Clinical, sociodemographic and outcome characteristics of pregnant women hospitalized with COVID-19

Authors

DOI:

https://doi.org/10.33448/rsd-v10i17.23049

Keywords:

Pregnancy; Coronavirus; Coronavirus Infections; Maternal Mortality; Pregnancy complications.

Abstract

This study aims to describe the clinical and epidemiological characteristics, risk factors and outcome of COVID-19 in pregnant women. This is a quantitative study with a descriptive approach. The sample consisted of 54 volunteers assisted in a high-risk maternity hospital located in Aracaju, Sergipe, Brazil. Data were extracted from medical records and analyzed as maternal sociodemographic variables related to prenatal care, participation and immediate puerperium, the presence or absence of symptoms of COVID-19, admission to the ICU and outcome. Data were generated using absolute and related frequencies. It was also calculated to mean, standard deviation, minimum value, and maximum value of the quantitative variables in IBM® SPSS. Pregnant women aged between 20 and 34 years (64.8%; n=35) and brown (61.1%; n=33) predominated. Regarding the mode of delivery, cesarean sections stood out (76.9%; n= 30). Symptoms such as headache (51.8%; n=28), fever (51.8%; n=28), cough (44.4%; n=24), runny nose (35.1%; n= 19) and dyspnea (20.3%; n=11). Most participants had at least some sign of severity (87%; n=47) and had comorbidities (77.7%; n=42). Three maternal deaths were registered. It is concluded that the presence of comorbidity was a relevant risk factor in participants who developed more severe disease, possibly indicating a predefined profile that contributes to a higher risk of severe maternal outcomes.

Author Biography

Jaqueline Guimarães Elói de Brito, Universidade Federal de Sergipe

Enfermeira pela Universidade Federal de Sergipe (2014-2019), Enfermeira Obstetra no Programa de Residência Multiprofissional da Universidade Federal de Sergipe e Mestranda em Enfermagem pelo Programa de Pós-Graduação da Universidade Federal de Sergipe. 

References

Allotey, J, Stallings, E., Bonet, M., Yap, M., Chatterjee, S., Kew, T. … Thangaratinam, S. (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. The BMJ, 370, m3320. Recuperado de https://www.bmj.com/content/370/bmj.m3320. Data de recuperado: 01 março 2021.

Amorim, M. M. R., Melo, A. S. O., Neto, A. H. F., & Oliveira, T. V. (2020). Protocolo de atendimento de pacientes com covid-19 (infecção suspeita ou confirmada) do instituto de saúde Elpídio de Almeida – ISEA. Recuperado de http://rehuna.org.br/wp-content/uploads/2020/04/PROTOCOLO-DE-CRISE-COVID19-ISEA.pdf

Brasil. Conselho Nacional de Saúde. (2012). Resolução nº 466, de 12 de dezembro de 2012. Recuperado de https://wp-sites.info.ufrn.br/admin/facisa/wp-content/uploads/sites/4/2020/07/RESOLU%C3%87%C3%95ES-466-12-510-16-e-580-18.pdf. Data de recuperado 10 dezembro 2021

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2021). Boletim Epidemiológico Especial COE- COVID-19 nº 44. Recuperado de https://www.gov.br/saude/pt-br/media/pdf/2021/janeiro/07/boletim_epidemiologico_covid_44.pdf

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2020). Boletim Epidemiológico Especial COE- COVID-19 nº 21. Recuperado de http://antigo.saude.gov.br/images/pdf/2020/July/08/Boletim-epidemiologico-COVID-21-corrigido-13h35--002-.pdf

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2021). Boletim Epidemiológico Especial COE- COVID-19 nº 86. Recuperado de https://www.gov.br/saude/pt-br/media/pdf/2021/outubro/29/boletim_epidemiologico_covid_86-final-_29out.pdf

Brasil. Ministério da Saúde. Secretaria de Atenção Primária à Saúde. (2021). Manual de recomendações para a assistência à gestante e puérpera frente à pandemia de Covid-19. 2. ed. Brasília: Ministério da Saúde, 2021. Recuperado de https://portaldeboaspraticas.iff.fiocruz.br/wp-content/uploads/2021/09/manual_assistencia_gestante.pdf. Data de recuperado: 09 dezembro 2021

Czeresnia, R. M., Trad, A. T. A., Britto, I. S. W., Negrini, R., Nomura, M. L., Pires, P. ... Ruano R. (2020). SARS-CoV-2 and Pregnancy: A Review of the Facts. Revista Brasileira de Ginecologia e Obstetrícia, 42 (9), 562-568. Recuperado de http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020000900562&lng=en. Data de recuperado: 01 março 2021

Dashraath, P., Wong, J. L. J., Lim, M. X. K., Lim, L. M., Li, S., Biswas, A. … Su, L. L. (2020). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. American Journal of Obstetrics & Gynecology, 222(6), 521-531. Recuperado de https://www.ajog.org/article/S0002-9378(20)30343-4/fulltext. Data de recuperado: 27 abril 2021

Elshafeey, F., Magdi, R., Hindi, N., Elshebiny, M., Farrag, N., Mahdy, S. … Nabhan, A. (2020). A systematic scoping review of COVID-19 during pregnancy and childbirth. International Journal of Gynecology & Obstetrics, 150(01), 47–52. Recuperado de https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.13182. Data de recuperado: 01 março 2021

Fiocruz. (2020). Pesquisa Nascer no Brasil: Inquérito Nacional sobre Parto e Nascimento. Recuperado de http://www6.ensp.fiocruz.br/nascerbrasil/questionarios-eletronicos/

Gajbhiye, R. K., Modi, D. N., & Mahale, S. D. (2020). Pregnancy outcomes, Newborn complications and Maternal-Fetal Transmission of SARS-CoV-2 in women with COVID-19: a systematic review of 441 cases. The BMJ. Recuperado de https://www.medrxiv.org/content/10.1101/2020.04.11.20062356v2. Data de recuperado: 05 julho 2020

Huang, C., Wang, Y., Li, X., Ren, L., Zhao J., Hu, Y., … Cao B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395, 497–506. Recuperado de https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext. Data de recuperado: 04 julho 2020

Jering, K. S., Claggett, B. L., Cunningham, J. W., Rosenthal, N., Vardeny, O., Greene, M. F., … Solomon, S. D. (2021). Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without Covid-19. JAMA Internal Medicine, 181 (5), 714-717. Recuperado de https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2775396. Data de recuperado: 20 junho 2021

Juan, J., Gil, M. M., Rong, Z., Zhang, Y., Yang H., & Poon L. C. (2020). Effects of Coronavirus Disease 2019 (COVID-19) on Maternal, Perinatal and Neonatal Outcomes: a Systematic Review of 266 Pregnancies. The BMJ, 56,15–27. Recuperado de https://www.medrxiv.org/content/10.1101/2020.05.02.20088484v1. Data de recuperado: 5 julho 2020

Knight, M., Bunch, K., Vousden, N., Morris, E., Simpson, N., Gale, C. … Kurinczuk, J. J. (2020). Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. The BMJ, 369, m2107. Recuperado de https://www.bmj.com/content/369/bmj.m2107. Data de recuperado: 22 fevereiro 2021

Ko, J.Y., DeSisto, C. L., Simeone, R. M., Ellington, S., Galang, R. R., Oduyebo, T., ... Shapiro-Mendoza, C. K. (2021). Adverse pregnancy outcomes, maternal complications, and severe illness among US delivery hospitalizations with and without a Coronavirus disease 2019 (COVID-19) diagnosis. Clinical Infectious Diseases, 73, S24–31. Recuperado de https://academic.oup.com/cid/article/73/Supplement_1/S24/6274300. Data de recuperado: 31 outubro 2021

Lima, R. C. H. M. (2021). Cartilha Direito Sexuais e Reprodutivos das Mulheres. Brasília: Escola de Assistência Jurídica da Defensoria Pública. Recuperado de https://www.planaltina.df.gov.br/wp-conteudo//uploads/2021/07/Cartilha_Direito_Sexuais_e_Reprodutivos_das_Mulheres.pdf. Data de recuperado: 31 outubro 2021

Martinez-Portilla, R. J., Sotiriadis, A., Chatzakis, C., Torres-Torres, J., Espino Y Sosa, S., Sandoval-Mandujano, K., ... Poon, L. C. (2021). Pregnant women with SARS-CoV-2 infection are at higher risk of death and pneumonia: propensity score matched analysis of a nationwide prospective cohort (COV19Mx). Ultrasound in Obstetrics & Ginecology, 57(2), 224-231. Recuperado de https://pubmed.ncbi.nlm.nih.gov/33320401/. Data de recuperado: 20 junho 2021

Mendoza, M., Garcia-Ruiz, I., Maiz, N., Rodo, C., Garcia-Manau, P., Serrano, B., ... Suy, A. (2020). Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. An International Journal of Obstetrics and Gynaecology, 127(11), 1374-1380. Recuperado de https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.16339. Data de recuperado: 04 julho 2020

Organização Mundial da Saúde. (2020). Q&A on coronaviruses (COVID-19). Genebra. Recuperado de https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/q-a-coronaviruses. Data de recuperado: 04 julho 2021.

Panahi, L., Amiri, M., & Pouy, S. (2020). Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy: a Narrative Review. Archives of Academic Emergency Medicine, 8(1), e34. Recuperado de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092922/. Data de recuperado: 28 fevereiro 2021

Schwartz, D. A., & Dhaliwal, A. (2020). Infections in pregnancy with covid-19 and other respiratory rna virus diseases are rarely, if ever, transmitted to the fetus: experiences with coronaviruses, HPIV, hMPV RSV, and Influenza. Archives of Pathology & Laboratory Medicine, 144, 920-8. Recuperado de https://meridian.allenpress.com/aplm/article/144/8/920/442144/Infections-in-Pregnancy-With-COVID-19-and-Other. Data de recuperado: 27 abril 2021

Souza, A. S. R., & Amorim, M. M. R. (2021). Mortalidade materna pela COVID-19 no Brasil. Revista Brasileira de Saúde Materno Infantil, 21(Suppl1), 253-256. Recuperado de http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292021000100253&lng=pt. Data de recuperado: 01 março 2021

Takemoto, M. L. S., Menezes, M. O., Andreucci, C. B., Nakamura‐Pereira, M., Amorim, M. M., Katz, L., … Knobel, R. (2020). The tragedy of COVID‐19 in Brazil: 124 maternal deaths and counting. International Journal of Gynecology & Obstetrics, 151, 154-6. Recuperado de https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/ijgo.13300. Data de recuperado: 01 março 2021

The American College of Obstetricians and Gynecologists (ACOG). (2020). COVID-19 FAQs for Obstetrician-Gynecologists, Obstetrics. Recuperado de /www.acog.org/clinical-information/physician-faqs/covid-19-faqs-for-ob-gyns-obstetrics. Data de recuperado: 28 fevereiro 2021

Verity, R., Okell, L. C., Dorigatti, I., Winskill, P., Whittaker, C., Imai, N., ... Ferguson, N. M. (2020). Estimates of the severity of coronavirus disease 2019: a model-based analysis. The Lancet Infections Diseases, 20, 669-677. Recuperado de https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30243-7/fulltext. Data de recuperado: 4 julho 2020

Wen, R., Sun, P., & Xing, Q-S. (2020). A Patient with SARS-CoV-2 Infection during Pregnancy in Qingdao, China. Journal of Microbiology, Immunology and Infection, 3–4. Recuperado de https://doi.org/10.1016/j.jmii.2020.03.004. Data de recuperado: 25 março 2021

Yu, N., Li, W., Kang, Q., Xiong, Z., Wang, S., Lin, X., … Wu, J. (2020). Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. The Lancet Infections Diseases, 3099(20), 1–6. Recuperado de https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30176-6/fulltext. Data de recuperado: 25 março 2021

Zaigham, M., & Andersson, O. (2020). Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstetricia ET Gynecologica Scandinavica, 99(07), 823–829. Recuperado de https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.13867. Data de recuperado: 28 fevereiro 2021

Zamaniyan, M., Ebadi, A., Aghajanpoor, M. S., Rahmani, Z., Haghshenas, M., … Azizi, S. (2020). Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission. Prenatal Diagnosis, 40, 1759–1761. Recuperado de https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/pd.5713. Data de recuperado: 28 fevereiro 2021

Published

20/12/2021

How to Cite

BRITO, J. G. E. de; ALENCAR, C. C. A. de; LEMOS, A. C.; CAETANO, C. L. dos R.; MENEZES, M. O.; BARREIRO, M. do S. C. Clinical, sociodemographic and outcome characteristics of pregnant women hospitalized with COVID-19 . Research, Society and Development, [S. l.], v. 10, n. 17, p. e33101723049, 2021. DOI: 10.33448/rsd-v10i17.23049. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/23049. Acesso em: 27 jan. 2022.

Issue

Section

Health Sciences