Clinical and radiographic analysis of an endodontic paste based on calcium hydroxide and Aloe vera: randomized clinical trial

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20136

Keywords:

Calcium hydroxide; Aloe; Root channel therapy.

Abstract

This randomized clinical trial evaluated an intracanal medicinal paste based on Ca(OH)2 and Aloe vera in necrotic teeth with periapical lesions. Sixty-four teeth, from 60 patients, were divided according to the intracanal medication used: Control (Ca(OH)2 and saline solution), and experimental (Ca(OH)2 and Aloe vera). Endodontic instrumentation and insertion of intracanal medication were performed according to the group. After 15 days, the teeth were filled and restored. Postoperative symptoms were assessed following a pain scale. Clinical and radiographic evaluation was performed at three, six and nine months after treatment. Treatments were classified into success (those with partial or complete healing) and failure. For statistical analysis of postoperative pain between groups, the Mann-Whitney test was used. The intragroup analysis used the Friedmann test. To assess treatment success, the chi-square test was used. It was considered significant p<0.05. Forty-eight patients, one tooth in each, completed the study. Postoperative pain values ​​at 04 and 24 hours were significant for the Aloe vera group (p<0.001), with no statistical difference between groups (p=0.307) at 48 hours. After nine months, success rates were 95.8% for the experimental group and 83.3% for the control, with no significant difference (p=0.348). Aloe vera and Ca(OH)2 paste provided remission of postoperative pain, without significant clinical and radiographic changes. Aloe vera is believed to be an alternative vehicle for calcium hydroxide as an intracanal medication.

References

Abbaszadegan, A., Sahebi, S., Gholami, A., Delroba, A., Kiani, A., Iraji, A., & Abbott, P. V. (2016). Time‐dependent antibacterial effects of Aloe vera and Zataria multiflora plant essential oils compared to calcium hydroxide in teeth infected with Enterococcus faecalis. Journal of Investigative and Clinical Dentistry, 7(1), 93-101.

Ali, S., & Wahbi, W. (2017). The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta‐analysis. Oral diseases, 23(7), 913-918.

Batista, V. E. D. S., Olian, D. D., & Mori, G. G. (2014). Diffusion of hydroxyl ions from calcium hydroxide and Aloe vera pastes. Brazilian dental journal, 25, 212-216.

Davis, R. H., Donato, J. J., Hartman, G. M., & Haas, R. C. (1994). Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Journal of the American Podiatric Medical Association, 84(2), 77-81.

Endodontics, A. R. (2013). Endodontics colleagues for excellence. Chicago, Illinois: American Association of Endodontists, 1-8.

Fani, M., & Kohanteb, J. (2012). Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. Journal of oral science, 54(1), 15-21.

Fé, J. L. M., Coelho, C. D. A., Damascena, G. M., Soares, I. M. V., Alves, F. R., Santos, Í. M. S. P., & Carvalho, C. M. R. S. (2014). Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair. Revista de Odontologia da UNESP, 43, 299-304.

Hussein, F. E., Liew, A. K. C., Ramlee, R. A., Abdullah, D., & San Chong, B. (2016). Factors associated with apical periodontitis: a multilevel analysis. Journal of endodontics, 42(10), 1441-1445.

Jittapiromsak, N., Sahawat, D., Banlunara, W., Sangvanich, P., & Thunyakitpisal, P. (2010). Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Tissue Engineering Part A, 16(6), 1997-2006.

Kalra, M., Garg, N., Rallan, M., Pathivada, L., & Yeluri, R. (2017). Comparative evaluation of fresh Aloe barbadensis plant extract and mineral trioxide aggregate as pulpotomy agents in primary molars: A 12-month follow-up study. Contemporary clinical dentistry, 8(1), 106.

Liapatas, S., Nakou, M., & Rontogianni, D. (2003). Inflammatory infiltrate of chronic periradicular lesions: an immunohistochemical study. International endodontic journal, 36(7), 464-471.

Mohammadi, Z., & Dummer, P. M. H. (2011). Properties and applications of calcium hydroxide in endodontics and dental traumatology. International endodontic journal, 44(8), 697-730.

Molander, A., Warfvinge, J., Reit, C., & Kvist, T. (2007). Clinical and radiographic evaluation of one-and two-visit endodontic treatment of asymptomatic necrotic teeth with apical periodontitis: a randomized clinical trial. Journal of endodontics, 33(10), 1145-1148.

Morsani, J. M., Aminoshariae, A., Han, Y. W., Montagnese, T. A., & Mickel, A. (2011). Genetic predisposition to persistent apical periodontitis. Journal of endodontics, 37(4), 455-459.

Nair, P. N. R. (2006). On the causes of persistent apical periodontitis: a review. International endodontic journal, 39(4), 249-281.

Paqué, F., Ganahl, D., & Peters, O. A. (2009). Effects of root canal preparation on apical geometry assessed by micro–computed tomography. Journal of Endodontics, 35(7), 1056-1059.

Rezende, G. C., Massunari, L., Queiroz, I. O. D. A., Gomes, J. E., Jacinto, R. C., Lodi, C. S., & Dezan, E. (2016). Antimicrobial action of calcium hydroxide-based endodontic sealers after setting, against E. faecalis biofilm. Brazilian oral research, 30.

Silva N. N. (2001). Amostragem Probabilística: um curso introdutório. 2th ed. São Paulo: EDUSP.

Singh, R. D., Khatter, R., Bal, R. K., & Bal, C. S. (2013). Intracanal medications versus placebo in reducing postoperative endodontic pain–a double–blind randomized clinical trial. Brazilian dental journal, 24, 25-29. Silva N. N. (2001). Amostragem Probabilística: um curso introdutório. 2th ed. São Paulo: EDUSP.

Sholehvar, F., Mehrabani, D., Yaghmaei, P., & Vahdati, A. (2016). The effect of Aloe vera gel on viability of dental pulp stem cells. Dental Traumatology, 32(5), 390-396.

Songsiripradubboon, S., Banlunara, W., Sangvanich, P., Trairatvorakul, C., & Thunyakitpisal, P. (2016). Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes. Odontology, 104(3), 329-337.

Sudarshan, R., Annigeri, R. G., & Sree Vijayabala, G. (2012). Aloe vera in the treatment for oral submucous fibrosis–a preliminary study. Journal of oral pathology & medicine, 41(10), 755-761.

Van der Sluis, L. W. M., Versluis, M., Wu, M. K., & Wesselink, P. R. (2007). Passive ultrasonic irrigation of the root canal: a review of the literature. International endodontic journal, 40(6), 415-426.

Vianna, M. E., Zilio, D. M., Ferraz, C. C. R., Zaia, A. A., Souza-Filho, F. J. D., & Gomes, B. P. F. D. A. (2009). Concentration of hydrogen ions in several calcium hydroxide pastes over different periods of time. Brazilian dental journal, 20, 382-388.

Zhou, W., Zheng, Q., Tan, X., Song, D., Zhang, L., & Huang, D. (2017). Comparison of mineral trioxide aggregate and iRoot BP plus root repair material as root-end filling materials in endodontic microsurgery: a prospective randomized controlled study. Journal of endodontics, 43(1), 1-6.

Published

13/09/2021

How to Cite

CAVALCANTE, L. C.; SOARES, I. M. V.; CARVALHO, C. M. R. S. Clinical and radiographic analysis of an endodontic paste based on calcium hydroxide and Aloe vera: randomized clinical trial. Research, Society and Development, [S. l.], v. 10, n. 12, p. e72101220136, 2021. DOI: 10.33448/rsd-v10i12.20136. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20136. Acesso em: 7 nov. 2024.

Issue

Section

Health Sciences