Ozone therapy as a treatment option against COVID-19: a literature review
DOI:
https://doi.org/10.33448/rsd-v10i13.21228Keywords:
Ozone; Ozone Therapy; COVID-19; Coronavirus.Abstract
Ozone therapy is a treatment that uses ozonized medicinal gas, with a mixture of ozone and pure oxygen in concentrations of 5% and 95% respectively. This therapy has considerable and expressive benefits when administered in adequate doses, as it has a strong antioxidant, bactericidal, fungicidal and antiviral action. Among the antiviral actions, ozone therapy has interesting characteristics to fight the coronavirus. In this sense, this research intends to carry out a literature review on the application of ozone therapy in the treatment of COVID-19 infection. This study is an integrative bibliographic review of the exploratory type of qualitative character, with data collected in articles, monographs and Brazilian legislation from March 2011 to March 2021. Through the results, it was possible to see that ozone therapy can be used as monotherapy or adjuvant in association with other drugs in the treatment against COVID-19, since after the use of this therapy there was an improvement in the clinical picture, in the biochemical markers of inflammation and radiological without presenting side effects, becoming effective and beneficial treatment for patients. This work corroborates the expansion of the understanding and spread of ozone therapy and reports the social and scientific relevance of the use of ozone therapy in the treatment of COVID-19.
References
ABOZ. (2019, julho 4). Regulamentação da Ozonioterapia e o que cada profissional pode fazer conforme o conselho de classe de cada um. https://www.aboz.org.br/noticias/regulamentacao-da-ozonioterapia-e-o-que-cadaprofissional-pode-fazer-conforme-o-conselho-de-classe-de-cada-um-/114/
ABOZ. (2020, junho 1). Os avanços da regulamentação da Ozonioterapia nos Conselhos de Classes. https://www.aboz.org.br/noticias/os-avancos-da-regulamentacao-da-ozonioterapia-nos-conselhos-de-classes-/138/
Brasil, no Resolução No 685, DE 30 De Janeiro De 2020, 267 (2020). https://www.in.gov.br/en/web/dou/-/resolucao-n-685-de-30-de-janeiro-de-2020-255613547
Brasil. (2020). Projeto autoriza uso da ozonioterapia como tratamento complementar para Covid-19. Camara dos deputados. https://www.camara.leg.br/noticias/653829-projeto-autoriza-uso-da-ozonioterapia-como-tratamento-complementar-para-covid-19
Cattel, F., Giordano, S., Bertiond, C., Lupia, T., Corcione, S., Scaldaferri, M., Angelone, L., & De Rosa, F. G. (2021). Ozone therapy in COVID-19: A narrative review. Virus Research, 291, 198207. https://doi.org/10.1016/j.virusres.2020.198207
Fernández-Cuadros, M. E., Albaladejo-Florín, M. J., Álava-Rabasa, S., Usandizaga-Elio, I., Martinez-Quintanilla Jimenez, D., Peña-Lora, D., Neira-Borrajo, I., López-Muñoz, M. J., Rodríguez-de-Cía, J., & Pérez-Moro, O. S. (2020). Effect of Rectal Ozone (O3) in Severe COVID-19 Pneumonia: Preliminary Results. SN Comprehensive Clinical Medicine, 2(9), 1328–1336. https://doi.org/10.1007/s42399-020-00374-1
Ferreira, S. K. S., Cunha, I. P., Meneghim, M. C., & De Checchi, M. H. R. (2020). Política Nacional de Práticas Integrativas e Complementares no Sistema Único de Saúde. Revista Faipe, 10(1), 21–39.
Galiè, M., Covi, V., Tabaracci, G., & Malatesta, M. (2019). The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure. International Journal of Molecular Sciences, 20(16), 4009. https://doi.org/10.3390/ijms20164009
Hernández, A., Viñals, M., Pablos, A., Vilás, F., Papadakos, P. J., Wijeysundera, D. N., Bergese, S. D., & Vives, M. (2021). Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study. International Immunopharmacology, 90, 107261. https://doi.org/10.1016/j.intimp.2020.107261
Izadi, M., Cegolon, L., Javanbakht, M., Sarafzadeh, A., Abolghasemi, H., Alishiri, G., Zhao, S., Einollahi, B., Kashaki, M., Jonaidi-Jafari, N., Asadi, M., Jafari, R., Fathi, S., Nikoueinejad, H., Ebrahimi, M., Imanizadeh, S., & Ghazale, A. H. (2021). Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review. International Immunopharmacology, 92, 107307. https://doi.org/10.1016/j.intimp.2020.107307
Lima, F. B. (2021). Ozonioterapia: Uma abordagem profissional e a aplicação da técnica em pacientes no Município de Patos/PB. Rev. Bras. de Educação e saúde. Município de Patos-PB, 11(1), 113–121.
Martínez-Sánchez, G., Schwartz, A., & Di Donna, V. (2020). Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19. Antioxidants, 9(5), 389. https://doi.org/10.3390/antiox9050389
Merhi, Z., Garg, B., Moseley-LaRue, R., Moseley, A. R., Smith, A. H., & Zhang, J. (2019). Ozone therapy: A potential therapeutic adjunct for improving female reproductive health. Medical Gas Research, 9(2), 101–105. https://doi.org/10.4103/2045-9912.260652
Ornelas, P. T. S. F., Sousa, C. M. de, Silva, I. C. R. da, & Fratelli, C. F. (2020). As evidências científicas da eficácia do uso da ozonioterapia frente à legislação sanitária brasileira. Revista de Divulgação Científica Sena Aires, 9(2), 320–326.
Páez, T. T., Pereira, P. A. I., Assis, L., dos Santos, L., & Tim, C. R. (2020). Ozonioterapia E Seus Aspectos Controvertidos. Diálogos Interdisciplinares, 9(5), 1–21.
Peña-Lora, D. Y., Albaladejo-Florín, M. J., & Fernández-Cuadros, M. E. (2020). Uso de ozonoterapia rectal en paciente anciana con neumonía grave por COVID-19. Revista Española de Geriatría y Gerontología, 55(6), 362–364. https://doi.org/10.1016/j.regg.2020.07.005
Piovesan, A., & Temporini, E. R. (1995). Pesquisa exploratória: Procedimento metodológico para o estudo de fatores humanos no campo da saúde pública. Revista de Saúde Pública, 29(4), 318–325. https://doi.org/10.1590/S0034-89101995000400010
Ranaldi, G., Villani, E., & Franza, L. (2020). Rationale for ozone-therapy as an adjuvant therapy in COVID-19: A narrative review. Medical Gas Research, 10(3), 0. https://doi.org/10.4103/2045-9912.289462
Rowen, R. J. (2019). Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: A review of current knowledge and experience. Medical Gas Research, 9(4), 232–237. https://doi.org/10.4103/2045-9912.273962
Sagai, M., & Bocci, V. (2011). Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? Medical Gas Research, 1(1), 29. https://doi.org/10.1186/2045-9912-1-29
Shah, M., Captain, J., Vaidya, V., Kulkarni, A., Valsangkar, K., Nair, P. M. K., & Ganu, G. (2021). Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study). International Immunopharmacology, 91, 107301. https://doi.org/10.1016/j.intimp.2020.107301
Silva, T. C., Shiosi, R. K., & Raineri Neto, R. (2018). Ozonioterapia: Um tratamento clínico em ascensão na medicina veterinária-revisão de literatura. R. cient. eletr. Med. Vet.
Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Integrative review: What is it? How to do it? Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Renata Braga Barbosa; Rubens do Espírito Santo; Zilma Miranda Navegante; Sonia Lhamas Santana Santos; Juan Gonzalo Bardález Rivera; Antonio Taylon Aguiar Gomes
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
