Phytomedicines used in popular medicine and their underexplored potential
DOI:
https://doi.org/10.33448/rsd-v10i16.23017Keywords:
Biotechnology; Medicinal plants; Patents.Abstract
The study aimed to demonstrate that plant species commonly used in folk medicine, released for use by ANVISA and described in the scientific literature, have great therapeutic potential and have not yet been fully explored. A survey was carried out in the Brazilian Pharmacopoeia – ANVISA. From this survey, three plant species were randomly selected: Achyrocline satureioides, Echinodorus grandiflorus and Schinus terebinthifolius. Soon after, a technological survey of them was carried out in order to identify possible patents related to plant species. After searching the databases, a total of 28 patents for the species A. satureioides, 22 patents for the species E. grandiflorus and 38 patents for the species S. terebinthifolius were found. After using the inclusion and exclusion criteria, there remained a total of 8 patents for the species A. satureioides, 8 patents for the species E. grandiflorus and 8 patents for the species S. terebinthifolius. The number of patent filings involving plant species studied in the service sector and/or products aimed at human health is still reduced, since all species are already described in the scientific literature, are in common use in popular medicine and are part of of the Brazilian Pharmacopoeia. Furthermore, not all uses described by folk medicine through ethnopharmacological studies are covered.
References
Affonso, C. R. G., Fernandes, R. M., Oliveira, J. M. G., Martins, M. C. C. E., Lima, S. G., Sousa Júnior, G. R., et al. (2012). Efeitos do óleo essencial de frutos de Schinus terebinthifolius Raddi (Anacardiaceae) nas funções reprodutivas de ratos machos. Jornal da Sociedade Brasileira de Química, 23(1), 180-185.
Brasil. (2016). Política e Programa Nacional de Plantas Medicinais e Fitoterápicos - PNPMF.
Carvalho, E. S. (2018). Estudo do mecanismo vasorrelaxante do extrato etanólico e frações, das folhas de Echinodorus grandiflorus (Cham. & Schltdl.) Micheli, em leitos mesentéricos isolados. Dissertação, UFGD.
Costa, E. M. M. B., Barbosa, A. S., Arruda, T. A., Oliveira, P. T., Dametto, F. R., Carvalho, R. A., & Melo, M. D. (2010). Estudo in vitro da ação antimicrobiana de extratos de plantas contra Enterococcus faecalis. J. Bras. Patol. Med. Lab., 46(3), 175-180.
Dias, E. G. E., Valenzuela, V. C. T., Alves, M. R., Duarte, M. G. R., & Garcia, E. F. (2013). Qualidade e autenticidade de folhas de chapéu-de-couro (Echinodorus grandiflorus) oriundas de fornecedores de São Paulo. Rev. bras. plantas med., 15(2), 250-256.
Estevão, L. R. M., Simões, R. S., Cassini-Vieira, P., Canesso, M. C. C., Barcelos, L. S., Rachid, M. A. et al. (2017). Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice. Acta Cir Bras., 32(9), 726-35.
França, E., & Vasconcellos, A. G. (2018). Herbal Medicine Patents In Brazil: An Analysis Of Status Of Patent Applications In The Period Of 1995-2017. Cadernos de Ciência&Tecnologia, 35(3), 329-359.
Galvan, N.S. (2018). Teores de elementos essenciais e não essenciais em Achyrocline satureioides. Dissertassão, UDESC.
Guariniello, J., Iannicelli, J., Peralta, P. A., & Escandon, A. S. (2018). Propagação in vivo e in vitro da “macela”: planta medicinal aromática nativa com potencial ornamental. Ornam. Hortic., 24(4), 361-370.
Gutiérrez, I. E. M., Góes-Neto, A. (2012). Exploitation of Bioactive: Partnerships and Patents. Revista Fitos, 07(01).
hidroalcoólicos e alcoólicos de espécies da família anacardiaceae. Rev. Ciênc. Méd. Biol, 15(1), 56-61.
Lorenzi, H., Matos, F. J. A. (2002). Plantas medicinais no Brasil: nativas e exóticas cultivadas. (2a ed.), Instituto Plantarum.
Marques, A. M., Provance, D. W., Kaplan, M. A. C., & Figueiredo, M. R. (2017). Echinodorus grandiflorus: Ethnobotanical, phytochemical and pharmacological overview of a medicinal plant used in Brazil. FoodChemToxicol., 109(2), 1032-1047.
Mendonça, V. M., Silva-Mann, R., & Rabbani, A. R. C. (2014). Prospecção tecnológica de óleo essencial de aroeira-da-praia (Schinus terebinthifolius RADDI). Revista GEINTEC Gestão, Inovação e Tecnologia, 4(1), 704-715.
Oliveira, A. C. D., & Ropke, C. D. (2016). The ten years of the National Policy of Medicinal Plants and Herbal Medicines (PNPMF) and the main obstacles in the production chain of plant extracts and herbal medicines in Brazil. RevistaFitos, 10(2), 95-219.
Oliveira, M. B. a, Valentim, I. B., Rocha, T. S., Santos, J. C., Pires, K. S. N., Tanabe, E. L. L., et al. (2020). Schinus terebenthifolius Raddi extracts: from sunscreen activity toward protection of the placenta to Zika virus infection, new uses for a well-known medicinal plant. Industrial Crops and Products., 152, 112503.
Oliveira, V. S. b, Augusta, I. M, Braz, M. V. C., Riger, C. J, Prudêncio, E. R., Sawaya, A. C. H. F., et al. (2020). Aroeira fruit (Schinus terebinthifolius Raddi) as a natural antioxidant: Chemical constituents, bioactive compounds and in vitro and in vivo antioxidant capacity. Food Chemistry., 135, 126274.
Pereira, D. P., Silva, A. I. B., Nunes, L. E., Sá-Filho, G. F., & Ribeiro, L. H. F. (2021). Potencial biotecnológico da aroeira vermelha (schinus terebinthifolius raddi): uma revisão narrativa. Revista Saúde e Meio Ambiente – RESMA-UFMS- Três Lagoas, 13(1), 25-37.
Sá Junior, P. F., Muniz, E. B., Pereira, N. A., & Oliveira, M. A. S. (2016). Atividade antimicrobiana in vitro dos extratos aquosos,
Salgueiro, A., Folmer, V., Rosa, H. S., Costa, M. T, Boligon, A. A., Paula, F. R. et al. (2016). In vitro and in silico antioxidant and toxicological activities of Achyroclinesatureioides. JournalofEthnopharmacology, 194, 6-14.
Santos, A. A. J. C., Barros, B. R. S., Aguiar, L. M. S., & Patriota, L. L. S. (2020). Schinus terebinthifolia leaf lectin (SteLL) is an immunomodulatory agent by altering cytokine release by mice splenocytes. Biotech, 10, 144.
Silva, A. B., Silva,T., Franco, E. S., Rabelo, S. A., Lima, E. R., Mota, R. A., Câmara, C. A. G., Pontes Filho, N. T., & Lima Filho, J. V. (2010). Antibacterial activity, chemical composition, and cytotoxicity of leaf's essential oil from Brazilian pepper tree (Schinus terebinthifolius Raddi). Braz. J. Microbiol, 41(1).
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