Metastatic tumors in the maxillofacial region: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20076

Keywords:

Metastasis; Oral Region; Jaw; Incidence.

Abstract

Metastasis is a consequence of a complex biological cascade, which begins with the detachment of tumor cells from the primary site and, via blood or lymph, spread to other sites, where they form a new neoplastic colony. They represent about 1% of all malignant tumors in this region, the oral cavity being the site most affected by neoplasms. Oral and maxillofacial cancer has high morbidity and mortality rates. Thus, it is necessary that the physician and/or dental surgeon take into account metastases to this region, as, despite being a rare case, they are signs of disseminated neoplasms. Given the above, this study aimed to conduct a systematic review of the literature on the sites of the primary tumor that have metastases to the maxillofacial region, as well as the site of metastasis, the most affected gender and the most common histological type. For the construction of this article, a bibliographic survey was carried out in the SciVerse Scopus, Scientific Electronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) and ScienceDirect databases, with the help of Mendeley. The articles were collected from April to August 2021 and covered between 2010 and 2021. From a systematic review of the literature, 282 cases of metastasis to the maxillofacial region were observed. The primary sites that metastasize the most are lung, kidney, breast and liver. The most affected gender is the male and the mandible is the most affected location, followed by the gums and tongue. The most common histological type is carcinoma.

References

Andabak Rogulj, A., C. Tomasovic Loncaric, D. Muller, I. Blivajs, M. Andabak, V. Vucicevic Boras, & Sekerija. M. (2018). “Solid Malignant Metastases in the Jaw Bones.” British Journal of Oral and Maxillofacial Surgery 56(8):705–8.

Cai, Z., Chao, Z., Lizhen, W., Ling, Z., Zhiyuan, Z., Hanguang, Z., & Yan’na, W. (2016). “A Retrospective Study of Six Patients with Mandibular Metastatic Carcinoma.” Oncology Letters 11(6):3650–54.

Canto, L. 2017. “Mariana Ferreira Fernandes Da Silva Incidência De Tumores Metastáticos Na Região Buco-Maxilo-Facial: Uma Meta-Análise.”

Chen, C. Y., Wen, C. W., Chih, H. T., Chang, W. S., & Yuk, K. C. (2020). “Clinicopathological Study of 13 Cases of Intraoral Soft Tissue Metastatic Carcinomas.” Journal of Dental Sciences 15(1):92–95.

Daley, T., & Mark R. Darling. (2011). “Metastases to the Mouth and Jaws: A Contemporary Canadian Experience.” Journal of the Canadian Dental Association 77.

Irani, S. (2016). “Metastasis to the Oral Soft Tissues: A Review of 412 Cases.” Journal of International Society of Preventive & Community Dentistry 6(5):393–401.

Jham, B. C., Andrew R. S., Shawn A. McClure, & Robert A. (2011). “Metastatic Tumors to the Oral Cavity: A Clinical Study of 18 Cases.” Head and Neck Pathology 5(4):355–58.

Kaplan, I., Vadim R., Amir S., Benjamin S., Eli R., Adi G., Avraham H., Ran Y., Anna S-S, & Marilena V. (2019). “Metastatic Tumors in Oral Mucosa and Jawbones: Unusual Primary Origins and Unusual Oral Locations.” Acta Histochemica 121(8):151448.

Lawes, K. P., Martin D., & Silvana Di P. (2013). “Delayed Metastasis to the Mandible of Esophageal Adenocarcinoma.” Head and Neck Pathology 7(4):416–20.

Lee, Y. H., & Jae Il L. (2017). “Metastatic Carcinoma of the Oral Region: An Analysis of 21 Cases.” Medicina Oral, Patologia Oral y Cirugia Bucal 22(3):e359–65.

Liu, Y., Richard J. V., & Elizabeth A. B. (2018). “Analytic Survey of 57 Cases of Oral Metastases.” Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 47(3):275–80.

Maschino, F., J. Guillet, R. Curien, G. Dolivet, & Bravetti, P. (2013). “Oral Metastasis: A Report of 23 Cases.” International Journal of Oral and Maxillofacial Surgery 42(2):164–68.

Metzger, K., Julius M., Dominik H., Maximilian P., Oliver R., Jürgen H., Kolja F., Michael E., & Christian F. (2021). “Treatment Delay in Early-Stage Oral Squamous Cell Carcinoma and Its Relation to Survival.” Journal of Cranio-Maxillofacial Surgery 49(6):462–67.

Nawale, K. K., Monika V., Shubhada K., & Asawari P. (2016). “Metastatic Tumors in the Jaw Bones: A Retrospective Clinicopathological Study of 12 Cases at Tertiary Cancer Center.” Journal of Oral and Maxillofacial Pathology 20(2):252–55.

Owosho, A. A., Bin X., Arvin K., Sae H. K. Yom, J. R., Ronald A. Ghossein, J. M. H., & Cherry L. E. (2016). “Metastatic Solid Tumors to the Jaw and Oral Soft Tissue: A Retrospective Clinical Analysis of 44 Patients from a Single Institution.” Journal of Cranio-Maxillofacial Surgery 44(8):1047–53.

Reymond, N., Bárbara B. d’Á., and Anne J. R.. (2013). “Crossing the Endothelial Barrier during Metastasis.” Nature Reviews. Cancer 13(12):858–70.

Shimono, H., Hideaki H., Yu Oikawa, Y. M., Takeshi K., Hirofumi T., Kou K., Tohru I., & Hiroyuki H. (2021). “Metastatic Tumors in the Oral Region: A Retrospective Chart Review of Clinical Characteristics and Prognosis.” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.

Shin, S. J., Jong L. R., Seung H C., Soon Y. N., Sang Y. K., Sung B. K., Sang W. L., & Kyung J. C. (2012). “Metastatic Carcinomas to the Oral Cavity and Oropharynx.” Korean Journal of Pathology 46(3):266–71.

Waltz, M. (2013). “Autism: A Social and Medical History.” Autism: A Social and Medical History 1–188.

Zalaudek, I., A. Ciarrocchi, S. Piana, G. Argenziano, F. Torricelli, V. Sancisi, G. Gandolfi, C. Longo, E. Moscarella, C. Banzi, & Nicoli. (2015). “A Novel BRAF Mutation in Association with Primary Amelanotic Melanoma with Oral Metastases.” Journal of the European Academy of Dermatology and Venereology : JEADV 29(2):387–90.

Published

12/09/2021

How to Cite

BINDA, N. C. .; BINDA , A. L. C. .; PINHO , R. A. de; RAMALHO, M. A. .; GIRARD, B. P.; FERNANDES, N. D. L.; FERNANDES, J. D. L.; NASCIMENTO , M. B. do; SILVA, A. C. F. da; SILVA, J. V. L. .; SÁTIRO, V. D. de S. .; SILVA, M. K. G. da; BRAGA, B. M. R. .; MORO, G. de O. L. .; SOUSA, Z. da S. .; REIS, J. L. .; LEÃO, M. J. da R. . Metastatic tumors in the maxillofacial region: a systematic review. Research, Society and Development, [S. l.], v. 10, n. 12, p. e32101220076, 2021. DOI: 10.33448/rsd-v10i12.20076. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20076. Acesso em: 20 may. 2024.

Issue

Section

Health Sciences