HTLV seroprevalence in pregnant women: integrative review
DOI:
https://doi.org/10.33448/rsd-v10i15.22755Keywords:
Seroprevalent; HTLV; T lymphocyte; Pregnant.Abstract
Introduction: Speculated that about 10 to 20 million individuals are contaminated by HTLV in the world. Brazil reaches the top positions in the ranking. The means of spreading the virus occur through breastfeeding, vertical, sexual and parenteral transmission. The marker to identify the high risk of TMI is the PVL of HLTV-1 in mononuclear cells in the peripheral blood of the pregnant woman. Objective: to investigate the seroprevalence of HTLV in pregnant women, performing an integrative review of the subject in question and to analyze the preventive forms for the offspring of the host. Methodology: Refers to an integrative review using online databases such as: Google School, BIREME, SCIELO, PUBMED, FIOCRUZ, MS, USP, LILACS, Science Direct. Results and Discussions: The complexity of diagnosing mild cases located in plasma and the scarcity of confirmatory tests for the detection of anti-HTLV by PCR, ELISA or Western Blot, complicate the diagnosis of ATLL in adults aged 20 to 30 years, which occurs after the infection in children. Breastfeeding becomes the main route of transmission, surpassing the cases reported by sexual and parenteral routes. However, since research on transmission, whether by sexual route or TMI, is not employed in Brazil, it causes recurrent endemicity in the country. Making the prevention of the incidence the most appropriate means of combating it, since there are no vaccines or treatment. Conclusion: The SUS needs to improve epidemiological research to investigate endemicity and provide tracking and assistance for HIV-positive pregnant women.
References
Alcarraz Alfaro, W. & Quispe Huaraca, Y. Y. (2019). Prevalencia y factores determinantes del vírus linfotrópico de células T humanas I-II (HTLV I-II) em donantes voluntários en Banco de sangre del hospital sub regional de Andahuaylas, durante el periodo 2012-2016. Tese do programa de segunda especialidad de ciências biológicas. Trujillo, Perú. http://dspace.unitru.edu.pe/handle/UNITRU/15153.
Alcântara Maneschy, C. Barile, K.A. Castro, J.A. Palmeira, M. Castro, R. & Amaral, C.E. (2021). Epidemiological and Molecular Profile of Blood Donors Infected With HTLV-1/2 in the State of Pará, Northern Brazil. Braz J Microbiol. 2021 Dec;52(4):2001-2006. 10.1007/s42770-021-00609-w.
BRASIL. (2017). Ministério da Saúde. Gabinete do Ministro. Portaria nº 2.349, de 14 de setembro. https://www.in.gov.br/materia/-/asset_publisher/Kujrw0TZC2Mb/ content/id/19308017/do1-2017-09-22-portaria-n-2-349-de-14-de-setembro-de-2017—9307768.
Casseb, J. (2020). Manejo multidisciplinar de pessoas vivendo com HTLV: Vírus Linfotrópico de Células T Humanas. Lura Editorial. ISBM: 9786586626278.
D Oliveira, P. Kachimarek, A. C. & Bittencourt, A. L. (2018). Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Searchand Review. Journal of Tropical Pediatrics, 64, 151–161. 10.1093/tropej/fmx039.
Eusebio‐Ponce, E. Candel, F. J. & Anguita, E. (2019). Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America. Tropical Medicine International Health, 24(8), 934-953. 10.1111/tmi.13278.
Garcia, I. F. S. & Hennington, E. A. (2019). HTLV: uma infecção estigmatizante? Cadernos de Saúde Pública, 35 (11). 10.1590/0102-311X00005419.
Janampa, A. Magda, M. Viacaba, R. & Elizabeth S. (2020). Seroprevalencia Del Virus Linfotropico Humano (HTLV I/II) em donantes de sangre del Hospital Regional de Ayacucho entre los años 2015 al 2018. Tese do programa de segunda especialidad de ciências biológicas. Trujillo, Perú. Recuperado de http://dspace.unitru.edu.pe/handle/UNITRU/15725.
Kassay N. Mótyán J.A. Matúz K. Golda M. & Tőzsér J. (2021). Biochemical Characterization, Specificity and Inhibition Studies of HTLV-1, HTLV-2, and HTLV-3 Proteases. Life (Basel). Feb 6;11(2):127. 10.3390/life11020127.
Mata, E. C. G. Bezerra, R. M. Proietti Junior, A. A. Pamplona, L.K.S. Gomes, L.O. Corrêa, V. C. Caluff, J.S.R. Borges, G.S. Casseb, J.S.R. & Kanzaki, L.I.B. (2018). HTLV-1/2 prevalence in two Amazonian communities. Journal of Virus Eradication. 4(3), 174-178.
Mendes M. F. C. Lima J. R. O. Melo B. O. Pinto C. M. F. S. Maia, H. S. Ferro T. A. F. Monteiro S. G. Stancioli E. F. B. & Bomfim M. R. Q. (2020). Molecular detection of human T cell lymphotropic virus type 1 in pregnant women from Maranhão state, Brazil. Braz J Microbiol. Jun;51(2):637-645. 10.1007/s42770-020-00233-0.
Morais, M. P. E. Gato, C. M. Maciel, L. A. Lalwani, P. Costa, C. A. & Lalwani, J. D. B. (2017). Prevalence of Human T-lymphotropic vírus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 59. 0.1590/S1678-9946201759080.
Organização Mundial Da Saúde. (2021). Temas nutricionais: Aleitamento Materno. Recuperados de http://www.who.int/nutrition/topics/exclusive. Acesso em: 07 jun.
Paiva, A. M. (2016). Infecção pelo vírus linfotrópico de células T humanas do tipo 1 (HTLV-1) em uma coorte acompanhada em São Paulo. Tese de Doutorado, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo. 10.11606/T.99.2017.tde-23032017-132706.
Penova, M. Kawaguchi, S. Yasunaga, J. Kawaguchi, T. Sato, T. Takahashi, M. Shimizu, M. Saito, M. Tsukasaki, K... et al. (2021). Genome wide association study of HTLV-1–associated myelopathy/ tropical spastic paraparesis in the Japanes e population. Proceedings of the National Academy of Sciences, 118(11). 10.1073/pnas.2004199118.
Pereira, F. M. (2019). Taxa de infecção do vírus linfotrópico de células humanas (HTLV), vírus da hepatite C (HCV), coinfecção HTLV/HCV no Estado da Bahia e impacto da coinfecção HTLV/HCV no perfil de citocinas. Tese de Doutorado. Instituto Gonçalo Moniz. https://www.arca.fiocruz.br/handle/icict/39637.
Prendergast, A. J. Goga, A. E. Waitt, C. Gessain, A. Taylor, G. P. Rollins, N. de Perre, P. V... et al. (2019). Transmission of CMV, HTLV-1, and HIV through breas milk. The Lancet: Child Adolescent Health, 3(4), 264–273. 10.1016/S2352-4642(19)30024-0.
Puccioni-Sohler, M. Grassi, M. F. R. Galvão-Castro, B. Group, Caterino, A. Vicente, A. C. P. Vallinoto, A. C... et al. (2019). Increasing awareness of human T-lymphotropic virus type-1 infection: a serious, invisible, and neglected health problem in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 52. 10.1590/0037-8682-0343-2019.
Ramos-Rincón, J. M. Martínez, S. O. Chasnamote, M. E. V. Balsa, E. M. Paredes, O. N. G. Albujar, M. J. T... et al. (2021). Screening for Human T-CellLymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Reviewwith Meta-Analysis of HTLV Infection in Peru. Pathogens, 25; 10 (3): 260. 10.3390/pathogens10030260.
Rosadas, C. Brites, C. Sanchez, D. A. Casseb, J. & Ishak, R. (2021). Protocolo Brasileño para Infecciones de Transmisión Sexual 2020: infección por vírus linfotrópico de células T humanas (HTLV). Epidemiologia e Serviços de Saúde, 30. 10.1590/S1679-497420200006000015.esp1.
Santos, C. M. Aguiar, R. S. Bencz, E. Amorim, V. O. Barreto, Í. D. C. Ramos, E. R. P. & Góes, M. A. O. (2020). Seroprevalence of human T-cell lymphotropic virus I and II (HTLV I/II) among blood donors in a public blood center of Sergipe State, northeastern Brazil. Original Article. 31(3). 96-101. 10.5327/DST-2177-8264-201931305.
Silva, I. C. Pinheiro, B. T. Nobre, A. F. S. Coelho, J. L. Pereira, C. C. C. Ferreira, L. S. C. Almeida, C. P. S. Viana, M. N. S. A... et al. (2018). Moderada endemicidade da infecção pelo vírus linfotrópico-T humano na região metropolitana de Belém, Pará, Brasil. Revista Brasileira de Epidemiologia, 21. 10.1590/1980-549720180018.
Siravelha, L. Q. (2018). Obtenção de peptídeos recombinantes por meio da técnica de phage display para aplicação no diagnóstico da infecção pelo vírus linfotrópico de células t humana 1 (htlv-1). Tese de doutorado (Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários) - Instituto de Ciências Biológicas da Universidade Federal do Pará, Belém-Pará, f. 92. http://hdl.handle.net/1884/26434.
Takatani, M. Crispim, M. E. Fraiji, N. Stefani, M. & Kiesslich, D. (2017). Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic parapares is from the Brazilian Amazon. Revista do Instituto de Medicina Tropical de São Paulo. 59. 10.1590/S1678-9946201759005.
Yendewa, G. A. Lakoh, S. Yendewa, S. A. Bangura, K. Lawrence, H. Patino, L. Jiba, D. F. Vandy, A. O. Murray, M. J. S... et al. (2021). Prevalence of hepatitis B surface antigen and serological markers of other endemic infections in HIV-infected children, adolescents and pregnant women in Sierra Leone: A cross-sectional study. International Journal of Infectious Diseases. 102, 45-52. 10.1016/j.ijid.2020.09.1459.
Zihlmann, K. F. Mazzaia, M. C. & Alvarenga, A. T. (2017). Meanings of breastfeeding interruption due to infection by human T cell lymphotrophic vírus type 1 (HTLV-1). Acta Paulista de Enfermagem, 30, 80-86. 10.1590/1982- 0194201700012.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Luiza Aragão Paiva Pires Ferreira Mendes; Nagila Iane Pacheco; Jorge Davi de Sousa e Silva; Gabriel de Sousa Carneiro; Danielle Costa Lopes; Ivanira Vieira Loiola Coutinho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
