Association between hyperuricemia and factors related to metabolic syndrome in a mixed population in the City of Salvador, Bahia, Brazil.

Authors

DOI:

https://doi.org/10.33448/rsd-v10i13.20934

Keywords:

Hyperuricemia; Metabolic syndrome; Uric acid; Obesity; Cardiovascular diseases.

Abstract

Hyperuricemia is commonly seen in patients with metabolic syndrome (MS) and both are related to the risk of developing cardiovascular disease. Thus, the present study aims to verify whether there is an association between hyperuricemia and MS related factors in a mixed population in the city of Salvador, Bahia, Brazil. Method: Cross-sectional study with 610 patients, adults and elderly, of both sexes, with MS and attended at a nutrition school clinic between the years 2013-2018. To analyze the results, a descriptive assessment of sociodemographic data, Pearson's Chi-Square test and Fisher's exact test were performed. Results were considered significant p≤ 0.05. Results: The prevalence of hyperuricemia was 14% (n=79). There was an association between hyperuricemia and hypertension (p=0.035) and hyperuricemia and hypertriglyceridemia (p=0.002), but there was no significant association between hyperuricemia and hyperglycemia (p= 0.56) and low concentration of high density lipoprotein (p=0. 90), as well as body mass index (p=0.165) and C-reactive protein (p=0.801). Conclusion: There was a significant association between hyperuricemia and metabolic syndrome cofactors.

References

Brandão, A. L. R. B. S., Giovanella, L., & Campos, C. E. A. (2013). Avaliação da atenção básica pela perspectiva dos usuários: adaptação do instrumento EUROPEP para grandes centros urbanos brasileiros. Cien Saude Colet, 18(1), 103-114. 10.1590/S1413-81232013000100012

Campana, A. O. (1999). Metodologia da investigação científica aplicada à área biomédica: 2. Investigações na área médica. Jornal de Pneumologia [online], 25 (2), 84-93. 10.1590/S0102-35861999000200005

Carvalho, M. H. C., Colaço, A. L., & Fortes, Z. B. (2006). Citocinas, disfunção endotelial e resistência à insulina. Arq Bras Endocrinol Metab, 50(2), 304-312. 10.1590/S0004-27302006000200016

Clausen, J. O., Borch-Johnsen, K., Ibsen, H., & Pedersen, O. (1998). Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians. Eur J Endocrinol, 38(1), 63-9. 10.1530/eje.0.1380063

Costa, M. F. L. (2004). Influência da idade e da escolaridade no uso de serviços preventivos de saúde - Inquérito de Saúde da Região Metropolitana de Belo Horizonte, MG, Brasil. Epidemiol Serv Saude, 13(4), 209-215. 10.1590/S1413-81232004000400008

Furukawa, S., Takuya, F., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., et al. (2004). Increased oxidative stress in obesity and its impact on metabolic syndrome. Journal of Clinical Investigation, 114(12), 1752–1761. 10.1172 / JCI21625

Gattás, G. J. F., Kato, M., Soares-Vieira, J. A., Siraque, M. S., Kohler, P., Gomes, L., et al. (2004). Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population. Brazilian Journal of Medical and Biological Research, 37(4), 451-458. 10.1590/S0100-879X2004000400002

Hunter, D. J., York, M., Chaisson, C. E., Woods, R., Niu, J., & Zhang, Y. (2006). Recent diuretic use and the risk of recurrent gout attacks: the online case-crossover gout study. J Rheumatol, 33(7),1341–5. Obtido em: https://pubmed.ncbi.nlm.nih.gov/16758506/

Instituto Brasileiro de Geografia e Estatística (IBGE). (2010). Censo demográfico 2010. Obtido em 8 de dezembro de 2018, de: https://www.ibge.gov.br/

International Diabetes Federation (2006). Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation (IDF). Diabetic Medicine, 23, 469-480. 10.1111 / j.1464-5491.2006.01858.x

Kanbay, M., Segal, M., Afsar, B., Kang, D. H., Rodriguez-Iturbe, B., & Johnson, R. J. (2013). The role of uric acid in the pathogenesis of human cardiovascular disease. Heart, 99(11), 759–766. 10.1136/heartjnl-2012-302535

Klisic, A., Kocic, G., Kavaric, N., Jovanovic, M., Stanisic, V., & Ninic, A. (2018). Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. Eat Weight Disord, 25(1), 9-15. 10.1007 / s40519-018-0490-5

Lipschitz, D. A. (1994). Screening for nutritional status in the elderly. Primary care, 21(1), 55-67. Obtido em: https://pubmed.ncbi.nlm.nih.gov/8197257/

Mandal, A. K. & Mount, D. B. (2015). The molecular physiology of uric acid homeostasis. Annu Rev Physiol, 77, 323–45. 10.1146 / annurev-physiol-021113-170343

Manfredi, J. P. & Holmes, E. W. (1985). Purine salvage pathways in myocardium. Annu Rev Physiol, 47, 691-705. 10.1146 / annurev.ph.47.030185.003355

Matsuura, F., Yamashita, S., Nakamura, T., Nishida, M., Nozaki, S., & Funahashi, T. (1998). Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism, 47(8), 929-33. 10.1016 / s0026-0495 (98) 90346-8

Messerli, F. H., Frohlich, E. D., Dreslinski, G. R., Suarez, D. H., & Aristimuno, G. G. (1980). Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med, 93(6), 817-821. 10.7326 / 0003-4819-93-6-817

Nieto, F. J., Iribarren, C., Gross, M. D., Comstock, G. W., & Cutler, R. G. (2000). Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis, 148(1), 131-9. 10.1016 / s0021-9150 (99) 00214-2

Oliveira, E. P., Moreto, F., Silveira, L. V., & Burini, R. C. (2013). Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults. Nutr J, 12, 11. 10.1186 / 1475-2891-12-11

Onat, A., Uyarel, H., Hergenç, G., Karabulut, A., Albayrak, S., Sari, I., et al. (2006). Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens, 19(10),1055–1062. 10.1016 / j.amjhyper.2006.02.014

Schmidt, M. I., Duncan, B. B., Watson, R. L., Sharrett, A. R., Brancati, F. L., & Heiss, G. (1996). A metabolic syndrome in whites and African-Americans. The Atherosclerosis Risk in Communities baseline study. Diabetes Care, v.19(5), 414-8. 10.2337 / diacare.19.5.414

Silva, H. A., Carraro, J. C., Bressan, J., & Hermsdorff, H. H. (2015). Relation between uric acid and metabolic syndrome in subjects with cardiometabolic risk. Einstein (São Paulo), 13(2), 202-208. 10.1590/S1679-45082015AO3194

Sociedade Brasileira de Cardiologia. (2010). VI Diretrizes Brasileiras de Hipertensão. Arquivos Brasileiros de Cardiologia, 95 (1 supl.1), 1-51. http://publicacoes.cardiol.br/consenso/2010/Diretriz_hipertensao_associados.pdf

Ter Maaten, J. C., Voorburg, A., Heine, R. J., Ter Wee, P. M., Donker, A. J., & Gans, R. O. (1997). Renal handling of urate and sodium during acute physiological hyperinsulinaemia in healthy subjects. Clin Sci, Lond, 92(1), 51-58. 10.1042 / cs0920051

Vieira, K. L. D., Gomes, V. L. O., Borba, M. R., & Costa, C. F. S. (2013). Atendimento da população masculina em unidade básica saúde da família: motivos para a (não) procura. Esc. Anna Nery, 17 (1), 120-127. 10.1590/S1414-81452013000100017

World Health Organization. (2019). Physical Status: The Use and Interpretation of Anthropometry. https://www.who.int/childgrowth/publications/physical_status/en/

Published

16/10/2021

How to Cite

SILVA, J. M.; SILVA, T. T. R. de A. .; FATAL, L. B. da S.; SILVA, . C. F.; MEIRA, D. da S.; LIMA, C. R. O. C. de; SANTOS, L. A. dos; BRANDÃO, N. A. .; SACRAMENTO, J. M.; BORDALLO, C. de O. S.; RIOS, D. L. S.; ARAÚJO, E. M. Q. Association between hyperuricemia and factors related to metabolic syndrome in a mixed population in the City of Salvador, Bahia, Brazil. Research, Society and Development, [S. l.], v. 10, n. 13, p. e379101320934, 2021. DOI: 10.33448/rsd-v10i13.20934. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20934. Acesso em: 6 dec. 2021.

Issue

Section

Health Sciences