Vitamin D in the prevention and treatment of periodontal diseases: an integrative review




Calcitriol receptors; Oral pathology; Pathologic bone demineralization; Periodontal diseases; Vitamin D.


Introduction: Vitamin D is synthesized from 7-dehydrocholesterol during a photochemical reaction, under the effect of ultraviolet radiation on the skin, obtained from food. It is hydroxylated in the liver to 25-hydroxyvitamin D3 (25(OH)D3). It is an active metabolite, which maintains the balance of calcium and phosphorus concentration in the blood, in addition to helping bone remodeling. Vitamin D deficiency promotes rickets in children and osteoporosis in adults, with a risk of bone fracture. Vitamin D acts in the pathogenesis of periodontal diseases via immunomodulation, increases mineral density and reduces bone resorption, which is important in combating agents that cause periodontal diseases. Objectives: Evaluate the importance of vitamin D in the prevention and treatment of periodontal diseases. Methods: A search was carried out in the PubMed/Medline, Scopus, Scielo, Embase, Web of Science and Google Scholar databases on scientifically proven evidence on the subject. Results: The present review demonstrated the importance of vitamin D in the prevention and treatment of periodontitis and the consequences of its deficiency on the oral health of patients. Conclusion: Vitamin D plays an important role in oral homeostasis and vitamin deficiency results in periodontal disease.


Adams, J. S., & Hewison, M. (2010). Update in vitamin D. J Clin Endocrinol Metab. 95:471-478.

Al Habashneh, R., Alchalabi, H., Khader, Y. S., Hazza’a, A. M., Odat, Z., & Johnson, G. K. (2010). Association between periodontal disease and osteoporosis in postmenopausal women in Jordan. J. Periodontol. 81:1613-1621.

Alshouibi, E. N., Kaye, E. K., Cabral, H. J., Leone, C. W., & Garcia, R. I. (2013). Vitamin D and periodontal health in older men. J. Dent. Res. 92:689-693.

Amano, Y., Komiyama, K., & Makishima, M. (2009). Vitamin D and periodontal disease. J. Oral Sci. 51:11-20.

Andresen, C., Olson, E., Nduaka, C., Pero, R., & Bagi, C. M. (2006). Action of calciotropic hormones on bone metabolism – Role of Vitamin D3 in bone remodeling events. Am J Immunol. 2:40‑51.

Bashutski, J. D., Eber, R. M., Kinney, J. S., & Benavides, A. L. (2011). The impact of vitamin D status on periodontal surgery outcomes. J. Dent. Res. 90:1007-1012.

Bikle, D. D. (2008). Vitamin D and the immune system: Role in protection against bacterial infection. Curr. Opin. Nephrol. Hypertens. 17:348-352.

Brett, P. M., Zygogianni, P., & Griffiths, G. S. (2005). Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res. 84:1149-1153.

Chen, L. L., Li, H., & Zhang, P. P. (2012). Association between vitamin D receptor polymorphisms and periodontitis: a meta-analysis. J Periodontol. 83:1095-103.

Chen, T. C., Chimeh, F., Lu, Z., Mathieu, J., Person, K. S., & Zhang, A. (2007). Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys. 460:213‑217.

Cheng, J. B., Motola, D. L., Mangelsdorf, D. J., & Russell, D. W. (2003). De-orphanization of cytochrome P450 2R1:a microsomal vitamin D 25-hydroxylase. J Biol Chem. 278:38084-38093.

Garcia, M. N.; Hildebolt, C. F., Miley, D., Dixon, D. A., Couture, R. A., & Spearie, C. L. A. (2011). One-year effects of vitamin D and calcium supplementation on chronic periodontitis. J Periodontol. 82(1):25-32.

Giovannucci, E., Liu, Y., Rimm, E. B., Hollis, B. W., Fuchs, C. S., Stampfer, M. J., & Willett, W. C. (2006). Prospective study of predictors of vitamin D status and câncer incidence and mortality in men. J Natl Cancer Inst. 98:451-459

Gunes, S., Sumer, A. P., & Keles, G. C. (2008). Analysis of vitamin D receptor gene polymorphisms in patients with chronic periodontitis. Indian J Med Res. 127:58-64.

Haussler, M. R., Whitfield, G. K., Haussler, C. A., Hsieh, J. C., Thompson, P. D., Selznick, S. H., Dominguez, C. E., & Jurutka, P. W. ( 1998) . The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res. 13:325-349.

Heaney, R. P., Davies, K. M., Chen, T. C., Holick, M. F., & Barger‑Lux, M. J. (2003). Human serum 25‑hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 77:204‑10.

Hennig, B. J., Parkhill, J. M., Chapple, I. L., Heasman, P. A., & Taylor, J. J. (1999). Association of a vitamin D receptor gene polymorphism with localized early‑onset periodontal diseases. J Periodontol. 70:1032‑1038.

Hildebolt, C. F. (2005). Effect of vitamin D and calcium periodontitis. J. Periodontol. 76: 1576-1587.

Hiremath, V. P., Rao, C. B., Naiak, V., & Prasad, K. V. (2013). Anti-inflammatory effect of vitamin D on gingivitis: A dose response randomized controlled trial. Indian J. Public Health. 57: 29-32.

Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med. 357:266‑281.

Holick, M. F. (2009). Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 19:73-78.

Holick, M. F. (2004). Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 79:362‑71.

Huet, T., Laverny, G., & Ciesielski, F. (2015). A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep. 10:516-526.

Jabbar, S., Drury, J., Fordham, J., Datta, H. K., Francis, R. M., & Tuck, S. P. (2011). Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis. J. Periodontal Res. 46:97-104.

Jones, G. (2008). Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 88:582-586.

Kitazawa, S., Kajimoto, K., & Kondo T. (2001). Vitamin D3 supports osteoclastogenesis via functional parathyroid growth arrest by vitamin D and high calcium. Kidney Int. 60:2109‑17.

Lacey, D. L., Timms, E., Tan, H. L., Kelley, M. J., Dunstan, C. R., & Burgess, T. (1998). Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165‑176.

Laine, M. L., Crielaard, W., & Loos, B. G. (2012). Genetic susceptibility to periodontitis. Periodontol. 58:37-68.

Liu, K, Meng, H., & Hou, J. (2012). Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. PLoS ONE. 7:e52053.

Liu, K, Meng H, Tang X, Xu L, Zhang L, Chen Z, Shi D, Feng X & Lu R. (2009). Elevated plasma calcifediol is associated with aggressive periodontitis. J. Periodontol. 80:1114-1120.

Lou Y. R, Molnár F & Peräkylä M. (2010). 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand. J Steroid Biochem Mol Biol. 118:162-170.

Makishima M., & Yamada S. (2005). Targeting the vitamin D receptor: advances in drug discovery. Expert Opin Ther Pat. 15:1133-1145.

Martelli F. S, Martelli M, & Rosati C. (2014). Vitamin D: relevance in dental practice. Clin Cases Miner Bone Metab. 11:15.

McMahon L, Schwartz K, Yilmaz O, Brown E, Ryan L. .K, & Diamond G. (2011). Vitamin D-mediated induction of innate immunity in gingival epithelial cells. Infect. Immun. 79:2250-2256.

Millen A. E, Hovey K. M, LaMonte M. J, Swanson M, Andrews, C. .A & Kluczynski M. A. (2013). Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. J. Periodontol. 84:1243-1256.

Nagpal S., & Rathnachalam R. (2005). Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 26:662-687.

Nibali L, Di Iorio A., & Tu Y. K. (2017). Host genetics role in the pathogenesis of periodontal disease and caries. J Clin Periodontol. 44(18): S52-S78.

Nibali L, Parkar M., & D'Aiuto F. (2008). Vitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis. J Clin Periodontol. 35:561-567.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J. & Shitsuka, R. (2018). Metodologia Da Pesquisa Científica (1st ed.). Santa Maria: Universidade Federal de Santa Maria.

Schwalfenberg G. K. (2011). A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol. Nutr. Food Res. 55:96-108.

Stein S. H., & Tipton D. A. (2011). Vitamin D and its impact on oral health – An update. J. Tenn. Dent. Assoc. 91:30-33.

Stewart S., & Hanning R. (2012). Building osteoporosis prevention into dental practice. J. Can. Dent. Assoc. 78:c29.

Sun J. L, Meng H. X., & Cao C. F. (2002). Relationship between vitamin D receptor gene polymorphism and periodontitis. J Periodontal Res. 37:263-267.

Tachi Y, Shimpuku H., & Nosaka Y. (2003). Vitamin D receptor gene polymorphism is associated with chronic periodontitis. Life Sci. 73:3313-3321.

Tang X, Pan Y & Zhao Y. (2013). Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis. Arch. Oral Biol. 58:397-407.

Teles F. R, Teles R. P, Martin L, Socransky S. S., & Haffajee A. D. (2012). Relationships among interleukin-6, tumor necrosis factor-a, adipokines, vitamin D, and chronic periodontitis. J. Periodontol. 83:1183-1191.

Valdivielso J. M., & Fernandez E. (2006). Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 371:1‑12.

Van der Velden U, Kuzmanova D & Chapple I. L. (2011). Micronutritional approaches to periodontal therapy. J. Clin. Periodontol. 38(11):142-158.

Wactawski-Wende J, Hausmann E, Hovey K, Trevisan M, Grossi S & Genco R. J. (2005). The association between osteoporosis and alveolar crestal height in postmenopausal women. J. Periodontol. 76(11):2116-2124.

Wang . TJ, Pencina M. J, Booth S. L, Jacques P. F, Ingelsson E, Lanier K, Benjamin E. J, D’Agostino R. B, Wolf, M., & Vasan R. S. (2008). Vitamin D deficiency and risk of cardiovascular disease. Circulation. 117:503-511.

Wang Y., Zhu J., & DeLuca H. F. (2012). Where is the vitamin D receptor? Arch Biochem Biophys. 523:123-33.

Zerwekh, J. E. (2008). Blood biomarkers of vitamin D status. Am J Clin Nutr. 87:1087-1091.

Zhang X, Meng H, Sun X, Xu L, Zhang L., & Shi D. (2013). Elevation of vitamin D-binding protein levels in the plasma of patients with generalized aggressive periodontitis. J. Periodontal Res. 48:74-79.

Zhanyi, G, Kaining, L., & Huanxin, M. (2018). Preliminary investigation of the vitamin D pathway in periodontal connective tissue cells. 89(3):294-302.

Zittermann A. (2003). Vitamin D in preventive medicine: Are we ignoring the evidence? Br J Nutr. 89:552‑72.

Zuk A. M, Quiñonez C. R., & Saarela O. (2018). Joint effects of serum vitamin D insufficiency and periodontitis on insulin resistance, pre-diabetes, and type 2 diabetes: results from the National Health and Nutrition Examination Survey (NHANES) 2009–2010. BMJ Open Diab Res Care. 6:e000535.




How to Cite

LAYBER, M. M. .; GOÉS, A. B. M. de . .; VILLARIM, C. V. de O. .; CALDAS, D. M. D. R. .; ARAÚJO-NETO, I. .; SILVA, L. C. C. e .; RÊGO, A. C. M. .; ARAÚJO-FILHO, I. . Vitamin D in the prevention and treatment of periodontal diseases: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 13, p. e25101320738, 2021. DOI: 10.33448/rsd-v10i13.20738. Disponível em: Acesso em: 2 dec. 2021.



Review Article