Inertial sensors in the motor assessment of Parkinson's Disease in patients who underwent Pallidotomy

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22825

Keywords:

Parkinson Disease; Symptom assessment; Pallidotomy.

Abstract

Parkinson's Disease is a neurodegenerative disorder with a great global impact and, despite recent advances, it still needs improvement in the methods for assessing motor alterations. This study aimed at evaluating a system (hardware and software) capable of accurately quantifying tremor in patients with Parkinson's disease that underwent pallidotomy. The Mean Absolute Value (MAV) of the involuntary activity of three patients that underwent pallidotomy surgery - in the pre and postoperative scenarios- was evaluated. The Mean Absolute Value of involuntary activity obtained through the suggested device (TREMSEN) showed a good correlation with the clinical findings, as well as with the findings already described in previous studies. The present study showed that MAV alterations were always positively related to tremor, or negatively related to bradykinesia and rigidity, or possibly both. A tendency towards greater tremor influence on the MAV than bradykinesia and rigidity was also observed. The positive correlation among the values measured by the TREMSEN device and the patients´ clinical result opens doors for the future application of technology, such as accurate and objective assessment of motor disorders, continuous monitoring and remote monitoring.

References

Arora, S., Venkataraman, V., Zhan, A., Donohue, S., Biglan, K. M., Dorsey, E. R., & Little, M. A. (2015). Detecting and monitoring the symptoms of Parkinson’s disease using smartphones: A pilot study. Parkinsonism and Related Disorders, 21(6), 650–653. https://doi.org/10.1016/j.parkreldis.2015.02.026

Ascherio, A., & Schwarzschild, M. A. (2016). The epidemiology of Parkinson’s disease: risk factors and prevention. The Lancet Neurology, 15(12), 1257–1272. https://doi.org/10.1016/S1474-4422(16)30230-7

Balás, I., Llumiguano, C., & Dóczi, T. P. (2006). Ablative stereotactic surgery improves manual performance time in Parkinson’s disease. Parkinsonism and Related Disorders, 12(4), 223–227. https://doi.org/10.1016/j.parkreldis.2005.11.010

de Oliveira Andrade, A., Paixão, A. P. S., Cabral, A. M., Rabelo, A. G., Luiz, L. M. D., Dionísio, V. C., Vieira, M. F., Pereira, J. M., Rueda, A., Krishnan, S., & Pereira, A. A. (2020). Task-Specific Tremor Quantification in a Clinical Setting for Parkinson’s Disease. Journal of Medical and Biological Engineering, 40(6), 821–850. https://doi.org/10.1007/s40846-020-00576-x

Defer, G.-L., Widner, H., Marié, R.-M., Rémy, P., Levivier, M., & Participants, C. (1999). Core Assessment Program for Surgical Interventional Therapies in Parkinson’s Disease (CAPSIT-PD). Movement Disorders, 14(4), 572–584. www.bm.lu.se/

Elbaz, A., Carcaillon, L., Kab, S., & Moisan, F. (2016). Epidemiology of Parkinson’s disease. Revue Neurologique, 172(1), 14–26. https://doi.org/10.1016/j.neurol.2015.09.012

Esselink, R. A. J., de Bie, R. M. A., de Haan, R. J., Steur, E. N. H. J., Beute, G. N., Portman, A. T., Schuurman, P. R., Bosch, D. A., & Speelman, J. D. (2006). Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in Parkinson’s disease: One year follow-up of a randomised observer-blind multi centre trial. Acta Neurochirurgica, 148(12), 1247–1255. https://doi.org/10.1007/s00701-006-0907-1

Gibb, G., & Lees, A. J. (1988). The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. Neurosurgery, and Psychiatry, 51, 745–752.

Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., & Zweig, R. M. (2008). Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129–2170. https://doi.org/10.1002/mds.22340

Hariz, M. I., & Bergenheim, A. T. (2001). A 10-year follow-up review of patientes who underwent Leksell´s posteroventral pallidotomy for Parkinson disease. J Neurosurg, 94, 552–558.

Hua, Z., Guodong, G., Qinchuan, L., Yaqun, Z., Qinfen, W., & Xuelian, W. (2003). ANALYSIS OF COMPLICATIONS OF RADIOFREQUENCY PALLIDOTOMY. Neurosurgery, 52, 89–101. https://doi.org/10.1227/01.NEU.0000038933.95427.AE

Laitinen, L. V., Bergenheim, A. T., & Hariz, M. I. (1992). Ventroposterolateral Pallidotomy Can Abolish All Parkinsonian Symptoms. Stereotact Funct Neurosurg, 58, 14–21.

Lozano, A., Hutchison, W., Kiss, Z., Tasker, R., Davis, K., & Dostrovsky, J. (1996). Methods for microelectrode-guided posteroventral. J Neurosurg, 84, 194–202.

Lozano, A. M., Lang, A. E., & Hutchison, W. D. (1998). Pallidotomy for tremor. Movement Disorders, 13(SUPPL. 3), 107–110. https://doi.org/10.1002/mds.870131319

Mera, T. O., Burack, M. A., & Giuffrida, J. P. (2013). Objective motion sensor assessment highly correlated with scores of global levodopa-induced dyskinesia in Parkinson’s disease. Journal of Parkinson’s Disease, 3(3), 399–407. https://doi.org/10.3233/JPD-120166

Monje, M. H. G., Foffani, G., Obeso, J., & Sánchez-Ferro, Á. (2019). New Sensor and Wearable Technologies to Aid in the Diagnosis and Treatment Monitoring of Parkinson’s Disease. Annual Review of Biomedical Engineering, 21, 111–143. https://doi.org/10.1146/annurev-bioeng-062117

Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., Halliday, G., Goetz, C. G., Gasser, T., Dubois, B., Chan, P., Bloem, B. R., Adler, C. H., & Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson’s disease. Movement Disorders, 30(12), 1591–1601. https://doi.org/10.1002/mds.26424

Ray Dorsey, E., Elbaz, A., Nichols, E., Abd-Allah, F., Abdelalim, A., Adsuar, J. C., Ansha, M. G., Brayne, C., Choi, J. Y. J., Collado-Mateo, D., Dahodwala, N., Do, H. P., Edessa, D., Endres, M., Fereshtehnejad, S. M., Foreman, K. J., Gankpe, F. G., Gupta, R., Hankey, G. J., & Murray, C. J. L. (2018). Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 939–953. https://doi.org/10.1016/S1474-4422(18)30295-3

Rigas, G., Tzallas, A. T., Tsipouras, M. G., Bougia, P., Tripoliti, E. E., Baga, D., Fotiadis, D. I., Tsouli, S. G., & Konitsiotis, S. (2012). Assessment of tremor activity in the parkinsons disease using a set of wearable sensors. IEEE Transactions on Information Technology in Biomedicine, 16(3), 478–487. https://doi.org/10.1109/TITB.2011.2182616

Spindola, B., Leite, M. A., Orsini, M., Fonoff, E., Landeiro, J. A., & Pessoa, B. L. (2017). Ablative surgery for Parkinson’s disease: Is there still a role for pallidotomy in the deep brain stimulation era? Clinical Neurology and Neurosurgery, 158, 33–39. https://doi.org/10.1016/j.clineuro.2017.04.018

Tysnes, O. B., & Storstein, A. (2017). Epidemiology of Parkinson’s disease. Journal of Neural Transmission, 124(8), 901–905. https://doi.org/10.1007/s00702-017-1686-y

Yang, K., Xiong, W. X., Liu, F. T., Sun, Y. M., Luo, S., Ding, Z. T., Wu, J. J., & Wang, J. (2016). Objective and quantitative assessment of motor function in Parkinson’s disease-from the perspective of practical applications. Annals of Translational Medicine, 4(5). https://doi.org/10.21037/atm.2016.03.09

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Published

28/11/2021

How to Cite

ESCUDEIRO, G. P.; ANDRADE, A. de O.; CABRAL, A. M.; LEITE, M. A. A.; MONTEIRO, L. V.; SILVA, I. D. G. da .; PESSÔA, B. L. Inertial sensors in the motor assessment of Parkinson’s Disease in patients who underwent Pallidotomy. Research, Society and Development, [S. l.], v. 10, n. 15, p. e373101522825, 2021. DOI: 10.33448/rsd-v10i15.22825. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22825. Acesso em: 22 nov. 2024.

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Section

Health Sciences