Analysis of the effects of supplementation of certain antioxidants on adjustive cancer treatment

Authors

DOI:

https://doi.org/10.33448/rsd-v9i2.1964

Keywords:

Treatments; vitamins; neoplasms.

Abstract

Objective: To present an analysis of the effect of supplementation of certain antioxidants on adjuvant cancer treatment. Methodology: This is an integrative literature review conducted through the databases of the Virtual Health Library (VHL), Scientific Electronic Library Online (SCIELO) and Medical Literature Analysis and Retrieval System Online (MEDLINE). Results: Twenty-seven articles were selected. After analyzing the inclusion and exclusion criteria, only seven were part of the final research sample. According to the results found, regarding breast cancer GLN antioxidants (15gs / day) do not offer protection against systemic or local oxidative stress. Noting also that the consumption of antioxidant vitamins A, C and E by this population is below the necessary, and these are primordial during chemotherapy treatment. For the 2-methoxyestradiol (2-ME) and Resveratrol compounds, effective antimelanoma agents have been shown. The antioxidant effects of Libidibia ferrea extract on adjuvant treatment of colorectal cancer have important effects. Already the aqueous extract of Carya illinoinensis in relation to its antioxidant effects, it is likely that cell infeasibility and antiproliferative activity are dependent on different types of phenolic compounds. Conclusion: This research proves to be of great relevance since it presents positive results regarding treatment as well as cancer prevention. The bottom line is that further in-depth studies regarding the effectiveness of antioxidants in adjuvant cancer treatment are needed, as studies such as these are scarce in the literature.

 

References

Araujo, LRL, Viana, FCV, Caimiro, VC, Nogueira, TBSS & Souza, MNA (2016). Antioxidantes na prevenção do câncer em idosos. Journal of Medicine and Health Promotion, 1 (1), 18-26.

Bonner, MY & Arbiser, JL (2014). The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer. Future Med Chem, 6 (12), 1413-22.

Chai, W, Bostick, RM, Ahearn, TU; Franke, AA; Custer, LJ; Cooney, RV (2011). Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites. Nutr Cancer, 63 (4), 573-82.

Farias, JWM (2014). Avaliação da concentração sérica de substancias antioxidantes em pacientes portadoras de câncer de mama, tratadas com doses nutracêuticas de glutamina: ensaio clínico duplo cego randomizado. (Dissertação de mestrado) Universidade Federal do Ceara, Fortaleza.

Guerra, ACVA (2017). Avaliação das atividades antitumoral e antioxidante in vitro de extratos de Libidibia ferrea em células de câncer colorretal/ Andreza Conceição Véras de Aguiar Guerra. - Natal, 60f.: il.

Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) (2014). Estimativa 2014 – Incidência de Câncer no Brasil. Rev Bras Cancerol, 60 (1), 63-4.

Joseph, EK; Chen, X; Bogen, O; Levine, JD (2008). Oxaliplatin Acts on IB4-Positive Nociceptors to Induce na Oxidative Stress-Dependent Acute Painful Peripheral Neuropathy. J Pain, 9 (5), 463-472.

Massaro, RR (2013). Efeito do Resveratrol e do 2-Metoxiestradiol em linhagens de melanoma humano em modelos de monocamada e de pele reconstituída. 2014. 180f. (Tese de Doutorado) Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo.

Mclean, RC, Logue, J (2015). The individual and combined effects of obesity and type 2 diabetes on cancer predisposition and survival. Curr Nutr Rep, 4 (1), 22-32.

Pereira, A.S. et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Disponível em: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 25 out. 2019.

Portantiolo, TN; Vale, IAV; Bergmann, RB; Abib, RT (2014). Consumo de Vitaminas Antioxidantes por Mulheres com Câncer de Mama submetidas ao Tratamento Quimioterápico na Cidade de Pelotas-RS. Revista Brasileira de Cancerologia, 60 (4), 323-329.

Rohenkohl, CC; Carniel, AP; Colpo, E (2011). Consumo de antioxidantes durante o tratamento quimioterápico. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 24 (2), 107-112.

Stewart, BW; Wild, CP (2014). World Cancer Report 2014. France: WHO Press.

Santos, JLS (2016). Proteoma comparativo entre células tronco mesenquimais humanas com cariótipo normal e invertido. 2016. Monografia (Graduação) Universidade Federal do Rio Grande do Norte, Natal-RN.

World Health Organization (WHO) (2017). Cancer [Internet]. [cited 2017 Sep 21]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/ Accesso em: 25 out. 2019.

Weber, AV (2018). Potencial Efeito Antioxidante e Antiproliferativo do Extrato Aquoso de Carya illinoinensis Sobre Células Tumorais. Editora Unijuí – Revista Contexto & Saúde, 18 (35), 91-94.

Published

01/01/2020

How to Cite

DA SILVA, H. R.; COSTA, R. H. F.; NETO, J. C. P.; JÚNIOR, C. A. A. de M.; COUTINHO, I. V. L.; MACÊDO, L. O. de; LIMA, D. C. dos S.; SAMPAIO, L. L.; SOUSA, L. K. R. de; SANTOS, L. K. B.; PESSOA, G. T. Analysis of the effects of supplementation of certain antioxidants on adjustive cancer treatment. Research, Society and Development, [S. l.], v. 9, n. 2, p. e28921964, 2020. DOI: 10.33448/rsd-v9i2.1964. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/1964. Acesso em: 22 nov. 2024.

Issue

Section

Review Article