Vitamin D in the prevention and treatment of periodontal diseases: an integrative review




Calcitriol receptors; Oral pathology; Pathologic bone demineralization; Periodontal diseases; Vitamin D.


Introduction: Vitamin D is synthesized from 7-dehydrocholesterol during a photochemical reaction, under the effect of ultraviolet radiation on the skin, obtained from food. It is hydroxylated in the liver to 25-hydroxyvitamin D3 (25(OH)D3). It is an active metabolite, which maintains the balance of calcium and phosphorus concentration in the blood, in addition to helping bone remodeling. Vitamin D deficiency promotes rickets in children and osteoporosis in adults, with a risk of bone fracture. Vitamin D acts in the pathogenesis of periodontal diseases via immunomodulation, increases mineral density and reduces bone resorption, which is important in combating agents that cause periodontal diseases. Objectives: Evaluate the importance of vitamin D in the prevention and treatment of periodontal diseases. Methods: A search was carried out in the PubMed/Medline, Scopus, Scielo, Embase, Web of Science and Google Scholar databases on scientifically proven evidence on the subject. Results: The present review demonstrated the importance of vitamin D in the prevention and treatment of periodontitis and the consequences of its deficiency on the oral health of patients. Conclusion: Vitamin D plays an important role in oral homeostasis and vitamin deficiency results in periodontal disease.


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How to Cite

LAYBER, M. M. .; GOÉS, A. B. M. de . .; VILLARIM, C. V. de O. .; CALDAS, D. M. D. R. .; ARAÚJO-NETO, I. .; SILVA, L. C. C. e .; RÊGO, A. C. M. .; ARAÚJO-FILHO, I. . Vitamin D in the prevention and treatment of periodontal diseases: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 13, p. e25101320738, 2021. DOI: 10.33448/rsd-v10i13.20738. Disponível em: Acesso em: 21 may. 2022.



Review Article