4 million of people in the United States only. This work aims to talk a little about the disease and report possible complications, diagnosis and treatment of the disease. This review is intended to help bring more knowledge about the disease using the set of several articles to confirm the information. The work developed is an exploratory study, carried out through a systematic review research. According to Marconi and Lakatos (2011), a systematic search covers the entire bibliography already made public in relation to the subject of study. The search strategy used to obtain the articles was the important databases in the health area, with MEDLINE (Medical Literature Analysis and Retrieval System), Science Direct and SCIELO (Scientific Electronic Library Online), ARCA (Fiocruz Institutional Repository), Lilics available online in full text, published in Portuguese (Brazil), English and Spanish. The following descriptors were applied: AUTOIMMUNE DISEASE, CROHN'S DISEASE, INTESTINE SYNDROME. A total of 10,050 articles were found in the scientific databases: Latin American and Caribbean Literature on Health Sciences (LILACS), MEDLINE (Medical Literature Analysis and Retrieval System), Science Direct and SCIELO (Scientific Electronic Library Online), ARCA (Repository Institutional of Fiocruz), Lilics. The following descriptors were used: AUTOIMMUNE DISEASE, CROHN'S DISEASE, INTESTINE SYNDROME, in English, Portuguese and Spanish. Where we obtained the articles described below in table 1 and discussed in the form of topics related to the topic. The present study shows that there are still many problems in identifying the disease, as most doctors research infectious diseases, but this disease, although mysterious, has treatment and diagnosis, which are already used in everyday life and need to be improved for a better quality of life for patients.


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Fiocchi, C.. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998;115:182-205. Acesso em:12 de jul de 2021.

Hanauer, S. B. Inflammatory bowel disease. N Engl J Med 1996;334:841-8. Acesso em:12 de jul de 2021.

Langholz, E., Munkholm, P., Krasilnikoff, P. A., Binder, V. Inflammatory bowel diseases with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort. Scand J Gastroenterol 1997;32: 139-47. Acesso em:12 de jul de 2021.

Kirschner, B. S. Differences in the management of inflammatory bowel disease in children and adolescents compared to adults. Neth J Med 1998;53:S13-8. Acesso em:12 de jul de 2021.

Hanauer, S. B., Sandborn, W.; Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn’s disease in adults. Am J Gastroenterol 2001;96:635-43. Acesso em:12 de jul de 2021.

Sachar, D. B., Andrews, H. A., Farmer, R. G., Pallone, F., Pena, A. S., Prantera, C., et al. Proposed classification of patient subgroups in Crohn’s disease. Gastroenterol Intl1992;5:141-54. Acesso em:12 de jul de 2021.

Moum. B., Ekbom, A., Vatn, M. H., Aadland, E., Sauar, J., Lygren, I., et al. Clinical course during the 1st year after diagnosis in ulcerative colitis and Crohn’s disease. Results of a large, prospective population-based study in southeastern Norway, 1990-93. Scand J Gastroenterol 1997;32:1005-12. Acesso em:12 de jul de 2021.

Lapidus, A., Bernell, O., Hellers, G., Löfberg, R. Clinical course of colorectal Crohn’s disease: a 35-year follow-up study of 507 patients. Gastroenterology 1998;114: 1151-60. Acesso em:12 de jul de 2021.

Price, A. B. Overlap in the spectrum of nonspecific inflammatory bowel disease: “colitis indeterminate”. J Clin Pathol 1978;31: 567-77. Acesso em:12 de jul de 2021.

Present, D. H., Korelitz, B. I., Wisch, N., Glass, J. L., Sachar, D. B., Pasternack, B. S. Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980;302:981-7. Acesso em:12 de jul de 2021.

Scotiniotis, I., Rubesin, S. E., Ginsberg, G. G. Imaging modalities in inflammatory bowel disease. Gastroenterol Clin North Am 1999;28:391-421. Acesso em:12 de jul de 2021.

Kidd, R., Mezwa, D. G., Ralls, P. W., Balfe, D. M., Bree, R. L., Disantis, D. J., et al. Imaging recommendations for patients with newly suspected Crohn’s disease, and in patients with known Crohn’s disease and acute exacerbation or suspected complications. American College of Radiology. ACR Appropriateness Criteria. Radiology 2000;215(Suppl.):181-92. Acesso em:12 de jul de 2021.

Alves, P. R. A. (1990). Contribuição do estudo colonoscópico nas doenças inflamatórias Projeto Diretrizes Associação Médica Brasileira e Conselho Federal de Medicina 10 Doença de Crohn Intestinal: Manejo do cólon. Análise dos índices histológicos e imunohistoquímicos [Tese de Doutorado]. São Paulo:Faculdade de Medicina da Universidade de São Paulo. 104p.

American Society For Gastrointestinal Endoscopy. (1998). The role of colonoscopy in the management of patients with inflammatory bowel disease. Gastrointest Endosc. 48:689-90.

Singleton, J. W., Hanauer, S. B., Gitnick, G. L., Peppercorn, M. A., Robinson, M. G., Wruble, L. D. et al. (1993). Mesalamine capsules for the treatment of active Crohn’s disease: results of a 16 week trial. Pentasa Crohn’s Disease Study Group. Gastroenterology.104: 1293-301.

Tremaine, W. J., Schroeder, K. W., Harrison, J. M., Zinsmeister, A. R. (1994). A randomized, double-blind, placebo-controlled trial of the oral mesalamine (5-ASA) preparation, Asacol, in the treatment of symptomatic Crohn’s colitis and ileocolitis. J Clin Gastroenterol. 19:278-82. Acesso em 12 de jul de 2021.

Prantera, C., Cottone, M., Pallone, F., Annese, V., Franzè, A., Cerutti, R., et al. (1999). Mesalamine in the treatment of mild to moderate active Crohn’s ileitis: results of a randomized, multicenter trial. Gastroenterology. 116:521-6.

Summers, R. W., Switz, D. M., Sessions, J. T. J. R., Becktel, J. M., Best, W. R., Kern, F. J. R., et al. (1979). National Cooperative Crohn’s Disease Study: results of drug treatment. Gastroenterology. 77:847-69.

Colombel, J. F., Lémann, M., Cassagnou, M., Bouhnik, Y., Duclos, B., Dupas, J. L., et al. (1999). A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn’s disease. Groupe d’Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID). Am J Gastroenterol. 94:674-8. Acesso em:12 de jul de 2021.

Sutherland, L., Singleton, J., Sessions, J., Hanauer, S., Krawitt, E., Rankin, G., et al. (1991). Double blind, placebo controlled trial of metronidazole in Crohn’s disease. Gut. 32:1071-5.

Prantera, C., Berto, E., Scribano, M. L., Falasco, G. (1998). Use of antibiotics in the treatment of active Crohn’s disease: experience with metronidazole and ciprofloxacin. Ital J Gastroenterol Hepatol. 30:602-6. Acesso em:12 de jul de 2021.

Greenberg, G. R., Feagan, B. G., Martin, F., Sutherland, L. R., Thomson, A. B., Williams, C. N., et al. (1994). Oral budesonide for active Crohn’s disease. Canadian Inflammatory Bowel Disease Study Group. N Engl J Med. 331:836-41.

Pearson, D. C., May, G. R., Fick, G. H., Sutherland, L. R. (1995). Azathioprine and 6- mercaptopurine in Crohn disease. A metaanalysis. Ann Intern Med. 123:132-42.

Targan, S. R., Hanauer, S. B., Van Deventer. S. J., Mayer, L., Present, D. H., Braakman, T., et al. (1997). A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease. Crohn’s Disease cA2 Study Group. N Engl J Med. 337: 1029-35. Doença de Crohn Intestinal: Manejo 11 Projeto Diretrizes Associação Médica Brasileira e Conselho Federal de Medicina.



How to Cite

AGUIAR , U. N. de .; AGUIAR , M. P. de Q. .; SÁ, L. F. P. de .; MATA, J. P. de O. .; TEIXEIRA , A. da S. .; CRISANTO, A. V. S. de M. S. .; AMORIM, G. R. .; PINHEIRO, F. P. .; GUILHON, L. A. .; SILVA, Ícaro A. .; SOUSA, G. F. de .; GONÇALVES, W. V. E. .; MARTINS , L. A. .; ROCHA, T. S. .; SILVA , A. M. da . Clinical and diagnostic aspects of Crohn Syndrome. Research, Society and Development, [S. l.], v. 11, n. 10, p. e04111019041, 2022. DOI: 10.33448/rsd-v11i10.19041. Disponível em: Acesso em: 4 oct. 2022.



Health Sciences