Atypical presentation of gastric adenocarcinoma metastasis: case report

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20901

Keywords:

Gastric cancer; Metastasis.; Adenocarcinomas

Abstract

Introduction: Gastric cancer is the 5th most incident cancer, except for non-melanoma skin tumors and the 3rd leading cause of cancer death in the world. The most common sites of gastric cancer metastases are: liver (48%), peritoneum (32%), lung (15%) and bone (12%). Objective: to present the course of cutaneous metastasis due to gastric adenocarcinoma. Methodology: Descriptive study of the case report type, whose data were obtained from the patient's medical record. Case presentation: We report the case of a 44-year-old female patient who underwent surgical and chemotherapy treatment due to gastric adenocarcinoma. One year and four months after the initial intervention, hyperchromic, painful, diffuse and non-pruritic skin lesions appeared, located mainly on the chest, back and upper limbs. Skin biopsy confirmed the hypothesis of cutaneous metastasis from gastric adenocarcinoma. Conclusion: In the context of gastric cancer treatment, it is important to monitor new signs and symptoms, such as insidious skin lesions, suggesting the possibility of metastatic skin tumor.

Author Biographies

Maria Clara Faustino Linhares, Hospital Hélio Angotti

Médica formada pela Universidade de Uberaba

Carolina Bugiato Faria Salge, Hospital Hélio Angotti

Médica formada pela Universidade de Uberaba

Fernanda Dias de Paula, Universidade de Uberaba

Acadêmica de Medicina da Universidade de Uberaba

Guilherme Nascentes Schmitt, Hospital Hélio Angotti

Médico formado pela Universidade de Uberaba.

Heloísa Paula Yamaguti, Universidade Federal do Triângulo Mineiro

Médica formada pela Universidade Federal do Triângulo Mineiro

Guilherme Freire Angotti Carrara, Hospital Hélio Angotti

Cirurgião Oncológico do Hospital Hélio Angotti

Luiz Carlos Furtado de Almeida Junior, Hospital Hélio Angotti

Cirurgião Oncológico e Diretor Clínico do Hospital Hélio Angotti

References

Asplund, J., Kauppila, J. H., Mattsson, F. & Lagergren, J. (2018). Survival Trends in Gastric Adenocarcinoma: A Population-Based Study in Sweden. Ann Surg Oncol. 25 (9): 2693-702

Cesaretti, M., Malerba, M., Basso, V., Boccardo, C., Santoni, R., D'Alessandro, G., Weiss, A., Campisi, C. & De Cian, F. (2014). Cutaneous metastasis from primary gastric cancer: a case report and review of the literature. Cutis. 93(4):E9-E13.

Chen, Y., Yang, Y. C., Tang, L. Y., Ge, Q. M., Shi, W. Q., Su, T., Shu, H. Y., Pan, Y. C., Liang, R. B., Li, Q. Y., & Shao, Y. (2021). Risk Factors and Their Diagnostic Values for Ocular Metastases in Gastric Adenocarcinoma. Cancer management and research, 13, 5835–5843.

Cokgezer, S., Samanci, N. S., Bektas, M., Kepil, N. & Demirelli, F. H. (2020). Cutaneous Metastasis of Signet Cell Gastric Carcinoma. Indian J Dermatol. 65(2):148-50.

Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D. & Bray, F. (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer, 136(5), E359–E386.

Ghosh, J., Arun, I., Ganguly, A. & Ganguly. S. Cutaneous metastases in a patient with adenocarcinoma of the stomach. Indian J Dermatol Venereol Leprol 2021;87:699-701.

Gündüz, Ö., Emeksiz, M.C., Atasoy, P., Kidir, M., Yalçin, S. & Demirkan, S. (2017) Signet-ring Cells in the Skin: A Case of Late-onset Cutaneous Metastasis of Gastric Carcinoma and a Brief Review of Histological Approach. Dermatol Reports, 8.

Kirchberger, M. C. (2018). Unusual presentation of a cutaneous metastasis in the face arising from gastric cancer: a case report. SAGE Open Medical Case Reports.

Krathen, R. A., Orengo, I. F. & Rosen, T. (2003). Cutaneous metastasis: a meta-analysis of data. Southern medical journal, 96(2), 164–167.

Koyama, R., Maeda, Y., Minagawa, N., Shinohara, T. & Hamada, T. (2019) Late Cutaneous Metastasis Originating from Gastric Cancer with Synchronous Metastasis. Case Rep Gastroenterol. 26;13(1):95-101.

Machlowska, J., Baj, J., Sitarz, M., Maciejewski, R. & Sitarz, R. (2020) Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies. Int. J. Mol. Sci., 21, 4012.

Marqués-Lespier, J. M., González-Pons, M. & Cruz-Correa, M. (2016). Current Perspectives on Gastric Cancer. Gastroenterology clinics of North America, 45(3), 413–428.

Namikawa, T., Munekage, E., Munekage, M., Maeda, H., Yatabe, T., Kitagawa, H., Kobayashi, M. & Hanazaki, K. (2017) Subcutaneous metastasis arising from gastric cancer: A case report. Mol Clin Oncol.6(4):515-516.

Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Ed. UAB/NTE/UFSM.

Rakka, M., Haidar, A., Bazzi, N., Safadi, A.E. & Chahine, G. (2019). Metachronous Skin Metastasis of Gastric Cancer: Case Report. Juniper Online Journal of Case Studies, Juniper Publishers Inc., vol. 10(4), pages 74-77.

Riihimäki, M., Hemminki, A., Sundquist, K., Sundquist, J. & Hemminki, K. (2016). Propagação metastática em pacientes com câncer gástrico. Oncotarget. 7 (32): 52307-52316.

Smyth, E. C., Nilsson, M., Grabsch, H. I., van Grieken, N. C. & Lordick, F. (2020). Gastric cancer. Lancet (London, England), 396(10251), 635–648.

Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71(3):209-249.

Tan, Z. (2019). Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review. Medical science monitor : international medical journal of experimental and clinical research, 25, 3537–354.

Yang, S., Liu, X.L., Guo, X.L., Song, B., Li, S.Z., Sun, X.F. & Feng, Y. (2020) Solitary metastasis to the skin and colon from gastric cancer after curative gastrectomy and chemotherapy: A case report. Medicine (Baltimore). 31;99(31):e21532.

Downloads

Published

30/09/2021

How to Cite

LINHARES, M. C. F.; ASSIS, M. N. V.; SALGE, C. B. F. .; PAULA, F. D. de; SCHMITT, G. N.; YAMAGUTI, H. P.; ANJO, V. A. S.; CARRARA, G. F. A.; ALMEIDA JUNIOR, L. C. F. de. Atypical presentation of gastric adenocarcinoma metastasis: case report. Research, Society and Development, [S. l.], v. 10, n. 12, p. e534101220901, 2021. DOI: 10.33448/rsd-v10i12.20901. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20901. Acesso em: 12 nov. 2024.

Issue

Vol. 10 No. 12

Section

Health Sciences

License

Copyright (c) 2021 Maria Clara Faustino Linhares; Maria Nathalia Vilela Assis; Carolina Bugiato Faria Salge; Fernanda Dias de Paula; Guilherme Nascentes Schmitt; Heloísa Paula Yamaguti; Vitor Antônio Santos Anjo; Guilherme Freire Angotti Carrara; Luiz Carlos Furtado de Almeida Junior

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.