Profile of the use and handling of antihypertensives in individuals over 60 years of age
DOI:
https://doi.org/10.33448/rsd-v10i13.21325Keywords:
Elderly; Polypharmacy; Drug interactions; Oral administration of drugs; Anti-hypertensives; Drug storage.Abstract
Hypertension is one of the diseases that most affects the elderly, which, due to the influence of several factors, such as age and polypharmacy, may cause the incorrect administration or handling of antihypertensives. Thus, this study aims to analyze the habits of the elderly and/or their caregivers regarding the use of antihypertensives, which can be positive or negative for the treatment of the elderly. Through a virtual questionnaire in search of this information with a multivariate analysis and a cross-sectional study, 111 answers were obtained, of which 81 of the interviewees are using antihypertensives, the main ones being angiotensin receptor blocker, thiazide diuretic, angiotensin-converting enzyme inhibitor, and calcium channel blocker. It was found that most patients ingest the drugs correctly with water, and few cut the tablets and open the capsules. Regarding storage, the main places according to the survey are the kitchen and the bedroom, and many elderly people keep the medication in its original packaging. The survey presented positive results, but the errors identified could be avoided with correct and reinforced guidance from health professionals.
References
Auricchio, M. T., Yano, H. M., Santos, A. P., & Bugno, A. (2011). Avaliação do teor de Atenolol em comprimidos divididos com faca caseira e aparelho cortador. Acta Paulista de Enfermagem, 24(1), 74–79.
Borja-Oliveira, C. R. de. (2013). Pill organizers and pill cutters: risks and limitations. Revista de Saúde Pública, 47(1), 123–127.
Brasil. (1999) Ministério da Saúde. Resolução n 328, de 22 de julho de 1999. Dispõe sobre requisitos exigidos para a dispensação de produtos de interesse à saúde em farmácias e drogarias. https://www.cff.org.br/userfiles/file/resolucao_sanitaria/328.pdf
Brasil. (2012) Ministério da Saúde. Resolução n 466, de 12 de dezembro de 2012. Diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos, 150 Diário Oficial da União [da] República Federativa do Brasil 59 (2013). https://bvsms.saude.gov.br/bvs/saudelegis/cns/2013/res0466_12_12_2012.html
Burnier, M., Polychronopoulou, E., & Wuerzner, G. (2020). Hypertension and Drug Adherence in the Elderly. Frontiers in Cardiovascular Medicine, 7, 49.
Cardoso, G. da S., Sousa Neto, B. P. de, Magalhães, N. A., Cardoso, L. da S., Costa, G. O. P. da, Ribeiro, A. M. N., Jatobá, D. N. V., Mariano, S. C. B., Cruz, F. C. da, Pinheiro, D. M., Castro, M. C. de O., Paz, M. I., Araújo, D. S. de, & Jansen, R. C. S. (2021). Fatores que interferem na adesão ao tratamento farmacológico em idosos hipertensos. Research, Society and Development, 10(2), e17510212352.
Center for Drug Evaluation, & Research. (2021). About FDA Guidances. http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm
Didone, T. V. N., Melo, D. O. de, Lopes, L. da C., & Ribeiro, E. (2021). Conhecimento inadequado sobre medicamentos prescritos e seus preditores em pacientes muito idosos e seus cuidadores. Revista Brasileira de Geriatria e Gerontologia, 23(3). https://doi.org/10.1590/1981-22562020023.200193
Gill, D., Spain, M., & Edlund, B. J. (2012). Crushing or splitting medications: unrecognized hazards. Journal of Gerontological Nursing, 38(1), 8–12.
Haw, C., & Stubbs, J. (2010). Administration of medicines in food and drink: a study of older inpatients with severe mental illness. International Psychogeriatrics / IPA, 22(3), 409–416.
Holton, A. E., Gallagher, P., Fahey, T., & Cousins, G. (2017). Concurrent use of alcohol interactive medications and alcohol in older adults: a systematic review of prevalence and associated adverse outcomes. BMC Geriatrics, 17(1), 148.
Jacques, E. R., & Alexandridis, P. (2019). Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps. NATO Advanced Science Institutes Series E: Applied Sciences, 9(15), 3066.
Jankowska-Polańska, B., Dudek, K., Szymanska-Chabowska, A., & Uchmanowicz, I. (2016). The influence of frailty syndrome on medication adherence among elderly patients with hypertension. Clinical Interventions in Aging, 11, 1781–1790.
Jáuregui-Garrido, B., & Jáuregui-Lobera, I. (2012). Interactions between antihypertensive drugs and food. Nutricion Hospitalaria: Organo Oficial de La Sociedad Espanola de Nutricion Parenteral Y Enteral, 27(6), 1866–1875.
Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J. H., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., … Corsetti, M. (2019). The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences, 134, 31–59.
Malachias, M. V. B., Plavnik, F. L., & Machado, C. A. (2016). 7a Diretriz Brasileira de Hipertensão Arterial: Capítulo 1-Conceituação, Epidemiologia e Prevenção Primária. De Cardiologia. https://www.scielo.br/j/abc/a/LtmRBQ7ZnJ88SQxL64yFRyy/?format=pdf&lang=pt
Martins, R. R., Farias, A. D., Oliveira, Y. M. da C., Diniz, R. D. S., & Oliveira, A. G. (2017). Prevalence and risk factors of inadequate medicine home storage: a community-based study. Revista de Saúde Pública, 51, 95.
Nascimento, L.F., Cavalcante, M.M.D. (2018). Abordagem quantitativa na pesquisa em educação: investigações no cotidiano escolar. Revista Tempos e Espaços em Educação, 11(25), 251-262.,
Nobre de Menezes, T., Tôrres Oliveira, E. C., Abreu Tavares Sousa Fischer, M., & Esteves, G. H. (2016). Prevalência e controle da hipertensão arterial em idosos: um estudo populacional. Revista Portuguesa de Saúde Pública, 34(2), 117–124.
Paolinelli, J. P. V., Morais, D. B., Oliveira, W. N., Fernandes, M. R., Rocha, R. S., Figueiredo, R. C., Baldoni, A. O., & Pereira, M. L. (2021). Macroscopic signs of deterioration of medicines in home stocks. Research, Society and Development, 10(7), e28910716517–e28910716517.
Penha, B. C. M., Marques, G. P., & Rodrigues, K. M. R. (2021). Acompanhamento farmacoterapêutico do paciente idoso com hipertensão arterial em população brasileira: achados de revisão sistemática/ Pharmacotherapeutic follow-up of the elderly patient with hypertension in the brazilian population: findings from a systematic review. Brazilian Journal of Health Review, 4(3), 11412–11425.
Pereira, M. T. L., Queiroz, M. P., de Menezes Santos Bertozzo, C. C., Barbosa, M. Q. E., da Silva Campos, R., & Pinto, M. L. M. (2020). Drug-nutrient interactions of antihypertensives and antidiabetics prescribed at Alcides Carneiro University Hospital. Research, Society and Development, 9(7), e35973802–e35973802.
Rodrigues Júnior, F. A., Alencar, M. M. F., Menezes, J. J. de, & Galvão, P. V. M. (2019). A relação entre o uso de álcool e a não adesão ao tratamento em pacientes hipertensos. Multidisciplinary Reviews, 2(1), e2019009.
Sousa, A. L. L., Batista, S. R., Sousa, A. C., Pacheco, J. A. S., Vitorino, P. V. de O., & Pagotto, V. (2019). Hypertension Prevalence, Treatment and Control in Older Adults in a Brazilian Capital City. Arquivos Brasileiros de Cardiologia, 112(3), 271–278.
Teixeira, M. T., Sá-Barreto, L. C. L., Silva, D. L. M., & Cunha-Filho, M. S. S. (2016). Panorama dos aspectos regulatórios que norteiam a partição de comprimidos. Revista panamericana de salud publica = Pan American journal of public health, 39(6), 372–377.
Vlieland, N. D., van den Bemt, B. J. F., Bekker, C. L., Bouvy, M. L., Egberts, T. C. G., & Gardarsdottir, H. (2018). Older Patients’ Compliance with Drug Storage Recommendations. Drugs & Aging, 35(3), 233–241.
Weber, M. A., Schiffrin, E. L., White, W. B., Mann, S., Lindholm, L. H., Kenerson, J. G., Flack, J. M., Carter, B. L., Materson, B. J., Ram, C. V. S., Cohen, D. L., Cadet, J.-C., Jean-Charles, R. R., Taler, S., Kountz, D., Townsend, R. R., Chalmers, J., Ramirez, A. J., Bakris, G. L., … Harrap, S. B. (2014). Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. Journal of Clinical Hypertension , 16(1), 14–26.
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Copyright (c) 2021 Deborah Rito da Silva; Juliana Massucato Perez Chubaci; Guilherme Luis Toledo Barreto; Marie Jordão Khemiri; Leandro Giorgetti
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