The use of hyaluronic acid in arthroscopy: systematic review




Temporomandibular joint; Temporomandibular disorder; Arthroscopy; Hyaluronic acid; Viscosupplementation.


The aim of the present study was to evaluate the effectiveness of using hyaluronic acid injections after arthroscopic procedures in patients with temporomandibular disorders. The methodology used to achieve the proposed aim was a literature review currently available and conducted in MEDLINE databases via PubMed, Scopus, Scielo and Bireme, through controlled and uncontrolled terms, using Boolean operators and Descriptors in Sciences of the Health DeCS/MeSH previously chosen. After applying the search strategies and eligibility criteria, 13 articles were included and the following data were collected: author, year, study type, methodology for diagnosing temporomandibular disorder, sample size, hyaluronic acid used, use of other therapeutic agents, follow-up period and reported benefits. Interpretation of the evidence obtained in this study allowed us to conclude that the use of hyaluronic acid in arthroscopy procedures is effective and can be recommended for patients being treated for temporomandibular disorders. The need for further studies on the subject was highlighted, to establish a care standard protocol.


Al-Moraissi, E. A., Wolford, L. M., Ellis, E., & Neff, A. (2020). The hierarchy of different treatments for arthrogenous temporomandibular disorders: A network meta-analysis of randomized clinical trials. Journal of Cranio-Maxillofacial Surgery, 48(1), 9–23.

Bonotto, D., Custódio, L. G., & Cunali, P. A. (2011). Viscossuplementação como tratamento das alterações internas da articulação temporomandibular: relato de casos. Revista Dor, 12(3), 274–278.

Castaño-Joaqui, O. G., Cano-Sánchez, J., Campo-Trapero, J., & Muñoz-Guerra, M. F. (2021). TMJ arthroscopy with hyaluronic acid: A 12-month randomized clinical trial. Oral Diseases, 27(2), 301–311.

Castaño-Joaqui, O. G., Muñoz-Guerra, M. F., Campo, J., Martínez-Bernardini, G., & Cano, J. (2017). Estado actual de la viscosuplementación con ácido hialurónico en el tratamiento de los trastornos temporomandibulares: revisión sistemática. Revista Espanola de Cirugia Oral y Maxilofacial, 39(4), 213–220.

Cömert Kiliç S, Güngörmüş M, S. M. (2015). Is arthrocentesis plus platelet- rich plasma superior to arthrocentesis plus hyaluronic acid for the treatment of temporomandibular joint osteoarthritis : a randomized clinical trial. Int. J. Oral Maxillofac. Surg, 73(8), 1473–1483.

Fernández-Ferro M, Fernández-Sanromán J, Blanco-Carrión A, Costas-López A, López-Betancourt A, Arenaz-Bua J, S. M. B. (2017). Comparison of intra-articular injection of plasma rich in growth factors versus hyaluronic acid following arthroscopy in the treatment of temporomandibular dysfunction: A randomised prospective study. J Craniomaxillofac Surg, 45(4), 449–454.

Ferreira N, Masterson D, Lopes de Lima R, de Souza Moura B, Oliveira AT, Kelly da Silva Fidalgo T, Carvalho ACP, DosSantos MF, G. E. (2018). Efficacy of viscosupplementation with hyaluronic acid in temporomandibular disorders: A systematic review. Journal of Cranio-Maxillo-Facial Surgery, 46(11), 1943–1952.

Goiato, M. C., da Silva, E. V. F., de Medeiros, R. A., Túrcio, K. H. L., & dos Santos, D. M. (2016). Are intra-articular injections of hyaluronic acid effective for the treatment of temporomandibular disorders? A systematic review. International Journal of Oral and Maxillofacial Surgery, 45(12), 1531–1537.

Grossmann, E., Januzzi, E., & Iwaki Filho, L. (2013). O uso do hialuronato de sódio no tratamento das disfunções temporomandibulares articulares. Revista Dor, 14(4), 301–306.

Iturriaga, V., Bornhardt, T., Manterola, C., & Brebi, P. (2017). Effect of hyaluronic acid on the regulation of inflammatory mediators in osteoarthritis of the temporomandibular joint: a systematic review. International Journal of Oral and Maxillofacial Surgery, 46(5), 590–595.

Kütük N, Baş B, Soylu E, Gönen ZB, Yilmaz C, Balcioğlu E, Özdamar S, A. A. (2014). Effect of Platelet-Rich Plasma on Fibrocartilage , Cartilage , and Bone Repair in Temporomandibular Joint. J Oral Maxillofac Surg., 72(2), 277–284.

Liu, Y., Wu, J., Fei, W., Cen, X., Xiong, Y., Wang, S., … Liang, X. (2018). Is There a Difference in Intra-Articular Injections of Corticosteroids, Hyaluronate, or Placebo for Temporomandibular Osteoarthritis? In Journal of Oral and Maxillofacial Surgery (Vol. 76).

Moldez, M., Camones, V., Ramos, G., Padilla, M., & Enciso, R. (2018). Effectiveness of Intra-Articular Injections of Sodium Hyaluronate or Corticosteroids for Intracapsular Temporomandibular Disorders: A Systematic Review and Meta-Analysis. Journal of Oral & Facial Pain and Headache, 32(1), 53–66.

Oliveira, L. E. A. de, Brígido, J. A., & Saldanha, A. D. D. (2019). Effects of the hyaluronic acid infiltration in the treatment of internal temporomandibular joint disorders. Brazilian Journal Of Pain, 2(2), 182–186.

Pastore, G. P., Goulart, D. R., Pastore, P. R., & Prati, A. J. (2016). Removal of a solitary synovial chondromatosis of the temporomandibular joint using arthroscopy. Journal of Craniofacial Surgery, 27(4), 967–969.

Pihut, M., & Gala, A. (2020). The Application of Intra-Articulr Injections for Management of the Consequences of Disc Displacement without Reduction. Int. J. Environ. Res. Public Health, 17(4726), 1–10.

Sakalys, D., Dvylys, D., Simuntis, R., & Leketas, M. (2020). Comparison of Different Intraarticular Injection Substances Followed by Temporomandibular Joint Arthroscopy. The Journal of Craniofacial Surgery, 31(3), 637–641.

Sousa BM, López-Valverde N, López-Valverde A, Caramelo F, Fraile JF, Payo JH, R. M. (2020). Different Treatments in Patients with Temporomandibular Joint Disorders : A Comparative Randomized Study. Medicina (Kaunas), 56(3), 113.

Stasko J; Statelova D, Janickova M, Mikuskova K, Bacinsky M, Sokol J, Frlickova Z, Hvizdos D, M. I. (2020). Hyaluronic acid application vs arthroscopy in treatment of internal temporomandibular joint disorders. Bratisl Med J, 121(5), 352–357.

Toameh, M. H., Alkhouri, I., & Karman, M. A. (2019). Management of patients with disk displacement without reduction of the temporomandibular joint by arthrocentesis alone, plus hyaluronic acid or plus platelet-rich plasma. Dent Med Probl, 56(3), 265–272.



How to Cite

MARQUES, I. L. .; LEAL, M. de O. C. D. .; JODAS, C. R. P. .; TEIXEIRA , R. G. . The use of hyaluronic acid in arthroscopy: systematic review. Research, Society and Development, [S. l.], v. 10, n. 12, p. e33101219496, 2021. DOI: 10.33448/rsd-v10i12.19496. Disponível em: Acesso em: 22 feb. 2024.



Health Sciences