Use of Cannabis sativa in the treatment of epilepsy - a literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22553

Keywords:

Cannabis; Epilepsy; Cannabidiol; Convulsive crises.

Abstract

Epilepsy is a chronic neurological disorder, where abnormal electrical discharges occur, causing seizures in those affected with this pathology. The medicinal power of Cannabis sativa has been known for several centuries, but in recent years there has been an increase in studies on the use of one of its compounds, cannabidiol, for the treatment of various diseases, such as Parkinson's, Alzheimer's, Sclerosis Multiple, anxiety, depression and especially in epilepsy. This work is a literature review with the purpose of gathering information and describing it in a clear and objective way, providing a broader view on the use of Cannabis sativa in the treatment of epilepsy. Data were collected through documents, books, articles, magazines and texts, material available in the databases. The conclusion is that cannabidiol has therapeutic capacity for the treatment of patients with epilepsy and convulsive crisis, but further studies are still needed to understand the compounds of Cannabis sativa, both for the treatment and its side effects in

References

Atance, J. A. R., & Ruiz, J. F. (2000). Uso de los cannabinoides a través de la historia. Adicciones, 12(5), 19–30. https://doi.org/10.20882/adicciones.670

Ben Amar, M. (2006). Canabinóides na medicina: uma revisão de seu potencial terapêutico. Journal of Ethnopharmacology, 105 (1-2), 1-25. https://doi.org/10.1016/j.jep.2006.02.001

Betting, L. E., & Guerreiro, C. A. M. (2008). Tratamento das epilepsias generalizadas idiopáticas. Journal of Epilepsy and Clinical Neurophysiology, 14(suppl 2), 20–24. https://doi.org/10.1590/s1676-26492008000600004

Brucki, S. M. D., Frota, N. A., Schestatsky, P., Souza, A. H., Carvalho, V. N., Manreza, M. L. G., Mendes, M. F., Comini-Frota, E., Vasconcelos, C., Tumas, V., Ferraz, H. B., Barbosa, E., & Jurno, M. E. (2015). Cannabinoids in neurology – Brazilian Academy of Neurology. Arquivos de Neuro-Psiquiatria, 73(4), 371–374. https://doi.org/10.1590/0004-282x20150041

CFM – Conselho Federal de Medicina. (2014). Resolução CFM 2113/2014 aprova o uso compassivo do canabidiol para o tratamento de epilepsias da criança e do adolescente refratárias aos tratamentos convencionais. https://portal.cfm.org.br/canabidiol/motivos.php

Chiron, C., & Dulac, O. (2011). The pharmacologic treatment of Dravet syndrome. Epilepsia, 52 Suppl 2, 72–75. https://doi.org/10.1111/j.1528-1167.2011.03007.x

Crippa, J. A., Zuardi, A. W., & Hallak, J. E. (2010). Uso terapêutico dos canabinoides em psiquiatria [Therapeutical use of the cannabinoids in psychiatry]. Revista brasileira de psiquiatria, 32 Suppl 1, S56–S66. https://doi.org/10.1590/S1516-44462010000500009

Dravet C, Bureau M. (2008) Severe Myoclonic Epilepsy in Infancy (Dravet syndrome). In Engel J, Pedley TA (Eds) Epilepsy, a comprehensive textbook. 2nd ed. Lippincott Williams Wilkins, Philadelphia, pp. 2337–2342.

Friedman, D., & Devinsky, O. (2015). Canabinoides no tratamento da epilepsia (Cannabinoids in the treatment of epilepsy). The New England Journal of Medicine, 1048–1058. https://www.nejm.org/doi/10.1056/NEJMra1407304

Grotenhermen, F., & Russo, E. (2008). Cannabis and cannabinoids: pharmacology, toxicology, and therapeutic potential. Routledge.

Kruse, M., Souza, P., & Toma, W. (2015). A importância do princípio ativo canabidiol (CBD) presente na Cannabis sativa L. no tratamento da epilepsia [Sessão de pôsteres]. IV Simpósio de Ciências Farmacêuticas, São Camilo. http://www.saocamilo-sp.br/novo/eventos-noticias/simposio/15/SCF014_15.pdf

Kupczyk, P., Reich, A., & Szepietowski, J. C. (2009). Cannabinoid system in the skin - a possible target for future therapies in dermatology. Experimental dermatology, 18(8), 669–679. https://doi.org/10.1111/j.1600-0625.2009.00923.x

Kwan, P., & Brodie, M. J. (2000). Early identification of refractory epilepsy. The New England journal of medicine, 342(5), 314–319. https://doi.org/10.1056/NEJM200002033420503

Miller, I., Scheffer, I. E., Gunning, B., Sanchez-Carpintero, R., Gil-Nagel, A., Perry, M. S., Saneto, R. P., Checketts, D., Dunayevich, E., Knappertz, V., & GWPCARE2 Study Group (2020). Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial, JAMA neurology, 77(5), 613–621. https://doi.org/10.1001/jamaneurol.2020.0073

Moura, E. R.., Veras, L. B. S., Alencar, E. V. M., Frota, R. D. D. D., Santos, M. Y. B., & Maceno, G. A. (2017). POTÊNCIAL TRAPÊUTICO DA CANNABIS SATIVA: CANABIDIOL E TETRAHIDROCANABIDIOL [Sessão de pôsteres]. Revista Interdisciplinar de Ciências Médicas - Anais, Teresina. http://docplayer.com.br/81118404-Potencial-trapeutico-dacannabis-sativa-canabidiol-etetrahidrocanabidiol.html

Porter, B. E., & Jacobson, C. (2013). Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy & behavior: E&B, 29(3), 574–577. https://doi.org/10.1016/j.yebeh.2013.08.037

Reddy, D. S., & Golub, V. M. (2016). The Pharmacological Basis of Cannabis Therapy for Epilepsy. Journal of Pharmacology and Experimental Therapeutics, 357(1), 45–55. https://doi.org/10.1124/jpet.115.230151

Saito, V. M., Wotjak, C. T., & Moreira, F. A. (2010). Exploração farmacológica do sistema endocanabinoide: novas perspectivas para o tratamento de transtornos de ansiedade e depressão? Brazilian Journal of Psychiatry, 32 Suppl 1, S7–S14. SciElo. https://www.scielo.br/j/rbp/a/dPP9G5tCc8NNkbBj6cbjcwk/?lang=pt

Tzadok, M., Uliel-Siboni, S., Linder, I., Kramer, U., Epstein, O., Menascu, S., Nissenkorn, A., Yosef, O. B., Hyman, E., Granot, D., Dor, M., Lerman-Sagie, T., & Ben-Zeev, B. (2016). CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Seizure, 35, 41–44. https://doi.org/10.1016/j.seizure.2016.01.004

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x

Zuardi, A. W. (2006). História da cannabis como medicamento: uma revisão. Revista Brasileira de Psiquiatria, 153-157 SciElo. https://www.scielo.br/j/rbp/a/ZcwCkpVxkDVRdybmBGGd5NN/abstract/?lang=en

Published

24/11/2021

How to Cite

LIMA, H. L. V. .; SANTOS , J. da S. .; SILVA, J. E. de S. Use of Cannabis sativa in the treatment of epilepsy - a literature review. Research, Society and Development, [S. l.], v. 10, n. 15, p. e170101522553, 2021. DOI: 10.33448/rsd-v10i15.22553. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22553. Acesso em: 20 apr. 2024.

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Section

Review Article