Hematologic changes in patients infected with SARS-CoV-2: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20932

Keywords:

SARS-CoV-2; COVID-19; Hematological changes and coagulopathies.

Abstract

Objective: to carry out an integrative synthesis of the main hematological complications correlated with COVID-19, based on the analysis of articles and dissertations that address the subject. Methodology: several researches were carried out on articles published in full, between 2020 and 2021, in the following databases: Capes Journal Portal; MEDLINE (Medical Literature Analysis and Retrieval System Online); SciELO (Scientific Electronic Library Online) and VHL (Virtual Health Library); in addition to the guidelines of the Ministry of Health (WHO) and clinical and therapeutic protocols developed in Brazil. After analyzing the articles, 30 articles were chosen as the final sample for the review study, in addition to the guidelines of the Ministry of Health and other mentioned bodies. Results: this review made it possible to observe that most patients who had severe cases of the disease developed important hematological changes, such as a significant decrease in platelets and lymphocytes, increased D-dimer and prolonged prothrombin and thromboplastin time. These factors were linked to the evolution of cardiovascular problems such as Venous Thromboembolism, Intradisseminated vascular coagulation, often leading the patient to death. Conclusion: this review provides a broad overview of the current status of COVID-19 over the past year and reveals, explaining situations interconnected with its pathophysiology, clinical manifestations, the main characteristics of hematological and coagulopathic changes observed in the diagnosis and the impact of the pandemic on the system of world health.

References

Agbuduwe, C., & Basu, S. (2020). Haematological manifestations of COVID-19: From cytopenia to coagulopathy. European Journal of Haematology, (15), https://doi.org/10.1111/ejh.13491

Arbeláez, G. D., Vicente, A. M., Sánchez, I. G., Gutiérrez, G. A., Yéboles, C. A., Pérez, C. C., & Fajardo, G. A. J. (2021). Complicaciones trombóticas arteriales en pacientes COVID-19. Angiología, 73(3), 0003-3170. http://dx.doi.org/10.20960/angiologia.00285.

Asakura, H., & Ogawa, H. (2020). COVID-19-associated coagulopathy and disseminated intravascular coagulation. Int J Hematol, 1–13. https://dx.doi.org/10.1007%2Fs12185-020-03029-y

Dobesh, P. P., & Trujillo, C. T. (2020). Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID-19. Pharmacotherapy, 40(11), 1130-1151. https://doi.org/10.1002/phar.2465

Helms, J., Tacquard, D., & Severac, F. (2020). High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med, 46(6):1089–1098. 10.1007/s00134-020-06062-x

Huang, C., Wang, Y., & Li, X. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223):497–506. 10.1016/S0140-6736(20)30183-5

Iba, T., Levy, J. H., Levi, M., & Thachil, J. (2020). Coagulopathy in COVID-19. J Thromb Haemost, 18: 2103– 2109. https://doi.org/10.1111/jth.14975

Koche, J. C. (2011). Fundamentos de metodologia científica. Petrópolis: Vozes. http://www.brunovivas.com/wp-content/uploads/sites/10/2018/07/K%C3%B6che-Jos%C3%A9-Carlos0D0AFundamentos-de-metodologia-cient%C3%ADfica-_-teoria-da0D0Aci%C3%A Ancia-e-inicia%C3%A7%C3%A3o-%C3%A0-pesquisa.pdfhttps://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1 5.4)

Klok, F. A., Kruip, M. J., & Meer, N. J. (2020). Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res, 191:145–147. 10.1016/j.thromres.2020.04.013

Li, K., Wu, J., Wu, F., Guo, D., Chen, L., Fang, Z., & Li, C. (2020). The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia. Investigative radiology, 55(6), 327–331. https://doi.org/10.1097/RLI.0000000000000672

Meaghan, E. C., & Kanthi, Y. (2020). COVID-19-associated coagulopathy: An exploration of mechanisms. Vasc Med, 25(5), 471-478. https://doi.org/10.1177/1358863x20932640

Mesa, G. E. J., Coral, G. S., Montes, C. M., & Martin, M. J. A. (2021). Thrombosis and Coagulopathy in COVID-19. Curr Probl Cardiol, 46(3), 100742. https://dx.doi.org/10.1016%2Fj.cpcardiol.2020.100742

Mucha, R. S., Dugar, S., McCrae, K., Joseph, D, Bartholomeww, J., Sacha, L. L. G., & Militello, M. (2020). Coagulopathy in COVID-19: Manifestations and management. Cleveland Clinic Journal of Medicine August, 87(8), 461-468. https://doi.org/10.3949/ccjm.87a.ccc024

Nanshan, C. (2020). Epidemiologicalandclinicalcharacteristicsof 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptivestudy. The Lancet, 395(10223), 507-513.

Paramo, J. A. (2020). Coagulopatía y trombosis: similitudes y diferencias entre coronavirus patogénicos. Anales Sis San Navarra, 43(2), 1137-6627. https://dx.doi.org/10.23938/assn.0885

Perico, L., Benigni, A., Casiraghi, F, Lisa, F. P. N., Renia, L., & Remuzzi, G. (2020). Immunity, endothelial injury and complement-induced coagulopathy in COVID-19. Nat Rev Nephro, 17(1), 46-64. https://doi.org/10.1038/s41581-020-00357-4

Prado, M. E., Silva, U. F., Júnior, R. G. L. J., Rocha, Q. M. L., Petrola, S. N. L., Pereira, C. M. B., Costa, A. D., & Hall, R. P. (2021). Repercussões hematológicas, cardiovasculares e pulmonares no prognóstico de pacientes infectados por COVID-19: uma revisão integrativa/ Hematological, cardiovascular and pulmonary repercussions in the prognosis of patients infected by COVID-19: a literary review. Brazilian Journal of Health Review, Vol 4 (1): 2525-8761. https://doi.org/10.34119/bjhrv4n1-137

Rossi, F. H. (2020). Tromboembolismo venoso em pacientes COVID-19. J. Vasc. Bras, 2020,19: e20200107. https://doi.org/10.1590/1677-5449.200107

Rostami, M., & Mansouritorghabeh, H. (2020) D-dimer level in COVID-19 infection: a systematic review, Expert Review of Hematology, 13:11, 1265-1275, https://doi.org/10.1080/17474086.2020.1831383

Sharif, F., Khan, S., Junaid, A., Jahangir, S., Saeed, M., Ijaz, M., Ahmad, N. I., & Kamran, S. (2021). Early hematological indicators of severe COVID‐19 disease in hospitalized patients: Data from a South Asian population. Int J Lab Hematol, 10.1111/ijlh.13533. https://dx.doi.org/10.1111%2Fijlh.13533

Tang, N., Li, D., Wang, X., & Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost, 18(4):844–847. 10.1111/jth.14768

Wool, G. D., & Miller J. L. (2020). The Impact of COVID-19 Disease on Platelets and Coagulation. Pathobiology. 13, 1–13. https://dx.doi.org/10.1159%2F000512007

Wool, D. G., & Miller, L. J. (2021). The Impact of COVID-19 Disease on Platelets and Coagulation. Pathobiology, 88(1):15-27. https://doi.org/10.1159/000512007

Wu, C., Chen, X., & Cai, Y. (2020). Risk factors associated with acute respiratory dis tress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med, 200994. 10.1001/jamainternmed.2020.0994

Zancanaro, V., Moura, R. T., Bellaver, H. E,. & Javorski, M. J. (2021). Alterações nos parâmetros hematológicos e imunológicos observadas na infecção pelo sars-cov-2: uma revisão sistemática de literatura. Brazilian Journal of Development, 7 (5): 2525-8761. https://doi.org/10.34117/bjdv.v7i5.30097

Zhang, Y., Xiao, M., & Zhang, S. (2020). Coagulopathy and antiphospholipid antibodies in patients with COVID-19. N Engl J Med, 382(17):e38. 10.1056/NEJMc2007575

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Published

01/10/2021

How to Cite

SANTANA, A. de C. C.; SOUSA, C. J. P. de; RIBEIRO, C. H. M. A. Hematologic changes in patients infected with SARS-CoV-2: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 12, p. e578101220932, 2021. DOI: 10.33448/rsd-v10i12.20932. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20932. Acesso em: 25 apr. 2024.

Issue

Vol. 10 No. 12

Section

Health Sciences

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Copyright (c) 2021 Amanda de Cássia Castro Santana; Chriscia Jamilly Pinto de Sousa; Carolina Heitmann Mares Azevedo Ribeiro

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