Acellular dermal matrix used after large surgical ressection in ameloblastoma with buccal mucosa extension: a case report




Ameloblastoma; Acellular dermal membrane; Buccal reconstruction.


Neoplastic, traumatic, and inflammatory diseases of the oral cavity and oropharynx frequently result in significant defects after resection, also, they may present challenge reconstruction. Regional and distant flaps such as skin grafts (SGs) are routinely used to cover mucosal defects arising from large resections, to restore tissue volume and preserve function. However, there are some disadvantages, mainly related to the donor site morbidity, including pain, risk of infection, occasional hypertrophic scar, and additional contracture resulting from a relative lack of dermis. Therefore, acellular dermal membrane (ADM) seems to be an applicable option to avoid those issues, and it has been shown good results for covering tissue defects. Thus, this study reports the first experience of using the double-layer dermal substitute (DLDS) (NeveliaÒ made by Symatese, France) in oral cavity, to cover and repair a buccal defect, immediately after a large resection of ameloblastoma extending to buccal mucosa. After surgical intervention and actually in follow-up, the patient shows good aesthetic and functional status, 24 months postoperatively. Thus, this DLDS seems to be a good resource in primary buccal reconstruction after extensive tumor resection. However, more studies are needed to be performed.


Askin, S. B., Asku, A. E., Calis, M., Tulunoglu, I., Safak, T., Tozum, T. F. (2015). Report of multidisciplinary treatment of an extensive mandibular ameloblastoma with free iliac crest bone flap, dental implants, and acellular dermal matrix graft. J Oral Implantol, 41, 107-111.

Basso, F. G., Hebling, J., Marcelo, C. L., de Souza Costa, C. A., Feinberg, S. E. (2016). Development of an oral mucosa equivalent using a porcine dermal matrix. Br J Oral Maxillofac Surg, 55, 308-311.

Bohác, M., Danišovič, L., Koller, J., Dragúňová, J., Varga, I. (2018). What happens to an acellular dermal matrix after implanta- tion in the human body? A histological and electron microscopic study. European Journal of Histochemistry, 62, 2873.

Clark, R. A., Ghosh, K., Tonnesen, M. G. (2007). Tissue engineering for cutaneous wounds. J Invest Dermatol, 127, 1018-1029.

De Angelis, B., Orland, F., Morais Dáutilio, M. F. L., Scioli, M. G., Orlandi, A., Cervelli, V., Gentile, P. (2018). Long-term follow-up comparison of two different bi-layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings. Int Wound J, 15, 695-706.

Giord, D. A., Sykes, K., Jorgensen, J., Tawfik, O., Tsue, T. (2009). Acellular dermis compared to skin grafts in oral cavity reconstruction. Laryngoscope, 119, 2141-9.

Infante-Cossio, P., Prats-Golczer, V., Gonzalez-Perez, L. M., Belmonte-Caro, R., Martinez-De-Fuentes, R., Torres-Carranza, E., Gacto-Sanchez, P., Gomez-Cia, T. (2013). Treatment of recurrent mandibular ameloblastoma. Experimental and Therapeutic Medicine, 6, 579-583.

Menon, N. G., Rodriguez, E. D., Byrnes, C. K., Girotto, J. A., Goldberg, N. H., Silverman, R. P. (2003). Revascularization of human acellular dermis in full-thickness abdominal wall reconstruction in the rabbit model. Ann Plast Surg, 50, 523-7.

Milman, T., Ying, S., Pan, W., LiVolsi, V. (2016). Ameloblastoma: 25 Year Experience at a Single Institution. Head Neck Pathol, 10, 513–520.

Nicoletti, G., Tresoldi, M. M., Malovini, A., Visaggio, M., Faga, A., Scevola, S. (2018). Versatile use of dermal substitutes: A retrospective survey of 127 consecutive cases. Indian J Plast Surg, 51, 46–53.

Puisys, A., Vindasiute, E., Linkevciene, L., Linkevicius, T. (2014). The use of acellular dermal matrix membrane for vertical soft tissue augmentation during submerged implant placement: a case series. Clinical Oral Implants Research, 26, 465-470.

Reichart, P. A., Philipsen, H. P., Sonner, S. (1995). Ameloblastoma: biological profile of 3677 cases. Eur J Cancer Part B Oral Oncol, 31-D, 86–99.

Rhee, P. H., Friedman, C. D., Ridge, J. A., Kusiak, J. (1998) The use of processed allograft dermal matrix for intraoral resurfacing - An alternative to split-thickness grafts. Arch Otolaryngol Head Neck Surg, 124, 1201-1204.

Rijal, G. The decellularized extracellular matrix in regenerative medicine. (2017). Regen Med, 12, 475-7.

Schleifenbaum, S., Prietzel, T., Aust, G., Boldt, A., Fritsch, S., Keil, I., Koch, H., Möbius, R., Scheidt, H. A., Wagner M. F. X., Hammer, N. (2016). Acellularization-induced changes in tensile properties are organ specific - an in vitro mechanical and structural analysis of porcine soft tissues. PLoS One, 11.

Shi, L. J., Wang, Y., Yang, C., Jiang, W. W. (2012). Application of acellular dermal matrix in reconstruction of oral mucosal defects in 36 cases. J Oral Maxillofac Surg, 70, 586-91.

Singh, G., Mishra, M., Gaur, A., Srivastava, A., Shukla, B. (2018). Collagen Membrane Over Buccal Fat Pad Versus Buccal Fat Pad in Management of Oral Submucous Fibrosis: A Comparative Prospective Study. J. Maxillofac. Oral Surg 17, 484-487.

Wainwright, D. J. (1995) Use of an acellular allo- graft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns, 21, 243-8.

Wright, J. M., Vered, M. (2017). Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours. Neck Pathol, 11, 68–77.

Xu, X., Cui, N., Wang, E. (2018). Application of an acellular dermal matrix to a rabbit model of oral mucosal defects. Experimental and therapeutic medicine, 15, 2450-2456.




How to Cite

JÁCOME-SANTOS, H.; CASTRO, F. L. A. de L. .; RESENDE, R. G. .; LACERDA, R. de C.; CRUZ, A. F. .; LACERDA, J. C. T. de. Acellular dermal matrix used after large surgical ressection in ameloblastoma with buccal mucosa extension: a case report. Research, Society and Development, [S. l.], v. 10, n. 13, p. e564101321634, 2021. DOI: 10.33448/rsd-v10i13.21634. Disponível em: Acesso em: 6 dec. 2021.



Health Sciences