The Genetic Polymorphism of TNF-α Associated with the Anti-TNF-α Therapy Used for COVID-19 Patients – Another Possible Approach
DOI:
https://doi.org/10.33448/rsd-v11i1.21576Keywords:
Cell-free nucleic acids; Genetic polymorphism; Polymorphism, single nucleotide; DNA.Abstract
Objective: This work aimed of to review the implications of anti-TNF-α therapy in COVID-19 patients associated with the genetic polymorphism (TNF-α polymorphisms in the region-308) of this pertinent cytokine Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web of Science and The Cochrane Library with the aid of key-words. Results: Twenty-six articles were collected. Anti-TNF-α therapy was interpreted and evaluated. Conclusions: Although scarce information is available in the current literature, anti- TNF-α therapy seems to be a viable clinical approach for hospitalized COVID-19 patients who do not need oxygen supply. The genetic polymorphisms, although relevant, may be useful for further researched to assess the clinical response in different research groups.
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Copyright (c) 2022 Luciano Barreto Silva; Guilherme Marinho Sampaio; Rodolfo Scavuzzi Carneiro Cunha; Caroline Isabele Félix Muniz; Alexandrino Pereira Santos Neto; Hemanuelly Albuquerque dos Anjos; Felipe Leonardo de Melo Almeida Fonseca; Ailton Coelho de Ataíde Filho
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