Use of bismut subgalate as a hemostatic agent and its influence on tissue repair in dental surgerys
DOI:
https://doi.org/10.33448/rsd-v10i14.20791Keywords:
Bismuth; Hemostatics; Palate.Abstract
During dental surgical procedures, there is a risk of bleeding episodes that may be associated with local and / or systemic factors. The bismuth subgalate (BS) may be used as a local hemostatic. The aim of this study was to evaluate the use of BS in dental surgery, addressing its effectiveness as a hemostatic substance. For the literature review, articles were searched in the SciELO, PubMed and Scopus databases. Pre-clinical and clinical articles that discuss BS influence in dental surgeries were selected. BS is a heavy metal and insoluble in water and can be used orally or topically. It has effectiveness in hemostasis of palatal donor areas, in dental extraction surgeries and even in dialysis patients. Studies carried out in humans and animals have shown deleterious effects on tissue repair using BS. Despite its effectiveness as a hemostatic agent, it can cause changes in tissue repair, limiting its use to specific cases in order to avoid risks of trans or postoperative hemorrhage. Therefore, although the literature demonstrates advantages in the use of BS as a hemostatic agent, there are not many clinical studies. Further research is needed in order to analyze the clinical efficiency on tissue repair.
References
Arroyo Júnior, P. C., Silva, R. D. C. M. A. D., Santi Neto, D. D., Santana Júnior, D. D., Ferreira, F. D., & Silva, R. F. D. (2004). Uso do subgalato de bismuto para hemostasia local em hepatectomias parciais em ratos. Revista do Colégio Brasileiro de Cirurgiões, 31, 165-171.
Baldelomar Carballo, K. E., & Guerrero Petterson, J. D. L. A. (2020). Eficacia del subsalicilato y subgalato de bismuto como agentes hemostáticos después de la extracción quirúrgica de terceros molares en pacientes atendidos en el Hospital Amistad Japón-Nicaragua, Granada, durante el segundo semestre 2019 (Doctoral dissertation, Universidad Nacional Autónoma de Nicaragua, Managua).
Barbosa, L. M., da Silva, M. S. A., Cavalcanti, A. M. F., de Melo Nogueira, L. D., Francisco, M. A., de Morais Santos, M. P., ... & Laureano Filho, J. R. (2020). Protocolo de tratamento cirúrgico de pacientes em uso de anticoagulante e antiagregante plaquetário. Research, Society and Development, 9(9), e670997726-e670997726.
Brasileiro, H. M., Lee, I. W., Rapport, A. (2006). “Uso do subgalato de bismuto como agente hemostático em tonsiléctomia palatina: estudo de 201 casos”, ACTA ORL/Técnicas em Otorrinolaringologia. São Paulo: Atha, p. 181-5.
Couto, E. V., Ballin, C. R., Sampaio, C. P. P., Maeda, C. A. S., Ballin, C. H., Dassi, C. S., & Yukari Miura, L. (2016). Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa☆☆☆. Brazilian journal of otorhinolaryngology, 82, 17-25.
Cozzi, L. M., Megerian, C. A., Dugue, C., Barcello, M., Abdul‐Karim, F. W., Arnold, J. E., & Maniglia, A. J. (1992). Pulmonary sequelae of intraparenchymal bismuth subgallate. The Laryngoscope, 102(6), 597-599.
de Campos, N., Furlaneto, F., e Buischi, Y. D. P. (2019). Contemporary Applications of Biologic Hemostatic Agents across Surgical Specialties: Bleeding in Dental Surgery. In Contemporary Applications of Biologic Hemostatic Agents across Surgical Specialties-Volume 2. IntechOpen.
de Sousa Pinheiro, E., Veloso, K. M. M., de Andrade, S. M., & de Oliveira, E. H. (2021). Efetividade do ácido tranexâmico em pacientes sistemicamente comprometidos na odontologia: Revisão integrativa. Research, Society and Development, 10(7), e3110716119-e3110716119.
Dos Santos, R. M. F., Sampaio, C. P. P., de Moraes, D. P., & de Lima, R. L. (2016). Evaluation of the effects of bismuth subgallate on wound healing in rats. Histological findings. International archives of otorhinolaryngology, 20(04), 377-381.
Dym, H., & Ogle, O. E. (2004). Atlas de cirurgia oral menor. Livraria Santos Editora.
Holck, D. E., Foster, J. A., Dutton, J. J., & Dillon, H. D. (1999). Hard palate mucosal grafts in the treatment of the contracted socket. Ophthalmic plastic and reconstructive surgery, 15(3), 202-209.
Kawakami, P. A., Velez-Montoya, R., Castillejos-Chevez, A., Remolina, A., Garcia-Aguirre, G., Rodriguez-Reyes, A., & Salcedo, G. (2014). Safety and efficacy of bismuth subgallate as an hemostatic agent in an animal experimental model. Investigative Ophthalmology & Visual Science, 55(13), 1510-1510.
Kim, S. H., Tramontina, V. A., Papalexiou, V., & Luczyszyn, S. M. (2010). Bismuth subgallate as a topical hemostatic agent at palatal donor sites. Quintessence International, 41(8).
Kim, S. H., Tramontina, V. A., Papalexiou, V., Luczsyzyn, S. M., De Lima, A. A. S., & Do Prado, A. M. B. (2012). Bismuth subgallate as a topical haemostatic agent at the palatal wounds: a histologic study in dogs. International journal of oral and maxillofacial surgery, 41(2), 239-243.
Levine, M. N., Raskob, G., Landefeld, S., & Hirsh, J. (1995). Hemorrhagic complications of anticoagulant treatment. Chest, 108(4), 276S-290S.
Lima, R. L. D., Sampaio, C. P., Seidel, K. C., Branco, M., & Sobreiro, R. M. (2016). Avaliação dos efeitos do subgalato de bismuto na proliferação de miofibroblastos. Jornal Vascular Brasileiro, 15, 210-216.
Lin, C. Y., Liu, Y. F., & Tsai, Y. C. (2015). Differential Effects on Fibroblast Cells Proliferation and Migration by Bismuth Subgallate and Borneol Individual and Combination. International Journal of Pharmacology.
Liu, L., Rodman, C., Worobetz, N. E., Johnson, J., Elmaraghy, C., & Chiang, T. (2019). Topical biomaterials to prevent post-tonsillectomy hemorrhage. Journal of Otolaryngology-Head & Neck Surgery, 48(1), 1-17.
Loya, T. A. M., Fandiño, J. J. T., & Sierra, J. S. M. (2003). Eficacia y seguridad de la aplicación de subgalato y subsalicilato de bismuto como agentes hemostáticos después de la extracción quirúrgica de terceros molares. Revista de la Asociación Dental Mexicana, 60(3), 90-94.
Luzzi, T., Adilson, A., de Lima, S., Augusto, V., Papalexiou, V., Mara, S., ... & Martinez, A. Lucinara Ignez (2018). “Use of fibrinolisin / deoxyribonuclease and bismutal subgalate in wound palatine mucosa repair. Histological study in rats”, Paripex-Indian Journal of Research, 7(6).
Manterola, E. R., & Smerilli, A. L. (2007). Uso del subgalato de bismuto como técnica hemostática en la exodoncia para pacientes dializados. Rev Fac Odontol (UBA), 22, 52-5325.
Mendes, K. D. S., Silveira, R. C. D. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto-enfermagem, 17, 758-764.
O'Neil, M. J., Smith, A., Heckelman, P. E., & Budavari, S. (2001). The merck index-An encyclopedia of chemicals, drugs, and biologicals. whitehouse station, NJ: Merck and Co. Inc, 767, 4342.
Peterson, L. J. (2000). Cirurgia oral e maxilofacial contemporânea. In Cirurgia oral e maxilofacial contemporanea (pp. 772-772).
Pires, W. R., Mota, M. O., Mizuno, E. H. F., & Mizuno, L. T. (2016). Subgalato de bismuto atuando como agente hemostático pós exérese de hiperplasia papilomatosa. Rev. Odontol. Araçatuba (Online), 25-29.
Puia, S. A., Hilber, E. M., & Garcia-Blanco, M. (2020). Randomized Clinical Trial Comparing Three Local Hemostatic Agents for Dental Extractions in Patients under Chronic Anticoagulant Therapy - A Comparative Study. Annals of maxillofacial surgery, 10(2), 292–296.
Puia, S. A., Renou, S. J., Rey, E. A., Guglielmotti, M. B., & Bozzini, C. E. (2009). Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats. International journal of oral and maxillofacial surgery, 38(7), 785-789.
Quintero Parada, E., Sabater Recolons, M. D. M., Chimenos Kustner, E., & López López, J. (2004). Hemostasia y tratamiento odontológico. Avances en Odontoestomatología, 20(5), 247-261.
Sampognaro, P., Vo, K. T., Richie, M., Blanc, P. D., & Keenan, K. (2017). Bismuth Subgallate toxicity in the age of online supplement use. The neurologist, 22(6), 237-240.
Subgalato De Bismuto (2016). Iberoquímica Magistral. Bula de remédio, 2016.
Tramontina, V. A., Machado, M. A. N., Filho, G. D. R. N., Kim, S. H., Vizzioli, M. R., & Toledo, S. (2002). Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings. Brazilian dental journal, 13(1), 11-16.
Thorisdottir, H., Ratnoff, O. D., & Maniglia, A. J. (1988). Activation of Hageman factor (factor XII) by bismuth subgallate, a hemostatic agent. The Journal of laboratory and clinical medicine, 112(4), 481-486. Manterola, E. R., & Smerilli, A. L. (2007). Uso del subgalato de bismuto como técnica hemostática en la exodoncia para pacientes dializados. Rev Fac Odontol (UBA), 22, 52-5325.
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Copyright (c) 2021 Leticia Perez Mazzoni; Járcio Victorio Baldi; José Sidney Roque; Luiz Alberto Dib Canonico; Vitor de Toledo Stuani; Matheus Völz Cardoso; Gustavo Gonçalves do Prado Manfredi; Ísis De Fátima Balderrama; Rafael Ferreira
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