Geraniol, a component of essential plant oils - a scientific mapping of its pharmacological properties
DOI:
https://doi.org/10.33448/rsd-v10i12.20805Keywords:
Geraniol; Geraniol;; Essential oil; essential oil;; Pharmacology; pharmacology;; Monoterpene.; monoterpene.Abstract
Nature offers a wide chemical diversity. Thus, plants represent an important source of new substances, mainly due to secondary metabolites. Geraniol is an acyclic isoprenoid monoterpene isolated from aromatic plant essential oils. Geraniol's diverse activities suggest that this molecule could treat various diseases as a promising drug candidate. To assess the potential of geraniol applied in a clinical trial, this review aims to provide a comprehensive summary of the pharmacological effects of geraniol. The retrieved publications Pubmed / NCBI, Science Direct, SCIELO and Google Scholar were collected and summarized between the years 2013 to 2021. Next, the potential application of geraniol as a medicine is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidant and antimicrobial activities and hepatoprotective effects. Therefore, it is noteworthy that future investigations can significantly contribute to the follow-up of works with the GOH, making it possible to assess its pharmacological potential.
References
Babukumar, S., Vinothkumar, V., Sankaranarayanan, C. & Srinivasan, S. (2017). Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Pharmaceutical biology, 55(1), 1442-1449.
Bezerra, D. R. C., do Espírito Santo, F. H., Monteiro, J. K. D. M. F., & Muto, T. S. (2020). Os vulneráveis no período do COVID-19: uma revisão integrativa de literatura. Research, Society and Development, 9(10), e4699108860-e4699108860. https://rsdjournal.org/index.php/rsd/article/view/8860/7816.
Canbek, M., Uyanoglu, M., Canbek, S., Ceyhan, E., Ozen, A., Durmus, B. & Turgak, O. (2017). The effect of geraniol on liver regeneration after hepatectomy in rats. in vivo, 31(2), 209-213.
Ceyhan, E. & Canbek, M. (2017). Determining the Effects of Geraniol on Liver Regeneration Via the Nuclear Factor κB Pathway After Partial Hepatectomy. Alternative therapies in health and medicine, 23(3), 38-45.
Chen, J., Fan, X., Zhou, L. & Gao, X. (2016). Treatment with geraniol ameliorates methionine‐choline‐deficient diet‐induced non‐alcoholic steatohepatitis in rats. Journal of gastroenterology and hepatology, 31(7), 1357-1365.
da Silva, B. C. M., Paula, C. R., Auler, M. E., Ruiz, L. D. S., Dos Santos, J. I., Yoshioka, M. C. N., Fabris, A., Castro, L. G. M., Duarte, A. J. S. & Gambale, W. (2014). Dermatophytosis and immunovirological status of HIV‐infected and AIDS patients from Sao Paulo city, Brazil. Mycoses, 57(6), 371-376.
da Silva, R. E., Ribeiro, F. D. O. S., de Araújo, G. S., Iles, B., Pessoa, O. D. L., de Araújo, A. R. & dos Santos Soares, M. J. (2021). Biological properties of Oncocalyxone A: a review. Research, Society and Development, 10(4), e57810414343-e57810414343.
Dong, G. & Golden, S. S. (2008). How a cyanobacterium tells time. Current opinion in microbiology, 11(6), 541-546.
Elshafie, H. S. & Camele, I. (2017). An overview of the biological effects of some mediterranean essential oils on human health. BioMed research international, 2017.
Ercole, F. F., Melo, L. S. D. & Alcoforado, C. L. G. C. (2014). Revisão integrativa versus revisão sistemática. Revista Mineira de Enfermagem, 18(1), 9-12.
Jayachandran, M., Chandrasekaran, B. & Namasivayam, N. (2015). Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis. Journal of basic and clinical physiology and pharmacology, 26(4), 335-346.
Khan, A. Q., Khan, R., Qamar, W., Lateef, A., Rehman, M. U., Tahir, M., Ali, F., Hamiza, O. O., Hasan, S. K. & Sultana, S. (2013). Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: Possible role of p38 MAP Kinase and NF-κB. Experimental and molecular pathology, 94(3), 419-429.
Koziol, A., Stryjewska, A., Librowski, T., Salat, K., Gawel, M., Moniczewski, A. & Lochynski, S. (2014). An overview of the pharmacological properties and potential applications of natural monoterpenes. Mini reviews in medicinal chemistry, 14(14), 1156-1168.
Leite, M. C. A., de Brito Bezerra, A. P., de Sousa, J. P. & de Oliveira Lima, E. (2015). Investigating the antifungal activity and mechanism (s) of geraniol against Candida albicans strains. Medical mycology, 53(3), 275-284.
Mendez‐Perez, D., Alonso‐Gutierrez, J., Hu, Q., Molinas, M., Baidoo, E. E., Wang, G., Chan, L. J. G., Adams, P. D., Petzold, C. J., Keasling, J. D. & Lee, T. S. (2017). Production of jet fuel precursor monoterpenoids from engineered Escherichia coli. Biotechnology and bioengineering, 114(8), 1703-1712.
Murbach Teles Andrade, B. F., Conti, B. J., Santiago, K. B., Fernandes, A. & Sforcin, J. M. (2014). C ymbopogon martinii essential oil and geraniol at noncytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytes. Journal of Pharmacy and Pharmacology, 66(10), 1491-1496.
Naveed, R., Hussain, I., Tawab, A., Tariq, M., Rahman, M., Hameed, S., Mahmood, M.S., Siddique, A. B., Iqbal., M. Antimicrobial activity of the bioactive components of essential oils from Pakistani spices against Salmonella and other multi-drug resistant bacteria. BMC Complementary and Alternative Medicine, 13 (1) (2013) 265. https://link.springer.com/article/10.1186/1472-6882-13-265
Naz, R., Ayub, H., Nawaz, S., Islam, Z. U., Yasmin, T., Bano, A., & Roberts, T. H. (2017). Antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from Punjab, Pakistan. BMC complementary and alternative medicine, 17(1), 1-13. https://link.springer.com/article/10.1186/s12906-017-1815-z.
Newman, D. J. & Cragg, G. M. (2016). Natural products as sources of new drugs from 1981 to 2014. Journal of natural products, 79(3), 629-661.
Noriega, P. (2020). Terpenes in Essential Oils: Bioactivity and Applications. In Terpenes and Terpenoids. IntechOpen.
Olajuyigbe, O. & Ashafa, A. (2014). Chemical composition and antibacterial activity of essential oil of Cosmos bipinnatus Cav. leaves from South Africa. Iranian journal of pharmaceutical research: IJPR, 13(4), 1417.
Pereira, F. D. O., Mendes, J. M., Lima, I. O., Mota, K. S. D. L., Oliveira, W. A. D. & Lima, E. D. O. (2015). Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharmaceutical biology, 53(2), 228-234.
Prasad, S. N. (2014). Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: attenuation of behavioral impairments and biochemical perturbations. Journal of neuroscience research, 92(9), 1205-1216.
Prodanov, C. C. & De Freitas, E. C. (2013). Metodologia do trabalho científico: métodos e técnicas da pesquisa e do trabalho acadêmico-2ª Edição. Editora Feevale.
Qi, F., Yan, Q., Zheng, Z., Liu, J., Chen, Y. & Zhang, G. (2018). Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest. J BUON, 23(2), 346-352.
Rekha, K. R. & Selvakumar, G. P. (2014). Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson’s disease. Chemico-biological interactions, 217, 57-66.
Rekha, K. R., Selvakumar, G. P., Sethupathy, S., Santha, K. & Sivakamasundari, R. I. (2013). Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson’s disease. Journal of Molecular Neuroscience, 51(3), 851-862.
Singh, S., Fatima, Z. & Hameed, S. (2016). Insights into the mode of action of anticandidal herbal monoterpenoid geraniol reveal disruption of multiple MDR mechanisms and virulence attributes in Candida albicans. Archives of microbiology, 198(5), 459-472.
Sofowora, A., Ogunbodede, E., & Onayade, A. (2013). The role and place of medicinal plants in the strategies for disease prevention. African journal of
traditional, complementary and alternative medicines, 10(5), 210-229. https://www.ajol.info/index.php/ajtcam/article/view/92333.
Soubh, A. A., Abdallah, D. M.; & El-Abhar, H. S. (2015). Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways. Life sciences, 136 (8), 142-150.
Sousa, C. J. P., Prete, A. C. L., Gomes, A. G. P., de Castro, E. F. R. & Ribeiro, C. H. M. A. (2021). Adverse drug events in hospitalized patients in Brazil: Integrative literature review. Research, Society and Development, 10(4), e3410413818-e3410413818.
Stephane, F. F. Y. & Juleshttps, B. K. J. (2020). Terpenoids as important bioactive constituents of essential oils. In Essential Oils-Bioactive Compounds, New Perspectives and Applications. IntechOpen.
Su, Y. W., Chao, S. H., Lee, M. H., Ou, T. Y. & Tsai, Y. C. (2010). Inhibitory effects of citronellol and geraniol on nitric oxide and prostaglandin E2 production in macrophages. Planta medica, 76(15), 1666-1671.
Xue-Y., D., Jin-S. X., Hong-Y. L,Zhan-Q.M., & Qiang., F. R. (2015). Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model. Physiology & Behavior, 152 (9), 264-271.
Wadhwa, G., Kumar, S., Chhabra, L., Mahant, S. & Rao, R. (2017). Essential oil–cyclodextrin complexes: An updated review. Journal of inclusion phenomena and macrocyclic chemistry, 89(1), 39-58.
Wittig, C., Scheuer, C., Parakenings, J., Menger, M. D. & Laschke, M. W. (2015). Geraniol suppresses angiogenesis by downregulating vascular endothelial growth factor (VEGF)/VEGFR-2 signaling. PLoS One, 10(7), e0131946.
Zhang, Z., Zhao, S., Li, X., Zhuo, X., Zhang, W., Nie, Q., Wang, S., Yan, L. & Sun, Y. (2018). Amentoflavone inhibits osteoclastogenesis and wear debris-induced osteolysis via suppressing NF-κB and MAPKs signaling pathways. Planta medica, 84(11), 759-767.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Rodrigo Elisío de Sá; Lucicleia Dias Monteiro; Priscila Costa Silva; Esley da Silva Santos; Valentina Rhémily de Melo Vasconcelos; Rafaela de Brito Vieira; Jhoana D'arc Lopes de Sousa; Antonia Luzia Lima do Nascimento; Bruna Letícia Lima Carvalho; Lucas Florencia da Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
