Hematologic changes in patients infected with SARS-CoV-2: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20932

Keywords:

SARS-CoV-2; COVID-19; Hematological changes and coagulopathies.

Abstract

Objective: to carry out an integrative synthesis of the main hematological complications correlated with COVID-19, based on the analysis of articles and dissertations that address the subject. Methodology: several researches were carried out on articles published in full, between 2020 and 2021, in the following databases: Capes Journal Portal; MEDLINE (Medical Literature Analysis and Retrieval System Online); SciELO (Scientific Electronic Library Online) and VHL (Virtual Health Library); in addition to the guidelines of the Ministry of Health (WHO) and clinical and therapeutic protocols developed in Brazil. After analyzing the articles, 30 articles were chosen as the final sample for the review study, in addition to the guidelines of the Ministry of Health and other mentioned bodies. Results: this review made it possible to observe that most patients who had severe cases of the disease developed important hematological changes, such as a significant decrease in platelets and lymphocytes, increased D-dimer and prolonged prothrombin and thromboplastin time. These factors were linked to the evolution of cardiovascular problems such as Venous Thromboembolism, Intradisseminated vascular coagulation, often leading the patient to death. Conclusion: this review provides a broad overview of the current status of COVID-19 over the past year and reveals, explaining situations interconnected with its pathophysiology, clinical manifestations, the main characteristics of hematological and coagulopathic changes observed in the diagnosis and the impact of the pandemic on the system of world health.

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Published

01/10/2021

How to Cite

SANTANA, A. de C. C.; SOUSA, C. J. P. de; RIBEIRO, C. H. M. A. Hematologic changes in patients infected with SARS-CoV-2: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 12, p. e578101220932, 2021. DOI: 10.33448/rsd-v10i12.20932. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20932. Acesso em: 12 nov. 2024.

Issue

Vol. 10 No. 12

Section

Health Sciences

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Copyright (c) 2021 Amanda de Cássia Castro Santana; Chriscia Jamilly Pinto de Sousa; Carolina Heitmann Mares Azevedo Ribeiro

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