Potential action on the central nervous system of neroli oil extracted from Citrus aurantium





Linalool; Citrus aurantium; Volatile oils; Anti-anxiety agents.


The essential oil from C. aurantium has been widely studied due to its potential anxiolytic action on several receptors in the Central Nervous System (CNS). Although it presents variations in its phytochemical composition depending on its origin, we can highlight that many compounds remain present, such as linalool that demonstrated antagonistic activity on glutamatergic receptors, possible inhibitory action of noradrenaline and serotonin receptors, besides the ability to activate GABA receptors in association with some flavonoids present in the oil. It is globally known that the underlying pathology called anxiety influences worldwide as an antecedent of conflicting psychological and physical disorders, which are associated with various neuronal disorders. In this regard, the oil extracted from C. aurantium flowers shows a potential therapeutic application for the treatment of anxiety disorders. However, more studies are needed to elucidate its complete role on the CNS and to verify and prove its safety and efficacy profile.


Acar, Ü., et al. (2021) Effects of Essential Oil Derived from the Bitter Orange (Citrus aurantium) on Growth Performance, Histology and Gene Expression Levels in Common Carp Juveniles (Cyprinus carpio). Animals 2021, 11, 143.

Akhlaghi, M., et al. (2011) Citrus aurantium flower and preoperative anxiety. Rev. Bras. Anestesiol., 61(6), 707-712.

Amravati, J. & Suryawanshi, S. (2011) An overview of Citrus aurantium used in treatment of various diseases. African Journal of Plant Science, 5(7), 390-395.

Astani, A, Reichling, J., & Schnitzler P. (2010) Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. PhytotherRes. 2010, 24(5):673-79.

Batista, P. A. et al. (2008) Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (-)-Linalool in mice. Neurosci. Lett. 440(3), 299-303.

Bourin, M., et al. (1991). Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity, J. Psychiatry Neurosci. 16. 199-203.

Boussaada, O., & Chemli, R. (2006) Chemical Composition of Essential Oils from Flowers, Leaves and Peel of Citrus aurantium L. var amara from Tunisia, Journal of Essential Oil-Bearing Plants, 9:2, 133-139

Brum, L. F. S. et al. (2001) Effects of Linalool on Glutamate Release and Uptake in Mouse Cortical Synaptosomes. Neurochem. Res., 26(3), 191-194.

Carobrez, A. P (2003) Glutamatergic neurotransmission as molecular target in anxiety. Brazilian Journal of Psychiatry. 25 Suppl 2.

Carvalho-Freitas, M. I., & Costa, M. (2002) Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol Pharm Bull. 25(12):1629-33

Dosoky, N. S., & William, N. S. (2018). "Biological Activities and Safety of Citrus spp. Essential Oils." International journal of molecular sciences vol. 19,7 1966.

Elisa bestky, E., et al. (1995a). Effects of Linalool on glutamatergic system in the rat cerebral cortex. Neurochem. Res. 20, 461-465.

Elisabetsky, et al. (1999). Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine 6(2),107-113.

Elisabetsky, E., et al, (1995b). Sedative properties of Linalool. Phytotherapy 15 (5),407-414.

Fonsêca, D. V., et al. (2019)."Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy" Biomolecules 9, no. 12: 835

Golechha, M., et al. (2011). Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. 2011,34(3):360-5

Guzmán-Gutiérrez, L. et.al. (2015) Linalool and β-pineneexert their antidepressant-like activity through the monoaminergic pathway.LifeSciencies, 24-29.

Haj Ammar et al. (2012) Chemical Composition and in vitro Antimicrobial and Antioxidant Activities of Citrus aurantium L. Flowers Essential Oil (neroli Oil). Pakistan Journal of Biological Sciences, 15(21), 1034-1040.

Heldwein, C. G. et al. (2014) S- (+)-Linalool from Lippiaalba: sedative and anesthetic for silver catfish (Rhamdiaquelen). Vet. Anaesth.Analg. 41(6), 621-629.

Hwang, S. L., Shih, P., & Yen, G. C. (2012) Neuroprotective effects of Citrus flavonoids. J Agric Food Chem. 1,60(4):877-85.

Jeannot, V., Chahboun, J, Russell D., & Baret, P. (2005) Quantification and determination of chemical composition of the essential oil extracted from natural orange blossom water (Citrus aurantium L. ssp. aurantium), International Journal of Aromatherapy, 15(2), 94-9

Karimi, E. et al. (2012) Phenolic Compounds Characterization and Biological Activities of Citrus aurantium. Bloom.Molecules. 17(2): 1203-1218.

Khosravi, M. et al. (2014) A Study of the Effect of Citrus aurantium L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice Journal of Behavioral and Brain Science, 470-476.

Kobori C. N., & Jorge N. (2005) Characterization of some seed oils of fruits for utilization of industrial residues. Cienc Agrotec. 29(5):1008-14.

Linck, V. M. et al. (2010) Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice Phytomedicine, Stuttgart, 17(8-9), 679-683.

Manthey J. A., Grohmann K., & Guthrie N. (2001) Biological properties of Citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 8(2):135-53.

Marder, M. et al. (2001) Molecular Modeling and Analysis of the Interaction of Flavone Derivatives with the Benzodiazepine Binding Site of the GABAA Receptor Complex. Bioorganic& Medicinal Chemistry, 9, 323-335.

Medina J. et al. (1990) (5,7-di-OH-flavone), a naturally occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol. 40(10):2227-31.

Millan M. J. (2004) The role of monoamines in the actions of established and "novel" antidepressant agents: a critical review, Eur. J Pharmacol. 500, 371–384.

Namazi, M. et al. (2014) Aromatherapy with Citrus aurantium oil and anxiety during the first stage of labor Iran Red Crescent Med J. 16(6): e18371.

Pimenta, F. C. et al. (2016) Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia.Phytother Res. 30(4):613-7.

Quintans-Junior, L. J. et al. (2013) B-Cyclodextrin-complexed (-)-Linalool produces antinociceptive effect superior to that of (-)-Linalool in experimental pain protocols.Basic Clin. Pharmacol.Toxicol., 113(3), 167-172.

Rahnama, S., et al. (2015) Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurol Sci, 36(4):553-60.

Sarrou E., et al. (2013) Volatile constituents and antioxidant activity of peel, flowers and leaf oils of Citrus aurantium L. growing in Greece Molecules, 18(9):10639-47.

Schildkraut, J. J. (1995), The catecholamine hypothesis of affective disorders: a review of supporting evidence, J. Neuropsychiatr. Clin Neurosci. 524-533.

Shen, C., et al (2017) Various Antioxidant Effects Were Attributed to Different Components in the Dried Blossoms of Citrus aurantium L. var amara Engl. J Agric Food Chem. 65(30):6087-6092.

Silva Brum, L. F. (2001) Effects of Linalool on Glutamate release and Up take in Mouse Cortical Synaptosomes. Neurochemical Research, 26, 191-194.

Siqueira, R. J. et al. (2014) Linalool-rich Rosewood Oil Induces Bradycardic and Depressor Reflex in Rats. Phytother. Res. 28(1), 42-48.

Sousa, D. P. et al. (2015) A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models. Molecules, 20, 18620-18660.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.

Tankam, J. M., & Ito, M. (2013) Inhalation of the Essential Oil of Piperguineense from Cameroon Shows Sedative and Anxiolytic-Like Effects in Mice. Biol. Pharm.Bull., 36(10), 1608-1614.

Wu M. et al. (2015) Identification of the chemical constituents in aqueous extract of Zhi-Qiaoand evaluation of its antidepressant effect. Molecules, 20(4):6925-40.

Yang, T. S. et al. (2014) Antimicrobial activity of the essential oil of Glossogynetenuifolia against selected pathogens. J. Sci. Food Agric. 94(14), 2965-71.

Yu L. et al. (2020) Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var amara Using HPLC-Q-TOF-MS Combined with a Screening Method. Molecules, 25(2):357.




How to Cite

BORBA, C. A.; FERNANDES, G. V. .; CAMPOS, J. C. .; SILVA, T. B. da .; GONZAGA, R. V. . Potential action on the central nervous system of neroli oil extracted from Citrus aurantium. Research, Society and Development, [S. l.], v. 10, n. 13, p. e418101321447, 2021. DOI: 10.33448/rsd-v10i13.21447. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21447. Acesso em: 2 mar. 2024.



Health Sciences